Alzheimer Disease
"Alzheimer Disease" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
Descriptor ID |
D000544
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MeSH Number(s) |
C10.228.140.380.100 C10.574.945.249 F03.087.400.100
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Concept/Terms |
Alzheimer Disease- Alzheimer Disease
- Disease, Alzheimer
- Alzheimer Sclerosis
- Sclerosis, Alzheimer
- Alzheimer Syndrome
- Syndrome, Alzheimer
- Alzheimer Type Senile Dementia
- Senile Dementia, Alzheimer Type
- Alzheimer-Type Dementia (ATD)
- Alzheimer Type Dementia (ATD)
- Dementia, Alzheimer-Type (ATD)
- Dementia, Alzheimer Type
- Alzheimer Type Dementia
- Dementia, Primary Senile Degenerative
- Dementia, Senile
- Senile Dementia
- Primary Senile Degenerative Dementia
- Alzheimer Dementia (AD)
- Dementia, Alzheimer (AD)
- Alzheimer's Disease
- Disease, Alzheimer's
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Below are MeSH descriptors whose meaning is more general than "Alzheimer Disease".
Below are MeSH descriptors whose meaning is more specific than "Alzheimer Disease".
This graph shows the total number of publications written about "Alzheimer Disease" by people in this website by year, and whether "Alzheimer Disease" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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1987 | 1 | 0 | 1 | 1988 | 2 | 0 | 2 | 1989 | 1 | 0 | 1 | 1990 | 2 | 0 | 2 | 1991 | 3 | 0 | 3 | 1992 | 2 | 1 | 3 | 1993 | 1 | 0 | 1 | 1994 | 3 | 1 | 4 | 1996 | 0 | 1 | 1 | 1997 | 7 | 0 | 7 | 1998 | 5 | 0 | 5 | 1999 | 8 | 1 | 9 | 2000 | 13 | 2 | 15 | 2001 | 5 | 1 | 6 | 2002 | 16 | 1 | 17 | 2003 | 22 | 1 | 23 | 2004 | 22 | 4 | 26 | 2005 | 35 | 4 | 39 | 2006 | 20 | 4 | 24 | 2007 | 19 | 4 | 23 | 2008 | 16 | 2 | 18 | 2009 | 17 | 1 | 18 | 2010 | 21 | 2 | 23 | 2011 | 32 | 7 | 39 | 2012 | 32 | 7 | 39 | 2013 | 25 | 4 | 29 | 2014 | 42 | 3 | 45 | 2015 | 36 | 8 | 44 | 2016 | 28 | 8 | 36 | 2017 | 31 | 6 | 37 | 2018 | 54 | 6 | 60 | 2019 | 46 | 13 | 59 | 2020 | 48 | 10 | 58 | 2021 | 33 | 5 | 38 |
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Below are the most recent publications written about "Alzheimer Disease" by people in Profiles.
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Davis EJ, Solsberg CW, White CC, Miñones-Moyano E, Sirota M, Chibnik L, Bennett DA, De Jager PL, Yokoyama JS, Dubal DB. Sex-Specific Association of the X Chromosome With Cognitive Change and Tau Pathology in Aging and Alzheimer Disease. JAMA Neurol. 2021 10 01; 78(10):1249-1254.
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Agrawal S, Yu L, Nag S, Arfanakis K, Barnes LL, Bennett DA, Schneider JA. The association of Lewy bodies with limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes and their role in cognition and Alzheimer's dementia in older persons. Acta Neuropathol Commun. 2021 09 25; 9(1):156.
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Jacobs HIL, Becker JA, Kwong K, Engels-DomÃnguez N, Prokopiou PC, Papp KV, Properzi M, Hampton OL, d'Oleire Uquillas F, Sanchez JS, Rentz DM, El Fakhri G, Normandin MD, Price JC, Bennett DA, Sperling RA, Johnson KA. In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer's disease pathology and cognitive decline. Sci Transl Med. 2021 Sep 22; 13(612):eabj2511.
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Ma Y, Yu L, Olah M, Smith R, Oatman SR, Allen M, Pishva E, Zhang B, Menon V, Ertekin-Taner N, Lunnon K, Bennett DA, Klein HU, De Jager PL. Epigenomic features related to microglia are associated with attenuated effect of APOE e4 on Alzheimer's disease risk in humans. Alzheimers Dement. 2022 Apr; 18(4):688-699.
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Panitch R, Hu J, Chung J, Zhu C, Meng G, Xia W, Bennett DA, Lunetta KL, Ikezu T, Au R, Stein TD, Farrer LA, Jun GR. Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE e2 protective effect in Alzheimer disease. Mol Psychiatry. 2021 10; 26(10):6054-6064.
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Boyle PA, Wang T, Yu L, Wilson RS, Dawe R, Arfanakis K, Schneider JA, Bennett DA. To what degree is late life cognitive decline driven by age-related neuropathologies? Brain. 2021 08 17; 144(7):2166-2175.
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Makkinejad N, Evia AM, Tamhane AA, Javierre-Petit C, Leurgans SE, Lamar M, Barnes LL. ARTS: A novel In-vivo classifier of arteriolosclerosis for the older adult brain. Neuroimage Clin. 2021; 31:102768.
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Huang Y, Sun X, Jiang H, Yu S, Robins C, Armstrong MJ, Li R, Mei Z, Shi X, Gerasimov ES, De Jager PL, Bennett DA, Wingo AP, Jin P, Wingo TS, Qin ZS. A machine learning approach to brain epigenetic analysis reveals kinases associated with Alzheimer's disease. Nat Commun. 2021 07 22; 12(1):4472.
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Wilson RS, Wang T, Yu L, Grodstein F, Bennett DA, Boyle PA. Cognitive Activity and Onset Age of Incident Alzheimer Disease Dementia. Neurology. 2021 08 31; 97(9):e922-e929.
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Raman R, Quiroz YT, Langford O, Choi J, Ritchie M, Baumgartner M, Rentz D, Aggarwal NT, Aisen P, Sperling R, Grill JD. Disparities by Race and Ethnicity Among Adults Recruited for a Preclinical Alzheimer Disease Trial. JAMA Netw Open. 2021 07 01; 4(7):e2114364.
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