"Metalloendopeptidases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
ENDOPEPTIDASES which use a metal such as ZINC in the catalytic mechanism.
| Descriptor ID |
D008666
|
| MeSH Number(s) |
D08.811.277.656.300.480 D08.811.277.656.675.374
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Metalloendopeptidases".
Below are MeSH descriptors whose meaning is more specific than "Metalloendopeptidases".
This graph shows the total number of publications written about "Metalloendopeptidases" by people in this website by year, and whether "Metalloendopeptidases" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1995 | 0 | 2 | 2 |
| 1996 | 0 | 1 | 1 |
| 1997 | 1 | 2 | 3 |
| 1998 | 1 | 0 | 1 |
| 1999 | 0 | 1 | 1 |
| 2001 | 2 | 1 | 3 |
| 2002 | 1 | 0 | 1 |
| 2003 | 1 | 0 | 1 |
| 2004 | 1 | 1 | 2 |
| 2005 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
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Below are the most recent publications written about "Metalloendopeptidases" by people in Profiles.
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Expression and functional profiling of neprilysin, insulin-degrading enzyme, and endothelin-converting enzyme in prospectively studied elderly and Alzheimer's brain. J Neurochem. 2010 Oct; 115(1):47-57.
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Thrombotic thrombocytopenic purpura in the setting of systemic sclerosis. Semin Arthritis Rheum. 2005 Feb; 34(4):683-8.
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Regulated expression of ADAMTS family members in follicles and cumulus oocyte complexes: evidence for specific and redundant patterns during ovulation. Biol Reprod. 2005 May; 72(5):1241-55.
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ADAMTS4 (aggrecanase-1) cleaves human brain versican V2 at Glu405-Gln406 to generate glial hyaluronate binding protein. Biochem J. 2004 Feb 01; 377(Pt 3):787-95.
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Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes. J Biol Chem. 2004 Apr 23; 279(17):17554-61.
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Regulation of anabolic and catabolic gene expression in normal and osteoarthritic adult human articular chondrocytes by osteogenic protein-1. Clin Exp Rheumatol. 2004 Jan-Feb; 22(1):103-6.
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ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan-1. J Biol Chem. 2004 Mar 12; 279(11):10042-51.
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Processing and localization of ADAMTS-1 and proteolytic cleavage of versican during cumulus matrix expansion and ovulation. J Biol Chem. 2003 Oct 24; 278(43):42330-9.
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Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage. J Biol Chem. 2002 Jun 21; 277(25):22201-8.
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ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain. J Biol Chem. 2002 May 03; 277(18):16059-66.