Last Name

Meghan Moran

TitleAssistant Professor
InstitutionRush University, Rush Medical College
DepartmentAnatomy and Cell Biology
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    My Scopus ID is 40762104000.

    Research Areas:
    I am a bone biologist interested in the molecular interactions between the gut, gut microbiome and bone as a mechanistic pathway to delaying or mitigating arthroplasty failure due to peri-implant particle-induced osteolysis. Osteolysis is inflammatory bone loss, in this case, stimulated by wear particles from the implant. The gut may provide a point of intervention in the inflammatory response to an orthopedic implant and the gut microbiome may act as a biomarker for implant health. My research may lead to a reduced need for invasive revision surgery, which is currently the treatment for failed implants. Previously, I focused on bone regeneration genetics to identify poor bone repair post-injury.

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    PhD, Kent State University/Northeast Ohio Medical University

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ko FC, Moran MM, Ross RD, Sumner DR. Activation of canonical Wnt signaling accelerates intramembranous bone regeneration in male mice. J Orthop Res. 2021 Nov 22. PMID: 34811780.
      View in: PubMed
    2. Moran MM, Wessman P, Rolfson O, Bohl DD, Kärrholm J, Keshavarzian A, Sumner DR. The risk of revision following total hip arthroplasty in patients with inflammatory bowel disease, a registry based study. PLoS One. 2021; 16(11):e0257310. PMID: 34735461.
      View in: PubMed
    3. Moran MM, Wilson BM, Li J, Engen PA, Naqib A, Green SJ, Virdi AS, Plaas A, Forsyth CB, Keshavarzian A, Sumner DR. The gut microbiota may be a novel pathogenic mechanism in loosening of orthopedic implants in rats. FASEB J. 2020 11; 34(11):14302-14317. PMID: 32931052.
      View in: PubMed
    4. Wilson BM, Moran MM, Meagher MJ, Ross RD, Mashiatulla M, Virdi AS, Sumner DR. Early changes in serum osteocalcin and body weight are predictive of implant fixation in a rat model of implant loosening. J Orthop Res. 2020 06; 38(6):1216-1227. PMID: 31825107.
      View in: PubMed
    5. Moran MM, Wilson BM, Ross RD, Virdi AS, Sumner DR. Arthrotomy-based preclinical models of particle-induced osteolysis: A systematic review. J Orthop Res. 2017 12; 35(12):2595-2605. PMID: 28548682.
      View in: PubMed
    6. Mashiatulla M, Moran MM, Chan D, Li J, Freedman JD, Snyder BD, Grinstaff MW, Plaas A, Sumner DR. Murine articular cartilage morphology and compositional quantification with high resolution cationic contrast-enhanced µCT. J Orthop Res. 2017 12; 35(12):2740-2748. PMID: 28471533.
      View in: PubMed
    7. Moran MM, Sena K, McNulty MA, Sumner DR, Virdi AS. Intramembranous bone regeneration and implant placement using mechanical femoral marrow ablation: rodent models. Bonekey Rep. 2016; 5:837. PMID: 27648259.
      View in: PubMed
    8. Moran MM, Virdi AS, Sena K, Mazzone SR, McNulty MA, Sumner DR. Intramembranous bone regeneration differs among common inbred mouse strains following marrow ablation. J Orthop Res. 2015 Sep; 33(9):1374-81. PMID: 25808034.
      View in: PubMed
    9. Moran MM, Nummela S, Thewissen JG. Development of the skull of the pantropical spotted dolphin (Stenella attenuata). Anat Rec (Hoboken). 2011 Oct; 294(10):1743-56. PMID: 21901843.
      View in: PubMed
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