"Neurofibrillary Tangles" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Abnormal structures located in various parts of the brain and composed of dense arrays of paired helical filaments (neurofilaments and microtubules). These double helical stacks of transverse subunits are twisted into left-handed ribbon-like filaments that likely incorporate the following proteins: (1) the intermediate filaments: medium- and high-molecular-weight neurofilaments; (2) the microtubule-associated proteins map-2 and tau; (3) actin; and (4) UBIQUITINS. As one of the hallmarks of ALZHEIMER DISEASE, the neurofibrillary tangles eventually occupy the whole of the cytoplasm in certain classes of cell in the neocortex, hippocampus, brain stem, and diencephalon. The number of these tangles, as seen in post mortem histology, correlates with the degree of dementia during life. Some studies suggest that tangle antigens leak into the systemic circulation both in the course of normal aging and in cases of Alzheimer disease.
| Descriptor ID |
D016874
|
| MeSH Number(s) |
A08.675.609.520 A11.284.430.214.190.750.640.520 A11.671.573.520
|
| Concept/Terms |
Neurofibrillary Tangles- Neurofibrillary Tangles
- Neurofibrillary Tangle
- Tangle, Neurofibrillary
- Tangles, Neurofibrillary
|
Below are MeSH descriptors whose meaning is more general than "Neurofibrillary Tangles".
Below are MeSH descriptors whose meaning is more specific than "Neurofibrillary Tangles".
This graph shows the total number of publications written about "Neurofibrillary Tangles" by people in this website by year, and whether "Neurofibrillary Tangles" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 3 | 3 |
| 2003 | 2 | 1 | 3 |
| 2004 | 2 | 0 | 2 |
| 2005 | 1 | 4 | 5 |
| 2006 | 2 | 3 | 5 |
| 2007 | 0 | 3 | 3 |
| 2008 | 1 | 1 | 2 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 3 | 3 |
| 2011 | 1 | 1 | 2 |
| 2012 | 1 | 5 | 6 |
| 2013 | 1 | 4 | 5 |
| 2014 | 3 | 0 | 3 |
| 2015 | 0 | 2 | 2 |
| 2016 | 2 | 1 | 3 |
| 2017 | 3 | 5 | 8 |
| 2018 | 1 | 3 | 4 |
| 2019 | 2 | 1 | 3 |
| 2020 | 0 | 2 | 2 |
| 2021 | 0 | 4 | 4 |
| 2022 | 0 | 2 | 2 |
| 2023 | 0 | 4 | 4 |
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Below are the most recent publications written about "Neurofibrillary Tangles" by people in Profiles.
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Cell-type-specific Alzheimer's disease polygenic risk scores are associated with distinct disease processes in Alzheimer's disease. Nat Commun. 2023 Nov 30; 14(1):7659.
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Estrogen Receptor Genes, Cognitive Decline, and Alzheimer Disease. Neurology. 2023 04 04; 100(14):e1474-e1487.
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Mixed pathology as a rule, not exception: Time to reconsider disease nosology. Handb Clin Neurol. 2023; 192:57-71.
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Alzheimer's Disease Pathology Outside of the Cerebrum Is Related to a Higher Odds of Dementia. J Alzheimers Dis. 2023; 96(2):563-578.
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Multiple gene variants linked to Alzheimer's-type clinical dementia via GWAS are also associated with non-Alzheimer's neuropathologic entities. Neurobiol Dis. 2022 Nov; 174:105880.
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Pelargonidin and Berry Intake Association with Alzheimer's Disease Neuropathology: A Community-Based Study. J Alzheimers Dis. 2022; 88(2):653-661.
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Sex-Specific Association of the X Chromosome With Cognitive Change and Tau Pathology in Aging and Alzheimer Disease. JAMA Neurol. 2021 10 01; 78(10):1249-1254.
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Epigenomic features related to microglia are associated with attenuated effect of APOE e4 on Alzheimer's disease risk in humans. Alzheimers Dement. 2022 04; 18(4):688-699.
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What is 'Alzheimer's disease'? The neuropathological heterogeneity of clinically defined Alzheimer's dementia. Curr Opin Neurol. 2021 04 01; 34(2):237-245.
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Early Selective Vulnerability of the CA2 Hippocampal Subfield in Primary Age-Related Tauopathy. J Neuropathol Exp Neurol. 2021 01 20; 80(2):102-111.