"TDP-43 Proteinopathies" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Diseases characterized by the presence of abnormally phosphorylated, ubiquitinated, and cleaved DNA-binding protein TDP-43 in affected brain and spinal cord. Inclusions of the pathologic protein in neurons and glia, without the presence of AMYLOID, is the major feature of these conditions, thus making these proteinopathies distinct from most other neurogenerative disorders in which protein misfolding leads to brain amyloidosis. Both frontotemporal lobar degeneration and AMYOTROPHIC LATERAL SCLEROSIS exhibit this common method of pathogenesis and thus they may represent two extremes of a continuous clinicopathological spectrum of one disease.
| Descriptor ID |
D057177
|
| MeSH Number(s) |
C10.574.950 C18.452.845.800
|
| Concept/Terms |
TDP-43 Proteinopathies- TDP-43 Proteinopathies
- Proteinopathies, TDP-43
- Proteinopathy, TDP-43
- TDP 43 Proteinopathies
- TDP-43 Proteinopathy
|
Below are MeSH descriptors whose meaning is more general than "TDP-43 Proteinopathies".
Below are MeSH descriptors whose meaning is more specific than "TDP-43 Proteinopathies".
This graph shows the total number of publications written about "TDP-43 Proteinopathies" by people in this website by year, and whether "TDP-43 Proteinopathies" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 1 | 2 |
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Below are the most recent publications written about "TDP-43 Proteinopathies" by people in Profiles.
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The association of Lewy bodies with limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes and their role in cognition and Alzheimer's dementia in older persons. Acta Neuropathol Commun. 2021 09 25; 9(1):156.
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Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change and microvascular pathologies in community-dwelling older persons. Brain Pathol. 2021 05; 31(3):e12939.
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Limbic-predominant age-related TDP-43 encephalopathy in Black and White decedents. Neurology. 2020 10 13; 95(15):e2056-e2064.
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Limbic-predominant age-related TDP-43 encephalopathy, ADNC pathology, and cognitive decline in aging. Neurology. 2020 10 06; 95(14):e1951-e1962.
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Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data. PLoS Med. 2017 04; 14(4):e1002287.
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TDP-43 pathology and memory impairment in elders without pathologic diagnoses of AD or FTLD. Neurology. 2017 Feb 14; 88(7):653-660.
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TDP-43 stage, mixed pathologies, and clinical Alzheimer's-type dementia. Brain. 2016 11 01; 139(11):2983-2993.
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TDP-43 Proteinopathy: Aggregation and Propagation in the Pathogenesis of Amyotrophic Lateral Sclerosis. Mov Disord. 2016 08; 31(8):1139.