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Search Results to Jitesh Pratap

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overview My Scopus ID is 6603617139. My NIH COMMONS name is PRATAPJ. Research Areas: Metastasis is a step in advanced cancer development that is lethal as cancer cells often spread to bone. The current understanding of the regulatory mechanisms of bone metastasis is still not clear. Pratap is investigating cellular and molecular events during bone and cancer cell interactions that influence cancer cell survival during metastases. His team combines genetics, molecular, biochemical and cell biological approaches to address two aspects of bone metastasis: growth factor signaling and cancer cell metabolism. My Faculty Profile at Rush University Medical Center: https://www.rushu.rush.edu/faculty/jitesh-pratap-phd My Laboratory: https://www.rushu.rush.edu/research/departmental-research/cell-molecular-medicine-research/laboratory-jitesh-pratap-phd My NCBI Bibliography: https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/47732476/?sort=date&direction=descending My Scopus: https://www.scopus.com/authid/detail.uri?authorId=6603617139 Education: PhD, Panjab University, India

One or more keywords matched the following items that are connected to Pratap, Jitesh

Item TypeName
Concept Transforming Growth Factor beta
Concept Core Binding Factor Alpha 2 Subunit
Concept Core Binding Factor Alpha 1 Subunit
Concept Core Binding Factor alpha Subunits
Concept Epidermal Growth Factor
Concept Core Binding Factor Alpha 3 Subunit
Concept Growth Differentiation Factor 10
Concept Transcription Factor AP-2
Concept Granulocyte-Macrophage Colony-Stimulating Factor
Concept Transforming Growth Factor beta1
Academic Article Temporal and spatial parameters of skeletal gene expression: targeting RUNX factors and their coregulatory proteins to subnuclear domains.
Academic Article Cell growth regulatory role of Runx2 during proliferative expansion of preosteoblasts.
Academic Article Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development.
Academic Article SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation.
Academic Article Smad function and intranuclear targeting share a Runx2 motif required for osteogenic lineage induction and BMP2 responsive transcription.
Academic Article Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo.
Academic Article The dynamic organization of gene-regulatory machinery in nuclear microenvironments.
Academic Article The bone-specific expression of Runx2 oscillates during the cell cycle to support a G1-related antiproliferative function in osteoblasts.
Academic Article Combinatorial organization of the transcriptional regulatory machinery in biological control and cancer.
Academic Article The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion.
Academic Article Reconstitution of Runx2/Cbfa1-null cells identifies a requirement for BMP2 signaling through a Runx2 functional domain during osteoblast differentiation.
Academic Article Alterations in intranuclear localization of Runx2 affect biological activity.
Academic Article Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2.
Academic Article Nuclear microenvironments in biological control and cancer.
Academic Article Runx2 deficiency and defective subnuclear targeting bypass senescence to promote immortalization and tumorigenic potential.
Academic Article Structural coupling of Smad and Runx2 for execution of the BMP2 osteogenic signal.
Academic Article Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors.
Academic Article Specific residues of RUNX2 are obligatory for formation of BMP2-induced RUNX2-SMAD complex to promote osteoblast differentiation.
Academic Article Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cells.
Academic Article A Runx2 threshold for the cleidocranial dysplasia phenotype.
Academic Article Transcription-factor-mediated epigenetic control of cell fate and lineage commitment.
Academic Article The osteogenic transcription factor runx2 controls genes involved in sterol/steroid metabolism, including CYP11A1 in osteoblasts.
Academic Article Ectopic runx2 expression in mammary epithelial cells disrupts formation of normal acini structure: implications for breast cancer progression.
Academic Article The human SWI/SNF complex associates with RUNX1 to control transcription of hematopoietic target genes.
Academic Article Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility.
Academic Article Activation of the ERK1/2 mitogen-activated protein kinase cascade by dentin matrix protein 1 promotes osteoblast differentiation.
Academic Article Runx2 mediates epigenetic silencing of the bone morphogenetic protein-3B (BMP-3B/GDF10) in lung cancer cells.
Academic Article Integrin avß6 promotes an osteolytic program in cancer cells by upregulating MMP2.
Academic Article Runx2 activates PI3K/Akt signaling via mTORC2 regulation in invasive breast cancer cells.
Academic Article Role of Runx2 in crosstalk between Mek/Erk and PI3K/Akt signaling in MCF-10A cells.
Academic Article Intranuclear organization of RUNX transcriptional regulatory machinery in biological control of skeletogenesis and cancer.
Academic Article The role of Runx2 in facilitating autophagy in metastatic breast cancer cells.
Academic Article Role of Runx2 in IGF-1Rß/Akt- and AMPK/Erk-dependent growth, survival and sensitivity towards metformin in breast cancer bone metastasis.

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