 Protein C
"Protein C" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A vitamin-K dependent zymogen present in the blood, which, upon activation by thrombin and thrombomodulin exerts anticoagulant properties by inactivating factors Va and VIIIa at the rate-limiting steps of thrombin formation.
| Descriptor ID |
D011486
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| MeSH Number(s) |
D08.622.705 D12.776.124.650 D12.776.395.635 D23.113.700
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Protein C".
Below are MeSH descriptors whose meaning is more specific than "Protein C".
This graph shows the total number of publications written about "Protein C" by people in this website by year, and whether "Protein C" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 | | 1996 | 1 | 0 | 1 | | 1997 | 1 | 0 | 1 | | 2001 | 0 | 1 | 1 | | 2003 | 1 | 2 | 3 | | 2004 | 0 | 1 | 1 | | 2011 | 1 | 0 | 1 | | 2012 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 | | 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protein C" by people in Profiles.
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Madhusudhan T, Ghosh S, Wang H, Dong W, Gupta D, Elwakiel A, Stoyanov S, Al-Dabet MM, Krishnan S, Biemann R, Nazir S, Zimmermann S, Mathew A, Gadi I, Rana R, Zeng-Brouwers J, Moeller MJ, Schaefer L, Esmon CT, Kohli S, Reiser J, Rezaie AR, Ruf W, Isermann B. Podocyte Integrin-ß3 and Activated Protein C Coordinately Restrict RhoA Signaling and Ameliorate Diabetic Nephropathy. J Am Soc Nephrol. 2020 08; 31(8):1762-1780.
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Madhusudhan T, Wang H, Ghosh S, Dong W, Kumar V, Al-Dabet MM, Manoharan J, Nazir S, Elwakiel A, Bock F, Kohli S, Marquardt A, Sögüt I, Shahzad K, Müller AJ, Esmon CT, Nawroth PP, Reiser J, Chavakis T, Ruf W, Isermann B. Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function. Blood. 2017 09 21; 130(12):1445-1455.
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Rimmer E, Kumar A, Doucette S, Marshall J, Dial S, Gurka D, Dellinger RP, Sharma S, Penner C, Kramer A, Wood K, Ronald J, Kumar A, Turgeon AF, Houston DS, Zarychanski R. Activated protein C and septic shock: a propensity-matched cohort study*. Crit Care Med. 2012 Nov; 40(11):2974-81.
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Madhusudhan T, Wang H, Straub BK, Gröne E, Zhou Q, Shahzad K, Müller-Krebs S, Schwenger V, Gerlitz B, Grinnell BW, Griffin JH, Reiser J, Gröne HJ, Esmon CT, Nawroth PP, Isermann B. Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes. Blood. 2012 Jan 19; 119(3):874-83.
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Balk RA. Optimum treatment of severe sepsis and septic shock: evidence in support of the recommendations. Dis Mon. 2004 Apr; 50(4):168-213.
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Patel GP, Gurka DP, Balk RA. New treatment strategies for severe sepsis and septic shock. Curr Opin Crit Care. 2003 Oct; 9(5):390-6.
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Kleinpell R. Advances in treating patients with severe sepsis. Role of drotrecogin alfa (activated). Crit Care Nurse. 2003 Jun; 23(3):16-29; quiz 67-8.
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Kleinpell RM. The role of the critical care nurse in the assessment and management of the patient with severe sepsis. Crit Care Nurs Clin North Am. 2003 Mar; 15(1):27-34.
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Piette WW, Lentz SR. Endothelial protein C activation in meningococcal sepsis. N Engl J Med. 2001 Dec 13; 345(24):1776; author reply 1777.
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Camici M, Evangelisti L, Balestri P, Cioni L, Rindi P, Sagripanti A, Meriggioli M, Giordani R. Coagulation activation in extracorporeal hemodialysis. Int J Artif Organs. 1997 Mar; 20(3):163-5.
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