Interleukin-1alpha treatment of meniscal explants stimulates the production and release of aggrecanase-generated, GAG-substituted aggrecan products and also the release of pre-formed, aggrecanase-generated G1 and m-calpain-generated G1-G2.

Interleukin-1alpha treatment of meniscal explants stimulates the production and release of aggrecanase-generated, GAG-substituted aggrecan products and also the release of pre-formed, aggrecanase-generated G1 and m-calpain-generated G1-G2. Cell Tissue Res. 2010 Apr; 340(1):179-88.

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subject areas

ADAM Proteins
ADAMTS4 Protein
Aggrecans
Animals
Arthritis
Calpain
Cattle
Endopeptidases
Extracellular Matrix
Glycosaminoglycans
Hyaluronic Acid
Inflammation Mediators
Interleukin-1alpha
Matrix Metalloproteinases
Menisci, Tibial
Models, Biological
Procollagen N-Endopeptidase
RNA, Messenger
Tissue Inhibitor of Metalloproteinase-3