Last Name

Raj C. Shah

TitleAssociate Professor
InstitutionRush University, Rush Medical College
DepartmentFamily Medicine
Address600 S. Paulina St.
Chicago IL 60612
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    Associate Professor, Family Medicine and Rush Alzheimer’s Disease Center

    My academic career interest is the design and conduct of community-based, clinical trials for the prevention and treatment of age-related conditions including, but not limited to, memory loss, affecting diverse populations of older adults. I am the Leader of the Outreach and Recruitment Core of the Rush Alzheimer’s Disease Core Center funded by the National Institutes on Aging. I am also co-Leader of the Community Engagement/Outreach Core and Leader of the Research Training/Education Core at the Rush Center of Excellence on Disparities in HIV and Aging funded by the National Institute on Minority Health and Health Disparities. I am the co-Director of the Center for Community Health Equity, an initiative jointly led by DePaul University and Rush University Medical Center. I also am the Rush University Medical Center Site Principal Investigator for the Chicago Area Patient-Centered Outcomes Research Network (CAPriCORN), a consortium of health systems and other partners committed to working together to develop, test, and implement strategies to improve care for diverse residents in the metropolitan Chicago region in order to improve health care quality, health outcomes, and health equity.

    My ORCID is 0000-0001-9706-9730.
    My Scopus ID is 10046255700.
    My NIH COMMONS name is rshah1.

    BS, Northwestern University – Evanston, Illinois (Chemical Engineering)
    MD, University of Illinois at Chicago College of Medicine – Chicago, Illinois (Medicine)
    Residency, West Suburban Hospital & Medical Center – Oak Park, Illinois (Family Medicine)
    Fellowship, Rush University Medical Center – Chicago, Illinois (Geriatric Medicine)

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. McNeil JJ, Woods RL, Nelson MR, Murray AM, Reid CM, Kirpach B, Storey E, Shah RC, Wolfe RS, Tonkin AM, Newman AB, Williamson JD, Lockery JE, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Trevaks RE, Orchard SG, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Grimm RH. Baseline Characteristics of Participants in the ASPREE (ASPirin in Reducing Events in the Elderly) Study. J Gerontol A Biol Sci Med Sci. 2017 Oct 12; 72(11):1586-1593. PMID: 28329340.
      View in: PubMed
    2. Mohebbi M, Nguyen V, McNeil JJ, Woods RL, Nelson MR, Shah RC, Storey E, Murray AM, Reid CM, Kirpach B, Wolfe R, Lockery JE, Berk M. Psychometric properties of a short form of the Center for Epidemiologic Studies Depression (CES-D-10) scale for screening depressive symptoms in healthy community dwelling older adults. Gen Hosp Psychiatry. 2017 Aug 18. PMID: 28890280.
      View in: PubMed
    3. Krueger KR, Adeyemi O, Leurgans S, Shah RC, Jimenez AD, Ouellet L, Landay AL, Bennett DA, Barnes LL. Association of cognitive activity and neurocognitive function in blacks and whites with HIV. AIDS. 2017 Jan 28; 31(3):437-441. PMID: 27835616.
      View in: PubMed
    4. Yarchoan M, James BD, Shah RC, Arvanitakis Z, Wilson RS, Schneider J, Bennett DA, Arnold SE. Association of Cancer History with Alzheimer's Disease Dementia and Neuropathology. J Alzheimers Dis. 2017; 56(2):699-706. PMID: 28035936.
      View in: PubMed
    5. Wolfe R, Murray AM, Woods RL, Kirpach B, Gilbertson D, Shah RC, Nelson MR, Reid CM, Ernst ME, Lockery J, Donnan GA, Williamson J, McNeil JJ. The aspirin in reducing events in the elderly trial: Statistical analysis plan. Int J Stroke. 2017 Jan 01; 1747493017741383. PMID: 29111960.
      View in: PubMed
    6. Cummings J, Scheltens P, McKeith I, Blesa R, Harrison JE, Bertolucci PH, Rockwood K, Wilkinson D, Wijker W, Bennett DA, Shah RC. Effect Size Analyses of Souvenaid in Patients with Alzheimer's Disease. J Alzheimers Dis. 2017; 55(3):1131-1139. PMID: 27767993.
      View in: PubMed
    7. Lamotte G, Shah RC, Lazarov O, Corcos DM. Exercise Training for Persons with Alzheimer's Disease and Caregivers: A Review of Dyadic Exercise Interventions. J Mot Behav. 2017 Jul-Aug; 49(4):365-377. PMID: 27870597.
      View in: PubMed
    8. Debrey SM, Leehey MA, Klepitskaya O, Filley CM, Shah RC, Kluger B, Berry-Kravis E, Spector E, Tassone F, Hall DA. Clinical Phenotype of Adult Fragile X Gray Zone Allele Carriers: a Case Series. Cerebellum. 2016 Oct; 15(5):623-31. PMID: 27372099.
      View in: PubMed
    9. De Maio F, Shah RC. Community Response to a Public Health Advertisement. Am J Public Health. 2016 Nov; 106(11):1979. PMID: 27552278.
      View in: PubMed
    10. Farran CJ, Etkin CD, Eisenstein A, Paun O, Rajan KB, Sweet CMC, McCann JJ, Barnes LL, Shah RC, Evans DA. Effect of Moderate to Vigorous Physical Activity Intervention on Improving Dementia Family Caregiver Physical Function: A Randomized Controlled Trial. J Alzheimers Dis Parkinsonism. 2016 Aug; 6(4). PMID: 28752016.
      View in: PubMed
    11. Wilson RS, Boyle PA, Capuano AW, Shah RC, Hoganson GM, Nag S, Bennett DA. Late-life depression is not associated with dementia-related pathology. Neuropsychology. 2016 Feb; 30(2):135-42. PMID: 26237627; PMCID: PMC4740262 [Available on 02/01/17].
    12. Perlman A, Shah RC, Bennett DA, Buchman AS, Matok I. Antihypertensive and Statin Medication Use and Motor Function in Community-Dwelling Older Adults. J Am Med Dir Assoc. 2016 Mar 01; 17(3):220-4. PMID: 26597419; PMCID: PMC4769919 [Available on 03/01/17].
    13. Lugli G, Cohen AM, Bennett DA, Shah RC, Fields CJ, Hernandez AG, Smalheiser NR. Plasma Exosomal miRNAs in Persons with and without Alzheimer Disease: Altered Expression and Prospects for Biomarkers. PLoS One. 2015; 10(10):e0139233. PMID: 26426747; PMCID: PMC4591334.
    14. Aggarwal NT, Shah RC, Bennett DA. Alzheimer's disease: Unique markers for diagnosis & new treatment modalities. Indian J Med Res. 2015 Oct; 142(4):369-82. PMID: 26609028; PMCID: PMC4683821.
    15. Sheft S, Shafiro V, Wang E, Barnes LL, Shah RC. Relationship between Auditory and Cognitive Abilities in Older Adults. PLoS One. 2015; 10(8):e0134330. PMID: 26237423; PMCID: PMC4523175.
    16. Rijpma A, Meulenbroek O, van Hees AM, Sijben JW, Vellas B, Shah RC, Bennett DA, Scheltens P, Olde Rikkert MG. Effects of Souvenaid on plasma micronutrient levels and fatty acid profiles in mild and mild-to-moderate Alzheimer's disease. Alzheimers Res Ther. 2015; 7(1):51. PMID: 26213579; PMCID: PMC4513634.
    17. Barnes LL, Leurgans S, Aggarwal NT, Shah RC, Arvanitakis Z, James BD, Buchman AS, Bennett DA, Schneider JA. Mixed pathology is more likely in black than white decedents with Alzheimer dementia. Neurology. 2015 Aug 11; 85(6):528-34. PMID: 26180136; PMCID: PMC4540250.
    18. Langbaum JB, Hendrix S, Ayutyanont N, Bennett DA, Shah RC, Barnes LL, Lopera F, Reiman EM, Tariot PN. Establishing Composite Cognitive Endpoints for Use in Preclinical Alzheimer's Disease Trials. J Prev Alzheimers Dis. 2015 Mar; 2(1):2-3. PMID: 26273569.
      View in: PubMed
    19. Gustafson DR, Clare Morris M, Scarmeas N, Shah RC, Sijben J, Yaffe K, Zhu X. New Perspectives on Alzheimer's Disease and Nutrition. J Alzheimers Dis. 2015; 46(4):1111-27. PMID: 26402637.
      View in: PubMed
    20. Xiong C, Weng H, Bennett DA, Boyle PA, Shah RC, Fague S, Hall CB, Lipton RB, Morris JC. Subsets of a large cognitive battery better power clinical trials on early stage Alzheimer's disease. Neuroepidemiology. 2014; 43(2):131-9. PMID: 25376544; PMCID: PMC4237272.
    21. Wilson RS, Capuano AW, Boyle PA, Hoganson GM, Hizel LP, Shah RC, Nag S, Schneider JA, Arnold SE, Bennett DA. Clinical-pathologic study of depressive symptoms and cognitive decline in old age. Neurology. 2014 Aug 19; 83(8):702-9. PMID: 25080520; PMCID: PMC4150132.
    22. Hall DA, Bennett DA, Filley CM, Shah RC, Kluger B, Ouyang B, Berry-Kravis E. Fragile X gene expansions are not associated with dementia. Neurobiol Aging. 2014 Nov; 35(11):2637-2638. PMID: 24958193; PMCID: PMC4273643.
    23. Langbaum JB, Hendrix SB, Ayutyanont N, Chen K, Fleisher AS, Shah RC, Barnes LL, Bennett DA, Tariot PN, Reiman EM. An empirically derived composite cognitive test score with improved power to track and evaluate treatments for preclinical Alzheimer's disease. Alzheimers Dement. 2014 Nov; 10(6):666-74. PMID: 24751827; PMCID: PMC4201904.
    24. Dacks PA, Andrieu S, Blacker D, Carman AJ, Green AM, Grodstein F, Henderson VW, James BD, Lane RF, Lau J, Lin PJ, Reeves BC, Shah RC, Vellas B, Yaffe K, Yurko-Mauro K, Shineman DW, Bennett DA, Fillit HM. Dementia Prevention: optimizing the use of observational data for personal, clinical, and public health decision-making. J Prev Alzheimers Dis. 2014 Feb; 1(2):117-123. PMID: 26146610.
      View in: PubMed
    25. Shah RC, Matthews DC, Andrews RD, Capuano AW, Fleischman DA, VanderLugt JT, Colca JR. An evaluation of MSDC-0160, a prototype mTOT modulating insulin sensitizer, in patients with mild Alzheimer's disease. Curr Alzheimer Res. 2014; 11(6):564-73. PMID: 24931567; PMCID: PMC4153084.
    26. Wilson RS, Nag S, Boyle PA, Hizel LP, Yu L, Buchman AS, Shah RC, Schneider JA, Arnold SE, Bennett DA. Brainstem aminergic nuclei and late-life depressive symptoms. JAMA Psychiatry. 2013 Dec; 70(12):1320-8. PMID: 24132763; PMCID: PMC3856195.
    27. Shah RC, Kamphuis PJ, Leurgans S, Swinkels SH, Sadowsky CH, Bongers A, Rappaport SA, Quinn JF, Wieggers RL, Scheltens P, Bennett DA. The S-Connect study: results from a randomized, controlled trial of Souvenaid in mild-to-moderate Alzheimer's disease. Alzheimers Res Ther. 2013; 5(6):59. PMID: 24280255; PMCID: PMC3978853.
    28. Shah RC, Janos AL, Kline JE, Yu L, Leurgans SE, Wilson RS, Wei P, Bennett DA, Heilman KM, Tsao JW. Cognitive decline in older persons initiating anticholinergic medications. PLoS One. 2013; 8(5):e64111. PMID: 23741303; PMCID: PMC3669362.
    29. Shah RC, Buchman AS, Leurgans S, Boyle PA, Bennett DA. Association of total daily physical activity with disability in community-dwelling older persons: a prospective cohort study. BMC Geriatr. 2012 Oct 16; 12:63. PMID: 23072476; PMCID: PMC3492176.
    30. Barnes LL, Shah RC, Aggarwal NT, Bennett DA, Schneider JA. The Minority Aging Research Study: ongoing efforts to obtain brain donation in African Americans without dementia. Curr Alzheimer Res. 2012 Jul; 9(6):734-45. PMID: 22471868; PMCID: PMC3409294.
    31. Park M, Hood MM, Shah RC, Fogg LF, Wyatt JK. Sleepiness, parkinsonian features and sustained attention in mild Alzheimer's disease. Age Ageing. 2012 Nov; 41(6):765-70. PMID: 22743151.
      View in: PubMed
    32. Shah RC, Maitra K, Barnes LL, James BD, Leurgans S, Bennett DA. Relation of driving status to incident life space constriction in community-dwelling older persons: a prospective cohort study. J Gerontol A Biol Sci Med Sci. 2012 Sep; 67(9):984-9. PMID: 22546958; PMCID: PMC3436089.
    33. Rogalski E, Stebbins GT, Barnes CA, Murphy CM, Stoub TR, George S, Ferrari C, Shah RC, deToledo-Morrell L. Age-related changes in parahippocampal white matter integrity: a diffusion tensor imaging study. Neuropsychologia. 2012 Jul; 50(8):1759-65. PMID: 22561887; PMCID: PMC3576131.
    34. Buchman AS, Boyle PA, Yu L, Shah RC, Wilson RS, Bennett DA. Total daily physical activity and the risk of AD and cognitive decline in older adults. Neurology. 2012 Apr 24; 78(17):1323-9. PMID: 22517108; PMCID: PMC3335448.
    35. Buchman AS, Yu L, Boyle PA, Shah RC, Bennett DA. Total daily physical activity and longevity in old age. Arch Intern Med. 2012 Mar 12; 172(5):444-6. PMID: 22412115; PMCID: PMC3366177.
    36. Bakken TE, Roddey JC, Djurovic S, Akshoomoff N, Amaral DG, Bloss CS, Casey BJ, Chang L, Ernst TM, Gruen JR, Jernigan TL, Kaufmann WE, Kenet T, Kennedy DN, Kuperman JM, Murray SS, Sowell ER, Rimol LM, Mattingsdal M, Melle I, Agartz I, Andreassen OA, Schork NJ, Dale AM. Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans. Proc Natl Acad Sci U S A. 2012 Mar 06; 109(10):3985-90. PMID: 22343285; PMCID: PMC3309762.
    37. Shah RC, Schneider JA, Leurgans S, Bennett DA. Association of lower hemoglobin level and neuropathology in community-dwelling older persons. J Alzheimers Dis. 2012; 32(3):579-86. PMID: 22869465; PMCID: PMC3496930.
    38. Etkin CD, Farran CJ, Barnes LL, Shah RC. Recruitment and enrollment of caregivers for a lifestyle physical activity clinical trial. Res Nurs Health. 2012 Feb; 35(1):70-81. PMID: 22083931; PMCID: PMC3729020.
    39. Shah RC, Buchman AS, Wilson RS, Leurgans SE, Bennett DA. Hemoglobin level in older persons and incident Alzheimer disease: prospective cohort analysis. Neurology. 2011 Jul 19; 77(3):219-26. PMID: 21753176; PMCID: PMC3136057.
    40. Shah RC. Medical foods for Alzheimer's disease. Drugs Aging. 2011 Jun 01; 28(6):421-8. PMID: 21534638.
      View in: PubMed
    41. Trivedi MA, Stoub TR, Murphy CM, George S, deToledo-Morrell L, Shah RC, Whitfield-Gabrieli S, Gabrieli JD, Stebbins GT. Entorhinal cortex volume is associated with episodic memory related brain activation in normal aging and amnesic mild cognitive impairment. Brain Imaging Behav. 2011 Jun; 5(2):126-36. PMID: 21328083; PMCID: PMC3164997.
    42. Dickerson BC, Stoub TR, Shah RC, Sperling RA, Killiany RJ, Albert MS, Hyman BT, Blacker D, Detoledo-Morrell L. Alzheimer-signature MRI biomarker predicts AD dementia in cognitively normal adults. Neurology. 2011 Apr 19; 76(16):1395-402. PMID: 21490323; PMCID: PMC3087406.
    43. Stoub TR, Barnes CA, Shah RC, Stebbins GT, Ferrari C, deToledo-Morrell L. Age-related changes in the mesial temporal lobe: the parahippocampal white matter region. Neurobiol Aging. 2012 Jul; 33(7):1168-76. PMID: 21459484; PMCID: PMC3158300.
    44. Park M, Shah RC, Fogg LF, Wyatt JK. Daytime sleepiness in mild Alzheimer's disease with and without parkinsonian features. Sleep Med. 2011 Apr; 12(4):397-402. PMID: 21388877.
      View in: PubMed
    45. Shah RC, Buchman AS, Boyle PA, Leurgans SE, Wilson RS, Andersson GB, Bennett DA. Musculoskeletal pain is associated with incident mobility disability in community-dwelling elders. J Gerontol A Biol Sci Med Sci. 2011 Jan; 66(1):82-8. PMID: 20966101; PMCID: PMC3011961.
    46. Buchman AS, Shah RC, Leurgans SE, Boyle PA, Wilson RS, Bennett DA. Musculoskeletal pain and incident disability in community-dwelling older adults. Arthritis Care Res (Hoboken). 2010 Sep; 62(9):1287-93. PMID: 20853470; PMCID: PMC3445435.
    47. Hebert LE, Bienias JL, Aggarwal NT, Wilson RS, Bennett DA, Shah RC, Evans DA. Change in risk of Alzheimer disease over time. Neurology. 2010 Aug 31; 75(9):786-91. PMID: 20805524; PMCID: PMC2938969.
    48. Wang C, Stebbins GT, Medina DA, Shah RC, Bammer R, Moseley ME, deToledo-Morrell L. Atrophy and dysfunction of parahippocampal white matter in mild Alzheimer's disease. Neurobiol Aging. 2012 Jan; 33(1):43-52. PMID: 20359781; PMCID: PMC2910843.
    49. George S, Mufson EJ, Leurgans S, Shah RC, Ferrari C, deToledo-Morrell L. MRI-based volumetric measurement of the substantia innominata in amnestic MCI and mild AD. Neurobiol Aging. 2011 Oct; 32(10):1756-64. PMID: 20005600; PMCID: PMC2888825.
    50. Shah RC, Wilson RS, Tang Y, Dong X, Murray A, Bennett DA. Relation of hemoglobin to level of cognitive function in older persons. Neuroepidemiology. 2009; 32(1):40-6. PMID: 19001795; PMCID: PMC2739739.
    51. Trivedi MA, Murphy CM, Goetz C, Shah RC, Gabrieli JD, Whitfield-Gabrieli S, Turner DA, Stebbins GT. fMRI activation changes during successful episodic memory encoding and recognition in amnestic mild cognitive impairment relative to cognitively healthy older adults. Dement Geriatr Cogn Disord. 2008; 26(2):123-37. PMID: 18663302; PMCID: PMC2760214.
    52. Bennett DA, Schneider JA, Aggarwal NT, Arvanitakis Z, Shah RC, Kelly JF, Fox JH, Cochran EJ, Arends D, Treinkman AD, Wilson RS. Decision rules guiding the clinical diagnosis of Alzheimer's disease in two community-based cohort studies compared to standard practice in a clinic-based cohort study. Neuroepidemiology. 2006; 27(3):169-76. PMID: 17035694.
      View in: PubMed
    53. Shah RC. Shift shown in influenza A adamantane resistance. JAMA. 2006 Oct 04; 296(13):1585-6; author reply 1586-7. PMID: 17018799.
      View in: PubMed
    54. Shah RC, Wilson RS, Bienias JL, Arvanitakis Z, Evans DA, Bennett DA. Blood pressure and lower limb function in older persons. J Gerontol A Biol Sci Med Sci. 2006 Aug; 61(8):839-43. PMID: 16912102.
      View in: PubMed
    55. Wilson RS, Buchman AS, Arnold SE, Shah RC, Tang Y, Bennett DA. Harm avoidance and disability in old age. Exp Aging Res. 2006 Jul-Sep; 32(3):243-61. PMID: 16754467.
      View in: PubMed
    56. Krueger KR, Wilson RS, Shah RC, Tang Y, Bennett DA. Personality and incident disability in older persons. Age Ageing. 2006 Jul; 35(4):428-33. PMID: 16788082.
      View in: PubMed
    57. Bennett DA, Schneider JA, Arvanitakis Z, Kelly JF, Aggarwal NT, Shah RC, Wilson RS. Neuropathology of older persons without cognitive impairment from two community-based studies. Neurology. 2006 Jun 27; 66(12):1837-44. PMID: 16801647.
      View in: PubMed
    58. Stoub TR, deToledo-Morrell L, Stebbins GT, Leurgans S, Bennett DA, Shah RC. Hippocampal disconnection contributes to memory dysfunction in individuals at risk for Alzheimer's disease. Proc Natl Acad Sci U S A. 2006 Jun 27; 103(26):10041-5. PMID: 16785436; PMCID: PMC1479867.
    59. Aggarwal NT, Bienias JL, Bennett DA, Wilson RS, Morris MC, Schneider JA, Shah RC, Evans DA. The relation of cigarette smoking to incident Alzheimer's disease in a biracial urban community population. Neuroepidemiology. 2006; 26(3):140-6. PMID: 16493200.
      View in: PubMed
    60. Shah RC, Wilson RS, Bienias JL, Arvanitakis Z, Evans DA, Bennett DA. Relation of blood pressure to risk of incident Alzheimer's disease and change in global cognitive function in older persons. Neuroepidemiology. 2006; 26(1):30-6. PMID: 16254451.
      View in: PubMed
    61. Buchman AS, Wilson RS, Bienias JL, Shah RC, Evans DA, Bennett DA. Change in body mass index and risk of incident Alzheimer disease. Neurology. 2005 Sep 27; 65(6):892-7. PMID: 16186530.
      View in: PubMed
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