"Epidermal Growth Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.
| Descriptor ID |
D004815
|
| MeSH Number(s) |
D06.472.317.350 D12.644.276.382.500 D12.776.467.382.500 D23.529.382.500
|
| Concept/Terms |
Epidermal Growth Factor- Epidermal Growth Factor
- Growth Factor, Epidermal
- Urogastrone
- Epidermal Growth Factor-Urogastrone
- Growth Factor-Urogastrone, Epidermal
- Human Urinary Gastric Inhibitor
- beta-Urogastrone
- beta Urogastrone
- EGF
|
Below are MeSH descriptors whose meaning is more general than "Epidermal Growth Factor".
Below are MeSH descriptors whose meaning is more specific than "Epidermal Growth Factor".
This graph shows the total number of publications written about "Epidermal Growth Factor" by people in this website by year, and whether "Epidermal Growth Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 2000 | 2 | 1 | 3 |
| 2001 | 3 | 0 | 3 |
| 2002 | 2 | 1 | 3 |
| 2003 | 4 | 1 | 5 |
| 2004 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2010 | 0 | 2 | 2 |
| 2014 | 0 | 2 | 2 |
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Below are the most recent publications written about "Epidermal Growth Factor" by people in Profiles.
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Role of Runx2 in crosstalk between Mek/Erk and PI3K/Akt signaling in MCF-10A cells. J Cell Biochem. 2014 Dec; 115(12):2208-17.
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Spatially defined InsP3-mediated signaling in embryonic stem cell-derived cardiomyocytes. PLoS One. 2014; 9(1):e83715.
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Biglycan regulates the expression of EGF receptors through EGF signaling pathways in human articular chondrocytes. Connect Tissue Res. 2010 Oct; 51(5):347-58.
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Long-term proliferation and dopaminergic differentiation of human mesencephalic neural precursor cells. Exp Neurol. 2001 Aug; 170(2):317-25.
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Epidermal growth factor negatively regulates chondrogenesis of mesenchymal cells by modulating the protein kinase C-alpha, Erk-1, and p38 MAPK signaling pathways. J Biol Chem. 2000 Apr 21; 275(16):12353-9.
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Differentiation of mesencephalic progenitor cells into dopaminergic neurons by cytokines. Exp Neurol. 1998 Feb; 149(2):411-23.
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Species-specific alternative splicing of the epidermal growth factor-like domain 1 of cartilage aggrecan. Biochem J. 1996 Nov 01; 319 ( Pt 3):935-40.
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Expression of alternatively spliced epidermal growth factor-like domains in aggrecans of different species. Evidence for a novel module. J Biol Chem. 1993 Aug 15; 268(23):17377-83.