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Konstantinos Arfanakis

TitleProfessor
InstitutionRush University, Rush Medical College
DepartmentDiagnostic Radiology and Nuclear Medicine
Address
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    1999Student Stipend, International Society for Magnetic Resonance in Medicine (ISMRM)
    2000Student Stipend, International Society for Magnetic Resonance in Medicine (ISMRM)
    2001Student Stipend, International Society for Magnetic Resonance in Medicine (ISMRM)
    2001Vilas Fellowship
    2002Student Stipend, International Society for Magnetic Resonance in Medicine (ISMRM)
    2002Magna Cum Laude, Radiological Society of North America (RSNA)
    2002Excellence in Design of Education Exhibit, Radiological Society of North America (RSNA)
    2002Figures from journal article AJNR Am. J. Neuroradiol 2002;23:794-802, Cover of that issue of the journal
    2003Journal article Magn. Reson. Med. 2002;47:354-363 was ranked in the Top 10 most assessed papers , Magnetic Resonance in Medicine for the period 2002-2003
    2004Dean's commendation for receiving outstanding teaching evaluations for my BME 535 course
    2005Dean's commendation for receiving outstanding teaching evaluations for my BME 430 course
    2006Dean's commendation for receiving outstanding teaching evaluations for my BME 438 course
    2007Sigma Xi / IIT Award for Excellence in University Research, Junior faculty category
    2008Top 3 for the Bodossaki Foundation Academic Prize , "Theories, Methods, and Techniques, of Biomedical Applications of Informtics and Telecommunications"
    2009Journal article Neuroimage 2009;46:967-980 ranked #11, List of "hottest articles" in Neuromage for April-June (out of 168 papers)
    2010Journal article Am. J. Neuroradiol. 2002:23:794-802 ranked #28, Most Frequently Cited Article in the history of the journal
    2012ISMRM Magna Cum Laude Merit Award, 20th Annual ISMRM international conference
    2012Journal article Nat Genet 2012;44:545-552, received the "Best paper" award, 2012 de Leon Prize in Neuroimaging
    2015Merit Abstract Award, Organization for Human Brain Mapping
    2015ISMRM Summa Cum Laude Merit Award, 23rd Annuial ISMRM international conference
    2017Scientific Sessions, Best Nursing Abstract, American Heart Association
    2017ISMRM Magna Cum Laude Merit Award, 25th Annual ISMRM international conference

    Collapse Overview 
    Collapse overview
    Konstantinos Arfanakis, PhD, is Professor of Biomedical Engineering at the Illinois Institute of Technology, and Leader of the Imaging and Bioengineering Studies at the Rush Alzheimer’s Disease Center. Dr. Arfanakis has expertise in MRI pulse sequence development, image reconstruction, and image processing. His research focuses on multi-parametric MRI in aging and dementia, ex-vivo brain MRI, and brain atlas development.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lamar M, Arfanakis K, Evia A, Makkinejad N, Capuano AW, Kim N, Leurgans SE, Fleischman DA, Duke Han S, Poole V, Barnes LL. Changes in an in-vivo classifier of ARTerioloSclerosis (ARTS) with simultaneous change in cognition for older African Americans. Neurobiol Aging. 2024 Feb; 134:21-27. PMID: 37979249.
      Citations:    
    2. Lamar M, Arfanakis K, Yu L, Kapasi A, Duke Han S, Fleischman DA, Bennett DA, Boyle P. The Relationship of MRI-Derived Alzheimer's and Cerebrovascular-Related Signatures With Level of and Change in Health and Financial Literacy. Am J Geriatr Psychiatry. 2023 12; 31(12):1129-1139. PMID: 37541932.
      Citations:    
    3. Nikseresht G, Evia AM, Nag S, Leurgans SE, Capuano AW, Agam G, Barnes LL, Bennett DA, Schneider JA, Arfanakis K. Neuropathologic correlates of cerebral microbleeds in community-based older adults. Neurobiol Aging. 2023 09; 129:89-98. PMID: 37279617.
      Citations:    
    4. Fleischman DA, Arfanakis K, Leurgans SE, Zhang S, Lamar M, Han SD, Poole VN, Kim N, Bennett DA, Barnes LL. Late-life depressive symptoms and white matter structural integrity within older Black adults. Front Aging Neurosci. 2023; 15:1138568. PMID: 37205056.
      Citations:    
    5. Ridwan AR, Niaz MR, Wu Y, Qi X, Zhang S, Kontzialis M, Javierre-Petit C, Tazwar M, Bennett DA, Yang Y, Arfanakis K. Development and evaluation of a high performance T1-weighted brain template for use in studies on older adults. Hum Brain Mapp. 2021 04 15; 42(6):1758-1776. PMID: 33449398.
      Citations:    
    6. Yu L, Tasaki S, Schneider JA, Arfanakis K, Duong DM, Wingo AP, Wingo TS, Kearns N, Thatcher GRJ, Seyfried NT, Levey AI, De Jager PL, Bennett DA. Cortical Proteins Associated With Cognitive Resilience in Community-Dwelling Older Persons. JAMA Psychiatry. 2020 11 01; 77(11):1172-1180. PMID: 32609320.
      Citations:    
    7. Bronas UG, Steffen A, Dion C, Boots EA, Arfanakis K, Marquez DX, Lamar M. Sedentary Time and White Matter Hyperintensity Volume in Older Adults. Med Sci Sports Exerc. 2019 08; 51(8):1613-1618. PMID: 30817720.
      Citations:    
    8. Gaiteri C, Dawe R, Mostafavi S, Blizinsky KD, Tasaki S, Komashko V, Yu L, Wang Y, Schneider JA, Arfanakis K, De Jager PL, Bennett DA. Gene expression and DNA methylation are extensively coordinated with MRI-based brain microstructural characteristics. Brain Imaging Behav. 2019 Aug; 13(4):963-972. PMID: 29934819.
      Citations:    
    9. Han SD, Arfanakis K, Fleischman DA, Yu L, Bennett DA, Boyle PA. White matter correlates of temporal discounting in older adults. Brain Struct Funct. 2018 Nov; 223(8):3653-3663. PMID: 29992469.
      Citations:    
    10. Yu L, Dawe RJ, Boyle PA, Gaiteri C, Yang J, Buchman AS, Schneider JA, Arfanakis K, De Jager PL, Bennett DA. Association Between Brain Gene Expression, DNA Methylation, and Alteration of Ex Vivo Magnetic Resonance Imaging Transverse Relaxation in Late-Life Cognitive Decline. JAMA Neurol. 2017 12 01; 74(12):1473-1480. PMID: 29084334.
      Citations:    
    11. White CC, Yang HS, Yu L, Chibnik LB, Dawe RJ, Yang J, Klein HU, Felsky D, Ramos-Miguel A, Arfanakis K, Honer WG, Sperling RA, Schneider JA, Bennett DA, De Jager PL. Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data. PLoS Med. 2017 04; 14(4):e1002287. PMID: 28441426.
      Citations:    
    12. Hibar DP, Adams HHH, Jahanshad N, Chauhan G, Stein JL, Hofer E, Renteria ME, Bis JC, Arias-Vasquez A, Ikram MK, Desrivi?res S, Vernooij MW, Abramovic L, Alhusaini S, Amin N, Andersson M, Arfanakis K, Aribisala BS, Armstrong NJ, Athanasiu L, Axelsson T, Beecham AH, Beiser A, Bernard M, Blanton SH, Bohlken MM, Boks MP, Bralten J, Brickman AM, Carmichael O, Chakravarty MM, Chen Q, Ching CRK, Chouraki V, Cuellar-Partida G, Crivello F, Den Braber A, Doan NT, Ehrlich S, Giddaluru S, Goldman AL, Gottesman RF, Grimm O, Griswold ME, Guadalupe T, Gutman BA, Hass J, Haukvik UK, Hoehn D, Holmes AJ, Hoogman M, Janowitz D, Jia T, J?rgensen KN, Karbalai N, Kasperaviciute D, Kim S, Klein M, Kraemer B, Lee PH, Liewald DCM, Lopez LM, Luciano M, Macare C, Marquand AF, Matarin M, Mather KA, Mattheisen M, McKay DR, Milaneschi Y, Mu?oz Maniega S, Nho K, Nugent AC, Nyquist P, Loohuis LMO, Oosterlaan J, Papmeyer M, Pirpamer L, P?tz B, Ramasamy A, Richards JS, Risacher SL, Roiz-Santia?ez R, Rommelse N, Ropele S, Rose EJ, Royle NA, Rundek T, S?mann PG, Saremi A, Satizabal CL, Schmaal L, Schork AJ, Shen L, Shin J, Shumskaya E, Smith AV, Sprooten E, Strike LT, Teumer A, Tordesillas-Gutierrez D, Toro R, Trabzuni D, Trompet S, Vaidya D, Van der Grond J, Van der Lee SJ, Van der Meer D, Van Donkelaar MMJ, Van Eijk KR, Van Erp TGM, Van Rooij D, Walton E, Westlye LT, Whelan CD, Windham BG, Winkler AM, Wittfeld K, Woldehawariat G, Wolf C, Wolfers T, Yanek LR, Yang J, Zijdenbos A, Zwiers MP, Agartz I, Almasy L, Ames D, Amouyel P, Andreassen OA, Arepalli S, Assareh AA, Barral S, Bastin ME, Becker DM, Becker JT, Bennett DA, Blangero J, van Bokhoven H, Boomsma DI, Brodaty H, Brouwer RM, Brunner HG, Buckner RL, Buitelaar JK, Bulayeva KB, Cahn W, Calhoun VD, Cannon DM, Cavalleri GL, Cheng CY, Cichon S, Cookson MR, Corvin A, Crespo-Facorro B, Curran JE, Czisch M, Dale AM, Davies GE, De Craen AJM, De Geus EJC, De Jager PL, De Zubicaray GI, Deary IJ, Debette S, DeCarli C, Delanty N, Depondt C, DeStefano A, Dillman A, Djurovic S, Donohoe G, Drevets WC, Duggirala R, Dyer TD, Enzinger C, Erk S, Espeseth T, Fedko IO, Fern?ndez G, Ferrucci L, Fisher SE, Fleischman DA, Ford I, Fornage M, Foroud TM, Fox PT, Francks C, Fukunaga M, Gibbs JR, Glahn DC, Gollub RL, G?ring HHH, Green RC, Gruber O, Gudnason V, Guelfi S, H?berg AK, Hansell NK, Hardy J, Hartman CA, Hashimoto R, Hegenscheid K, Heinz A, Le Hellard S, Hernandez DG, Heslenfeld DJ, Ho BC, Hoekstra PJ, Hoffmann W, Hofman A, Holsboer F, Homuth G, Hosten N, Hottenga JJ, Huentelman M, Hulshoff Pol HE, Ikeda M, Jack CR, Jenkinson M, Johnson R, J?nsson EG, Jukema JW, Kahn RS, Kanai R, Kloszewska I, Knopman DS, Kochunov P, Kwok JB, Lawrie SM, Lema?tre H, Liu X, Longo DL, Lopez OL, Lovestone S, Martinez O, Martinot JL, Mattay VS, McDonald C, McIntosh AM, McMahon FJ, McMahon KL, Mecocci P, Melle I, Meyer-Lindenberg A, Mohnke S, Montgomery GW, Morris DW, Mosley TH, M?hleisen TW, M?ller-Myhsok B, Nalls MA, Nauck M, Nichols TE, Niessen WJ, N?then MM, Nyberg L, Ohi K, Olvera RL, Ophoff RA, Pandolfo M, Paus T, Pausova Z, Penninx BWJH, Pike GB, Potkin SG, Psaty BM, Reppermund S, Rietschel M, Roffman JL, Romanczuk-Seiferth N, Rotter JI, Ryten M, Sacco RL, Sachdev PS, Saykin AJ, Schmidt R, Schmidt H, Schofield PR, Sigursson S, Simmons A, Singleton A, Sisodiya SM, Smith C, Smoller JW, Soininen H, Steen VM, Stott DJ, Sussmann JE, Thalamuthu A, Toga AW, Traynor BJ, Troncoso J, Tsolaki M, Tzourio C, Uitterlinden AG, Hern?ndez MCV, Van der Brug M, van der Lugt A, van der Wee NJA, Van Haren NEM, van 't Ent D, Van Tol MJ, Vardarajan BN, Vellas B, Veltman DJ, V?lzke H, Walter H, Wardlaw JM, Wassink TH, Weale ME, Weinberger DR, Weiner MW, Wen W, Westman E, White T, Wong TY, Wright CB, Zielke RH, Zonderman AB, Martin NG, Van Duijn CM, Wright MJ, Longstreth WT, Schumann G, Grabe HJ, Franke B, Launer LJ, Medland SE, Seshadri S, et al. Novel genetic loci associated with hippocampal volume. Nat Commun. 2017 01 18; 8:13624. PMID: 28098162.
      Citations:    
    13. . Association Between Brain Gene Expression, DNA Methylation, and Alteration of Ex Vivo Magnetic Resonance Imaging Transverse Relaxation in Late-Life Cognitive Decline. JAMA Neurol. 2017; 74:1473-1480.
    14. Adams HH, Hibar DP, Chouraki V, Stein JL, Nyquist PA, Renter?a ME, Trompet S, Arias-Vasquez A, Seshadri S, Desrivi?res S, Beecham AH, Jahanshad N, Wittfeld K, Van der Lee SJ, Abramovic L, Alhusaini S, Amin N, Andersson M, Arfanakis K, Aribisala BS, Armstrong NJ, Athanasiu L, Axelsson T, Beiser A, Bernard M, Bis JC, Blanken LM, Blanton SH, Bohlken MM, Boks MP, Bralten J, Brickman AM, Carmichael O, Chakravarty MM, Chauhan G, Chen Q, Ching CR, Cuellar-Partida G, Braber AD, Doan NT, Ehrlich S, Filippi I, Ge T, Giddaluru S, Goldman AL, Gottesman RF, Greven CU, Grimm O, Griswold ME, Guadalupe T, Hass J, Haukvik UK, Hilal S, Hofer E, Hoehn D, Holmes AJ, Hoogman M, Janowitz D, Jia T, Kasperaviciute D, Kim S, Klein M, Kraemer B, Lee PH, Liao J, Liewald DC, Lopez LM, Luciano M, Macare C, Marquand A, Matarin M, Mather KA, Mattheisen M, Mazoyer B, McKay DR, McWhirter R, Milaneschi Y, Mirza-Schreiber N, Muetzel RL, Maniega SM, Nho K, Nugent AC, Loohuis LM, Oosterlaan J, Papmeyer M, Pappa I, Pirpamer L, Pudas S, P?tz B, Rajan KB, Ramasamy A, Richards JS, Risacher SL, Roiz-Santia?ez R, Rommelse N, Rose EJ, Royle NA, Rundek T, S?mann PG, Satizabal CL, Schmaal L, Schork AJ, Shen L, Shin J, Shumskaya E, Smith AV, Sprooten E, Strike LT, Teumer A, Thomson R, Tordesillas-Gutierrez D, Toro R, Trabzuni D, Vaidya D, Van der Grond J, Van der Meer D, Van Donkelaar MM, Van Eijk KR, Van Erp TG, Van Rooij D, Walton E, Westlye LT, Whelan CD, Windham BG, Winkler AM, Woldehawariat G, Wolf C, Wolfers T, Xu B, Yanek LR, Yang J, Zijdenbos A, Zwiers MP, Agartz I, Aggarwal NT, Almasy L, Ames D, Amouyel P, Andreassen OA, Arepalli S, Assareh AA, Barral S, Bastin ME, Becker DM, Becker JT, Bennett DA, Blangero J, van Bokhoven H, Boomsma DI, Brodaty H, Brouwer RM, Brunner HG, Buckner RL, Buitelaar JK, Bulayeva KB, Cahn W, Calhoun VD, Cannon DM, Cavalleri GL, Chen C, Cheng CY, Cichon S, Cookson MR, Corvin A, Crespo-Facorro B, Curran JE, Czisch M, Dale AM, Davies GE, De Geus EJ, De Jager PL, de Zubicaray GI, Delanty N, Depondt C, DeStefano AL, Dillman A, Djurovic S, Donohoe G, Drevets WC, Duggirala R, Dyer TD, Erk S, Espeseth T, Evans DA, Fedko IO, Fern?ndez G, Ferrucci L, Fisher SE, Fleischman DA, Ford I, Foroud TM, Fox PT, Francks C, Fukunaga M, Gibbs JR, Glahn DC, Gollub RL, G?ring HH, Grabe HJ, Green RC, Gruber O, Gudnason V, Guelfi S, Hansell NK, Hardy J, Hartman CA, Hashimoto R, Hegenscheid K, Heinz A, Le Hellard S, Hernandez DG, Heslenfeld DJ, Ho BC, Hoekstra PJ, Hoffmann W, Hofman A, Holsboer F, Homuth G, Hosten N, Hottenga JJ, Hulshoff Pol HE, Ikeda M, Ikram MK, Jack CR, Jenkinson M, Johnson R, J?nsson EG, Jukema JW, Kahn RS, Kanai R, Kloszewska I, Knopman DS, Kochunov P, Kwok JB, Lawrie SM, Lema?tre H, Liu X, Longo DL, Longstreth WT, Lopez OL, Lovestone S, Martinez O, Martinot JL, Mattay VS, McDonald C, McIntosh AM, McMahon KL, McMahon FJ, Mecocci P, Melle I, Meyer-Lindenberg A, Mohnke S, Montgomery GW, Morris DW, Mosley TH, M?hleisen TW, M?ller-Myhsok B, Nalls MA, Nauck M, Nichols TE, Niessen WJ, N?then MM, Nyberg L, Ohi K, Olvera RL, Ophoff RA, Pandolfo M, Paus T, Pausova Z, Penninx BW, Pike GB, Potkin SG, Psaty BM, Reppermund S, Rietschel M, Roffman JL, Romanczuk-Seiferth N, Rotter JI, Ryten M, Sacco RL, Sachdev PS, Saykin AJ, Schmidt R, Schofield PR, Sigurdsson S, Simmons A, Singleton A, Sisodiya SM, Smith C, Smoller JW, Soininen H, Srikanth V, Steen VM, Stott DJ, Sussmann JE, Thalamuthu A, Tiemeier H, Toga AW, Traynor BJ, Troncoso J, Turner JA, Tzourio C, Uitterlinden AG, Hern?ndez MC, Van der Brug M, Van der Lugt A, Van der Wee NJ, Van Duijn CM, Van Haren NE, Van T Ent D, Van Tol MJ, Vardarajan BN, Veltman DJ, Vernooij MW, V?lzke H, Walter H, Wardlaw JM, Wassink TH, Weale ME, Weinberger DR, Weiner MW, Wen W, Westman E, White T, Wong TY, Wright CB, Zielke HR, Zonderman AB, Deary IJ, DeCarli C, Schmidt H, Martin NG, De Craen AJ, et al. Novel genetic loci underlying human intracranial volume identified through genome-wide association. Nat Neurosci. 2016 12; 19(12):1569-1582. PMID: 27694991.
      Citations:    
    15. Boyle PA, Yu L, Fleischman DA, Leurgans S, Yang J, Wilson RS, Schneider JA, Arvanitakis Z, Arfanakis K, Bennett DA. White matter hyperintensities, incident mild cognitive impairment, and cognitive decline in old age. Ann Clin Transl Neurol. 2016 10; 3(10):791-800. PMID: 27752514.
      Citations:    
    16. Dawe RJ, Yu L, Leurgans SE, Schneider JA, Buchman AS, Arfanakis K, Bennett DA, Boyle PA. Postmortem MRI: a novel window into the neurobiology of late life cognitive decline. Neurobiol Aging. 2016 09; 45:169-177. PMID: 27459937.
      Citations:    
    17. Arfanakis K, Wilson RS, Barth CM, Capuano AW, Vasireddi A, Zhang S, Fleischman DA, Bennett DA. Cognitive activity, cognitive function, and brain diffusion characteristics in old age. Brain Imaging Behav. 2016 06; 10(2):455-63. PMID: 25982658.
      Citations:    
    18. Han SD, Boyle PA, Arfanakis K, Fleischman D, Yu L, James BD, Bennett DA. Financial literacy is associated with white matter integrity in old age. Neuroimage. 2016 Apr 15; 130:223-229. PMID: 26899784.
      Citations:    
    19. Kotrotsou A, Schneider JA, Bennett DA, Leurgans SE, Dawe RJ, Boyle PA, Golak T, Arfanakis K. Neuropathologic correlates of regional brain volumes in a community cohort of older adults. Neurobiol Aging. 2015 Oct; 36(10):2798-805. PMID: 26195068.
      Citations:    
    20. Varentsova A, Zhang S, Arfanakis K. Development of a high angular resolution diffusion imaging human brain template. Neuroimage. 2014 May 01; 91:177-86. PMID: 24440528.
      Citations:    
    21. . Role of standardized and study-specific human brain diffusion tensor templates in inter-subject spatial normalization. J Magn Reson Imaging. 2013; 37:372-381.
    22. Han SD, Boyle PA, Arfanakis K, Fleischman DA, Yu L, Edmonds EC, Bennett DA. Neural intrinsic connectivity networks associated with risk aversion in old age. Behav Brain Res. 2012 Feb 01; 227(1):233-40. PMID: 22044475.
      Citations:    
    23. Wang Y, West JD, Flashman LA, Wishart HA, Santulli RB, Rabin LA, Pare N, Arfanakis K, Saykin AJ. Selective changes in white matter integrity in MCI and older adults with cognitive complaints. Biochim Biophys Acta. 2012 Mar; 1822(3):423-30. PMID: 21867750.
      Citations:    
    24. . Clinical MR Neuroimaging, 2nd Edition. Diffusion and perfusion MR imaging in seizure disorders. 2010; 546-556.
    25. Tamhane AA, Arfanakis K. Motion correction in periodically-rotated overlapping parallel lines with enhanced reconstruction (PROPELLER) and turboprop MRI. Magn Reson Med. 2009 Jul; 62(1):174-82. PMID: 19365858.
      Citations:    
    26. . Handbook of Research on Afvanced Techniques in Diagnostic Imaging and Biomedical Applications. Optimal diffusion encoding strategies for fiber mapping n diffusion MRI. 2009; 90-107.
    27. Gui M, Peng H, Carew JD, Lesniak MS, Arfanakis K. A tractography comparison between turboprop and spin-echo echo-planar diffusion tensor imaging. Neuroimage. 2008 Oct 01; 42(4):1451-62. PMID: 18621131.
      Citations:    
    28. . Investigating the Medial Temporal Lobe in Alzheimer's Disease and Mild Cognitive Impairment, with Turboprop Diffusion Tensor Imaging, MRI-Volumetry and T2-relaxometry. Brain Imaging and Behav. 2007; 1:11-21.
    29. Arfanakis K, Gui M, Lazar M. White matter tractography by means of Turboprop diffusion tensor imaging. Ann N Y Acad Sci. 2005 Dec; 1064:78-87. PMID: 16394149.
      Citations:    
    30. . Clinical MR Neuroimaging: Diffusion, Perfusion and Spectroscopy. Diffusion and perfusion MR imaging in seizure disorders. 2005; 509-520.
    31. . Imaging of the Nervous System: Diagnostic and Therapeutic Applications, Philadelphia, PA. Mapping brain function with functional magnetic resonance imaging. 2005; 89-100.
    32. Witwer BP, Moftakhar R, Hasan KM, Deshmukh P, Haughton V, Field A, Arfanakis K, Noyes J, Moritz CH, Meyerand ME, Rowley HA, Alexander AL, Badie B. Diffusion-tensor imaging of white matter tracts in patients with cerebral neoplasm. J Neurosurg. 2002 Sep; 97(3):568-75. PMID: 12296640.
      Citations:    
    33. . Application of image registration to measurement of intervertebral rotation in the lumbar spine. Magn Reson Med. 2002; 48:1072-1075.
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