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Al-Harthi, Lena
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overview Chairperson, The Thomas J. Coogan Sr., MD, Chair of Immunology, Department of Microbial Pathogens and Immunity (formerly, Immunology/Microbiology), RUSH Medical College, RUSH University Medical Center. Director of RUSH Initiative to Maximize Student Development (RUSH-IMSD). RUSH Medical College Acting Vice Dean for Research. My ORCID is 0000-0003-3915-3904. My Scopus ID is 7004503402. My NIH COMMONS name is LALHARTHI. Research Areas: HIV/AIDS, HIV/host interactions. Articles in the press and media coverage highlight my recent work: https://journals.plos.org/plospathogens/article/related?id=10.1371/journal.ppat.1008381 https://docs.google.com/document/d/1qfXvONEL91j15nVIcrpE4ZcnE4uJ0mm2KNQvfEnbVvo/edit?usp=sharing My Faculty Profile at RUSH University Medical Center: https://www.rushu.rush.edu/faculty/lena-al-harthi-phd My Laboratory: https://www.rushu.rush.edu/research/departmental-research/microbial-pathogens-and-immunity-research/laboratory-lena-al-harthi-phd My NCBI Bibliography: https://www.ncbi.nlm.nih.gov/pubmed/?term=Al-Harthi+L My ORCID: http://orcid.org/0000-0003-3915-3904 My Scopus: https://www.scopus.com/authid/detail.uri?authorId=7004503402 Education: PhD, George Washington University
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Concept Absorptiometry, Photon
Concept Lymphocytes
Concept Receptors, Prostaglandin
Concept Vibrio cholerae
Concept Longitudinal Studies
Concept Receptors, Lymphocyte Homing
Concept Estradiol
Concept 5' Untranslated Regions
Concept Vero Cells
Concept Genes, Reporter
Concept Heating
Concept Cytokines
Concept Saliva
Concept rev Gene Products, Human Immunodeficiency Virus
Concept Age Factors
Concept Disease Models, Animal
Concept Oman
Concept Saudi Arabia
Concept Ki-67 Antigen
Concept Interleukin-10
Concept Temperature
Concept Brain Neoplasms
Concept Prefrontal Cortex
Concept Hepatocyte Nuclear Factors
Concept Central Nervous System Stimulants
Concept Blood-Brain Barrier
Concept NF-kappa B
Concept Interferon-gamma
Concept Cell Lineage
Concept HIV Seropositivity
Concept Vitamin D
Concept Vaccines
Concept Hepacivirus
Concept Genes, gag
Concept Interleukin-16
Concept Antigens, CD1d
Concept Plasma
Concept CpG Islands
Concept Jurkat Cells
Concept Zidovudine
Concept beta Catenin
Concept Mitochondria
Concept Lymphoid Enhancer-Binding Factor 1
Concept Flow Cytometry
Concept CD8 Antigens
Concept CD4 Antigens
Concept Vaccines, DNA
Concept Sodium Chloride
Concept Cell Division
Concept Fetal Blood
Concept Gene Expression
Concept Membrane Potentials
Concept Lithium
Concept Reverse Transcription
Concept Activating Transcription Factor 2
Concept Antigens, CD1
Concept Immunophenotyping
Concept TCF Transcription Factors
Concept Dendritic Cells
Concept Microbiota
Concept Disease Susceptibility
Concept ADP-ribosyl Cyclase 1
Concept Glial Fibrillary Acidic Protein
Concept Lymphocyte Function-Associated Antigen-1
Concept T-Lymphocytes, Helper-Inducer
Concept Betaine
Concept Chemokine CCL3
Concept Immunomagnetic Separation
Concept HIV-1
Concept Antibodies, Neutralizing
Concept Interferon Regulatory Factor-1
Concept Transcription Factor AP-1
Concept Cytotoxicity, Immunologic
Concept Macrophage Inflammatory Proteins
Concept Dental Implantation
Concept Lithium Chloride
Concept Cell Culture Techniques
Concept Lymphocyte Activation
Concept Cost-Benefit Analysis
Concept Clone Cells
Concept Hepatitis C Antibodies
Concept Alzheimer Disease
Concept Leukocytes, Mononuclear
Concept Lamivudine
Concept Action Potentials
Concept Interferon-alpha
Concept Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Concept Vaginosis, Bacterial
Concept Interleukin-8
Concept California
Concept CD8-Positive T-Lymphocytes
Concept Interleukin-15
Concept Fluorescent Antibody Technique
Concept Disease Progression
Concept HIV Long Terminal Repeat
Concept Telomere
Concept Gingivitis
Concept Alveolar Bone Loss
Concept Cohort Studies
Concept CD4 Lymphocyte Count
Concept DNA, Mitochondrial
Concept Transcription Factor 7-Like 2 Protein
Concept Culture Media
Concept Calcium
Concept Acute Disease
Concept Cyclic AMP-Dependent Protein Kinases
Concept STAT3 Transcription Factor
Concept Antibodies, Viral
Concept Dental Caries
Concept Blotting, Western
Concept HIV Seronegativity
Concept Interleukin-4
Concept Dementia
Concept Dental Care
Concept Prevalence
Concept Case-Control Studies
Concept Chemokines, CXC
Concept Microfilament Proteins
Concept Fas Ligand Protein
Concept CD4-Positive T-Lymphocytes
Concept Prospective Studies
Concept Cross-Sectional Studies
Concept Interleukin-6
Concept DNA Virus Infections
Concept Interleukin-18
Concept Dentin
Concept Gene Products, tat
Concept Receptors, N-Methyl-D-Aspartate
Concept Trophoblasts
Concept Genes, pol
Concept Sp1 Transcription Factor
Concept Cervix Uteri
Concept Interleukin-12
Concept DNA Replication
Concept Smiling
Concept Th2 Cells
Concept Coinfection
Concept AIDS Vaccines
Concept Middle East
Concept Cell Line
Concept Observational Studies as Topic
Concept B-Lymphocytes
Concept HIV Protease Inhibitors
Concept Salicylates
Concept Injections, Subcutaneous
Concept Enhancer Elements, Genetic
Concept HIV-2
Concept Excitatory Amino Acid Transporter 2
Concept L-Selectin
Concept T-Lymphocyte Subsets
Concept HEK293 Cells
Concept Chromatin
Concept Clinical Trials as Topic
Concept Toll-Like Receptor 9
Concept DNA Primers
Concept Endopeptidases
Concept Cysteine
Concept Leukocyte Common Antigens
Concept AIDS Dementia Complex
Concept tat Gene Products, Human Immunodeficiency Virus
Concept Transcription, Genetic
Concept Histone Deacetylases
Concept Leukocytes
Concept Tumor Necrosis Factor-alpha
Concept Primary Cell Culture
Concept Hippocampus
Concept Virion
Concept Culture Media, Conditioned
Concept Periodontal Index
Concept Colon
Concept Chemokine CXCL10
Concept Risk Factors
Concept Promoter Regions, Genetic
Concept HIV Envelope Protein gp41
Concept Base Sequence
Concept HCT116 Cells
Concept Killer Cells, Natural
Concept HIV
Concept Comorbidity
Concept Colonic Neoplasms
Concept Cytomegalovirus
Concept Cell Line, Tumor
Concept Molecular Sequence Data
Concept Lymphocyte Subsets
Concept HIV Core Protein p24
Concept Gastrointestinal Neoplasms
Concept HIV Infections
Concept Chemokine CCL4
Concept Claudins
Concept Repressor Proteins
Concept Anti-HIV Agents
Concept CD4-CD8 Ratio
Concept Patch-Clamp Techniques
Concept T-Box Domain Proteins
Concept Interleukin-7
Concept Cyclin-Dependent Kinase Inhibitor p16
Concept Cells, Cultured
Concept Interleukins
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Concept T-Lymphocytes
Concept Oxygen
Concept Tertiary Care Centers
Concept Granulocyte-Macrophage Colony-Stimulating Factor
Concept Antigens, CD
Concept DNA Viruses
Concept Monocytes
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Concept Viral Load
Concept Interleukin-2
Concept Cell Proliferation
Academic Article Inhibition of cytokine-driven human immunodeficiency virus type 1 replication by protease inhibitor.
Academic Article Interleukin-7 induces HIV replication in primary naive T cells through a nuclear factor of activated T cell (NFAT)-dependent pathway.
Academic Article Dynamics of cytokine expression in HIV productively infected primary CD4+ T cells.
Academic Article Whole-blood interleukin-18 level during early HIV-1 infection is associated with reduced CXCR4 coreceptor expression and interferon- gamma levels.
Academic Article HIV infection of primary CD4+ Th2 cells, defined by expression of the chemoattractant receptor-homologous (CRTH2), induces a Th0 phenotype.
Academic Article Immune reconstitution after successful treatment with protease inhibitor-based and protease inhibitor-sparing antiretroviral regimens.
Academic Article Upregulation of CD4 on CD8+ T cells: CD4dimCD8bright T cells constitute an activated phenotype of CD8+ T cells.
Academic Article A human immunodeficiency virus (HIV)-inducing factor from the female genital tract activates HIV-1 gene expression through the kappaB enhancer.
Academic Article Induction of HIV-1 replication by type 1-like cytokines, interleukin (IL)-12 and IL-15: effect on viral transcriptional activation, cellular proliferation, and endogenous cytokine production.
Academic Article Evaluating the impact of hepatitis C virus (HCV) on highly active antiretroviral therapy-mediated immune responses in HCV/HIV-coinfected women: role of HCV on expression of primed/memory T cells.
Academic Article Maximum suppression of HIV replication leads to the restoration of HIV-specific responses in early HIV disease.
Academic Article Entrapment of recent thymic emigrants in lymphoid tissues from HIV-infected patients: association with HIV cellular viral load.
Academic Article Activation of plasmacytoid dendritic cells with TLR9 agonists initiates invariant NKT cell-mediated cross-talk with myeloid dendritic cells.
Academic Article A potent activator of HIV-1 replication is present in the genital tract of a subset of HIV-1-infected and uninfected women.
Academic Article Trophoblasts are productively infected by CD4-independent isolate of HIV type 1.
Academic Article Rationale for immune-based therapies for HIV-1 infection.
Academic Article A menstrual cycle pattern for cytokine levels exists in HIV-positive women: implication for HIV vaginal and plasma shedding.
Academic Article Impact of class A, B and C CpG-oligodeoxynucleotides on in vitro activation of innate immune cells in human immunodeficiency virus-1 infected individuals.
Academic Article Interleukin-7-treated naive T cells can be productively infected by T-cell-adapted and primary isolates of human immunodeficiency virus 1.
Academic Article Activation of CD8 T cells predicts progression of HIV infection in women coinfected with hepatitis C virus.
Academic Article Impact of Hepatitis C Virus on the Circulating Levels of IL-7 in HIV-1 Coinfected Women.
Academic Article Granulocyte-macrophage colony-stimulating factor induces modest increases in plasma human immunodeficiency virus (HIV) type 1 RNA levels and CD4+ lymphocyte counts in patients with uncontrolled HIV infection.
Academic Article CD8(+) T cell activation in women coinfected with human immunodeficiency virus type 1 and hepatitis C virus.
Academic Article CD8+ T cells that express CD4 on their surface (CD4dimCD8bright T cells) recognize an antigen-specific target, are detected in vivo, and can be productively infected by T-tropic HIV.
Academic Article HIV in the female genital tract: viral shedding and mucosal immunity.
Academic Article T cell receptor excision circle (TREC) content following maximum HIV suppression is equivalent in HIV-infected and HIV-uninfected individuals.
Academic Article Long-term mitochondrial toxicity in HIV-uninfected infants born to HIV-infected mothers.
Academic Article Bacterial vaginosis-associated microflora isolated from the female genital tract activates HIV-1 expression.
Academic Article Immune recovery in HIV disease: role of the thymus and T cell expansion in immune reconstitution strategies.
Academic Article Immunological effects of antiretroviral and immune therapies for HIV.
Academic Article CD1d-restricted natural killer T cells are potent targets for human immunodeficiency virus infection.
Academic Article Evaluation of the impact of highly active antiretroviral therapy on immune recovery in antiretroviral naive patients.
Academic Article The impact of the ovulatory cycle on cytokine production: evaluation of systemic, cervicovaginal, and salivary compartments.
Academic Article Immunophenotypic alterations in acute and early HIV infection.
Academic Article Interleukin-7 signalling is sufficient to phenotypically and functionally prime human CD4 naive T cells.
Academic Article Evaluation of thymopoiesis using T cell receptor excision circles (TRECs): differential correlation between adult and pediatric TRECs and na?ve phenotypes.
Academic Article Detection of T cell receptor circles (TRECs) as biomarkers for de novo T cell synthesis using a quantitative polymerase chain reaction-enzyme linked immunosorbent assay (PCR-ELISA).
Academic Article Methamphetamine and HIV-1 Tat down regulate ?-catenin signaling: implications for methampetamine abuse and HIV-1 co-morbidity.
Academic Article Combined chronic blockade of hyper-active L-type calcium channels and NMDA receptors ameliorates HIV-1 associated hyper-excitability of mPFC pyramidal neurons.
Academic Article Enriching for HIV-infected cells using anti-gp41 antibodies indirectly conjugated to magnetic microbeads.
Academic Article Immune modulation of HIV replication: relevance to HIV immuno- and neuro-pathogenesis.
Academic Article Assessing thymopoiesis in patients with common variable immunodeficiency as measured by T-cell receptor excision circles.
Academic Article Gamma interferon primes productive human immunodeficiency virus infection in astrocytes.
Academic Article Multiple populations of T lymphocytes are distinguished by the level of CD4 and CD8 coexpression and require individual consideration.
Academic Article Negative-strand hepatitis C virus (HCV) RNA in peripheral blood mononuclear cells from anti-HCV-positive/HIV-infected women.
Academic Article Human immunodeficiency virus-restricted replication in astrocytes and the ability of gamma interferon to modulate this restriction are regulated by a downstream effector of the Wnt signaling pathway.
Academic Article Active beta-catenin signaling is an inhibitory pathway for human immunodeficiency virus replication in peripheral blood mononuclear cells.
Academic Article Potent HIV-specific responses are enriched in a unique subset of CD8+ T cells that coexpresses CD4 on its surface.
Academic Article Beta-catenin signaling mediates CD4 expression on mature CD8+ T cells.
Academic Article Role of ?-catenin/TCF-4 signaling in HIV replication and pathogenesis: insights to informing novel anti-HIV molecular therapeutics.
Academic Article Inhibition of Tat-mediated HIV-1 replication and neurotoxicity by novel GSK3-beta inhibitors.
Academic Article IFN-gamma mediates enhancement of HIV replication in astrocytes by inducing an antagonist of the beta-catenin pathway (DKK1) in a STAT 3-dependent manner.
Academic Article Human FasL gene is a target of ?-catenin/T-cell factor pathway and complex FasL haplotypes alter promoter functions.
Academic Article Role of ?-catenin and TCF/LEF family members in transcriptional activity of HIV in astrocytes.
Academic Article NKG2D signaling on CD8? T cells represses T-bet and rescues CD4-unhelped CD8? T cell memory recall but not effector responses.
Academic Article Mechanisms of HIV-1 latency post HAART treatment area.
Academic Article Identification of novel T cell factor 4 (TCF-4) binding sites on the HIV long terminal repeat which associate with TCF-4, ?-catenin, and SMAR1 to repress HIV transcription.
Academic Article Comment on "CD4+ CD8+ T cells represent a significant portion of the anti-HIV T cell response to acute HIV infection".
Academic Article Interplay between Wnt/?-catenin signaling and HIV: virologic and biologic consequences in the CNS.
Academic Article Wnt/?-catenin and its diverse physiological cell signaling pathways in neurodegenerative and neuropsychiatric disorders.
Academic Article Human immunodeficiency virus type 1 (HIV-1) transactivator of transcription through its intact core and cysteine-rich domains inhibits Wnt/?-catenin signaling in astrocytes: relevance to HIV neuropathogenesis.
Academic Article 17?-Estradiol inhibits HIV-1 by inducing a complex formation between ?-catenin and estrogen receptor a on the HIV promoter to suppress HIV transcription.
Academic Article Epigenetic regulation of HIV-1 latency in astrocytes.
Academic Article HIV infection accelerates gastrointestinal tumor outgrowth in NSG-HuPBL mice.
Academic Article Porcupine is not required for the production of the majority of Wnts from primary human astrocytes and CD8+ T cells.
Academic Article Cellular Interactions and Signaling in neuroAIDS: Emerging Issues Colloquium.
Academic Article ?-Catenin/TCF-4 signaling regulates susceptibility of macrophages and resistance of monocytes to HIV-1 productive infection.
Academic Article Dynamic interaction between astrocytes and infiltrating PBMCs in context of neuroAIDS.
Academic Article HIV Infection Leads to Redistribution of Leaky Claudin-2 in the Intestine of Humanized SCID IL-2R(-/-) Hu-PBMC Mice.
Academic Article Migration of CD8+ T Cells into the Central Nervous System Gives Rise to Highly Potent Anti-HIV CD4dimCD8bright T Cells in a Wnt Signaling-Dependent Manner.
Academic Article ?-Catenin signaling positively regulates glutamate uptake and metabolism in astrocytes.
Academic Article Plasma dickkopf-related protein 1, an antagonist of the Wnt pathway, is associated with HIV-associated neurocognitive impairment.
Academic Article Wnt7a induces a unique phenotype of monocyte-derived macrophages with lower phagocytic capacity and differential expression of pro- and anti-inflammatory cytokines.
Academic Article HIV and drug abuse mediate astrocyte senescence in a ?-catenin-dependent manner leading to neuronal toxicity.
Academic Article Chronic periodontitis and implant dentistry.
Academic Article The periodontal restorative interface: esthetic considerations.
Academic Article Testing the Arabic short form versions of the Parental-Caregivers Perceptions Questionnaire and the Family Impact Scale in Oman.
Academic Article Periodontal diseases in an Omani adult population: a preliminary study.
Academic Article The impact of periodontitis on oral health-related quality of life: a review of the evidence from observational studies.
Academic Article Periodontitis among adult populations in the Arab World.
Academic Article Human immunodeficiency virus type-1 transcription: role of the 5'-untranslated leader region (review).
Academic Article Interleukin-10 enhances tumor necrosis factor-alpha activation of HIV-1 transcription in latently infected T cells.
Academic Article The cAMP-dependent protein kinase A and protein kinase C-beta pathways synergistically interact to activate HIV-1 transcription in latently infected cells of monocyte/macrophage lineage.
Academic Article Molecular inhibition of HIV type 1 by HIV type 2: effectiveness in peripheral blood mononuclear cells.
Academic Article TNFalpha cooperates with the protein kinase A pathway to synergistically increase HIV-1 LTR transcription via downstream TRE-like cAMP response elements.
Academic Article Induction of melanin biosynthesis in Vibrio cholerae.
Academic Article Aging alters voltage-gated calcium channels in prefrontal cortex pyramidal neurons in the HIV brain.
Academic Article Methamphetamine decreases K+ channel function in human fetal astrocytes by activating the trace amine-associated receptor type-1.
Academic Article Astrocytes as an HIV CNS reservoir: highlights and reflections of an NIMH-sponsored symposium.
Academic Article Letter to Editor.
Academic Article Correction to: Astrocytes as an HIV CNS reservoir: highlights and reflections of an NIMH-sponsored symposium.
Academic Article Aging and HIV-1 alter the function of specific K+ channels in prefrontal cortex pyramidal neurons.
Academic Article The far-reaching HAND of cART: cART effects on astrocytes.
Academic Article Ginkgolic acid inhibits fusion of enveloped viruses.
Academic Article Author Correction: Ginkgolic acid inhibits fusion of enveloped viruses.
Academic Article Circulating sclerostin is associated with bone mineral density independent of HIV-serostatus.
Academic Article HIV infects astrocytes in vivo and egresses from the brain to the periphery.
Academic Article ?-Catenin and TCFs/LEF signaling discordantly regulate IL-6 expression in astrocytes.
Academic Article What HIV in the Brain Can Teach Us About SARS-CoV-2 Neurological Complications?
Academic Article Negative regulation of IL-8 in human astrocytes depends on ?-catenin while positive regulation is mediated by TCFs/LEF/ATF2 interaction.
Academic Article Canonical Wnts Mediate CD8+ T Cell Noncytolytic Anti-HIV-1 Activity and Correlate with HIV-1 Clinical Status.
Academic Article CD32 is enriched on CD4dimCD8bright T cells.
Academic Article Change in Circulating Undercarboxylated Osteocalcin (ucOCN) Is Associated With Fat Accumulation in HIV-Seropositive Women.
Academic Article Placing a mask on COVID-19 patients during high-flow nasal cannula therapy reduces aerosol particle dispersion.
Academic Article Triumeq Increases Excitability of Pyramidal Neurons in the Medial Prefrontal Cortex by Facilitating Voltage-Gated Ca2+ Channel Function.
Academic Article ?-Catenin Restricts Zika Virus Internalization by Downregulating Axl.
Academic Article Next-generation Serology by Mass Spectrometry: Readout of the SARS-CoV-2 Antibody Repertoire.
Academic Article HIV in the Brain: Identifying Viral Reservoirs and Addressing the Challenges of an HIV Cure.
Academic Article Next-Generation Serology by Mass Spectrometry: Readout of the SARS-CoV-2 Antibody Repertoire.
Academic Article ?-catenin regulates HIV latency and modulates HIV reactivation.
Academic Article Anti-HIV Drugs Cause Mitochondrial Dysfunction in Monocyte-Derived Macrophages.
Academic Article Bone Quality in Relation to HIV and Antiretroviral Drugs.
Academic Article An Efficient Humanized Mouse Model for Oral Anti-Retroviral Administration.
Academic Article Bulk IgG glycosylation predicts COVID-19 severity and vaccine antibody response.
Academic Article Brain autopsies of critically ill COVID-19 patients demonstrate heterogeneous profile of acute vascular injury, inflammation and age-linked chronic brain diseases.
Academic Article An Efficient and Cost-Effective Approach to Generate Functional Human Inducible Pluripotent Stem Cell-Derived Astrocytes.
Academic Article The Human Microbiome and Its Role in Musculoskeletal Disorders.
Academic Article CD4dim CD8bright T Cells Home to the Brain and Mediate HIV Neuroinvasion.
Academic Article HIV infection of non-classical cells in the brain.
Academic Article Wnt/?-Catenin Protects Lymphocytes from HIV-Mediated Apoptosis via Induction of Bcl-xL.
Academic Article Hyperactivity of medial prefrontal cortex pyramidal neurons occurs in a mouse model of early-stage Alzheimer's disease without ?-amyloid accumulation.
Academic Article HIV-Induced Hyperactivity of Striatal Neurons Is Associated with Dysfunction of Voltage-Gated Calcium and Potassium Channels at Middle Age.
Academic Article CD4 dim CD8 bright T cells are inversely associated with neuro-inflammatory markers among people with HIV.
Concept Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination
Concept Gastrointestinal Microbiome
Concept Zika Virus Infection
Concept Zika Virus
Concept Transcription Factor 4
Academic Article Discovery of circulating blood biomarkers in patients with and without Modic changes of the lumbar spine: a preliminary analysis.
Academic Article Does Caffeine Intake Increase the Incidence of Tinnitus? A Systematic Review.
Academic Article Prevalence and correlates of depressive symptoms among people living with HIV attending tertiary care hospitals in Oman.
Academic Article Impact of vitamin D on neurocognitive function in dementia, depression, schizophrenia and ADHD.
Academic Article Dentine hypersensitivity and dentine exposure in Arab patient populations.
Academic Article Prevalence, severity and explanatory factors of tooth wear in Arab populations.
Academic Article Dental age estimation of Omani children using Demirjian's method.
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