 Alzheimer Disease
"Alzheimer Disease" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Descriptor ID |
D000544
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| MeSH Number(s) |
C10.228.140.380.100 C10.574.945.249 F03.087.400.100
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| Concept/Terms |
Alzheimer Disease- Alzheimer Disease
- Disease, Alzheimer
- Alzheimer Sclerosis
- Sclerosis, Alzheimer
- Alzheimer Syndrome
- Syndrome, Alzheimer
- Alzheimer Type Senile Dementia
- Senile Dementia, Alzheimer Type
- Alzheimer-Type Dementia (ATD)
- Alzheimer Type Dementia (ATD)
- Dementia, Alzheimer-Type (ATD)
- Dementia, Alzheimer Type
- Alzheimer Type Dementia
- Dementia, Primary Senile Degenerative
- Dementia, Senile
- Senile Dementia
- Primary Senile Degenerative Dementia
- Alzheimer Dementia (AD)
- Dementia, Alzheimer (AD)
- Alzheimer's Disease
- Disease, Alzheimer's
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Below are MeSH descriptors whose meaning is more general than "Alzheimer Disease".
Below are MeSH descriptors whose meaning is more specific than "Alzheimer Disease".
This graph shows the total number of publications written about "Alzheimer Disease" by people in this website by year, and whether "Alzheimer Disease" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1987 | 1 | 0 | 1 | | 1988 | 2 | 0 | 2 | | 1989 | 1 | 0 | 1 | | 1990 | 2 | 0 | 2 | | 1991 | 3 | 0 | 3 | | 1992 | 2 | 1 | 3 | | 1993 | 1 | 0 | 1 | | 1994 | 3 | 1 | 4 | | 1996 | 0 | 1 | 1 | | 1997 | 6 | 0 | 6 | | 1998 | 5 | 0 | 5 | | 1999 | 8 | 1 | 9 | | 2000 | 13 | 2 | 15 | | 2001 | 4 | 1 | 5 | | 2002 | 16 | 1 | 17 | | 2003 | 22 | 1 | 23 | | 2004 | 22 | 4 | 26 | | 2005 | 34 | 4 | 38 | | 2006 | 20 | 4 | 24 | | 2007 | 19 | 4 | 23 | | 2008 | 16 | 2 | 18 | | 2009 | 17 | 1 | 18 | | 2010 | 21 | 2 | 23 | | 2011 | 32 | 7 | 39 | | 2012 | 32 | 7 | 39 | | 2013 | 25 | 4 | 29 | | 2014 | 42 | 3 | 45 | | 2015 | 36 | 8 | 44 | | 2016 | 28 | 8 | 36 | | 2017 | 31 | 6 | 37 | | 2018 | 51 | 6 | 57 | | 2019 | 33 | 10 | 43 | | 2020 | 5 | 1 | 6 |
To return to the timeline, click here.
Below are the most recent publications written about "Alzheimer Disease" by people in Profiles.
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Oveisgharan S, Dawe RJ, Leurgans SE, Yu L, Schneider JA, Bennett DA, Buchman AS. Total daily physical activity, brain pathologies, and parkinsonism in older adults. PLoS One. 2020; 15(4):e0232404.
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Klein HU, Schäfer M, Bennett DA, Schwender H, De Jager PL. Bayesian integrative analysis of epigenomic and transcriptomic data identifies Alzheimer's disease candidate genes and networks. PLoS Comput Biol. 2020 04; 16(4):e1007771.
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Arnold M, Nho K, Kueider-Paisley A, Massaro T, Huynh K, Brauner B, MahmoudianDehkordi S, Louie G, Moseley MA, Thompson JW, John-Williams LS, Tenenbaum JD, Blach C, Chang R, Brinton RD, Baillie R, Han X, Trojanowski JQ, Shaw LM, Martins R, Weiner MW, Trushina E, Toledo JB, Meikle PJ, Bennett DA, Krumsiek J, Doraiswamy PM, Saykin AJ, Kaddurah-Daouk R, Kastenmüller G. Sex and APOE e4 genotype modify the Alzheimer's disease serum metabolome. Nat Commun. 2020 03 02; 11(1):1148.
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Reiman EM, Arboleda-Velasquez JF, Quiroz YT, Huentelman MJ, Beach TG, Caselli RJ, Chen Y, Su Y, Myers AJ, Hardy J, Paul Vonsattel J, Younkin SG, Bennett DA, De Jager PL, Larson EB, Crane PK, Keene CD, Kamboh MI, Kofler JK, Duque L, Gilbert JR, Gwirtsman HE, Buxbaum JD, Dickson DW, Frosch MP, Ghetti BF, Lunetta KL, Wang LS, Hyman BT, Kukull WA, Foroud T, Haines JL, Mayeux RP, Pericak-Vance MA, Schneider JA, Trojanowski JQ, Farrer LA, Schellenberg GD, Beecham GW, Montine TJ, Jun GR. Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study. Nat Commun. 2020 02 03; 11(1):667.
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Allnutt MA, Johnson K, Bennett DA, Connor SM, Troncoso JC, Pletnikova O, Albert MS, Resnick SM, Scholz SW, De Jager PL, Jacobson S. Human Herpesvirus 6 Detection in Alzheimer's Disease Cases and Controls across Multiple Cohorts. Neuron. 2020 03 18; 105(6):1027-1035.e2.
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Zhou Y, Song WM, Andhey PS, Swain A, Levy T, Miller KR, Poliani PL, Cominelli M, Grover S, Gilfillan S, Cella M, Ulland TK, Zaitsev K, Miyashita A, Ikeuchi T, Sainouchi M, Kakita A, Bennett DA, Schneider JA, Nichols MR, Beausoleil SA, Ulrich JD, Holtzman DM, Artyomov MN, Colonna M. Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease. Nat Med. 2020 01; 26(1):131-142.
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Agarwal P, Holland TM, Wang Y, Bennett DA, Morris MC. Association of Strawberries and Anthocyanidin Intake with Alzheimer's Dementia Risk. Nutrients. 2019 Dec 14; 11(12).
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Kaneshwaran K, Olah M, Tasaki S, Yu L, Bradshaw EM, Schneider JA, Buchman AS, Bennett DA, De Jager PL, Lim ASP. Sleep fragmentation, microglial aging, and cognitive impairment in adults with and without Alzheimer's dementia. Sci Adv. 2019 12; 5(12):eaax7331.
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Yu L, Boyle PA, Dawe RJ, Bennett DA, Arfanakis K, Schneider JA. Contribution of TDP and hippocampal sclerosis to hippocampal volume loss in older-old persons. Neurology. 2020 01 14; 94(2):e142-e152.
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James BD, Wilson RS, Capuano AW, Boyle PA, Shah RC, Lamar M, Ely EW, Bennett DA, Schneider JA. Hospitalization, Alzheimer's Disease and Related Neuropathologies, and Cognitive Decline. Ann Neurol. 2019 12; 86(6):844-852.
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