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Xiu-ti Hu

TitleProfessor
InstitutionRush University, Rush Medical College
DepartmentMicrobial Pathogens and Immunity
AddressChicago IL 60612
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    Collapse Overview 
    Collapse overview
    My Scopus ID is 7404709555.
    My NIH COMMONS name is XIUTIHU.

    Research Areas:
    Neurophysiology of drugs of abuse, neuropathogenesis of HIV and the comorbidity of drug addiction and neuroAIDS; cellular/molecular mechanisms that underlie neuroAIDS and cocaine/methamphetamine addiction; interactions between refrontal cortical/striatal neurons and astrocytes, with or without influences of drugs of abuse, HIV and aging; approaches are electrophysiology, qRT-PCR, immunohistochemistry, protein/mRNA analysis.

    My Faculty Profile at Rush University Medical Center:
    https://www.rushu.rush.edu/faculty/xiu-ti-hu-md-phd

    My Laboratory:
    https://www.rushu.rush.edu/research/departmental-research/microbial-pathogens-and-immunity-research/laboratory-xiu-ti-hu-md-phd

    My NCBI Bibliography:
    https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/43533745/?sort=date&direction=descending

    My Scopus:
    https://www.scopus.com/authid/detail.uri?authorId=7404709555

    Education:
    MD, Chongqing Medical College, China
    PhD, Wayne State University School of Medicine

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hu XL, Xiao W, Lei Y, Green A, Lee X, Maradana MR, Gao Y, Xie X, Wang R, Chennell G, Basson MA, Kille P, Maret W, Bewick GA, Zhou Y, Hogstrand C. Aryl hydrocarbon receptor utilises cellular zinc signals to maintain the gut epithelial barrier. Nat Commun. 2023 09 05; 14(1):5431. PMID: 37669965.
      Citations:    
    2. Chen L, Khodr CE, Al-Harthi L, Hu XT. Aging and HIV-1 alter the function of specific K+ channels in prefrontal cortex pyramidal neurons. Neurosci Lett. 2019 08 24; 708:134341. PMID: 31255727.
      Citations:    
    3. Khodr CE, Chen L, Al-Harthi L, Hu XT. Aging alters voltage-gated calcium channels in prefrontal cortex pyramidal neurons in the HIV brain. J Neurovirol. 2018 02; 24(1):113-118. PMID: 29090376.
      Citations:    
    4. Yu C, Narasipura SD, Richards MH, Hu XT, Yamamoto B, Al-Harthi L. HIV and drug abuse mediate astrocyte senescence in a ?-catenin-dependent manner leading to neuronal toxicity. Aging Cell. 2017 10; 16(5):956-965. PMID: 28612507.
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    5. Khodr CE, Chen L, Dave S, Al-Harthi L, Hu XT. Combined chronic blockade of hyper-active L-type calcium channels and NMDA receptors ameliorates HIV-1 associated hyper-excitability of mPFC pyramidal neurons. Neurobiol Dis. 2016 Oct; 94:85-94. PMID: 27326669.
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    6. Hu XT. HIV-1 Tat-Mediated Calcium Dysregulation and Neuronal Dysfunction in Vulnerable Brain Regions. Curr Drug Targets. 2016; 17(1):4-14. PMID: 26028040.
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    7. Wayman WN, Chen L, Hu XT, Napier TC. HIV-1 Transgenic Rat Prefrontal Cortex Hyper-Excitability is Enhanced by Cocaine Self-Administration. Neuropsychopharmacology. 2016 07; 41(8):1965-73. PMID: 26677947.
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    8. Wayman WN, Chen L, Napier TC, Hu XT. Cocaine self-administration enhances excitatory responses of pyramidal neurons in the rat medial prefrontal cortex to human immunodeficiency virus-1 Tat. Eur J Neurosci. 2015 May; 41(9):1195-206. PMID: 25707266.
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    9. Napier TC, Chen L, Kashanchi F, Hu XT. Repeated cocaine treatment enhances HIV-1 Tat-induced cortical excitability via over-activation of L-type calcium channels. J Neuroimmune Pharmacol. 2014 Jun; 9(3):354-68. PMID: 24567038.
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    10. Wayman WN, Dodiya HB, Persons AL, Kashanchi F, Kordower JH, Hu XT, Napier TC. Enduring cortical alterations after a single in-vivo treatment of HIV-1 Tat. Neuroreport. 2012 Oct 03; 23(14):825-9. PMID: 22828409.
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    11. Sharma A, Hu XT, Napier TC, Al-Harthi L. Methamphetamine and HIV-1 Tat down regulate ?-catenin signaling: implications for methampetamine abuse and HIV-1 co-morbidity. J Neuroimmune Pharmacol. 2011 Dec; 6(4):597-607. PMID: 21744004.
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    12. Heng LJ, Markham JA, Hu XT, Tseng KY. Concurrent upregulation of postsynaptic L-type Ca(2+) channel function and protein kinase A signaling is required for the periadolescent facilitation of Ca(2+) plateau potentials and dopamine D1 receptor modulation in the prefrontal cortex. Neuropharmacology. 2011 May; 60(6):953-62. PMID: 21288471.
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    13. Perez MF, Ford KA, Goussakov I, Stutzmann GE, Hu XT. Repeated cocaine exposure decreases dopamine D2-like receptor modulation of Ca(2+) homeostasis in rat nucleus accumbens neurons. Synapse. 2011 Feb; 65(2):168-80. PMID: 20665696.
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    14. Nasif FJ, Hu XT, Ramirez OA, Perez MF. Inhibition of neuronal nitric oxide synthase prevents alterations in medial prefrontal cortex excitability induced by repeated cocaine administration. Psychopharmacology (Berl). 2011 Nov; 218(2):323-30. PMID: 21125397.
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    15. Ford KA, Wolf ME, Hu XT. Plasticity of L-type Ca2+ channels after cocaine withdrawal. Synapse. 2009 Aug; 63(8):690-7. PMID: 19360908.
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    16. Ishikawa M, Mu P, Moyer JT, Wolf JA, Quock RM, Davies NM, Hu XT, Schl?ter OM, Dong Y. Homeostatic synapse-driven membrane plasticity in nucleus accumbens neurons. J Neurosci. 2009 May 06; 29(18):5820-31. PMID: 19420249.
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    17. Hu XT. Cocaine withdrawal and neuro-adaptations in ion channel function. Mol Neurobiol. 2007 Feb; 35(1):95-112. PMID: 17519508.
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    18. Kalivas PW, Hu XT. Exciting inhibition in psychostimulant addiction. Trends Neurosci. 2006 Nov; 29(11):610-6. PMID: 16956674.
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    19. Perez MF, White FJ, Hu XT. Dopamine D(2) receptor modulation of K(+) channel activity regulates excitability of nucleus accumbens neurons at different membrane potentials. J Neurophysiol. 2006 Nov; 96(5):2217-28. PMID: 16885524.
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    20. Hu XT, Ford K, White FJ. Repeated cocaine administration decreases calcineurin (PP2B) but enhances DARPP-32 modulation of sodium currents in rat nucleus accumbens neurons. Neuropsychopharmacology. 2005 May; 30(5):916-26. PMID: 15726118.
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    21. Nasif FJ, Hu XT, White FJ. Repeated cocaine administration increases voltage-sensitive calcium currents in response to membrane depolarization in medial prefrontal cortex pyramidal neurons. J Neurosci. 2005 Apr 06; 25(14):3674-9. PMID: 15814798.
      Citations:    
    22. Dong Y, Nasif FJ, Tsui JJ, Ju WY, Cooper DC, Hu XT, Malenka RC, White FJ. Cocaine-induced plasticity of intrinsic membrane properties in prefrontal cortex pyramidal neurons: adaptations in potassium currents. J Neurosci. 2005 Jan 26; 25(4):936-40. PMID: 15673674.
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    23. Hu XT, Dong Y, Zhang XF, White FJ. Dopamine D2 receptor-activated Ca2+ signaling modulates voltage-sensitive sodium currents in rat nucleus accumbens neurons. J Neurophysiol. 2005 Mar; 93(3):1406-17. PMID: 15590733.
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    24. Nasif FJ, Sidiropoulou K, Hu XT, White FJ. Repeated cocaine administration increases membrane excitability of pyramidal neurons in the rat medial prefrontal cortex. J Pharmacol Exp Ther. 2005 Mar; 312(3):1305-13. PMID: 15574686.
      Citations:    
    25. Hu XT, Basu S, White FJ. Repeated cocaine administration suppresses HVA-Ca2+ potentials and enhances activity of K+ channels in rat nucleus accumbens neurons. J Neurophysiol. 2004 Sep; 92(3):1597-607. PMID: 15331648.
      Citations:    
    26. Dong Y, Cooper D, Nasif F, Hu XT, White FJ. Dopamine modulates inwardly rectifying potassium currents in medial prefrontal cortex pyramidal neurons. J Neurosci. 2004 Mar 24; 24(12):3077-85. PMID: 15044547.
      Citations:    
    27. Hu XT, Koeltzow TE, Cooper DC, Robertson GS, White FJ, Vezina P. Repeated ventral tegmental area amphetamine administration alters dopamine D1 receptor signaling in the nucleus accumbens. Synapse. 2002 Sep 01; 45(3):159-70. PMID: 12112395.
      Citations:    
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