 Drug Tolerance
"Drug Tolerance" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL.
| Descriptor ID |
D004361
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| MeSH Number(s) |
G07.690.812.260 G07.700.680.260
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| Concept/Terms |
Drug Tolerance- Drug Tolerance
- Drug Tolerances
- Tolerance, Drug
- Tolerances, Drug
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Below are MeSH descriptors whose meaning is more general than "Drug Tolerance".
Below are MeSH descriptors whose meaning is more specific than "Drug Tolerance".
This graph shows the total number of publications written about "Drug Tolerance" by people in this website by year, and whether "Drug Tolerance" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1982 | 0 | 1 | 1 | | 1983 | 0 | 1 | 1 | | 1989 | 0 | 1 | 1 | | 1990 | 0 | 1 | 1 | | 1992 | 0 | 1 | 1 | | 1995 | 0 | 1 | 1 | | 1998 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2005 | 0 | 2 | 2 | | 2006 | 0 | 1 | 1 |
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Below are the most recent publications written about "Drug Tolerance" by people in Profiles.
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Friedman JH, Berman RM, Goetz CG, Factor SA, Ondo WG, Wojcieszek J, Carson WH, Marcus RN. Open-label flexible-dose pilot study to evaluate the safety and tolerability of aripiprazole in patients with psychosis associated with Parkinson's disease. Mov Disord. 2006 Dec; 21(12):2078-81.
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McKeith IG, Dickson DW, Lowe J, Emre M, O'Brien JT, Feldman H, Cummings J, Duda JE, Lippa C, Perry EK, Aarsland D, Arai H, Ballard CG, Boeve B, Burn DJ, Costa D, Del Ser T, Dubois B, Galasko D, Gauthier S, Goetz CG, Gomez-Tortosa E, Halliday G, Hansen LA, Hardy J, Iwatsubo T, Kalaria RN, Kaufer D, Kenny RA, Korczyn A, Kosaka K, Lee VM, Lees A, Litvan I, Londos E, Lopez OL, Minoshima S, Mizuno Y, Molina JA, Mukaetova-Ladinska EB, Pasquier F, Perry RH, Schulz JB, Trojanowski JQ, Yamada M. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology. 2005 Dec 27; 65(12):1863-72.
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Stevens JC, Pollack MH. Benzodiazepines in clinical practice: consideration of their long-term use and alternative agents. J Clin Psychiatry. 2005; 66 Suppl 2:21-7.
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Zajecka JM, Weisler R, Sachs G, Swann AC, Wozniak P, Sommerville KW. A comparison of the efficacy, safety, and tolerability of divalproex sodium and olanzapine in the treatment of bipolar disorder. J Clin Psychiatry. 2002 Dec; 63(12):1148-55.
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McCarthy RJ, Kroin JS, Tuman KJ, Penn RD, Ivankovich AD. Antinociceptive potentiation and attenuation of tolerance by intrathecal co-infusion of magnesium sulfate and morphine in rats. Anesth Analg. 1998 Apr; 86(4):830-6.
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Bonomi P, Faber LP, Recine D, Lincoln S. Carboplatin/etoposide/radiation plus escalating doses of paclitaxel in stage III non-small cell lung cancer: a preliminary report. Semin Oncol. 1995 Aug; 22(4 Suppl 9):42-7.
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Pottage JC, Benson CA, Sha BE, Urbanski P, Kessler HA. Treatment of patients with advanced HIV infection and zidovudine intolerance with dideoxyinosine. AIDS. 1992 Jul; 6(7):748-9.
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Pollack MH. Long-term management of panic disorder. J Clin Psychiatry. 1990 May; 51 Suppl:11-3; discussion 50-3.
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Carvey P, Nausieda P, Weertz R, Klawans H. LSD and other related hallucinogens elicit myoclonic jumping behavior in the guinea pig. Prog Neuropsychopharmacol Biol Psychiatry. 1989; 13(1-2):199-210.
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Tiffany ST, Petrie EC, Martin EM, Baker TB. Drug signals enhance morphine tolerance development in hypophysectomized rats. Psychopharmacology (Berl). 1983; 79(1):84-5.
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