"Huntington Disease" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
| Descriptor ID |
D006816
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| MeSH Number(s) |
C10.228.140.079.545 C10.228.140.380.278 C10.228.662.262.249.750 C10.574.500.497 C16.320.400.430 F03.615.250.400 F03.615.400.390
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| Concept/Terms |
Huntington Disease- Huntington Disease
- Huntington Chorea
- Chorea, Huntington
- Huntington's Disease
- Chronic Progressive Hereditary Chorea (Huntington)
- Huntington Chronic Progressive Hereditary Chorea
- Progressive Chorea, Chronic Hereditary (Huntington)
- Progressive Chorea, Hereditary, Chronic (Huntington)
- Huntington's Chorea
- Chorea, Huntington's
- Chorea, Chronic Progressive Hereditary (Huntington)
Juvenile Huntington Disease- Juvenile Huntington Disease
- Juvenile-Onset Huntington Disease
- Juvenile Onset Huntington Disease
- Huntington Disease, Juvenile-Onset
- Huntington Disease, Juvenile Onset
- Huntington Disease, Juvenile
|
Below are MeSH descriptors whose meaning is more general than "Huntington Disease".
Below are MeSH descriptors whose meaning is more specific than "Huntington Disease".
This graph shows the total number of publications written about "Huntington Disease" by people in this website by year, and whether "Huntington Disease" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 2 | 0 | 2 |
| 2010 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Huntington Disease" by people in Profiles.
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Neonatal immune-tolerance in mice does not prevent xenograft rejection. Exp Neurol. 2014 Apr; 254:90-8.
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Differential vulnerability of neurons in Huntington's disease: the role of cell type-specific features. J Neurochem. 2010 Jun; 113(5):1073-91.
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Neural transplants in patients with Huntington's disease undergo disease-like neuronal degeneration. Proc Natl Acad Sci U S A. 2009 Jul 28; 106(30):12483-8.
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Injectable hydrogels providing sustained delivery of vascular endothelial growth factor are neuroprotective in a rat model of Huntington's disease. Neurotox Res. 2010 Jan; 17(1):66-74.
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Intrastriatal CERE-120 (AAV-Neurturin) protects striatal and cortical neurons and delays motor deficits in a transgenic mouse model of Huntington's disease. Neurobiol Dis. 2009 Apr; 34(1):40-50.
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Viral delivery of glial cell line-derived neurotrophic factor improves behavior and protects striatal neurons in a mouse model of Huntington's disease. Proc Natl Acad Sci U S A. 2006 Jun 13; 103(24):9345-50.