"Protein Kinase C-theta" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A calcium-independent, phospholipid- and diacylglycerol-dependent, protein kinase C subtype that contains an N-terminal C2 DOMAIN and two diacylglycerol-binding ZINC FINGERS. It is expressed primarily by T-LYMPHOCYTES and localizes to IMMUNOLOGICAL SYNAPSES where it regulates downstream signaling for the activation, proliferation, and survival of mature T-cells. It plays a critical role in allergic, autoimmune, and alloimmune responses of TH2 CELLS and TH17 CELLS.
| Descriptor ID |
D000074121
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.725.075
|
| Concept/Terms |
Protein Kinase C-theta- Protein Kinase C-theta
- Protein Kinase C, theta
- PRKCQ
- Protein Kinase C theta
- PKC-theta
- PKC theta
|
Below are MeSH descriptors whose meaning is more general than "Protein Kinase C-theta".
Below are MeSH descriptors whose meaning is more specific than "Protein Kinase C-theta".
This graph shows the total number of publications written about "Protein Kinase C-theta" by people in this website by year, and whether "Protein Kinase C-theta" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Protein Kinase C-theta" by people in Profiles.
-
theta Isoform of protein kinase C alters barrier function in intestinal epithelium through modulation of distinct claudin isotypes: a novel mechanism for regulation of permeability. J Pharmacol Exp Ther. 2005 Jun; 313(3):962-82.
-
Theta-isoform of PKC is required for alterations in cytoskeletal dynamics and barrier permeability in intestinal epithelium: a novel function for PKC-theta. Am J Physiol Cell Physiol. 2004 Jul; 287(1):C218-34.