"Lactoferrin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An iron-binding protein that was originally characterized as a milk protein. It is widely distributed in secretory fluids and is found in the neutrophilic granules of LEUKOCYTES. The N-terminal part of lactoferrin possesses a serine protease which functions to inactivate the TYPE III SECRETION SYSTEM used by bacteria to export virulence proteins for host cell invasion.
| Descriptor ID |
D007781
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| MeSH Number(s) |
D08.811.277.656.300.760.471 D08.811.277.656.959.350.471 D12.776.157.427.750.249 D12.776.256.626.816.500.507 D12.776.377.457.507 D12.776.395.507 D12.776.556.579.750.249
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Lactoferrin".
Below are MeSH descriptors whose meaning is more specific than "Lactoferrin".
This graph shows the total number of publications written about "Lactoferrin" by people in this website by year, and whether "Lactoferrin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 3 | 0 | 3 |
| 2020 | 2 | 0 | 2 |
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Below are the most recent publications written about "Lactoferrin" by people in Profiles.
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Dose escalation study of bovine lactoferrin in preterm infants: getting the dose right. Biochem Cell Biol. 2021 02; 99(1):7-13.
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Systemic and mucosal levels of lactoferrin in very low birth weight infants supplemented with bovine lactoferrin. Biochem Cell Biol. 2021 02; 99(1):25-34.
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Bovine lactoferricin-induced anti-inflammation is, in part, via up-regulation of interleukin-11 by secondary activation of STAT3 in human articular cartilage. J Biol Chem. 2013 Nov 01; 288(44):31655-69.
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Lactoferricin mediates anti-inflammatory and anti-catabolic effects via inhibition of IL-1 and LPS activity in the intervertebral disc. J Cell Physiol. 2013 Sep; 228(9):1884-96.
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Lactoferricin enhances BMP7-stimulated anabolic pathways in intervertebral disc cells. Gene. 2013 07 25; 524(2):282-91.
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Bovine lactoferricin is anti-inflammatory and anti-catabolic in human articular cartilage and synovium. J Cell Physiol. 2013 Feb; 228(2):447-56.
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Lactoferricin mediates anabolic and anti-catabolic effects in the intervertebral disc. J Cell Physiol. 2012 Apr; 227(4):1512-20.
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Multiplex immunoassay of lower genital tract mucosal fluid from women attending an urban STD clinic shows broadly increased IL1? and lactoferrin. PLoS One. 2011 May 10; 6(5):e19560.
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A pilot study to determine the safety and feasibility of oropharyngeal administration of own mother's colostrum to extremely low-birth-weight infants. Adv Neonatal Care. 2010 Aug; 10(4):206-12.
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Cervicovaginal levels of lactoferrin, secretory leukocyte protease inhibitor, and RANTES and the effects of coexisting vaginoses in human immunodeficiency virus (HIV)-seronegative women with a high risk of heterosexual acquisition of HIV infection. Clin Vaccine Immunol. 2007 Sep; 14(9):1102-7.