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Chris Gaiteri

TitleAssistant Professor
InstitutionRush University, Rush Medical College
DepartmentNeurological Sciences
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    Collapse Overview 
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    How do interaction networks at the levels of genes, proteins and cells support healthy cognitive function? How do semi-independent regulatory systems such as epigenetics, chromosome configuration, miRNA and transcription factors combine to support homeostasis? How do biological networks that operate on vastly different spatial and temporal scales, mesh together seamlessly? Are there collective network “signatures” of disease? How does the connectivity of a network condition its dynamics? How can we use network insights to identify key mediators of pathology?

    Chris Gaiteri, PhD, is interested in answering these questions, and in the context of Alzheimer’s disease uses several types of omics data to identify networks of molecules that are closely related to brain pathology. He has also used related approaches to study major depression and schizophrenia. Living in between computation and biology is a tricky place, so he’s always on the lookout for collaborators. Feel free to email and stop by and discuss how a network approach may benefit your research.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. De Jager PL, Ma Y, McCabe C, Xu J, Vardarajan BN, Felsky D, Klein HU, White CC, Peters MA, Lodgson B, Nejad P, Tang A, Mangravite LM, Yu L, Gaiteri C, Mostafavi S, Schneider JA, Bennett DA. A multi-omic atlas of the human frontal cortex for aging and Alzheimer's disease research. Sci Data. 2018 Aug 07; 5:180142. PMID: 30084846.
      View in: PubMed
    2. Felsky D, Patrick E, Schneider JA, Mostafavi S, Gaiteri C, Patsopoulos N, Bennett DA, De Jager PL. Polygenic analysis of inflammatory disease variants and effects on microglia in the aging brain. Mol Neurodegener. 2018 07 24; 13(1):38. PMID: 30041668.
      View in: PubMed
    3. Gaiteri C, Dawe R, Mostafavi S, Blizinsky KD, Tasaki S, Komashko V, Yu L, Wang Y, Schneider JA, Arfanakis K, De Jager PL, Bennett DA. Gene expression and DNA methylation are extensively coordinated with MRI-based brain microstructural characteristics. Brain Imaging Behav. 2018 Jun 22. PMID: 29934819.
      View in: PubMed
    4. Yu L, Petyuk VA, Gaiteri C, Mostafavi S, Young-Pearse T, Shah RC, Buchman AS, Schneider JA, Piehowski PD, Sontag RL, Fillmore TL, Shi T, Smith RD, De Jager PL, Bennett DA. Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia. Ann Neurol. 2018 Jun 16. PMID: 29908079.
      View in: PubMed
    5. Mostafavi S, Gaiteri C, Sullivan SE, White CC, Tasaki S, Xu J, Taga M, Klein HU, Patrick E, Komashko V, McCabe C, Smith R, Bradshaw EM, Root DE, Regev A, Yu L, Chibnik LB, Schneider JA, Young-Pearse TL, Bennett DA, De Jager PL. A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer's disease. Nat Neurosci. 2018 Jun; 21(6):811-819. PMID: 29802388.
      View in: PubMed
    6. Oveisgharan S, Buchman AS, Yu L, Farfel J, Hachinski V, Gaiteri C, De Jager PL, Schneider JA, Bennett DA. APOE e2e4 genotype, incident AD and MCI, cognitive decline, and AD pathology in older adults. Neurology. 2018 Jun 12; 90(24):e2127-e2134. PMID: 29752306.
      View in: PubMed
    7. Dawe RJ, Leurgans SE, Yang J, Bennett JM, Hausdorff JM, Lim AS, Gaiteri C, Bennett DA, Buchman AS. Association Between Quantitative Gait and Balance Measures and Total Daily Physical Activity in Community-Dwelling Older Adults. J Gerontol A Biol Sci Med Sci. 2018 Apr 17; 73(5):636-642. PMID: 28957994.
      View in: PubMed
    8. Yu L, Dawe RJ, Boyle PA, Gaiteri C, Yang J, Buchman AS, Schneider JA, Arfanakis K, De Jager PL, Bennett DA. Association Between Brain Gene Expression, DNA Methylation, and Alteration of Ex Vivo Magnetic Resonance Imaging Transverse Relaxation in Late-Life Cognitive Decline. JAMA Neurol. 2017 Dec 01; 74(12):1473-1480. PMID: 29084334.
      View in: PubMed
    9. Ng B, White CC, Klein HU, Sieberts SK, McCabe C, Patrick E, Xu J, Yu L, Gaiteri C, Bennett DA, Mostafavi S, De Jager PL. An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome. Nat Neurosci. 2017 Oct; 20(10):1418-1426. PMID: 28869584.
      View in: PubMed
    10. Yu L, Lutz MW, Wilson RS, Burns DK, Roses AD, Saunders AM, Yang J, Gaiteri C, De Jager PL, Barnes LL, Bennett DA. APOE e4-TOMM40 '523 haplotypes and the risk of Alzheimer's disease in older Caucasian and African Americans. PLoS One. 2017; 12(7):e0180356. PMID: 28672022.
      View in: PubMed
    11. Yu L, Lutz MW, Wilson RS, Burns DK, Roses AD, Saunders AM, Gaiteri C, De Jager PL, Barnes LL, Bennett DA. TOMM40'523 variant and cognitive decline in older persons with APOE e3/3 genotype. Neurology. 2017 Feb 14; 88(7):661-668. PMID: 28108637.
      View in: PubMed
    12. Gaiteri C, Mostafavi S, Honey CJ, De Jager PL, Bennett DA. Genetic variants in Alzheimer disease - molecular and brain network approaches. Nat Rev Neurol. 2016 07; 12(7):413-27. PMID: 27282653.
      View in: PubMed
    13. Gaiteri C, Chen M, Szymanski B, Kuzmin K, Xie J, Lee C, Blanche T, Chaibub Neto E, Huang SC, Grabowski T, Madhyastha T, Komashko V. Identifying robust communities and multi-community nodes by combining top-down and bottom-up approaches to clustering. Sci Rep. 2015 Nov 09; 5:16361. PMID: 26549511; PMCID: PMC4637843.
    14. Yang J, Yu L, Gaiteri C, Srivastava GP, Chibnik LB, Leurgans SE, Schneider JA, Meissner A, De Jager PL, Bennett DA. Association of DNA methylation in the brain with age in older persons is confounded by common neuropathologies. Int J Biochem Cell Biol. 2015 Oct; 67:58-64. PMID: 26003740; PMCID: PMC4564337 [Available on 10/01/16].
    15. Tasaki S, Sauerwine B, Hoff B, Toyoshiba H, Gaiteri C, Chaibub Neto E. Bayesian network reconstruction using systems genetics data: comparison of MCMC methods. Genetics. 2015 Apr; 199(4):973-89. PMID: 25631319; PMCID: PMC4391572.
    16. Nichols TW, Gaiteri C. Morton's foot and pyridoxal 5'-phosphate deficiency: genetically linked traits. Med Hypotheses. 2014 Dec; 83(6):644-8. PMID: 25441836.
      View in: PubMed
    17. Gaiteri C, Ding Y, French B, Tseng GC, Sibille E. Beyond modules and hubs: the potential of gene coexpression networks for investigating molecular mechanisms of complex brain disorders. Genes Brain Behav. 2014 Jan; 13(1):13-24. PMID: 24320616; PMCID: PMC3896950.
    18. Zhang B, Gaiteri C, Bodea LG, Wang Z, McElwee J, Podtelezhnikov AA, Zhang C, Xie T, Tran L, Dobrin R, Fluder E, Clurman B, Melquist S, Narayanan M, Suver C, Shah H, Mahajan M, Gillis T, Mysore J, MacDonald ME, Lamb JR, Bennett DA, Molony C, Stone DJ, Gudnason V, Myers AJ, Schadt EE, Neumann H, Zhu J, Emilsson V. Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease. Cell. 2013 Apr 25; 153(3):707-20. PMID: 23622250; PMCID: PMC3677161.
    19. Giraldo M, Lopera F, Siniard AL, Corneveaux JJ, Schrauwen I, Carvajal J, Muñoz C, Ramirez-Restrepo M, Gaiteri C, Myers AJ, Caselli RJ, Kosik KS, Reiman EM, Huentelman MJ. Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease. Neurobiol Aging. 2013 Aug; 34(8):2077.e11-8. PMID: 23582655; PMCID: PMC3830921.
    20. Gaiteri C, Sibille E. Differentially expressed genes in major depression reside on the periphery of resilient gene coexpression networks. Front Neurosci. 2011; 5:95. PMID: 21922000; PMCID: PMC3166821.
    21. Gaiteri C, Rubin JE. The interaction of intrinsic dynamics and network topology in determining network burst synchrony. Front Comput Neurosci. 2011; 5:10. PMID: 21373358; PMCID: PMC3044261.
    22. Gaiteri C, Guilloux JP, Lewis DA, Sibille E. Altered gene synchrony suggests a combined hormone-mediated dysregulated state in major depression. PLoS One. 2010 Apr 01; 5(4):e9970. PMID: 20376317; PMCID: PMC2848620.
    23. Guilloux JP, Gaiteri C, Sibille E. Network analysis of positional candidate genes of schizophrenia highlights...more than... myelin-related pathways. Mol Psychiatry. 2010 Aug; 15(8):786-8. PMID: 20351722; PMCID: PMC2921453.
    24. Sibille E, Wang Y, Joeyen-Waldorf J, Gaiteri C, Surget A, Oh S, Belzung C, Tseng GC, Lewis DA. A molecular signature of depression in the amygdala. Am J Psychiatry. 2009 Sep; 166(9):1011-24. PMID: 19605536; PMCID: PMC2882057.
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