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Thomas DeCoursey

TitleProfessor
InstitutionRush University, Rush Medical College
DepartmentPhysiology and Biophysics
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    Collapse Overview 
    Collapse overview
    My ORCID is 0000-0002-4263-180X.
    My Scopus ID is 7005381745.
    My NIH COMMONS name is TDECOURSEY.

    Research Areas:
    The properties and biological functions of ion channels are long-term interests of Tom DeCoursey’s laboratory. A major focus in recent years is the voltage-gated proton channel {Table}. Modulation of the voltage-dependence of this channel by pHo and pHi ensures that it opens only when the electrochemical gradient for H+ is outward (in most species). In other words, when the proton channel opens, it extrudes acid from cells. In a long collaboration with Dr. Vladimir V. Cherny and others, the behavior of proton channels has been explored in alveolar epithelial cells and in white blood cells (human neutrophils and eosinophils). Immune cells engulf (phagocytose) bacteria and kill parasites by secreting reactive oxygen species (e.g., ChloroxTM). The enzyme responsible for these heroic actions is NADPH oxidase. This enzyme moves electrons across the cell membrane to form superoxide anion near the invading critters. We measure the electron movement directly as an electrical current. For each electron that leaves, one proton stays in the cell. To prevent massive depolarization as well as acidification, protons exit the cell through proton channels. Without H+ efflux, the killing process would be interrupted prematurely. Fortunately, proton channels are activated, relieving the cell of excess acid {Respiratory Burst figure; cartoon modified to show stoichiometry}, and preventing depolarization. The discovery of proton channels has been a great boon to cells, who until this time had to use other, less efficient means of extruding acid. Identification of proton channel genes in 2006 has transformed the field. More functions are described each year, and structure-function studies are appearing. The channel was shown to be a dimer, with conduction pathway in each protomer. The dimer gates cooperatively - both protomers need to move before either conducts. New genes (eight confirmed, dozens speculated) are appearing at a high rate. The proton channel resists efforts to crystallize it. The first crystal structure was reported in 2014 by Takeshita et al, is likely closed, and is of a chimera with a Voltage-Sensing Phosphatase. James Letts’ valiant efforts to determine the open structure of HV1 (a chimera with KVAP) can be found in his PhD dissertation, which also nicely shows that Asp112 mutants have severely compromised H+ flux! HV1 triggers the flash in bioluminescent dinoflagellates (Smith et al, 2011), which were recently active in Tasmania!

    My Faculty Profile at Rush University Medical Center:
    https://www.rushu.rush.edu/faculty/thomas-decoursey-phd

    My Laboratory:
    https://www.rushu.rush.edu/research/departmental-research/physiology-and-biophysics-research/laboratory-tom-decoursey-phd

    My NCBI Bibliography:
    https://www.ncbi.nlm.nih.gov/pubmed/?term=DeCoursey+TE

    My Scopus:
    https://www.scopus.com/authid/detail.uri?authorId=7005381745

    My ORCID:
    http://orcid.org/0000-0002-4263-180X

    Education:
    PhD, University of Cincinnati College of Medicine
    BA, McPherson College, Kansas


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. DeCoursey TE. Rebuttal from Thomas E. DeCoursey. J Physiol. 2017 Nov 15; 595(22):6801. PMID: 29023792.
      View in: PubMed
    2. DeCoursey TE. CrossTalk proposal: Proton permeation through HV 1 requires transient protonation of a conserved aspartate in the S1 transmembrane helix. J Physiol. 2017 Nov 15; 595(22):6793-6795. PMID: 29023793.
      View in: PubMed
    3. Rodriguez JD, Haq S, Bachvaroff T, Nowak KF, Nowak SJ, Morgan D, Cherny VV, Sapp MM, Bernstein S, Bolt A, DeCoursey TE, Place AR, Smith SM. Identification of a vacuolar proton channel that triggers the bioluminescent flash in dinoflagellates. PLoS One. 2017; 12(2):e0171594. PMID: 28178296.
      View in: PubMed
    4. DeCoursey TE. The intimate and controversial relationship between voltage-gated proton channels and the phagocyte NADPH oxidase. Immunol Rev. 2016 09; 273(1):194-218. PMID: 27558336; PMCID: PMC5000872 [Available on 09/01/17].
    5. DeCoursey TE, Morgan D, Musset B, Cherny VV. Insights into the structure and function of HV1 from a meta-analysis of mutation studies. J Gen Physiol. 2016 Aug; 148(2):97-118. PMID: 27481712; PMCID: PMC4969798 [Available on 02/01/17].
    6. DeCoursey TE. Structural revelations of the human proton channel. Proc Natl Acad Sci U S A. 2015 Nov 03; 112(44):13430-1. PMID: 26466610; PMCID: PMC4640730.
    7. Cherny VV, Morgan D, Musset B, Chaves G, Smith SM, DeCoursey TE. Tryptophan 207 is crucial to the unique properties of the human voltage-gated proton channel, hHV1. J Gen Physiol. 2015 Nov; 146(5):343-56. PMID: 26458876; PMCID: PMC4621752.
    8. DeCoursey TE. The Voltage-Gated Proton Channel: A Riddle, Wrapped in a Mystery, inside an Enigma. Biochemistry. 2015 Jun 02; 54(21):3250-68. PMID: 25964989; PMCID: PMC4736506.
    9. Dudev T, Musset B, Morgan D, Cherny VV, Smith SM, Mazmanian K, DeCoursey TE, Lim C. Selectivity Mechanism of the Voltage-gated Proton Channel, HV1. Sci Rep. 2015 May 08; 5:10320. PMID: 25955978; PMCID: PMC4429351.
    10. DeCoursey TE. Publishing: Double-blind peer review a double risk. Nature. 2015 Apr 30; 520(7549):623. PMID: 25925470; PMCID: PMC4764249.
    11. Hondares E, Brown MA, Musset B, Morgan D, Cherny VV, Taubert C, Bhamrah MK, Coe D, Marelli-Berg F, Gribben JG, Dyer MJ, DeCoursey TE, Capasso M. Enhanced activation of an amino-terminally truncated isoform of the voltage-gated proton channel HVCN1 enriched in malignant B cells. Proc Natl Acad Sci U S A. 2014 Dec 16; 111(50):18078-83. PMID: 25425665; PMCID: PMC4273330.
    12. Morgan D, Decoursey TE. Analysis of electrophysiological properties and responses of neutrophils. Methods Mol Biol. 2014; 1124:121-58. PMID: 24504950; PMCID: PMC3981097.
    13. DeCoursey TE, Hosler J. Philosophy of voltage-gated proton channels. J R Soc Interface. 2014 Mar 06; 11(92):20130799. PMID: 24352668; PMCID: PMC3899857.
    14. Morgan D, Musset B, Kulleperuma K, Smith SM, Rajan S, Cherny VV, Pomès R, DeCoursey TE. Peregrination of the selectivity filter delineates the pore of the human voltage-gated proton channel hHV1. J Gen Physiol. 2013 Dec; 142(6):625-40. PMID: 24218398; PMCID: PMC3840923.
    15. DeCoursey TE. Science and economy: Don't judge research on economics alone. Nature. 2013 May 02; 497(7447):40. PMID: 23636388.
      View in: PubMed
    16. Kulleperuma K, Smith SM, Morgan D, Musset B, Holyoake J, Chakrabarti N, Cherny VV, DeCoursey TE, Pomès R. Construction and validation of a homology model of the human voltage-gated proton channel hHV1. J Gen Physiol. 2013 Apr; 141(4):445-65. PMID: 23530137; PMCID: PMC3607825.
    17. DeCoursey TE. Voltage-gated proton channels: molecular biology, physiology, and pathophysiology of the H(V) family. Physiol Rev. 2013 Apr; 93(2):599-652. PMID: 23589829; PMCID: PMC3677779.
    18. Smith SM, DeCoursey TE. Consequences of dimerization of the voltage-gated proton channel. Prog Mol Biol Transl Sci. 2013; 117:335-60. PMID: 23663974; PMCID: PMC3963466.
    19. DeCoursey TE. Competing interests: Follow the money on climate controversy. Nature. 2012 Sep 27; 489(7417):502. PMID: 23018956.
      View in: PubMed
    20. Musset B, Decoursey T. Biophysical properties of the voltage gated proton channel H(V)1. Wiley Interdiscip Rev Membr Transp Signal. 2012 Sep 01; 1(5):605-620. PMID: 23050239.
      View in: PubMed
    21. Decoursey TE. Voltage-gated proton channels. Compr Physiol. 2012 Apr; 2(2):1355-85. PMID: 23798303; PMCID: PMC3965195.
    22. Musset B, Clark RA, DeCoursey TE, Petheo GL, Geiszt M, Chen Y, Cornell JE, Eddy CA, Brzyski RG, El Jamali A. NOX5 in human spermatozoa: expression, function, and regulation. J Biol Chem. 2012 Mar 16; 287(12):9376-88. PMID: 22291013; PMCID: PMC3308784.
    23. Musset B, Smith SM, Rajan S, Morgan D, Cherny VV, Decoursey TE. Aspartate?112 is the selectivity filter of the human voltage-gated proton channel. Nature. 2011 Oct 23; 480(7376):273-7. PMID: 22020278; PMCID: PMC3237871.
    24. Musset B, Cherny VV, DeCoursey TE. Strong glucose dependence of electron current in human monocytes. Am J Physiol Cell Physiol. 2012 Jan 01; 302(1):C286-95. PMID: 22012327; PMCID: PMC3328910.
    25. Smith SM, Morgan D, Musset B, Cherny VV, Place AR, Hastings JW, Decoursey TE. Voltage-gated proton channel in a dinoflagellate. Proc Natl Acad Sci U S A. 2011 Nov 01; 108(44):18162-7. PMID: 22006335; PMCID: PMC3207696.
    26. DeCoursey TE. NIH revamp: US health care at fault. Nature. 2011 May 05; 473(7345):31. PMID: 21544134.
      View in: PubMed
    27. Capasso M, DeCoursey TE, Dyer MJ. pH regulation and beyond: unanticipated functions for the voltage-gated proton channel, HVCN1. Trends Cell Biol. 2011 Jan; 21(1):20-8. PMID: 20961760; PMCID: PMC3014425.
    28. Musset B, Smith SM, Rajan S, Cherny VV, Morgan D, DeCoursey TE. Oligomerization of the voltage-gated proton channel. Channels (Austin). 2010 Jul-Aug; 4(4):260-5. PMID: 20676047; PMCID: PMC3025757.
    29. Musset B, Smith SM, Rajan S, Cherny VV, Sujai S, Morgan D, DeCoursey TE. Zinc inhibition of monomeric and dimeric proton channels suggests cooperative gating. J Physiol. 2010 May 01; 588(Pt 9):1435-49. PMID: 20231140; PMCID: PMC2876801.
    30. Capasso M, Bhamrah MK, Henley T, Boyd RS, Langlais C, Cain K, Dinsdale D, Pulford K, Khan M, Musset B, Cherny VV, Morgan D, Gascoyne RD, Vigorito E, DeCoursey TE, MacLennan IC, Dyer MJ. HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species. Nat Immunol. 2010 Mar; 11(3):265-72. PMID: 20139987; PMCID: PMC3030552.
    31. DeCoursey TE. Voltage-gated proton channels find their dream job managing the respiratory burst in phagocytes. Physiology (Bethesda). 2010 Feb; 25(1):27-40. PMID: 20134026; PMCID: PMC3023998.
    32. Musset B, Capasso M, Cherny VV, Morgan D, Bhamrah M, Dyer MJ, DeCoursey TE. Identification of Thr29 as a critical phosphorylation site that activates the human proton channel Hvcn1 in leukocytes. J Biol Chem. 2010 Feb 19; 285(8):5117-21. PMID: 20037153; PMCID: PMC2820736.
    33. Morgan D, Capasso M, Musset B, Cherny VV, Ríos E, Dyer MJ, DeCoursey TE. Voltage-gated proton channels maintain pH in human neutrophils during phagocytosis. Proc Natl Acad Sci U S A. 2009 Oct 20; 106(42):18022-7. PMID: 19805063; PMCID: PMC2764923.
    34. Decoursey TE. Unintended consequences at NIH. Science. 2009 Jan 09; 323(5911):209. PMID: 19131613.
      View in: PubMed
    35. Musset B, Cherny VV, Morgan D, DeCoursey TE. The intimate and mysterious relationship between proton channels and NADPH oxidase. FEBS Lett. 2009 Jan 05; 583(1):7-12. PMID: 19084015; PMCID: PMC2630394.
    36. DeCoursey TE. Voltage-gated proton channels: what's next? J Physiol. 2008 Nov 15; 586(22):5305-24. PMID: 18801839; PMCID: PMC2655391.
    37. DeCoursey TE. Voltage-gated proton channels. Cell Mol Life Sci. 2008 Aug; 65(16):2554-73. PMID: 18463791; PMCID: PMC3560420.
    38. Musset B, Morgan D, Cherny VV, MacGlashan DW, Thomas LL, Ríos E, DeCoursey TE. A pH-stabilizing role of voltage-gated proton channels in IgE-mediated activation of human basophils. Proc Natl Acad Sci U S A. 2008 Aug 05; 105(31):11020-5. PMID: 18664579; PMCID: PMC2504794.
    39. Musset B, Cherny VV, Morgan D, Okamura Y, Ramsey IS, Clapham DE, DeCoursey TE. Detailed comparison of expressed and native voltage-gated proton channel currents. J Physiol. 2008 May 15; 586(10):2477-86. PMID: 18356202; PMCID: PMC2464343.
    40. DeCoursey TE. Electrophysiology of the phagocyte respiratory burst. Focus on "Large-conductance calcium-activated potassium channel activity is absent in human and mouse neutrophils and is not required for innate immunity". Am J Physiol Cell Physiol. 2007 Jul; 293(1):C30-2. PMID: 17625039.
      View in: PubMed
    41. DeCoursey TE, Cherny VV. Pharmacology of voltage-gated proton channels. Curr Pharm Des. 2007; 13(23):2400-20. PMID: 17692009.
      View in: PubMed
    42. Morgan D, DeCoursey TE. Analysis of electrophysiological properties and responses of neutrophils. Methods Mol Biol. 2007; 412:139-75. PMID: 18453111.
      View in: PubMed
    43. Morgan D, Cherny VV, Finnegan A, Bollinger J, Gelb MH, DeCoursey TE. Sustained activation of proton channels and NADPH oxidase in human eosinophils and murine granulocytes requires PKC but not cPLA2 alpha activity. J Physiol. 2007 Mar 01; 579(Pt 2):327-44. PMID: 17185330; PMCID: PMC2075394.
    44. Femling JK, Cherny VV, Morgan D, Rada B, Davis AP, Czirják G, Enyedi P, England SK, Moreland JG, Ligeti E, Nauseef WM, DeCoursey TE. The antibacterial activity of human neutrophils and eosinophils requires proton channels but not BK channels. J Gen Physiol. 2006 Jun; 127(6):659-72. PMID: 16702353; PMCID: PMC2151543.
    45. DeCoursey TE. It's difficult to publish contradictory findings. Nature. 2006 Feb 16; 439(7078):784. PMID: 16482132.
      View in: PubMed
    46. Murphy R, DeCoursey TE. Charge compensation during the phagocyte respiratory burst. Biochim Biophys Acta. 2006 Aug; 1757(8):996-1011. PMID: 16483534.
      View in: PubMed
    47. Decoursey TE, Ligeti E. Regulation and termination of NADPH oxidase activity. Cell Mol Life Sci. 2005 Oct; 62(19-20):2173-93. PMID: 16132232.
      View in: PubMed
    48. Morgan D, Cherny VV, Murphy R, Katz BZ, DeCoursey TE. The pH dependence of NADPH oxidase in human eosinophils. J Physiol. 2005 Dec 01; 569(Pt 2):419-31. PMID: 16195320; PMCID: PMC1464255.
    49. Murphy R, Cherny VV, Morgan D, DeCoursey TE. Voltage-gated proton channels help regulate pHi in rat alveolar epithelium. Am J Physiol Lung Cell Mol Physiol. 2005 Feb; 288(2):L398-408. PMID: 15516489.
      View in: PubMed
    50. DeCoursey TE. During the respiratory burst, do phagocytes need proton channels or potassium channels, or both? Sci STKE. 2004 May 11; 2004(233):pe21. PMID: 15150421.
      View in: PubMed
    51. DeCoursey TE. Interactions between NADPH oxidase and voltage-gated proton channels: why electron transport depends on proton transport. FEBS Lett. 2003 Nov 27; 555(1):57-61. PMID: 14630319.
      View in: PubMed
    52. Morgan D, DeCoursey TE. Diversity of voltage gated proton channels. Front Biosci. 2003 Sep 01; 8:s1266-79. PMID: 12957841.
      View in: PubMed
    53. Cherny VV, Murphy R, Sokolov V, Levis RA, DeCoursey TE. Properties of single voltage-gated proton channels in human eosinophils estimated by noise analysis and by direct measurement. J Gen Physiol. 2003 Jun; 121(6):615-28. PMID: 12771195; PMCID: PMC2217352.
    54. Morgan D, Cherny VV, Murphy R, Xu W, Thomas LL, DeCoursey TE. Temperature dependence of NADPH oxidase in human eosinophils. J Physiol. 2003 Jul 15; 550(Pt 2):447-58. PMID: 12754316; PMCID: PMC2343059.
    55. DeCoursey TE, Morgan D, Cherny VV. The voltage dependence of NADPH oxidase reveals why phagocytes need proton channels. Nature. 2003 Apr 03; 422(6931):531-4. PMID: 12673252.
      View in: PubMed
    56. Decoursey TE. Voltage-gated proton channels and other proton transfer pathways. Physiol Rev. 2003 Apr; 83(2):475-579. PMID: 12663866.
      View in: PubMed
    57. DeCoursey TE, Morgan D, Cherny VV. The gp91phox component of NADPH oxidase is not a voltage-gated proton channel. J Gen Physiol. 2002 Dec; 120(6):773-9. PMID: 12451047; PMCID: PMC2229564.
    58. Schilling T, Gratopp A, DeCoursey TE, Eder C. Voltage-activated proton currents in human lymphocytes. J Physiol. 2002 Nov 15; 545(Pt 1):93-105. PMID: 12433952; PMCID: PMC2290658.
    59. Morgan D, Cherny VV, Price MO, Dinauer MC, DeCoursey TE. Absence of proton channels in COS-7 cells expressing functional NADPH oxidase components. J Gen Physiol. 2002 Jun; 119(6):571-80. PMID: 12034764; PMCID: PMC2233867.
    60. Cherny VV, Henderson LM, Xu W, Thomas LL, DeCoursey TE. Activation of NADPH oxidase-related proton and electron currents in human eosinophils by arachidonic acid. J Physiol. 2001 Sep 15; 535(Pt 3):783-94. PMID: 11559775; PMCID: PMC2278825.
    61. DeCoursey TE, Cherny VV, DeCoursey AG, Xu W, Thomas LL. Interactions between NADPH oxidase-related proton and electron currents in human eosinophils. J Physiol. 2001 Sep 15; 535(Pt 3):767-81. PMID: 11559774; PMCID: PMC2278831.
    62. DeCoursey TE, Cherny VV, Morgan D, Katz BZ, Dinauer MC. The gp91phox component of NADPH oxidase is not the voltage-gated proton channel in phagocytes, but it helps. J Biol Chem. 2001 Sep 28; 276(39):36063-6. PMID: 11477065.
      View in: PubMed
    63. Eder C, DeCoursey TE. Voltage-gated proton channels in microglia. Prog Neurobiol. 2001 Jun; 64(3):277-305. PMID: 11240310.
      View in: PubMed
    64. Schilling T, Quandt FN, Cherny VV, Zhou W, Heinemann U, Decoursey TE, Eder C. Upregulation of Kv1.3 K(+) channels in microglia deactivated by TGF-beta. Am J Physiol Cell Physiol. 2000 Oct; 279(4):C1123-34. PMID: 11003593.
      View in: PubMed
    65. DeCoursey TE, Cherny VV, Zhou W, Thomas LL. Simultaneous activation of NADPH oxidase-related proton and electron currents in human neutrophils. Proc Natl Acad Sci U S A. 2000 Jun 06; 97(12):6885-9. PMID: 10823889; PMCID: PMC18770.
    66. DeCoursey TE, Cherny VV. Common themes and problems of bioenergetics and voltage-gated proton channels. Biochim Biophys Acta. 2000 May 12; 1458(1):104-19. PMID: 10812027.
      View in: PubMed
    67. DeCoursey TE. Hypothesis: do voltage-gated H(+) channels in alveolar epithelial cells contribute to CO(2) elimination by the lung? Am J Physiol Cell Physiol. 2000 Jan; 278(1):C1-C10. PMID: 10644504.
      View in: PubMed
    68. Cherny VV, DeCoursey TE. pH-dependent inhibition of voltage-gated H(+) currents in rat alveolar epithelial cells by Zn(2+) and other divalent cations. J Gen Physiol. 1999 Dec; 114(6):819-38. PMID: 10578017; PMCID: PMC2230650.
    69. DeCoursey TE, Cherny VV. Temperature dependence of voltage-gated H+ currents in human neutrophils, rat alveolar epithelial cells, and mammalian phagocytes. J Gen Physiol. 1998 Oct; 112(4):503-22. PMID: 9758867; PMCID: PMC2229433.
    70. Pennefather PS, Zhou W, DeCoursey TE. Idiosyncratic gating of HERG-like K+ channels in microglia. J Gen Physiol. 1998 Jun; 111(6):795-805. PMID: 9607937; PMCID: PMC2217153.
    71. Zhou W, Cayabyab FS, Pennefather PS, Schlichter LC, DeCoursey TE. HERG-like K+ channels in microglia. J Gen Physiol. 1998 Jun; 111(6):781-94. PMID: 9607936; PMCID: PMC2217149.
    72. DeCoursey TE. Four varieties of voltage-gated proton channels. Front Biosci. 1998 05 01; 3:d477-482. PMID: 28481211.
      View in: PubMed
    73. DeCoursey TE, Cherny VV. Deuterium isotope effects on permeation and gating of proton channels in rat alveolar epithelium. J Gen Physiol. 1997 Apr; 109(4):415-34. PMID: 9101402; PMCID: PMC2219434.
    74. Cherny VV, Henderson LM, DeCoursey TE. Proton and chloride currents in Chinese hamster ovary cells. Membr Cell Biol. 1997; 11(3):337-47. PMID: 9460053.
      View in: PubMed
    75. DeCoursey TE, Kim SY, Silver MR, Quandt FN. Ion channel expression in PMA-differentiated human THP-1 macrophages. J Membr Biol. 1996 Jul; 152(2):141-57. PMID: 9139125.
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    76. Kim SY, Silver MR, DeCoursey TE. Ion channels in human THP-1 monocytes. J Membr Biol. 1996 Jul; 152(2):117-30. PMID: 9139123.
      View in: PubMed
    77. DeCoursey TE, Cherny VV. Voltage-activated proton currents in human THP-1 monocytes. J Membr Biol. 1996 Jul; 152(2):131-40. PMID: 9139124.
      View in: PubMed
    78. DeCoursey TE, Cherny VV. Effects of buffer concentration on voltage-gated H+ currents: does diffusion limit the conductance? Biophys J. 1996 Jul; 71(1):182-93. PMID: 8804602; PMCID: PMC1233470.
    79. DeCoursey TE, Cherny VV. Voltage-activated proton currents in membrane patches of rat alveolar epithelial cells. J Physiol. 1995 Dec 01; 489 ( Pt 2):299-307. PMID: 8847626; PMCID: PMC1156758.
    80. DeCoursey TE. Mechanism of K+ channel block by verapamil and related compounds in rat alveolar epithelial cells. J Gen Physiol. 1995 Oct; 106(4):745-79. PMID: 8576705; PMCID: PMC2229280.
    81. Cherny VV, Markin VS, DeCoursey TE. The voltage-activated hydrogen ion conductance in rat alveolar epithelial cells is determined by the pH gradient. J Gen Physiol. 1995 Jun; 105(6):861-96. PMID: 7561747; PMCID: PMC2216954.
    82. DeCoursey TE, Cherny VV. Voltage-activated hydrogen ion currents. J Membr Biol. 1994 Sep; 141(3):203-23. PMID: 7528804.
      View in: PubMed
    83. DeCoursey TE, Cherny VV. Na(+)-H+ antiport detected through hydrogen ion currents in rat alveolar epithelial cells and human neutrophils. J Gen Physiol. 1994 May; 103(5):755-85. PMID: 8035162; PMCID: PMC2219217.
    84. Silver MR, Shapiro MS, DeCoursey TE. Effects of external Rb+ on inward rectifier K+ channels of bovine pulmonary artery endothelial cells. J Gen Physiol. 1994 Apr; 103(4):519-48. PMID: 8057077; PMCID: PMC2216865.
    85. Pennefather PS, DeCoursey TE. A scheme to account for the effects of Rb+ and K+ on inward rectifier K channels of bovine artery endothelial cells. J Gen Physiol. 1994 Apr; 103(4):549-81. PMID: 8057078; PMCID: PMC2216860.
    86. DeCoursey TE, Cherny VV. Potential, pH, and arachidonate gate hydrogen ion currents in human neutrophils. Biophys J. 1993 Oct; 65(4):1590-8. PMID: 7506066; PMCID: PMC1225885.
    87. DeCoursey TE. Hydrogen ion currents in rat alveolar epithelial cells. Biophys J. 1991 Nov; 60(5):1243-53. PMID: 1722118; PMCID: PMC1260178.
    88. Shapiro MS, DeCoursey TE. Selectivity and gating of the type L potassium channel in mouse lymphocytes. J Gen Physiol. 1991 Jun; 97(6):1227-50. PMID: 1875188; PMCID: PMC2216514.
    89. Shapiro MS, DeCoursey TE. Permeant ion effects on the gating kinetics of the type L potassium channel in mouse lymphocytes. J Gen Physiol. 1991 Jun; 97(6):1251-78. PMID: 1875189; PMCID: PMC2216509.
    90. Jacobs ER, DeCoursey TE. Mechanisms of potassium channel block in rat alveolar epithelial cells. J Pharmacol Exp Ther. 1990 Nov; 255(2):459-72. PMID: 1700814.
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    91. Silver MR, DeCoursey TE. Intrinsic gating of inward rectifier in bovine pulmonary artery endothelial cells in the presence or absence of internal Mg2+. J Gen Physiol. 1990 Jul; 96(1):109-33. PMID: 2212977; PMCID: PMC2228980.
    92. DeCoursey TE. State-dependent inactivation of K+ currents in rat type II alveolar epithelial cells. J Gen Physiol. 1990 Apr; 95(4):617-46. PMID: 2338534; PMCID: PMC2216334.
    93. Jacobs ER, DeCoursey TE. Ion channels in the metabolic regulation of respiratory cells. Clin Chest Med. 1989 Mar; 10(1):25-36. PMID: 2468439.
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    94. DeCoursey TE, Jacobs ER, Silver MR. Potassium currents in rat type II alveolar epithelial cells. J Physiol. 1988 Jan; 395:487-505. PMID: 2457683; PMCID: PMC1192006.
    95. Decoursey TE, Chandy KG, Gupta S, Cahalan MD. Mitogen induction of ion channels in murine T lymphocytes. J Gen Physiol. 1987 Mar; 89(3):405-20. PMID: 2435845; PMCID: PMC2215901.
    96. Decoursey TE, Chandy KG, Gupta S, Cahalan MD. Two types of potassium channels in murine T lymphocytes. J Gen Physiol. 1987 Mar; 89(3):379-404. PMID: 2435844; PMCID: PMC2215902.
    97. Cahalan MD, Chandy KG, DeCoursey TE, Gupta S, Lewis RS, Sutro JB. Ion channels in T lymphocytes. Adv Exp Med Biol. 1987; 213:85-101. PMID: 2442978.
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    98. Chandy KG, DeCoursey TE, Fischbach M, Talal N, Cahalan MD, Gupta S. Altered K+ channel expression in abnormal T lymphocytes from mice with the lpr gene mutation. Science. 1986 Sep 12; 233(4769):1197-200. PMID: 2426784.
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    99. DeCoursey TE, Chandy KG, Gupta S, Cahalan MD. Voltage-dependent ion channels in T-lymphocytes. J Neuroimmunol. 1985 Nov; 10(1):71-95. PMID: 2414315.
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    100. Chandy KG, DeCoursey TE, Cahalan MD, Gupta S. Electroimmunology: the physiologic role of ion channels in the immune system. J Immunol. 1985 Aug; 135(2 Suppl):787s-791s. PMID: 2409167.
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    101. Cahalan MD, Chandy KG, DeCoursey TE, Gupta S. A voltage-gated potassium channel in human T lymphocytes. J Physiol. 1985 Jan; 358:197-237. PMID: 2580081; PMCID: PMC1193339.
    102. Chandy KG, DeCoursey TE, Cahalan MD, Gupta S. Ion channels in lymphocytes. J Clin Immunol. 1985 Jan; 5(1):1-6. PMID: 2579969.
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    103. Chandy KG, DeCoursey TE, Cahalan MD, McLaughlin C, Gupta S. Voltage-gated potassium channels are required for human T lymphocyte activation. J Exp Med. 1984 Aug 01; 160(2):369-85. PMID: 6088661; PMCID: PMC2187449.
    104. DeCoursey TE, Dempster J, Hutter OF. Inward rectifier current noise in frog skeletal muscle. J Physiol. 1984 Apr; 349:299-327. PMID: 6330346; PMCID: PMC1199339.
    105. DeCoursey TE, Hutter OF. Potassium current noise induced by barium ions in frog skeletal muscle. J Physiol. 1984 Apr; 349:329-51. PMID: 6330347; PMCID: PMC1199340.
    106. DeCoursey TE, Chandy KG, Gupta S, Cahalan MD. Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis? Nature. 1984 Feb 2-8; 307(5950):465-8. PMID: 6320007.
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    107. DeCoursey TE, Bryant SH, Lipicky RJ. Sodium currents in human skeletal muscle fibers. Muscle Nerve. 1982 Oct; 5(8):614-8. PMID: 6296672.
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    108. DeCoursey TE, Bryant SH, Owenburg KM. Dependence of membrane potential on extracellular ionic concentrations in myotonic goats and rats. Am J Physiol. 1981 Jan; 240(1):C56-63. PMID: 6257116.
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    109. DeCoursey TE, Younkin SG, Bryant SH. Neural control of chloride conductance in rat extensor digitorum longus muscle. Exp Neurol. 1978 Sep 15; 61(3):705-9. PMID: 710575.
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