 Protein Kinase C
"Protein Kinase C" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.
| Descriptor ID |
D011493
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| MeSH Number(s) |
D08.811.913.696.620.682.700.725
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| Concept/Terms |
Protein Kinase C- Protein Kinase C
- Calcium-Activated Phospholipid-Dependent Kinase
- Calcium Activated Phospholipid Dependent Kinase
- Phospholipid-Dependent Kinase, Calcium-Activated
- PKC Serine-Threonine Kinase
- PKC Serine Threonine Kinase
- Serine-Threonine Kinase, PKC
- Calcium Phospholipid-Dependent Protein Kinase
- Calcium Phospholipid Dependent Protein Kinase
- Phospholipid-Sensitive Calcium-Dependent Protein Kinase
- Phospholipid Sensitive Calcium Dependent Protein Kinase
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Below are MeSH descriptors whose meaning is more general than "Protein Kinase C".
Below are MeSH descriptors whose meaning is more specific than "Protein Kinase C".
This graph shows the total number of publications written about "Protein Kinase C" by people in this website by year, and whether "Protein Kinase C" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 1 | 0 | 1 | | 1994 | 1 | 0 | 1 | | 1995 | 0 | 1 | 1 | | 1998 | 2 | 0 | 2 | | 1999 | 4 | 0 | 4 | | 2000 | 2 | 1 | 3 | | 2001 | 4 | 0 | 4 | | 2002 | 5 | 0 | 5 | | 2003 | 3 | 3 | 6 | | 2004 | 2 | 0 | 2 | | 2005 | 2 | 0 | 2 | | 2006 | 1 | 0 | 1 | | 2008 | 1 | 2 | 3 | | 2009 | 0 | 2 | 2 | | 2011 | 1 | 0 | 1 | | 2012 | 0 | 1 | 1 | | 2013 | 1 | 2 | 3 | | 2014 | 0 | 1 | 1 | | 2017 | 0 | 1 | 1 | | 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protein Kinase C" by people in Profiles.
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Tandon M, Othman AH, Winogradzki M, Pratap J. Bone metastatic breast cancer cells display downregulation of PKC-? with enhanced glutamine metabolism. Gene. 2021 Apr 05; 775:145419.
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Silpanisong J, Kim D, Williams JM, Adeoye OO, Thorpe RB, Pearce WJ. Chronic hypoxia alters fetal cerebrovascular responses to endothelin-1. Am J Physiol Cell Physiol. 2017 Aug 01; 313(2):C207-C218.
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Hondares E, Brown MA, Musset B, Morgan D, Cherny VV, Taubert C, Bhamrah MK, Coe D, Marelli-Berg F, Gribben JG, Dyer MJ, DeCoursey TE, Capasso M. Enhanced activation of an amino-terminally truncated isoform of the voltage-gated proton channel HVCN1 enriched in malignant B cells. Proc Natl Acad Sci U S A. 2014 Dec 16; 111(50):18078-83.
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Taglieri DM, Johnson KR, Burmeister BT, Monasky MM, Spindler MJ, DeSantiago J, Banach K, Conklin BR, Carnegie GK. The C-terminus of the long AKAP13 isoform (AKAP-Lbc) is critical for development of compensatory cardiac hypertrophy. J Mol Cell Cardiol. 2014 Jan; 66:27-40.
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Sutton P, Borgia JA, Bonomi P, Plate JM. Lyn, a Src family kinase, regulates activation of epidermal growth factor receptors in lung adenocarcinoma cells. Mol Cancer. 2013 Jul 16; 12:76.
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Corbett GT, Roy A, Pahan K. Sodium phenylbutyrate enhances astrocytic neurotrophin synthesis via protein kinase C (PKC)-mediated activation of cAMP-response element-binding protein (CREB): implications for Alzheimer disease therapy. J Biol Chem. 2013 Mar 22; 288(12):8299-8312.
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Feng J, Chu LM, Dobrilovic N, Liu Y, Singh AK, Sellke FW. Decreased coronary microvascular reactivity after cardioplegic arrest in patients with uncontrolled diabetes mellitus. Surgery. 2012 Aug; 152(2):262-9.
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Usha L, Sill MW, Darcy KM, Benbrook DM, Hurteau JA, Michelin DP, Mannel RS, Hanjani P, De Geest K, Godwin AK. A Gynecologic Oncology Group phase II trial of the protein kinase C-beta inhibitor, enzastaurin and evaluation of markers with potential predictive and prognostic value in persistent or recurrent epithelial ovarian and primary peritoneal malignancies. Gynecol Oncol. 2011 Jun 01; 121(3):455-61.
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Amin MR, Ghannad L, Othman A, Gill RK, Dudeja PK, Ramaswamy K, Malakooti J. Transcriptional regulation of the human Na+/H+ exchanger NHE3 by serotonin in intestinal epithelial cells. Biochem Biophys Res Commun. 2009 May 08; 382(3):620-5.
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Zhao X, Lu L, Pokhriyal N, Ma H, Duan L, Lin S, Jafari N, Band H, Band V. Overexpression of RhoA induces preneoplastic transformation of primary mammary epithelial cells. Cancer Res. 2009 Jan 15; 69(2):483-91.
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