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David L Williams

TitleAssociate Professor
InstitutionRush University, Rush Medical College
DepartmentMicrobial Pathogens and Immunity
AddressChicago IL 60612
Phone312-942-1375
Fax312-942-2808
ORCID ORCID Icon0000-0002-6815-4909 Additional info
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    Collapse Biography 
    Collapse education and training
    Cornell University, Ithaca, NYBS5/1980Biochemistry
    University of Illinois, Urbana, IllinoisPh.D.3/1990Biochemistry
    Institut Pasteur, Lille, FrancePostdoc5/1995Molecular Parasitology
    Cornell University, Geneva, NYPostdoc5/1998Molecular Biology
    Illinois State University, Normal, IllinoisAssistant Professor2001Molecular Parasitology
    Illinois State University, Normal, IllinoisAssociate Professor2007Molecular Parasitology
    Illinois State University, Normal, IllinoisProfessor2008Molecular Parasitology
    Collapse awards and honors
    2015Students’ Choice Outstanding Mentor, Graduate College, Rush University Medical Center
    2008Outstanding University Researcher, Illinois State University
    2008Distinguished College of Arts and Science Lecturer, Illinois State University
    2006Outstanding College Researcher, Illinois State University
    1999College Teaching Initiative Award, Illinois State University
    1991Postdoctoral fellowship from the Fondation pour la Recherche Medicale, Institut Pasteur, Lille, France
    1990Fogarty Postdoctoral Fellow, US/NIH - INSERM, Lille, France

    Collapse Overview 
    Collapse overview
    My Scopus ID is 55574201569.
    My NIH COMMONS name is DLWILLI.

    Research Areas:
    Schistosomiasis, redox biology, drug development.

    My Faculty Profile at Rush University Medical Center:
    https://www.rushu.rush.edu/faculty/david-l-williams-phd

    My Laboratory:
    https://www.rushu.rush.edu/research/departmental-research/microbial-pathogens-and-immunity-research/laboratory-david-l-williams-phd

    My NCBI Bibliography:
    http://www.ncbi.nlm.nih.gov/sites/myncbi/david.williams.9/bibliography/41144295/public/?sort=date&direction=ascending

    My Scopus:
    https://www.scopus.com/authid/detail.uri?authorId=55574201569

    Collapse Research 
    Collapse research activities and funding
    R01AI177493     (PETUKHOV, PAVEL A)Jul 5, 2024 - Jun 30, 2029
    NIH
    Development of novel TGR inhibitors for the treatment of schistosomiasis
    Role: Co-Principle Investigator
    R41AI184237     (PETUKHOV, PAVEL)Jun 21, 2024 - May 31, 2025
    NIH
    Discovery and development of novel schistosomicidal agents
    Role: Co-Investigator
         (Williams David L)Jan 11, 2022 - Jan 11, 2023
    VILLYA LLC
    Praziquantel 2.0
    Role: CONTRACTOR
    R21AI149102     (PETUKHOV, PAVEL A;WILLIAMS, DAVID LEE)Feb 22, 2021 - Jan 31, 2023
    NIH
    Identification of the target of meclonazepam in schistosome worms
    Role: Principal Investigator
    R21AI146512     (ANGELUCCI, FRANCESCO ;PETUKHOV, PAVEL A ;WILLIAMS, DAVID LEE)Dec 4, 2020 - Nov 30, 2023
    NIH
    Discovery of novel smHDAC8 inhibitors for the treatment of schistosomiasis
    Role: Principal Investigator
    R33AI127635     (WILLIAMS, DAVID LEE)Dec 1, 2016 - Nov 30, 2021
    NIH
    Identification of preclinical drug candidates for the treatment of schistosomiasis
    Role: Principal Investigator
    R21AI127635     (WILLIAMS, DAVID LEE)Dec 1, 2016 - Nov 30, 2018
    NIH
    Identification of preclinical drug candidates for the treatment of schistosomiasis
    Role: Principal Investigator
    R21AI115208     (WILLIAMS, DAVID LEE)Mar 15, 2016 - Feb 28, 2019
    NIH
    Deorphanization of Schistosome Cytochrome P450
    Role: Principal Investigator
    R21AI097529     (WILLIAMS, DAVID LEE)Feb 15, 2012 - Jan 31, 2014
    NIH
    Development of a functional genomics toolbox for schistosome parasites
    Role: Principal Investigator
    HHSN268201000220P     (Austin Cristopher P)Jul 7, 2010 - Oct 31, 2011
    TRND/NIH/NHLBI
    Testing of oxadiazole-oxide chemotype as a therapeutic drug for the control of schistosomiasis
    Role: Co-Investigator
    R21AI081107     (WILLIAMS, DAVID LEE)Jun 1, 2009 - May 31, 2011
    NIH
    Is phytochelatin synthase an essential enzyme and drug target for schistosomiasis
    Role: Principal Investigator
    R01AI065622     (WILLIAMS, DAVID LEE)Apr 15, 2007 - Mar 31, 2013
    NIH
    Redox Balance &Drug Development in Schistosoma mansoni
    Role: Principal Investigator
    R03MH076449     (WILLIAMS, DAVID LEE)Sep 15, 2005 - Sep 30, 2007
    NIH
    HTS Inhibitors:Schistosoma Mansoni Peroxiredoxins(RMI)
    Role: Principal Investigator
    R21AI061671     (WILLIAMS, DAVID LEE)Mar 1, 2005 - Feb 29, 2008
    NIH
    Mechanisms of anti-schistosome artemisinin chemotherapy
    Role: Principal Investigator
    R21AI062845     (WILLIAMS, DAVID LEE)Mar 1, 2005 - Feb 29, 2008
    NIH
    Developmental Gene Regulation in Schistosoma mansoni
    Role: Principal Investigator
    R03AI059037     (WILLIAMS, DAVID LEE)Apr 1, 2004 - Mar 31, 2007
    NIH
    High Throughput Proteome Analysis of Schistosoma mansoni
    Role: Principal Investigator
    R15AI054403     (WILLIAMS, DAVID LEE)May 2, 2003 - Apr 30, 2005
    NIH
    Disulfide redox balance in Schistosoma mansoni
    Role: Principal Investigator
         (Wellcome Trust)Jan 1, 2001 - Dec 31, 2003
    The Wellcome Trust - Beowulf Genomics Initiative for Pathogen Sequencing
    An integrated HAPPY map and BAC tile path for the blood fluke Schistosoma mansoni as a resource for genome sequencing efforts
    Role: Co-Investigator
         (Williams David L)Jan 1, 1999 - Dec 31, 2000
    WHO/UNDP/World Bank/TDR
    Physical mapping of Schistosoma mansoni chromosomes
    R15AI041197     (WILLIAMS, DAVID LEE)Mar 1, 1998 - Feb 28, 2002
    NIH
    ENZYMOLOGY OF EGGSHELL FORMATION IN SCHISTOSOMA MANSONI
    Role: Principal Investigator
         (David L Williams)Jan 1, 1997 - Dec 31, 1998
    Alternatives Research and Development Foundation
    Extracellular matrix and cytokines: effect on the development of Schistosoma mansoni
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Villarreal ES, Marinho Y, Loya O, Aboagye SY, Costa G, Oliveira F, Gupta M, Oliveira KC, Silva CLM, Sun J, Erzurum SC, Lutz SE, Williams DL, Oliveira RKF, de Jesus Perez V, Oliveira SD. Endothelial c-IAP2 loss amplifies P2X7 receptor-driven inflammation and worsens schistosomiasis-associated pulmonary hypertension. Proc Natl Acad Sci U S A. 2026 06 23; 123(25):e2513158123. PMID: 42296370; PMCID: PMC13291602.
      Citations:    
    2. Cesar-Rodo E, Boilevin J, Richard J, Ziniel PD, Belorgey D, Maes L, Angelucci F, Williams DL, Davioud-Charvet E, Lanfranchi DA. Synthesis of Methoxylated Benzoxanthones as Drug Metabolites of Antischistosomal Schistodiones-A Limited Environmental Risk. Molecules. 2026 May 27; 31(11). PMID: 42280143; PMCID: PMC13258496.
      Citations:    
    3. Gabriele F, Palerma M, Bogard J, Paluzzi L, Zineddu S, Geri A, Vitali V, Massai L, Ardini M, Bellelli A, Petukhov PA, Ippoliti R, Messori L, Williams DL, Angelucci F. Gold-containing compounds target an apicomplexan Thioredoxin reductase: Disclosing reactivity through structural and functional characterization. Int J Biol Macromol. 2026 Jun; 369:152627. PMID: 42162589.
      Citations:    
    4. Villarreal W, Quadros HC, Colina-Vegas L, Aboagye SY, Dziwornu GA, Ribeiro GH, Barros AI, Kucharski DJ, Rahbari M, Brandst?dter C, D'Alessandro S, Basilico N, Masike K, Mehlala N, Nobrega JA, Deflon VM, Navarro M, Boratynski PJ, Chibale K, Williams DL, Batista AA, Moreira DRM. Examination of Coligands in Mefloquine-Metal Complexes Reveals the Structural Determinants of Activity against Plasmodium falciparum and Schistosoma mansoni. J Med Chem. 2026 Apr 23; 69(8):9242-9264. PMID: 41811093; PMCID: PMC13126674.
      Citations:    
    5. Rullo A, Flowers B, Chang K, Zhang A, Petukhova VZ, Harding L, Aboagye SY, Bocchetta M, Qiu W, Williams DL, Angelucci F, Petukhov PA, Kastrati I. Unravelling the anti-cancer mechanisms elicited by non-covalent thioredoxin reductase inhibitors for triple negative breast cancer therapy. Redox Biol. 2026 03; 90:103980. PMID: 41518849; PMCID: PMC12816872.
      Citations:    
    6. Rullo A, Flowers B, Chang K, Zhang A, Petukhova VZ, Harding L, Aboagye SY, Bocchetta M, Qiu W, Williams DL, Angelucci F, Petukhov PA, Kastrati I. Unravelling the anti-cancer mechanisms elicited by non-covalent thioredoxin reductase inhibitors for triple negative breast cancer therapy. bioRxiv. 2025 Sep 09. PMID: 40964317; PMCID: PMC12439938.
      Citations:    
    7. Gabriele F, Bogard JA, Palerma M, Ardini M, Byrne ME, Chen XM, Petukhov PA, Ippoliti R, Angelucci F, Williams DL. Targeting Apicomplexan Parasites: Structural and Functional Characterization of Cryptosporidium Thioredoxin Reductase as a Novel Drug Target. Biochemistry. 2025 05 20; 64(10):2212-2225. PMID: 40304242; PMCID: PMC12092171.
      Citations:    
    8. Flowers B, Rullo A, Zhang A, Chang K, Petukhova VZ, Aboagye SY, Angelucci F, Williams DL, Kregel S, Petukhov PA, Kastrati I. Pleiotropic anti-cancer activities of novel non-covalent thioredoxin reductase inhibitors against triple negative breast cancer. Free Radic Biol Med. 2025 02 01; 227:201-209. PMID: 39643141; PMCID: PMC12406651.
      Citations:    
    9. Cesar-Rodo E, Dupouy B, H?berli C, Strub JM, Williams DL, M?ser P, Rottmann M, Keiser J, Lanfranchi DA, Davioud-Charvet E. Regioselective Synthesis of Potential Non-Quinonoid Prodrugs of Plasmodione: Antiparasitic Properties Against Two Hemoglobin-Feeding Parasites and Drug Metabolism Studies. Molecules. 2024 Nov 07; 29(22). PMID: 39598657; PMCID: PMC11596610.
      Citations:    
    10. Ardini M, Aboagye SY, Petukhova VZ, Kastrati I, Ippoliti R, Thatcher GRJ, Petukhov PA, Williams DL, Angelucci F. The "Doorstop Pocket" In Thioredoxin Reductases-An Unexpected Druggable Regulator of the Catalytic Machinery. J Med Chem. 2024 Sep 26; 67(18):15947-15967. PMID: 39250602; PMCID: PMC12013724.
      Citations:    
    11. Marinho Y, Villarreal ES, Aboagye SY, Williams DL, Sun J, Silva CLM, Lutz SE, Oliveira SD. Schistosomiasis-associated pulmonary hypertension unveils disrupted murine gut-lung microbiome and reduced endoprotective Caveolin-1/BMPR2 expression. Front Immunol. 2023; 14:1254762. PMID: 37908354; PMCID: PMC10613683.
      Citations:    
    12. Petukhova VZ, Aboagye SY, Ardini M, Lullo RP, Fata F, Byrne ME, Gabriele F, Martin LM, Harding LNM, Gone V, Dangi B, Lantvit DD, Nikolic D, Ippoliti R, Effantin G, Ling WL, Johnson JJ, Thatcher GRJ, Angelucci F, Williams DL, Petukhov PA. Non-covalent inhibitors of thioredoxin glutathione reductase with schistosomicidal activity in vivo. Nat Commun. 2023 06 22; 14(1):3737. PMID: 37349300.
      Citations:    
    13. Smith MM, Alt TB, Williams DL, Moran GR. Descriptive Analysis of Transient-State Observations for Thioredoxin/Glutathione Reductase (Sec597Cys) from Schistosoma mansoni. Biochemistry. 2023 05 02; 62(9):1497-1508. PMID: 37071546.
      Citations:    
    14. De Souza Pereira C, Quadros HC, Aboagye SY, Fontinha D, D'Alessandro S, Byrne ME, Gendrot M, Fonta I, Mosnier J, Moreira DRM, Basilico N, Williams DL, Prud?ncio M, Pradines B, Navarro M. A Hybrid of Amodiaquine and Primaquine Linked by Gold(I) Is a Multistage Antimalarial Agent Targeting Heme Detoxification and Thiol Redox Homeostasis. Pharmaceutics. 2022 Jun 12; 14(6). PMID: 35745823; PMCID: PMC9229949.
      Citations:    
    15. Fata F, Gencheva R, Cheng Q, Lullo R, Ardini M, Silvestri I, Gabriele F, Ippoliti R, Bulman CA, Sakanari JA, Williams DL, Arn?r ESJ, Angelucci F, Fata F, Gencheva R, Cheng Q, Lullo R, Ardini M, Silvestri I, Gabriele F, Ippoliti R, Bulman CA, Sakanari JA, Williams DL, Arn?r ESJ, Angelucci F. Biochemical and structural characterizations of thioredoxin reductase selenoproteins of the parasitic filarial nematodes Brugia malayi and Onchocerca volvulus. Redox Biol. 2022 05; 51:102278. PMID: 35276442; PMCID: PMC8914392.
      Citations:    
    16. Ndegwa FK, Kondam C, Aboagye SY, Esan TE, Waxali ZS, Miller ME, Gikonyo NK, Mbugua PK, Okemo PO, Williams DL, Hagen TJ. Traditional Kenyan herbal medicine: exploring natural products' therapeutics against schistosomiasis. J Helminthol. 2022 Mar 03; 96:e16. PMID: 35238288; PMCID: PMC10030042.
      Citations:    
    17. Gallinger TL, Aboagye SY, Obermann W, Weiss M, Gr?nweller A, Unverzagt C, Williams DL, Schlitzer M, Haeberlein S. First In Silico Screening of Insect Molecules for Identification of Novel Anti-Parasitic Compounds. Pharmaceuticals (Basel). 2022 Jan 19; 15(2). PMID: 35215232; PMCID: PMC8877563.
      Citations:    
    18. Fata F, Silvestri I, Ardini M, Ippoliti R, Di Leandro L, Demitri N, Polentarutti M, Di Matteo A, Lyu H, Thatcher GRJ, Petukhov PA, Williams DL, Angelucci F, Fata F, Silvestri I, Ardini M, Ippoliti R, Di Leandro L, Demitri N, Polentarutti M, Di Matteo A, Lyu H, Thatcher GRJ, Petukhov PA, Williams DL, Angelucci F. Probing the Surface of a Parasite Drug Target Thioredoxin Glutathione Reductase Using Small Molecule Fragments. ACS Infect Dis. 2021 07 09; 7(7):1932-1944. PMID: 33950676; PMCID: PMC8273128.
      Citations:    
    19. Ardini M, Bellelli A, Williams DL, Di Leandro L, Giansanti F, Cimini A, Ippoliti R, Angelucci F, Ardini M, Bellelli A, Williams DL, Di Leandro L, Giansanti F, Cimini A, Ippoliti R, Angelucci F. Taking Advantage of the Morpheein Behavior of Peroxiredoxin in Bionanotechnology. Bioconjug Chem. 2021 01 20; 32(1):43-62. PMID: 33411522; PMCID: PMC8023583.
      Citations:    
    20. Feng L, Pomel S, Latre de Late P, Taravaud A, Loiseau PM, Maes L, Cho-Ngwa F, Bulman CA, Fischer C, Sakanari JA, Ziniel PD, Williams DL, Davioud-Charvet E, Feng L, Pomel S, Latre de Late P, Taravaud A, Loiseau PM, Maes L, Cho-Ngwa F, Bulman CA, Fischer C, Sakanari JA, Ziniel PD, Williams DL, Davioud-Charvet E. Repurposing Auranofin and Evaluation of a New Gold(I) Compound for the Search of Treatment of Human and Cattle Parasitic Diseases: From Protozoa to Helminth Infections. Molecules. 2020 Nov 01; 25(21). PMID: 33139647; PMCID: PMC7663263.
      Citations:    
    21. Lyu H, Petukhov PA, Banta PR, Jadhav A, Lea WA, Cheng Q, Arn?r ESJ, Simeonov A, Thatcher GRJ, Angelucci F, Williams DL. Characterization of Lead Compounds Targeting the Selenoprotein Thioredoxin Glutathione Reductase for Treatment of Schistosomiasis. ACS Infect Dis. 2020 03 13; 6(3):393-405. PMID: 31939288.
      Citations:    
    22. Silvestri I, Lyu H, Fata F, Banta PR, Mattei B, Ippoliti R, Bellelli A, Pitari G, Ardini M, Petukhova V, Thatcher GRJ, Petukhov PA, Williams DL, Angelucci F. Ectopic suicide inhibition of thioredoxin glutathione reductase. Free Radic Biol Med. 2020 02 01; 147:200-211. PMID: 31870799.
      Citations:    
    23. Abriola L, Hoyer D, Caffrey CR, Williams DL, Yoshino TP, Vermeire JJ, Abriola L, Hoyer D, Caffrey CR, Williams DL, Yoshino TP, Vermeire JJ. Development and optimization of a high-throughput screening method utilizing Ancylostoma ceylanicum egg hatching to identify novel anthelmintics. PLoS One. 2019; 14(6):e0217019. PMID: 31158236; PMCID: PMC6546214.
      Citations:    
    24. Silvestri I, Lyu H, Fata F, Boumis G, Miele AE, Ardini M, Ippoliti R, Bellelli A, Jadhav A, Lea WA, Simeonov A, Cheng Q, Arn?r ESJ, Thatcher GRJ, Petukhov PA, Williams DL, Angelucci F, Silvestri I, Lyu H, Fata F, Boumis G, Miele AE, Ardini M, Ippoliti R, Bellelli A, Jadhav A, Lea WA, Simeonov A, Cheng Q, Arn?r ESJ, Thatcher GRJ, Petukhov PA, Williams DL, Angelucci F. Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as "Doorstop" for NADPH Entry. ACS Chem Biol. 2018 08 17; 13(8):2190-2202. PMID: 29800515; PMCID: PMC6905387.
      Citations:    
    25. Rodo EC, Feng L, Jida M, Ernhardt K, Boilevin J, Lanzer M, Williams DL, Lanfranchi DA, Davioud-Charvet E. . A Platform of Regioive Methodologies to Access Polysubstituted 2‐Methyl‐1,4‐naphthoquinone Derivatives: Scope and Limitations. European journal of organic chemistry. 2016; (11):1982-1993. View Publication.
    26. Ziniel PD, Karumudi B, Barnard AH, Fisher EM, Thatcher GR, Podust LM, Williams DL. The Schistosoma mansoni Cytochrome P450 (CYP3050A1) Is Essential for Worm Survival and Egg Development. PLoS Negl Trop Dis. 2015 Dec; 9(12):e0004279. PMID: 26713732.
      Citations:    
    27. Li T, Ziniel PD, He PQ, Kommer VP, Crowther GJ, He M, Liu Q, Van Voorhis WC, Williams DL, Wang MW. High-throughput screening against thioredoxin glutathione reductase identifies novel inhibitors with potential therapeutic value for schistosomiasis. Infect Dis Poverty. 2015 Aug 31; 4:40. PMID: 26341081.
      Citations:    
    28. Johann L, Belorgey D, Huang HH, Day L, Chess? M, Becker K, Williams DL, Davioud-Charvet E, Johann L, Belorgey D, Huang HH, Day L, Chess? M, Becker K, Williams DL, Davioud-Charvet E. Synthesis and evaluation of 1,4-naphthoquinone ether derivatives as SmTGR inhibitors and new anti-schistosomal drugs. FEBS J. 2015 Aug; 282(16):3199-217. PMID: 26111549; PMCID: PMC4804716.
      Citations:    
    29. Bielitza M, Belorgey D, Ehrhardt K, Johann L, Lanfranchi DA, Gallo V, Schwarzer E, Mohring F, Jortzik E, Williams DL, Becker K, Arese P, Elhabiri M, Davioud-Charvet E, Bielitza M, Belorgey D, Ehrhardt K, Johann L, Lanfranchi DA, Gallo V, Schwarzer E, Mohring F, Jortzik E, Williams DL, Becker K, Arese P, Elhabiri M, Davioud-Charvet E. Antimalarial NADPH-Consuming Redox-Cyclers As Superior Glucose-6-Phosphate Dehydrogenase Deficiency Copycats. Antioxid Redox Signal. 2015 May 20; 22(15):1337-51. PMID: 25714942; PMCID: PMC4410756.
      Citations:    
    30. Bulman CA, Bidlow CM, Lustigman S, Cho-Ngwa F, Williams D, Rasc?n AA, Tricoche N, Samje M, Bell A, Suzuki B, Lim KC, Supakorndej N, Supakorndej P, Wolfe AR, Knudsen GM, Chen S, Wilson C, Ang KH, Arkin M, Gut J, Franklin C, Marcellino C, McKerrow JH, Debnath A, Sakanari JA. Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis. PLoS Negl Trop Dis. 2015 Feb; 9(2):e0003534. PMID: 25700363.
      Citations:    
    31. Guglielmo S, Cortese D, Vottero F, Rolando B, Kommer VP, Williams DL, Fruttero R, Gasco A, Guglielmo S, Cortese D, Vottero F, Rolando B, Kommer VP, Williams DL, Fruttero R, Gasco A. New praziquantel derivatives containing NO-donor furoxans and related furazans as active agents against Schistosoma mansoni. Eur J Med Chem. 2014 Sep 12; 84:135-45. PMID: 25016371; PMCID: PMC4160910.
      Citations:    
    32. Wang YT, Piyankarage SC, Williams DL, Thatcher GR. Proteomic profiling of nitrosative stress: protein S-oxidation accompanies S-nitrosylation. ACS Chem Biol. 2014 Mar 21; 9(3):821-30. PMID: 24397869.
      Citations:    
    33. Ziniel PD, Desai J, Cass CL, Gatto C, Oldfield E, Williams DL. Characterization of potential drug targets farnesyl diphosphate synthase and geranylgeranyl diphosphate synthase in Schistosoma mansoni. Antimicrob Agents Chemother. 2013 Dec; 57(12):5969-76. PMID: 24041901.
      Citations:    
    34. Rigouin C, Vermeire JJ, Nylin E, Williams DL. Characterization of the phytochelatin synthase from the human parasitic nematode Ancylostoma ceylanicum. Mol Biochem Parasitol. 2013 Sep; 191(1):1-6. PMID: 23916800.
      Citations:    
    35. Nguyen JB, Pool CD, Wong CY, Treger RS, Williams DL, Cappello M, Lea WA, Simeonov A, Vermeire JJ, Modis Y, Nguyen JB, Pool CD, Wong CY, Treger RS, Williams DL, Cappello M, Lea WA, Simeonov A, Vermeire JJ, Modis Y. Peroxiredoxin-1 from the human hookworm Ancylostoma ceylanicum forms a stable oxidized decamer and is covalently inhibited by conoidin A. Chem Biol. 2013 Aug 22; 20(8):991-1001. PMID: 23891152; PMCID: PMC3755041.
      Citations:    
    36. Rigouin C, Nylin E, Cogswell AA, Schauml?ffel D, Dobritzsch D, Williams DL. Towards an understanding of the function of the phytochelatin synthase of Schistosoma mansoni. PLoS Negl Trop Dis. 2013; 7(1):e2037. PMID: 23383357.
      Citations:    
    37. Belorgey D, Lanfranchi DA, Davioud-Charvet E. 1,4-naphthoquinones and other NADPH-dependent glutathione reductase-catalyzed redox cyclers as antimalarial agents. Curr Pharm Des. 2013; 19(14):2512-28. PMID: 23116403; PMCID: PMC3676941.
      Citations:    
    38. Mott BT, Cheng KC, Guha R, Kommer VP, Williams DL, Vermeire JJ, Cappello M, Maloney DJ, Rai G, Jadhav A, Simeonov A, Inglese J, Posner GH, Thomas CJ, Mott BT, Cheng KC, Guha R, Kommer VP, Williams DL, Vermeire JJ, Cappello M, Maloney DJ, Rai G, Jadhav A, Simeonov A, Inglese J, Posner GH, Thomas CJ. A furoxan-amodiaquine hybrid as a potential therapeutic for three parasitic diseases(). Medchemcomm. 2012 Dec; 3(12):1505-1511. PMID: 23205265; PMCID: PMC3509744.
      Citations:    
    39. Cogswell AA, Kommer VP, Williams DL. Transcriptional analysis of a unique set of genes involved in Schistosoma mansoni female reproductive biology. PLoS Negl Trop Dis. 2012; 6(11):e1907. PMID: 23166854.
      Citations:    
    40. Williams DL, Bonilla M, Gladyshev VN, Salinas G. Thioredoxin glutathione reductase-dependent redox networks in platyhelminth parasites. Antioxid Redox Signal. 2013 Sep 01; 19(7):735-45. PMID: 22909029.
      Citations:    
    41. Lanfranchi DA, Cesar-Rodo E, Bertrand B, Huang HH, Day L, Johann L, Elhabiri M, Becker K, Williams DL, Davioud-Charvet E, Lanfranchi DA, Cesar-Rodo E, Bertrand B, Huang HH, Day L, Johann L, Elhabiri M, Becker K, Williams DL, Davioud-Charvet E. Synthesis and biological evaluation of 1,4-naphthoquinones and quinoline-5,8-diones as antimalarial and schistosomicidal agents. Org Biomol Chem. 2012 Aug 21; 10(31):6375-6387. PMID: 22777178; PMCID: PMC3423093.
      Citations:    
    42. Skinner DE, Rinaldi G, Suttiprapa S, Mann VH, Smircich P, Cogswell AA, Williams DL, Brindley PJ, Skinner DE, Rinaldi G, Suttiprapa S, Mann VH, Smircich P, Cogswell AA, Williams DL, Brindley PJ. Vasa-Like DEAD-Box RNA Helicases of Schistosoma mansoni. PLoS Negl Trop Dis. 2012; 6(6):e1686. PMID: 22720105; PMCID: PMC3373655.
      Citations:    
    43. Treger RS, Cook AG, Rai G, Maloney DJ, Simeonov A, Jadhav A, Thomas CJ, Williams DL, Cappello M, Vermeire JJ. Oxadiazole 2-oxides are toxic to the human hookworm, Ancylostoma ceylanicum, however glutathione reductase is not the primary target. Int J Parasitol Drugs Drug Resist. 2012 Dec 01; 2:171-177. PMID: 22844653.
      Citations:    
    44. Saccoccia F, Di Micco P, Boumis G, Brunori M, Koutris I, Miele AE, Morea V, Sriratana P, Williams DL, Bellelli A, Angelucci F. Moonlighting by different stressors: crystal structure of the chaperone species of a 2-Cys peroxiredoxin. Structure. 2012 Mar 07; 20(3):429-39. PMID: 22405002.
      Citations:    
    45. Huang HH, Rigouin C, Williams DL. The redox biology of schistosome parasites and applications for drug development. Curr Pharm Des. 2012; 18(24):3595-611. PMID: 22607149.
      Citations:    
    46. Saccoccia F, Angelucci F, Boumis G, Brunori M, Miele AE, Williams DL, Bellelli A, Saccoccia F, Angelucci F, Boumis G, Brunori M, Miele AE, Williams DL, Bellelli A. On the mechanism and rate of gold incorporation into thiol-dependent flavoreductases. J Inorg Biochem. 2012 Mar; 108:105-11. PMID: 22166353; PMCID: PMC3396563.
      Citations:    
    47. Prast-Nielsen S, Huang HH, Williams DL, Prast-Nielsen S, Huang HH, Williams DL. Thioredoxin glutathione reductase: its role in redox biology and potential as a target for drugs against neglected diseases. Biochim Biophys Acta. 2011 Dec; 1810(12):1262-71. PMID: 21782895; PMCID: PMC3210934.
      Citations:    
    48. Huang HH, Day L, Cass CL, Ballou DP, Williams CH, Williams DL. Investigations of the catalytic mechanism of thioredoxin glutathione reductase from Schistosoma mansoni. Biochemistry. 2011 Jul 05; 50(26):5870-82. PMID: 21630672.
      Citations:    
    49. Ray D, Williams DL. Characterization of the phytochelatin synthase of Schistosoma mansoni. PLoS Negl Trop Dis. 2011 May; 5(5):e1168. PMID: 21629724.
      Citations:    
    50. Cogswell AA, Collins JJ, Newmark PA, Williams DL. Whole mount in situ hybridization methodology for Schistosoma mansoni. Mol Biochem Parasitol. 2011 Jul-Aug; 178(1-2):46-50. PMID: 21397637.
      Citations:    
    51. Collins JJ, King RS, Cogswell A, Williams DL, Newmark PA. An atlas for Schistosoma mansoni organs and life-cycle stages using cell type-specific markers and confocal microscopy. PLoS Negl Trop Dis. 2011 Mar 08; 5(3):e1009. PMID: 21408085.
      Citations:    
    52. Oke TT, Moskovitz J, Williams DL. Characterization of the methionine sulfoxide reductases of Schistosoma mansoni. J Parasitol. 2009 Dec; 95(6):1421-8. PMID: 19604033.
      Citations:    
    53. Rai G, Sayed AA, Lea WA, Luecke HF, Chakrapani H, Prast-Nielsen S, Jadhav A, Leister W, Shen M, Inglese J, Austin CP, Keefer L, Arn?r ES, Simeonov A, Maloney DJ, Williams DL, Thomas CJ, Rai G, Sayed AA, Lea WA, Luecke HF, Chakrapani H, Prast-Nielsen S, Jadhav A, Leister W, Shen M, Inglese J, Austin CP, Keefer L, Arn?r ES, Simeonov A, Maloney DJ, Williams DL, Thomas CJ. Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis. J Med Chem. 2009 Oct 22; 52(20):6474-83. PMID: 19761212; PMCID: PMC2772170.
      Citations:    
    54. Caffrey CR, Williams DL, Todd MH, Nelson DL, Keiser J, Utzinger J. Antiparasitic and Antibacterial Drug Discovery: From Molecular Targets to Drug Candidates. Selzer PM, editor. Chemotherapeutic Development Strategies for Schistosomiasis. 2009; 299 - 321. View Publication.
    55. Angelucci F, Sayed AA, Williams DL, Boumis G, Brunori M, Dimastrogiovanni D, Miele AE, Pauly F, Bellelli A, Angelucci F, Sayed AA, Williams DL, Boumis G, Brunori M, Dimastrogiovanni D, Miele AE, Pauly F, Bellelli A. Inhibition of Schistosoma mansoni thioredoxin-glutathione reductase by auranofin: structural and kinetic aspects. J Biol Chem. 2009 Oct 16; 284(42):28977-85. PMID: 19710012; PMCID: PMC2781444.
      Citations:    
    56. Berriman M, Haas BJ, LoVerde PT, Wilson RA, Dillon GP, Cerqueira GC, Mashiyama ST, Al-Lazikani B, Andrade LF, Ashton PD, Aslett MA, Bartholomeu DC, Blandin G, Caffrey CR, Coghlan A, Coulson R, Day TA, Delcher A, DeMarco R, Djikeng A, Eyre T, Gamble JA, Ghedin E, Gu Y, Hertz-Fowler C, Hirai H, Hirai Y, Houston R, Ivens A, Johnston DA, Lacerda D, Macedo CD, McVeigh P, Ning Z, Oliveira G, Overington JP, Parkhill J, Pertea M, Pierce RJ, Protasio AV, Quail MA, Rajandream MA, Rogers J, Sajid M, Salzberg SL, Stanke M, Tivey AR, White O, Williams DL, Wortman J, Wu W, Zamanian M, Zerlotini A, Fraser-Liggett CM, Barrell BG, El-Sayed NM, Berriman M, Haas BJ, LoVerde PT, Wilson RA, Dillon GP, Cerqueira GC, Mashiyama ST, Al-Lazikani B, Andrade LF, Ashton PD, Aslett MA, Bartholomeu DC, Blandin G, Caffrey CR, Coghlan A, Coulson R, Day TA, Delcher A, DeMarco R, Djikeng A, Eyre T, Gamble JA, Ghedin E, Gu Y, Hertz-Fowler C, Hirai H, Hirai Y, Houston R, Ivens A, Johnston DA, Lacerda D, Macedo CD, McVeigh P, Ning Z, Oliveira G, Overington JP, Parkhill J, Pertea M, Pierce RJ, Protasio AV, Quail MA, Rajandream MA, Rogers J, Sajid M, Salzberg SL, Stanke M, Tivey AR, White O, Williams DL, Wortman J, Wu W, Zamanian M, Zerlotini A, Fraser-Liggett CM, Barrell BG, El-Sayed NM. The genome of the blood fluke Schistosoma mansoni. Nature. 2009 Jul 16; 460(7253):352-8. PMID: 19606141; PMCID: PMC2756445.
      Citations:    
    57. Knight M, Raghavan N, Goodall C, Cousin C, Ittiprasert W, Sayed A, Miller A, Williams DL, Bayne CJ, Knight M, Raghavan N, Goodall C, Cousin C, Ittiprasert W, Sayed A, Miller A, Williams DL, Bayne CJ. Biomphalaria glabrata peroxiredoxin: effect of schistosoma mansoni infection on differential gene regulation. Mol Biochem Parasitol. 2009 Sep; 167(1):20-31. PMID: 19439374; PMCID: PMC2705950.
      Citations:    
    58. Donnelly S, Stack CM, O'Neill SM, Sayed AA, Williams DL, Dalton JP, Donnelly S, Stack CM, O'Neill SM, Sayed AA, Williams DL, Dalton JP. Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages. FASEB J. 2008 Nov; 22(11):4022-32. PMID: 18708590; PMCID: PMC3980656.
      Citations:    
    59. Lea WA, Jadhav A, Rai G, Sayed AA, Cass CL, Inglese J, Williams DL, Austin CP, Simeonov A, Lea WA, Jadhav A, Rai G, Sayed AA, Cass CL, Inglese J, Williams DL, Austin CP, Simeonov A. A 1,536-well-based kinetic HTS assay for inhibitors of Schistosoma mansoni thioredoxin glutathione reductase. Assay Drug Dev Technol. 2008 Aug; 6(4):551-5. PMID: 18665782; PMCID: PMC2669305.
      Citations:    
    60. Sayed AA, Simeonov A, Thomas CJ, Inglese J, Austin CP, Williams DL. Identification of oxadiazoles as new drug leads for the control of schistosomiasis. Nat Med. 2008 Apr; 14(4):407-12. PMID: 18345010.
      Citations:    
    61. Simeonov A, Jadhav A, Sayed AA, Wang Y, Nelson ME, Thomas CJ, Inglese J, Williams DL, Austin CP, Simeonov A, Jadhav A, Sayed AA, Wang Y, Nelson ME, Thomas CJ, Inglese J, Williams DL, Austin CP. Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade. PLoS Negl Trop Dis. 2008 Jan 02; 2(1):e127. PMID: 18235848; PMCID: PMC2217675.
      Citations:    
    62. Cass CL, Williams DL. Flavins and Flavoproteins. Frago S, Gomez-Moreno C, Medina M, editors. Characterizing the Functional Role of the Glutaredoxin Domain of the Flavoenzyme Thioredoxin Glutathione Reductase from Schistosoma mansoni. 2008; 327-332.
    63. Cass CL, Johnson JR, Califf LL, Xu T, Hernandez HJ, Stadecker MJ, Yates JR, Williams DL. Proteomic analysis of Schistosoma mansoni egg secretions. Mol Biochem Parasitol. 2007 Oct; 155(2):84-93. PMID: 17644200.
      Citations:    
    64. Kuntz AN, Davioud-Charvet E, Sayed AA, Califf LL, Dessolin J, Arn?r ES, Williams DL. Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target. PLoS Med. 2007 Jun; 4(6):e206. PMID: 17579510.
      Citations:    
    65. Williams DL, Sayed AA, Bernier J, Birkeland SR, Cipriano MJ, Papa AR, McArthur AG, Taft A, Vermeire JJ, Yoshino TP. Profiling Schistosoma mansoni development using serial analysis of gene expression (SAGE). Exp Parasitol. 2007 Nov; 117(3):246-58. PMID: 17577588.
      Citations:    
    66. Williams DL, Sayed AA, Ray D, McArthur AG. Schistosoma mansoni albumin, a major defense against oxidative damage, was acquired by lateral gene transfer from a mammalian host. Mol Biochem Parasitol. 2006 Dec; 150(2):359-63. PMID: 16934344.
      Citations:    
    67. Sayed AA, Cook SK, Williams DL. Redox balance mechanisms in Schistosoma mansoni rely on peroxiredoxins and albumin and implicate peroxiredoxins as novel drug targets. J Biol Chem. 2006 Jun 23; 281(25):17001-17010. PMID: 16606626.
      Citations:    
    68. Williams DL, Asahi H, Oke TT, Lopes da Rosa J, Stadecker MJ. Murine immune responses to a novel schistosome egg antigen, SmEP25. Int J Parasitol. 2005 Jul; 35(8):875-82. PMID: 15970293.
      Citations:    
    69. Williams DL, Pierce RJ. Schistosomiasis. World Class Parasites Secor, W.E., Colley, D.G. (eds). Schistosoma Genomics. 2005; 10:45–64. View Publication.
    70. Sayed AA, Williams DL. Biochemical characterization of 2-Cys peroxiredoxins from Schistosoma mansoni. J Biol Chem. 2004 Jun 18; 279(25):26159-66. PMID: 15075328.
      Citations:    
    71. Vermeire JJ, Osman A, LoVerde PT, Williams DL. Characterisation of a Rho homologue of Schistosoma mansoni. Int J Parasitol. 2003 Jul; 33(7):721-31. PMID: 12814652.
      Citations:    
    72. Copeland CS, Brindley PJ, Heyers O, Michael SF, Johnston DA, Williams DL, Ivens AC, Kalinna BH, Copeland CS, Brindley PJ, Heyers O, Michael SF, Johnston DA, Williams DL, Ivens AC, Kalinna BH. Boudicca, a retrovirus-like long terminal repeat retrotransposon from the genome of the human blood fluke Schistosoma mansoni. J Virol. 2003 Jun; 77(11):6153-66. PMID: 12743272; PMCID: PMC154989.
      Citations:    
    73. B?niguel L, Diallo TO, Remou? F, Williams DL, Cognasse F, Charrier-Mze N, N'Diaye AA, Perraut R, Capron M, Riveau G, Garraud O. Differential production in vitro of antigen specific IgG1, IgG3 and IgA: a study in Schistosoma haematobium infected individuals. Parasite Immunol. 2003 Jan; 25(1):39-44. PMID: 12753436.
      Citations:    
    74. Foulk BW, Pappas G, Hirai Y, Hirai H, Williams DL. Adenylosuccinate lyase of Schistosoma mansoni: gene structure, mRNA expression, and analysis of the predicted peptide structure of a potential chemotherapeutic target. Int J Parasitol. 2002 Nov; 32(12):1487-95. PMID: 12392914.
      Citations:    
    75. Alger HM, Sayed AA, Stadecker MJ, Williams DL. Molecular and enzymatic characterisation of Schistosoma mansoni thioredoxin. Int J Parasitol. 2002 Sep; 32(10):1285-92. PMID: 12204228.
      Citations:    
    76. Alger HM, Williams DL. The disulfide redox system of Schistosoma mansoni and the importance of a multifunctional enzyme, thioredoxin glutathione reductase. Mol Biochem Parasitol. 2002 Apr 30; 121(1):129-39. PMID: 11985869.
      Citations:    
    77. Williams DL, Asahi H, Botkin DJ, Stadecker MJ. Schistosome infection stimulates host CD4(+) T helper cell and B-cell responses against a novel egg antigen, thioredoxin peroxidase. Infect Immun. 2001 Feb; 69(2):1134-41. PMID: 11160011.
      Citations:    
    78. Pullman DA, Williams DL, Broadway RM, Stewart CN. . Isolation and characterization of a serine proteinase inhibitor cDNA from cabbage and its antibiosis in transgenic tobacco plants. Cell Biotechnology and Molecular Biology. 2001; (2):19-32.
    79. Kwatia MA, Botkin DJ, Williams DL. Molecular and enzymatic characterization of Schistosoma mansoni thioredoxin peroxidase. J Parasitol. 2000 Oct; 86(5):908-15. PMID: 11128509.
      Citations:    
    80. Le Paslier MC, Pierce RJ, Merlin F, Hirai H, Wu W, Williams DL, Johnston D, LoVerde PT, Le Paslier D. Construction and characterization of a Schistosoma mansoni bacterial artificial chromosome library. Genomics. 2000 Apr 15; 65(2):87-94. PMID: 10783255.
      Citations:    
    81. Williams DL, Kain WC, Broadway RM. Isolation and characterization of a serine proteinase inhibitor cDNA (accession No. U18995) from cabbage (PGR97-083). Plant Physiology. 1997; (114):747-748.
    82. Broadway RM, Williams DL, Kain WC, Harman GE, Lorito M, Labeda DP. Partial characterization of chitinolytic enzymes from Streptomyces albidoflavus. Lett Appl Microbiol. 1995 May; 20(5):271-6. PMID: 7766226.
      Citations:    
    83. Pierce RJ, Khalife J, Williams DL, Kanno R, Trottein F, LePresle T, Sabatier J, Achstetter T, Capron A. Schistosoma mansoni: characterization of sequence variants of the 28-kDa glutathione S-transferase. Exp Parasitol. 1994 Aug; 79(1):81-4. PMID: 7519566.
      Citations:    
    84. Roche C, Williams DL, Khalife J, LePresle T, Capron A, Pierce RJ. Cloning and characterization of the gene encoding Schistosoma mansoni glutathione peroxidase. Gene. 1994 Jan 28; 138(1-2):149-52. PMID: 8125294.
      Citations:    
    85. Lorito M, Broadway RM, Hayes CK, Woo SL, Noviello C, Williams DL, Harman GE. Proteinase inhibitors from plants as a novel class of fungicides. Molecular Plant-Microbe Interactions. 1994; (7):525-527.
    86. Williams DL, Pierce RJ, Cookson E, Capron A. Molecular cloning and sequencing of glutathione peroxidase from Schistosoma mansoni. Mol Biochem Parasitol. 1992 May; 52(1):127-30. PMID: 1625700.
      Citations:    
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