"rho-Associated Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT-CHAIN PHOSPHATASE and LIM KINASES.
Descriptor ID |
D054460
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MeSH Number(s) |
D08.811.913.696.620.682.700.814 D12.644.360.590 D12.776.476.595
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Concept/Terms |
rho-Associated Kinases- rho-Associated Kinases
- rho Associated Kinases
- rho-Associated Kinase
- rho Associated Kinase
- ROCK Protein Kinases
- Protein Kinases, ROCK
- rho-Associated Coiled-Coil Kinase
- Coiled-Coil Kinase, rho-Associated
- rho Associated Coiled Coil Kinase
- rho-Kinase
- rho Kinase
- ROK Kinase
rho-Associated Kinase 1- rho-Associated Kinase 1
- rho Associated Kinase 1
- ROCK-I Protein Kinase
- ROCK I Protein Kinase
- p160ROCK
- rho-Associated Kinase beta
- rho Associated Kinase beta
- rho-Associated Protein Kinase beta
- rho Associated Protein Kinase beta
- rho-Associated Coiled-Coil Containing Protein Kinase 1
- rho Associated Coiled Coil Containing Protein Kinase 1
rho-Associated Kinase 2- rho-Associated Kinase 2
- rho Associated Kinase 2
- rho-Associated Kinase alpha
- rho Associated Kinase alpha
- rho-Associated Coiled-Coil Containing Protein Kinase 2
- rho Associated Coiled Coil Containing Protein Kinase 2
- ROCK-II Protein Kinase
- ROCK II Protein Kinase
- p160 rhoA-Binding Kinase ROKalpha
- p160 rhoA Binding Kinase ROKalpha
- rho-Associated Protein Kinase alpha
- rho Associated Protein Kinase alpha
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Below are MeSH descriptors whose meaning is more general than "rho-Associated Kinases".
Below are MeSH descriptors whose meaning is more specific than "rho-Associated Kinases".
This graph shows the total number of publications written about "rho-Associated Kinases" by people in this website by year, and whether "rho-Associated Kinases" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2009 | 0 | 2 | 2 |
2016 | 1 | 1 | 2 |
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Below are the most recent publications written about "rho-Associated Kinases" by people in Profiles.
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Physiological ranges of matrix rigidity modulate primary mouse hepatocyte function in part through hepatocyte nuclear factor 4 alpha. Hepatology. 2016 07; 64(1):261-75.
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Rho-Associated Kinase Inhibitor Immortalizes Rat Nucleus Pulposus and Annulus Fibrosus Cells: Establishment of Intervertebral Disc Cell Lines With Novel Approaches. Spine (Phila Pa 1976). 2016 Mar; 41(5):E255-61.
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LIM kinase 1 promotes endothelial barrier disruption and neutrophil infiltration in mouse lungs. Circ Res. 2009 Sep 11; 105(6):549-56.
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Overexpression of RhoA induces preneoplastic transformation of primary mammary epithelial cells. Cancer Res. 2009 Jan 15; 69(2):483-91.