Last Name

Eduardo Rios

InstitutionRush University, Rush Medical College
DepartmentPhysiology and Biophysics
Address1750 West Harrison St
Chicago IL 60612
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    My Scopus ID is 7101859118.

    Research Areas:
    Signals that control contraction in skeletal and cardiac muscle.

    My Faculty Profile at Rush University Medical Center:

    My Laboratory:

    My NCBI Bibliography:

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    School of Medicine, Uruguay National University
    School of Engineering, Montevideo, Uruguay
    School of Sciences, Montevideo, Uruguay

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ferreira Gregorio J, Pequera G, Manno C, Ríos E, Brum G. The voltage sensor of excitation-contraction coupling in mammals: Inactivation and interaction with Ca2. J Gen Physiol. 2017 Nov 06; 149(11):1041-1058. PMID: 29021148.
      View in: PubMed
    2. Ríos E. Perspectives on "Control of Ca release from within the cardiac sarcoplasmic reticulum". J Gen Physiol. 2017 Sep 04; 149(9):833-836. PMID: 28798278.
      View in: PubMed
    3. Palau J, Sancho E, Herrera M, Sánchez S, Mingot ME, Upegui RI, Rodríguez Salazar MJ, de la Cruz F, Fernández MC, González López TJ, Hernández JJ, Ríos E, López-Fernández MF, García M, Hernández JÁ, Sanz MA. Characteristics and management of primary and other immune thrombocytopenias: Spanish registry study. Hematology. 2017 Sep; 22(8):484-492. PMID: 28415913.
      View in: PubMed
    4. Manno C, Figueroa LC, Gillespie D, Fitts R, Kang C, Franzini-Armstrong C, Rios E. Calsequestrin depolymerizes when calcium is depleted in the sarcoplasmic reticulum of working muscle. Proc Natl Acad Sci U S A. 2017 01 24; 114(4):E638-E647. PMID: 28069951.
      View in: PubMed
    5. Lewis KM, Munske GR, Byrd SS, Kang J, Cho HJ, Ríos E, Kang C. Characterization of Post-Translational Modifications to Calsequestrins of Cardiac and Skeletal Muscle. Int J Mol Sci. 2016 Sep 13; 17(9). PMID: 27649144.
      View in: PubMed
    6. Campos LM, Rios EA, Guapyassu L, Midlej V, Atella GC, Herculano-Houzel S, Benchimol M, Mermelstein C, Costa ML. Alterations in zebrafish development induced by simvastatin: Comprehensive morphological and physiological study, focusing on muscle. Exp Biol Med (Maywood). 2016 11; 241(17):1950-1960. PMID: 27444151.
      View in: PubMed
    7. Lewis KM, Ronish LA, Ríos E, Kang C. Characterization of Two Human Skeletal Calsequestrin Mutants Implicated in Malignant Hyperthermia and Vacuolar Aggregate Myopathy. J Biol Chem. 2015 Nov 27; 290(48):28665-74. PMID: 26416891.
      View in: PubMed
    8. Saumell S, Solé F, Arenillas L, Montoro J, Valcárcel D, Pedro C, Sanzo C, Luño E, Giménez T, Arnan M, Pomares H, De Paz R, Arrizabalaga B, Jerez A, Martínez AB, Sánchez-Castro J, Rodríguez-Gambarte JD, Raya JM, Ríos E, Rodríguez-Rivera M, Espinet B, Florensa L. Trisomy 8, a Cytogenetic Abnormality in Myelodysplastic Syndromes, Is Constitutional or Not? PLoS One. 2015; 10(6):e0129375. PMID: 26066831; PMCID: PMC4466575.
    9. Ríos E, Figueroa L, Manno C, Kraeva N, Riazi S. The couplonopathies: A comparative approach to a class of diseases of skeletal and cardiac muscle. J Gen Physiol. 2015 Jun; 145(6):459-74. PMID: 26009541.
      View in: PubMed
    10. Campos LM, Rios EA, Midlej V, Atella GC, Herculano-Houzel S, Benchimol M, Mermelstein C, Costa ML. Structural analysis of alterations in zebrafish muscle differentiation induced by simvastatin and their recovery with cholesterol. J Histochem Cytochem. 2015 06; 63(6):427-37. PMID: 25786435; PMCID: PMC4872197.
    11. Manno C, Ríos E. A better method to measure total calcium in biological samples yields immediate payoffs. J Gen Physiol. 2015 Mar; 145(3):167-71. PMID: 25712015; PMCID: PMC4338160.
    12. Stern MD, Ríos E, Maltsev VA. Life and death of a cardiac calcium spark. J Gen Physiol. 2013 Sep; 142(3):257-74. PMID: 23980195; PMCID: PMC3753601.
    13. Manno C, Figueroa L, Royer L, Pouvreau S, Lee CS, Volpe P, Nori A, Zhou J, Meissner G, Hamilton SL, Ríos E. Altered Ca2+ concentration, permeability and buffering in the myofibre Ca2+ store of a mouse model of malignant hyperthermia. J Physiol. 2013 Sep 15; 591(18):4439-57. PMID: 23798496; PMCID: PMC3784192.
    14. Santiago DJ, Ríos E, Shannon TR. Isoproterenol increases the fraction of spark-dependent RyR-mediated leak in ventricular myocytes. Biophys J. 2013 Mar 05; 104(5):976-85. PMID: 23473480; PMCID: PMC3591256.
    15. Manno C, Figueroa L, Fitts R, Ríos E. Confocal imaging of transmembrane voltage by SEER of di-8-ANEPPS. J Gen Physiol. 2013 Mar; 141(3):371-87. PMID: 23440278; PMCID: PMC3581694.
    16. Figueroa L, Shkryl VM, Blatter LA, Ríos E. Using two dyes with the same fluorophore to monitor cellular calcium concentration in an extended range. PLoS One. 2013; 8(2):e55778. PMID: 23409040; PMCID: PMC3567097.
    17. Ríos E. On an early demonstration of the cell boundary theorem. J Physiol Sci. 2013 Mar; 63(2):161. PMID: 23263920.
      View in: PubMed
    18. Manno C, Sztretye M, Figueroa L, Allen PD, Ríos E. Dynamic measurement of the calcium buffering properties of the sarcoplasmic reticulum in mouse skeletal muscle. J Physiol. 2013 Jan 15; 591(2):423-42. PMID: 23148320; PMCID: PMC3577525.
    19. Else M, Marín-Niebla A, de la Cruz F, Batty P, Ríos E, Dearden CE, Catovsky D, Matutes E. Rituximab, used alone or in combination, is superior to other treatment modalities in splenic marginal zone lymphoma. Br J Haematol. 2012 Nov; 159(3):322-8. PMID: 23016878.
      View in: PubMed
    20. Shkryl VM, Blatter LA, Ríos E. Properties of Ca2+ sparks revealed by four-dimensional confocal imaging of cardiac muscle. J Gen Physiol. 2012 Mar; 139(3):189-207. PMID: 22330954; PMCID: PMC3289960.
    21. Figueroa L, Shkryl VM, Zhou J, Manno C, Momotake A, Brum G, Blatter LA, Ellis-Davies GC, Ríos E. Synthetic localized calcium transients directly probe signalling mechanisms in skeletal muscle. J Physiol. 2012 Mar 15; 590(6):1389-411. PMID: 22310315; PMCID: PMC3382330.
    22. Sztretye M, Yi J, Figueroa L, Zhou J, Royer L, Allen P, Brum G, Ríos E. Measurement of RyR permeability reveals a role of calsequestrin in termination of SR Ca(2+) release in skeletal muscle. J Gen Physiol. 2011 Aug; 138(2):231-47. PMID: 21788611; PMCID: PMC3149434.
    23. Sztretye M, Yi J, Figueroa L, Zhou J, Royer L, Ríos E. D4cpv-calsequestrin: a sensitive ratiometric biosensor accurately targeted to the calcium store of skeletal muscle. J Gen Physiol. 2011 Aug; 138(2):211-29. PMID: 21788610; PMCID: PMC3149433.
    24. Yi J, Ma C, Li Y, Weisleder N, Ríos E, Ma J, Zhou J. Mitochondrial calcium uptake regulates rapid calcium transients in skeletal muscle during excitation-contraction (E-C) coupling. J Biol Chem. 2011 Sep 16; 286(37):32436-43. PMID: 21795684; PMCID: PMC3173159.
    25. Casado LF, García Marco JA, Gilsanz F, González M, Ríos E, de la Serna J, Urbano A, Vicente V, Rubio-Terrés C, Castro AJ. [Economic evaluation of rituximab added to fludarabine plus cyclophosphamide versus fludarabine plus cyclophosphamide for the treatment of chronic lymphocytic leukemia]. Gac Sanit. 2011 Jul-Aug; 25(4):274-81. PMID: 21664727.
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    26. Alegre A, Aguado B, Giraldo P, Ríos E, Cánovas A, Ibáñez Á, Castillo I, Hernández MT, Oriol A, Palomera L, Rodríguez JN, García FL, Calvo JM, Martínez-Chamorro C, de la Serna J, Lahuerta JJ. Lenalidomide is effective as salvage therapy in refractory or relapsed multiple myeloma: analysis of the Spanish Compassionate Use Registry in advanced patients. Int J Hematol. 2011 Mar; 93(3):351-360. PMID: 21360065.
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    27. Vallejo C, Ríos E, de la Serna J, Jarque I, Ferrá C, Sánchez-Godoy P, Solano C, de la Cámara R, Rosell AI, Varela R, García MD, González-Barca E, López J, Pérez E, Ferrer S, Casado LF, Vázquez L, Villalón L, García-Marco JA. Incidence of cytomegalovirus infection and disease in patients with lymphoproliferative disorders treated with alemtuzumab. Expert Rev Hematol. 2011 Feb; 4(1):9-16. PMID: 21322774.
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    28. Ríos E. RyR1 expression and the cell boundary theorem. J Biol Chem. 2010 Aug 20; 285(34):le13; author reply le14. PMID: 20709761; PMCID: PMC2924118.
    29. Royer L, Sztretye M, Manno C, Pouvreau S, Zhou J, Knollmann BC, Protasi F, Allen PD, Ríos E. Paradoxical buffering of calcium by calsequestrin demonstrated for the calcium store of skeletal muscle. J Gen Physiol. 2010 Sep; 136(3):325-38. PMID: 20713548; PMCID: PMC2931149.
    30. Santiago DJ, Curran JW, Bers DM, Lederer WJ, Stern MD, Ríos E, Shannon TR. Ca sparks do not explain all ryanodine receptor-mediated SR Ca leak in mouse ventricular myocytes. Biophys J. 2010 May 19; 98(10):2111-20. PMID: 20483318; PMCID: PMC2872235.
    31. Di Prinzio CM, Botta PE, Barriga EH, Ríos EA, Reyes AE, Arranz SE. Growth hormone receptors in zebrafish (Danio rerio): adult and embryonic expression patterns. Gene Expr Patterns. 2010 Jun; 10(4-5):214-25. PMID: 20230916.
      View in: PubMed
    32. Ríos E. The cell boundary theorem: a simple law of the control of cytosolic calcium concentration. J Physiol Sci. 2010 Jan; 60(1):81-4. PMID: 19937486; PMCID: PMC2821834.
    33. Zhou J, Yi J, Fu R, Liu E, Siddique T, Ríos E, Deng HX. Hyperactive intracellular calcium signaling associated with localized mitochondrial defects in skeletal muscle of an animal model of amyotrophic lateral sclerosis. J Biol Chem. 2010 Jan 01; 285(1):705-12. PMID: 19889637; PMCID: PMC2804218.
    34. Morgan D, Capasso M, Musset B, Cherny VV, Ríos E, Dyer MJ, DeCoursey TE. Voltage-gated proton channels maintain pH in human neutrophils during phagocytosis. Proc Natl Acad Sci U S A. 2009 Oct 20; 106(42):18022-7. PMID: 19805063; PMCID: PMC2764923.
    35. Ríos E, Györke S. Calsequestrin, triadin and more: the molecules that modulate calcium release in cardiac and skeletal muscle. J Physiol. 2009 Jul 01; 587(Pt 13):3069-70. PMID: 19567746; PMCID: PMC2727014.
    36. Royer L, Ríos E. Deconstructing calsequestrin. Complex buffering in the calcium store of skeletal muscle. J Physiol. 2009 Jul 01; 587(Pt 13):3101-11. PMID: 19403601; PMCID: PMC2727020.
    37. Royer L, Pouvreau S, Ríos E. Evolution and modulation of intracellular calcium release during long-lasting, depleting depolarization in mouse muscle. J Physiol. 2008 Oct 01; 586(19):4609-29. PMID: 18687715; PMCID: PMC2614033.
    38. Musset B, Morgan D, Cherny VV, MacGlashan DW, Thomas LL, Ríos E, DeCoursey TE. A pH-stabilizing role of voltage-gated proton channels in IgE-mediated activation of human basophils. Proc Natl Acad Sci U S A. 2008 Aug 05; 105(31):11020-5. PMID: 18664579; PMCID: PMC2504794.
    39. Ríos E, Zhou J, Brum G, Launikonis BS, Stern MD. Calcium-dependent inactivation terminates calcium release in skeletal muscle of amphibians. J Gen Physiol. 2008 Apr; 131(4):335-48. PMID: 18347079; PMCID: PMC2279174.
    40. Launikonis BS, Ríos E. Store-operated Ca2+ entry during intracellular Ca2+ release in mammalian skeletal muscle. J Physiol. 2007 Aug 15; 583(Pt 1):81-97. PMID: 17569733; PMCID: PMC2277221.
    41. Pouvreau S, Royer L, Yi J, Brum G, Meissner G, Ríos E, Zhou J. Ca(2+) sparks operated by membrane depolarization require isoform 3 ryanodine receptor channels in skeletal muscle. Proc Natl Acad Sci U S A. 2007 Mar 20; 104(12):5235-40. PMID: 17360329; PMCID: PMC1829292.
    42. Curran J, Hinton MJ, Ríos E, Bers DM, Shannon TR. Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase. Circ Res. 2007 Feb 16; 100(3):391-8. PMID: 17234966.
      View in: PubMed
    43. Launikonis BS, Zhou J, Santiago D, Brum G, Ríos E. The changes in Ca2+ sparks associated with measured modifications of intra-store Ca2+ concentration in skeletal muscle. J Gen Physiol. 2006 Jul; 128(1):45-54. PMID: 16769796; PMCID: PMC2151548.
    44. Launikonis BS, Zhou J, Royer L, Shannon TR, Brum G, Ríos E. Depletion "skraps" and dynamic buffering inside the cellular calcium store. Proc Natl Acad Sci U S A. 2006 Feb 21; 103(8):2982-7. PMID: 16473932; PMCID: PMC1413852.
    45. Ríos E. Calcium signalling in muscle: a milestone for modulation studies. J Physiol. 2006 Apr 01; 572(Pt 1):1-2. PMID: 16469777; PMCID: PMC1779653.
    46. Zhou J, Brum G, González A, Launikonis BS, Stern MD, Ríos E. Concerted vs. sequential. Two activation patterns of vast arrays of intracellular Ca2+ channels in muscle. J Gen Physiol. 2005 Oct; 126(4):301-9. PMID: 16186560.
      View in: PubMed
    47. Zhou J, Yi J, Royer L, Launikonis BS, González A, García J, Ríos E. A probable role of dihydropyridine receptors in repression of Ca2+ sparks demonstrated in cultured mammalian muscle. Am J Physiol Cell Physiol. 2006 Feb; 290(2):C539-53. PMID: 16148029.
      View in: PubMed
    48. Launikonis BS, Zhou J, Royer L, Shannon TR, Brum G, Ríos E. Confocal imaging of [Ca2+] in cellular organelles by SEER, shifted excitation and emission ratioing of fluorescence. J Physiol. 2005 Sep 01; 567(Pt 2):523-43. PMID: 15946962; PMCID: PMC1474212.
    49. Zhou J, Launikonis BS, Ríos E, Brum G. Regulation of Ca2+ sparks by Ca2+ and Mg2+ in mammalian and amphibian muscle. An RyR isoform-specific role in excitation-contraction coupling? J Gen Physiol. 2004 Oct; 124(4):409-28. PMID: 15452201; PMCID: PMC2233900.
    50. Pizarro G, Ríos E. How source content determines intracellular Ca2+ release kinetics. Simultaneous measurement of [Ca2+] transients and [H+] displacement in skeletal muscle. J Gen Physiol. 2004 Sep; 124(3):239-58. PMID: 15337820; PMCID: PMC2233888.
    51. Wang SQ, Stern MD, Ríos E, Cheng H. The quantal nature of Ca2+ sparks and in situ operation of the ryanodine receptor array in cardiac cells. Proc Natl Acad Sci U S A. 2004 Mar 16; 101(11):3979-84. PMID: 15004280; PMCID: PMC374355.
    52. Ríos E, Zhou J. Control of dual isoforms of Ca2+ release channels in muscle. Biol Res. 2004; 37(4):583-91. PMID: 15709685.
      View in: PubMed
    53. Kettlun C, González A, Ríos E, Fill M. Unitary Ca2+ current through mammalian cardiac and amphibian skeletal muscle ryanodine receptor Channels under near-physiological ionic conditions. J Gen Physiol. 2003 Oct; 122(4):407-17. PMID: 12975450.
      View in: PubMed
    54. Montero I, Rios E, Parody R, Perez-Hurtado JM, Martin-Noya A, Rodriguez JM. CD56 in T-cell acute lymphoblastic leukaemia: a malignant transformation of an early myeloid-lymphoid progenitor? Haematologica. 2003 Jul; 88(7):ELT26. PMID: 12857578.
      View in: PubMed
    55. Brum G, Piriz N, DeArmas R, Rios E, Stern M, Pizarro G. Differential effects of voltage-dependent inactivation and local anesthetics on kinetic phases of Ca2+ release in frog skeletal muscle. Biophys J. 2003 Jul; 85(1):245-54. PMID: 12829480; PMCID: PMC1303081.
    56. Ferreira G, Ríos E, Reyes N. Two components of voltage-dependent inactivation in Ca(v)1.2 channels revealed by its gating currents. Biophys J. 2003 Jun; 84(6):3662-78. PMID: 12770874; PMCID: PMC1302950.
    57. Rengifo J, Rosales R, González A, Cheng H, Stern MD, Ríos E. Intracellular Ca(2+) release as irreversible Markov process. Biophys J. 2002 Nov; 83(5):2511-21. PMID: 12414685; PMCID: PMC1302337.
    58. Wang SQ, Song LS, Xu L, Meissner G, Lakatta EG, Ríos E, Stern MD, Cheng H. Thermodynamically irreversible gating of ryanodine receptors in situ revealed by stereotyped duration of release in Ca(2+) sparks. Biophys J. 2002 Jul; 83(1):242-51. PMID: 12080116; PMCID: PMC1302143.
    59. Ríos E, Brum G. Initiation and termination of calcium sparks in skeletal muscle Front Biosci. 2002 05 01; 7:d1212-1222. PMID: 11991852.
      View in: PubMed
    60. González N, Ríos E, Martín-Noya A, Rodríguez JM. Thrombotic thrombocytopenic purpura and bone marrow necrosis as a complication of gastric neoplasm. Haematologica. 2002 Jan; 87(1):ECR01. PMID: 11801475.
      View in: PubMed
    61. Bean BP, Rios E. Nonlinear charge movement in mammalian cardiac ventricular cells. Components from Na and Ca channel gating. J Gen Physiol. 1989 Jul; 94(1):65-93. PMID: 2553859; PMCID: PMC2228930.
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