"ADAMTS5 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An ADAMTS protease that contains two C-terminal thrombospondin (TS) motifs. It functions primarily as an aggrecanase, cleaving AGGRECAN in CARTILAGE, and may be involved in the destruction of aggrecan in ARTHRITIS.
| Descriptor ID |
D000071116
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| MeSH Number(s) |
D08.811.277.656.675.374.102.500.875 D09.400.430.500.500.875 D12.776.395.033.500.875 D12.776.860.300.085.875
|
| Concept/Terms |
ADAMTS5 Protein- ADAMTS5 Protein
- A Disintegrin And Metalloproteinase With Thrombospondin Motifs 5 Protein
- ADAMTS11 Protein
- Aggrecanase-2
- Aggrecanase 2
- ADAMTS-5 Protein
- ADAMTS 5 Protein
- ADAMTS5 Protease
|
Below are MeSH descriptors whose meaning is more general than "ADAMTS5 Protein".
Below are MeSH descriptors whose meaning is more specific than "ADAMTS5 Protein".
This graph shows the total number of publications written about "ADAMTS5 Protein" by people in this website by year, and whether "ADAMTS5 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2007 | 0 | 3 | 3 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 4 | 4 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 2 | 2 |
| 2018 | 0 | 2 | 2 |
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Below are the most recent publications written about "ADAMTS5 Protein" by people in Profiles.
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TGF-b1 or hypoxia enhance glucose metabolism and lactate production via HIF1A signaling in tendon cells. Connect Tissue Res. 2018 09; 59(5):458-471.
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An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2. JCI Insight. 2018 03 22; 3(6).
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Therapeutic effects of an anti-ADAMTS-5 antibody on joint damage and mechanical allodynia in a murine model of osteoarthritis. Osteoarthritis Cartilage. 2016 Feb; 24(2):299-306.
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Deletion of ADAMTS5 does not affect aggrecan or versican degradation but promotes glucose uptake and proteoglycan synthesis in murine adipose derived stromal cells. Matrix Biol. 2015 Sep; 47:66-84.
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MicroRNA-146a reduces IL-1 dependent inflammatory responses in the intervertebral disc. Gene. 2015 Jan 25; 555(2):80-7.
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ADAMTS5 is required for biomechanically-stimulated healing of murine tendinopathy. J Orthop Res. 2013 Oct; 31(10):1540-8.
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Hyaluronan injection in murine osteoarthritis prevents TGFbeta 1-induced synovial neovascularization and fibrosis and maintains articular cartilage integrity by a CD44-dependent mechanism. Arthritis Res Ther. 2012 Jun 21; 14(3):R151.
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Murine tendon function is adversely affected by aggrecan accumulation due to the knockout of ADAMTS5. J Orthop Res. 2012 Apr; 30(4):620-6.
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The relationship between fibrogenic TGF?1 signaling in the joint and cartilage degradation in post-injury osteoarthritis. Osteoarthritis Cartilage. 2011 Sep; 19(9):1081-90.
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Adamts5 deletion blocks murine dermal repair through CD44-mediated aggrecan accumulation and modulation of transforming growth factor ?1 (TGF?1) signaling. J Biol Chem. 2011 Jul 22; 286(29):26016-27.