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Xiu-ti Hu

TitleAssociate Professor
InstitutionRush University, Rush Medical College
DepartmentImmunity and Emergen Pathoges
AddressChicago IL 60612
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    Collapse Overview 
    Collapse overview
    My Scopus ID is 7404709555.
    My NIH COMMONS name is XIUTIHU.

    Research Areas:
    Neurophysiology of drugs of abuse, neuropathogenesis of HIV and the comorbidity of drug addiction and neuroAIDS; cellular/molecular mechanisms that underlie neuroAIDS and cocaine/methamphetamine addiction; interactions between refrontal cortical/striatal neurons and astrocytes, with or without influences of drugs of abuse, HIV and aging; approaches are electrophysiology, qRT-PCR, immunohistochemistry, protein/mRNA analysis.

    My Faculty Profile at Rush University Medical Center:
    https://www.rushu.rush.edu/faculty/xiu-ti-hu-md-phd

    My NCBI Bibliography:
    https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/43533745/?sort=date&direction=descending

    My Scopus:
    https://www.scopus.com/authid/detail.uri?authorId=7404709555

    Education:
    MD, Chongqing Medical College, China
    PhD, Wayne State University School of Medicine


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Yu C, Narasipura SD, Richards MH, Hu XT, Yamamoto B, Al-Harthi L. HIV and drug abuse mediate astrocyte senescence in a ß-catenin-dependent manner leading to neuronal toxicity. Aging Cell. 2017 Oct; 16(5):956-965. PMID: 28612507.
      View in: PubMed
    2. Khodr CE, Chen L, Dave S, Al-Harthi L, Hu XT. Combined chronic blockade of hyper-active L-type calcium channels and NMDA receptors ameliorates HIV-1 associated hyper-excitability of mPFC pyramidal neurons. Neurobiol Dis. 2016 Oct; 94:85-94. PMID: 27326669; PMCID: PMC4983475 [Available on 10/01/17].
    3. Hu XT. HIV-1 Tat-Mediated Calcium Dysregulation and Neuronal Dysfunction in Vulnerable Brain Regions. Curr Drug Targets. 2016; 17(1):4-14. PMID: 26028040; PMCID: PMC4772427.
    4. Wayman WN, Chen L, Hu XT, Napier TC. HIV-1 Transgenic Rat Prefrontal Cortex Hyper-Excitability is Enhanced by Cocaine Self-Administration. Neuropsychopharmacology. 2016 Jul; 41(8):1965-73. PMID: 26677947; PMCID: PMC4908633 [Available on 07/01/17].
    5. Wayman WN, Chen L, Napier TC, Hu XT. Cocaine self-administration enhances excitatory responses of pyramidal neurons in the rat medial prefrontal cortex to human immunodeficiency virus-1 Tat. Eur J Neurosci. 2015 May; 41(9):1195-206. PMID: 25707266; PMCID: PMC4533983.
    6. Graves SM, Clark MJ, Traynor JR, Hu XT, Napier TC. Nucleus accumbens shell excitability is decreased by methamphetamine self-administration and increased by 5-HT2C receptor inverse agonism and agonism. Neuropharmacology. 2015 Feb; 89:113-21. PMID: 25229719; PMCID: PMC4321813.
    7. Napier TC, Chen L, Kashanchi F, Hu XT. Repeated cocaine treatment enhances HIV-1 Tat-induced cortical excitability via over-activation of L-type calcium channels. J Neuroimmune Pharmacol. 2014 Jun; 9(3):354-68. PMID: 24567038; PMCID: PMC4019717.
    8. Wayman WN, Dodiya HB, Persons AL, Kashanchi F, Kordower JH, Hu XT, Napier TC. Enduring cortical alterations after a single in-vivo treatment of HIV-1 Tat. Neuroreport. 2012 Oct 03; 23(14):825-9. PMID: 22828409; PMCID: PMC3555038.
    9. Sharma A, Hu XT, Napier TC, Al-Harthi L. Methamphetamine and HIV-1 Tat down regulate ß-catenin signaling: implications for methampetamine abuse and HIV-1 co-morbidity. J Neuroimmune Pharmacol. 2011 Dec; 6(4):597-607. PMID: 21744004; PMCID: PMC3714216.
    10. Heng LJ, Markham JA, Hu XT, Tseng KY. Concurrent upregulation of postsynaptic L-type Ca(2+) channel function and protein kinase A signaling is required for the periadolescent facilitation of Ca(2+) plateau potentials and dopamine D1 receptor modulation in the prefrontal cortex. Neuropharmacology. 2011 May; 60(6):953-62. PMID: 21288471; PMCID: PMC3077898.
    11. Perez MF, Ford KA, Goussakov I, Stutzmann GE, Hu XT. Repeated cocaine exposure decreases dopamine D2-like receptor modulation of Ca(2+) homeostasis in rat nucleus accumbens neurons. Synapse. 2011 Feb; 65(2):168-80. PMID: 20665696; PMCID: PMC3686293.
    12. Nasif FJ, Hu XT, Ramirez OA, Perez MF. Inhibition of neuronal nitric oxide synthase prevents alterations in medial prefrontal cortex excitability induced by repeated cocaine administration. Psychopharmacology (Berl). 2011 Nov; 218(2):323-30. PMID: 21125397.
      View in: PubMed
    13. Ford KA, Wolf ME, Hu XT. Plasticity of L-type Ca2+ channels after cocaine withdrawal. Synapse. 2009 Aug; 63(8):690-7. PMID: 19360908; PMCID: PMC2862660.
    14. Ishikawa M, Mu P, Moyer JT, Wolf JA, Quock RM, Davies NM, Hu XT, Schlüter OM, Dong Y. Homeostatic synapse-driven membrane plasticity in nucleus accumbens neurons. J Neurosci. 2009 May 06; 29(18):5820-31. PMID: 19420249; PMCID: PMC2743333.
    15. Hu XT, Nasif FJ, Zhang J, Xu M. Fos regulates neuronal activity in the nucleus accumbens. Neurosci Lett. 2008 Dec 19; 448(1):157-60. PMID: 18938216; PMCID: PMC2605784.
    16. Hu XT. Cocaine withdrawal and neuro-adaptations in ion channel function. Mol Neurobiol. 2007 Feb; 35(1):95-112. PMID: 17519508.
      View in: PubMed
    17. Kalivas PW, Hu XT. Exciting inhibition in psychostimulant addiction. Trends Neurosci. 2006 Nov; 29(11):610-6. PMID: 16956674.
      View in: PubMed
    18. Perez MF, White FJ, Hu XT. Dopamine D(2) receptor modulation of K(+) channel activity regulates excitability of nucleus accumbens neurons at different membrane potentials. J Neurophysiol. 2006 Nov; 96(5):2217-28. PMID: 16885524.
      View in: PubMed
    19. Hu XT, Ford K, White FJ. Repeated cocaine administration decreases calcineurin (PP2B) but enhances DARPP-32 modulation of sodium currents in rat nucleus accumbens neurons. Neuropsychopharmacology. 2005 May; 30(5):916-26. PMID: 15726118.
      View in: PubMed
    20. Nasif FJ, Hu XT, White FJ. Repeated cocaine administration increases voltage-sensitive calcium currents in response to membrane depolarization in medial prefrontal cortex pyramidal neurons. J Neurosci. 2005 Apr 06; 25(14):3674-9. PMID: 15814798.
      View in: PubMed
    21. Dong Y, Nasif FJ, Tsui JJ, Ju WY, Cooper DC, Hu XT, Malenka RC, White FJ. Cocaine-induced plasticity of intrinsic membrane properties in prefrontal cortex pyramidal neurons: adaptations in potassium currents. J Neurosci. 2005 Jan 26; 25(4):936-40. PMID: 15673674.
      View in: PubMed
    22. Hu XT, Dong Y, Zhang XF, White FJ. Dopamine D2 receptor-activated Ca2+ signaling modulates voltage-sensitive sodium currents in rat nucleus accumbens neurons. J Neurophysiol. 2005 Mar; 93(3):1406-17. PMID: 15590733.
      View in: PubMed
    23. Nasif FJ, Sidiropoulou K, Hu XT, White FJ. Repeated cocaine administration increases membrane excitability of pyramidal neurons in the rat medial prefrontal cortex. J Pharmacol Exp Ther. 2005 Mar; 312(3):1305-13. PMID: 15574686.
      View in: PubMed
    24. Hu XT, Basu S, White FJ. Repeated cocaine administration suppresses HVA-Ca2+ potentials and enhances activity of K+ channels in rat nucleus accumbens neurons. J Neurophysiol. 2004 Sep; 92(3):1597-607. PMID: 15331648.
      View in: PubMed
    25. Dong Y, Cooper D, Nasif F, Hu XT, White FJ. Dopamine modulates inwardly rectifying potassium currents in medial prefrontal cortex pyramidal neurons. J Neurosci. 2004 Mar 24; 24(12):3077-85. PMID: 15044547.
      View in: PubMed
    26. Hu XT, Koeltzow TE, Cooper DC, Robertson GS, White FJ, Vezina P. Repeated ventral tegmental area amphetamine administration alters dopamine D1 receptor signaling in the nucleus accumbens. Synapse. 2002 Sep 01; 45(3):159-70. PMID: 12112395.
      View in: PubMed
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