Hyaluronan injection in murine osteoarthritis prevents TGFbeta 1-induced synovial neovascularization and fibrosis and maintains articular cartilage integrity by a CD44-dependent mechanism.

Hyaluronan injection in murine osteoarthritis prevents TGFbeta 1-induced synovial neovascularization and fibrosis and maintains articular cartilage integrity by a CD44-dependent mechanism. Arthritis Res Ther. 2012 Jun 21; 14(3):R151.

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subject areas

ADAM Proteins
ADAMTS5 Protein
Animals
Cartilage, Articular
Disease Models, Animal
Extracellular Matrix Proteins
Fibrosis
Hyaluronan Receptors
Hyaluronic Acid
Immunohistochemistry
Injections, Intra-Arterial
Male
Matrix Metalloproteinase 13
Mice
Mice, Inbred C57BL
Mice, Knockout
Neovascularization, Pathologic
Osteoarthritis
Polymerase Chain Reaction
Synovial Membrane
Transcriptome
Transforming Growth Factor beta
Viscosupplements