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overview Chair and The Francis N. and Catherine O. Bard Professor of Physiology, Department of Physiology & Biophysics, Rush Medical College, Rush University Medical Center. The research of Michael Fill, PhD, explores the local control of intracellular Ca signals mediated by the ryanodine receptor (RyR) Ca release channel in excitable cells. These control mechanisms are fundamental to many cellular phenomena and, thus, are often sites of pathological failure and potential targets for therapeutic intervention. Dr. Fill’s laboratory at Rush University is internationally recognized for its world-class RyR experimental expertise. The Ca signals generated by RyRs are known to modulate a myriad of physiological functions. Our lab details clinically significant structure-function attributes of single RyR function in health and disease, including local RyR control by Ca, closely regulatory proteins and post-translational modifications. This provides a strong mechanistic foundation for our group’s ongoing work toward developing new RyR-targeted drugs that will hopefully be applied to limit/treat diseases exacerbated or caused by hyperactive RyR Ca signaling. My Scopus ID is 7003468631. My NIH COMMONS name is MFILL2005. Research Areas: Ryanodine receptor calcium release channel, calcium signaling. My Faculty Profile at Rush University Medical Center: https://www.rushu.rush.edu/faculty/michael-fill-phd My Laboratory: https://www.rushu.rush.edu/research/departmental-research/physiology-and-biophysics-research/laboratory-michael-fill-phd My NCBI Bibliography: https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/45353019/?sort=date&direction=descending My Scopus: https://www.scopus.com/authid/detail.uri?authorId=7003468631 Education: PhD, University of Illinois at Urbana-Champaign MS, University of Illinois at Urbana-Champaign BS, University of Illinois at Urbana-Champaign

One or more keywords matched the following items that are connected to Fill, Michael

Item TypeName
Concept Calcium Channel Blockers
Concept Calcium Channels
Concept Calcium-Binding Proteins
Concept Calcium Channels, L-Type
Concept Calcium
Concept Sarcoplasmic Reticulum Calcium-Transporting ATPases
Concept Calcium Signaling
Concept Calcium-Transporting ATPases
Concept Calcium-Calmodulin-Dependent Protein Kinase Type 2
Concept Calcium Radioisotopes
Concept Ryanodine Receptor Calcium Release Channel
Concept Calcium Channel Agonists
Academic Article Intracellular calcium release channels mediate their own countercurrent: the ryanodine receptor case study.
Academic Article Reinterpreting the anomalous mole fraction effect: the ryanodine receptor case study.
Academic Article Is ryanodine receptor a calcium or magnesium channel? Roles of K+ and Mg2+ during Ca2+ release.
Academic Article Ryanodine receptor current amplitude controls Ca2+ sparks in cardiac muscle.
Academic Article Pernicious attrition and inter-RyR2 CICR current control in cardiac muscle.
Academic Article Sarcoplasmic reticulum K(+) (TRIC) channel does not carry essential countercurrent during Ca(2+) release.
Academic Article Unitary Ca2+ current through mammalian cardiac and amphibian skeletal muscle ryanodine receptor Channels under near-physiological ionic conditions.
Academic Article Calcium regulation of single ryanodine receptor channel gating analyzed using HMM/MCMC statistical methods.
Academic Article Ryanodine receptor function in newborn rat heart.
Academic Article Short-term regulation of excitation-contraction coupling by the beta1a subunit in adult mouse skeletal muscle.
Academic Article Calcium regulation of single cardiac ryanodine receptor channels.
Academic Article Ca2+ entry-independent effects of L-type Ca2+ channel modulators on Ca2+ sparks in ventricular myocytes.
Academic Article Luminal Ca2+ regulation of single cardiac ryanodine receptors: insights provided by calsequestrin and its mutants.
Academic Article Tricyclic antidepressant amitriptyline alters sarcoplasmic reticulum calcium handling in ventricular myocytes.
Academic Article Trifluoperazine: a rynodine receptor agonist.
Academic Article Ryanodine receptor luminal Ca2+ regulation: swapping calsequestrin and channel isoforms.
Academic Article Flux regulation of cardiac ryanodine receptor channels.
Academic Article Ryanodol action on calcium sparks in ventricular myocytes.
Academic Article Single ryanodine receptor channel basis of caffeine's action on Ca2+ sparks.
Academic Article Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release.
Academic Article Abnormal termination of Ca2+ release is a common defect of RyR2 mutations associated with cardiomyopathies.
Academic Article Decreased RyR2 refractoriness determines myocardial synchronization of aberrant Ca2+ release in a genetic model of arrhythmia.
Academic Article Mechanism of calsequestrin regulation of single cardiac ryanodine receptor in normal and pathological conditions.
Academic Article Potential role of cardiac calsequestrin in the lethal arrhythmic effects of cocaine.
Academic Article The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias.
Academic Article The cardiac ryanodine receptor luminal Ca2+ sensor governs Ca2+ waves, ventricular tachyarrhythmias and cardiac hypertrophy in calsequestrin-null mice.
Academic Article Cytosolic Ca²? buffering determines the intra-SR Ca²? concentration at which cardiac Ca²? sparks terminate.
Academic Article Non-ß-blocking R-carvedilol enantiomer suppresses Ca2+ waves and stress-induced ventricular tachyarrhythmia without lowering heart rate or blood pressure.
Academic Article Approaching ryanodine receptor therapeutics from the calcin angle.
Academic Article Block of contracture in skinned frog skeletal muscle fibers by calcium antagonists.
Academic Article Contractile activation and recovery in skinned frog muscle stimulated by ionic substitution.
Academic Article Identification and functional reconstitution of the type 2 inositol 1,4,5-trisphosphate receptor from ventricular cardiac myocytes.
Academic Article Isoform-specific function of single inositol 1,4,5-trisphosphate receptor channels.
Academic Article Single channel function of recombinant type-1 inositol 1,4,5-trisphosphate receptor ligand binding domain splice variants.
Academic Article Location of the permeation pathway in the recombinant type 1 inositol 1,4,5-trisphosphate receptor.
Academic Article Single-channel function of recombinant type 2 inositol 1,4, 5-trisphosphate receptor.
Academic Article Gating kinetics and ligand sensitivity modified by phosphorylation of cardiac ryanodine receptors.
Academic Article Ryanodine receptor calcium release channels.
Academic Article Mechanisms that turn-off intracellular calcium release channels.
Academic Article Pulsed local-field fluorescence microscopy: a new approach for measuring cellular signals in the beating heart.
Academic Article Single channel function of inositol 1,4,5-trisphosphate receptor type-1 and -2 isoform domain-swap chimeras.
Academic Article Extensive Ca2+ leak through K4750Q cardiac ryanodine receptors caused by cytosolic and luminal Ca2+ hypersensitivity.
Academic Article The Arrhythmogenic Calmodulin p.Phe142Leu Mutation Impairs C-domain Ca2+ Binding but Not Calmodulin-dependent Inhibition of the Cardiac Ryanodine Receptor.
Academic Article Sarcoplasmic reticulum Ca2+, Mg2+, K+, and Cl- concentrations adjust quickly as heart rate changes.
Academic Article Nebivolol suppresses cardiac ryanodine receptor-mediated spontaneous Ca2+ release and catecholaminergic polymorphic ventricular tachycardia.
Academic Article Differential Ca2+ and Sr2+ regulation of intracellular divalent cations release in ventricular myocytes.
Academic Article Differential activation by Ca2+, ATP and caffeine of cardiac and skeletal muscle ryanodine receptors after block by Mg2+.
Academic Article Ryanodine receptor adaptation.
Academic Article Sarcoplasmic reticulum calcium release is stimulated and inhibited by daunorubicin and daunorubicinol.
Academic Article Spatial Ca(2+) distribution in contracting skeletal and cardiac muscle cells.
Academic Article Ryanodine receptor permeation and gating: glowing cinders that underlie the Ca2+ spark.
Academic Article Unitary Ca2+ current through cardiac ryanodine receptor channels under quasi-physiological ionic conditions.
Academic Article Bay K 8644 increases resting Ca2+ spark frequency in ferret ventricular myocytes independent of Ca influx: contrast with caffeine and ryanodine effects.
Academic Article Coordinated feet and the dance of ryanodine receptors.
Academic Article Kinetic properties of DM-nitrophen and calcium indicators: rapid transient response to flash photolysis.
Academic Article Adaptation of single cardiac ryanodine receptor channels.
Academic Article Rectification of rabbit cardiac ryanodine receptor current by endogenous polyamines.
Academic Article Functionally heterogenous ryanodine receptors in avian cerebellum.
Academic Article Models of Ca2+ release channel adaptation.
Academic Article Streaming potentials reveal a short ryanodine-sensitive selectivity filter in cardiac Ca2+ release channel.
Academic Article Activation of single cardiac and skeletal ryanodine receptor channels by flash photolysis of caged Ca2+.
Academic Article Surface charge potentiates conduction through the cardiac ryanodine receptor channel.
Academic Article Cytoplasmic Ca2+ does not inhibit the cardiac muscle sarcoplasmic reticulum ryanodine receptor Ca2+ channel, although Ca(2+)-induced Ca2+ inactivation of Ca2+ release is observed in native vesicles.
Academic Article Ryanodine receptor adaptation: control mechanism of Ca(2+)-induced Ca2+ release in heart.
Academic Article Reconstitution of abnormalities in the malignant hyperthermia-susceptible pig ryanodine receptor.
Academic Article Abnormal human sarcoplasmic reticulum Ca2+ release channels in malignant hyperthermic skeletal muscle.
Academic Article Voltage-dependent inactivation of T-tubular skeletal calcium channels in planar lipid bilayers.
Academic Article Antibodies as probes for ligand gating of single sarcoplasmic reticulum Ca2(+)-release channels.
Academic Article Functional studies of Ca2+ channels from plasmalemma and sarcoplasmic reticulum membranes in muscle cells.
Academic Article Abnormal ryanodine receptor channels in malignant hyperthermia.
Academic Article Effect of perchlorate on calcium release in skinned fibres stimulated by ionic substitution and caffeine.
Academic Article [3H]PN200-110 and [3H]ryanodine binding and reconstitution of ion channel activity with skeletal muscle membranes.
Academic Article Role of the ryanodine receptor of skeletal muscle in excitation-contraction coupling.
Academic Article Ryanodine receptor of skeletal muscle is a gap junction-type channel.
Academic Article Ryanodine receptor channel of sarcoplasmic reticulum.
Academic Article Purified ryanodine receptor from rabbit skeletal muscle is the calcium-release channel of sarcoplasmic reticulum.
Academic Article Calcium release rate in skinned skeletal muscle fibers measured with arsenazo III.
Academic Article Stress Signaling JNK2 Crosstalk With CaMKII Underlies Enhanced Atrial Arrhythmogenesis.
Academic Article Sarcoplasmic Reticulum Ca2+ Release Uses a Cascading Network of Intra-SR and Channel Countercurrents.
Academic Article Transcriptional regulation of stress kinase JNK2 in pro-arrhythmic CaMKIId expression in the aged atrium.

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