 Thapsigargin
"Thapsigargin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A sesquiterpene lactone found in roots of THAPSIA. It inhibits CA(2+)-TRANSPORTING ATPASE mediated uptake of CALCIUM into SARCOPLASMIC RETICULUM.
| Descriptor ID |
D019284
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| MeSH Number(s) |
D02.455.426.392.368.284.500.888 D02.455.849.765.793.888
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Thapsigargin".
Below are MeSH descriptors whose meaning is more specific than "Thapsigargin".
This graph shows the total number of publications written about "Thapsigargin" by people in this website by year, and whether "Thapsigargin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 | | 2000 | 0 | 2 | 2 | | 2002 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 | | 2011 | 0 | 2 | 2 |
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Below are the most recent publications written about "Thapsigargin" by people in Profiles.
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Arrojo E Drigo R, Fonseca TL, Castillo M, Salathe M, Simovic G, Mohácsik P, Gereben B, Bianco AC. Endoplasmic reticulum stress decreases intracellular thyroid hormone activation via an eIF2a-mediated decrease in type 2 deiodinase synthesis. Mol Endocrinol. 2011 Dec; 25(12):2065-75.
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Bovo E, Mazurek SR, Blatter LA, Zima AV. Regulation of sarcoplasmic reticulum Ca²? leak by cytosolic Ca²? in rabbit ventricular myocytes. J Physiol. 2011 Dec 15; 589(Pt 24):6039-50.
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Florea SM, Blatter LA. The effect of oxidative stress on Ca2+ release and capacitative Ca2+ entry in vascular endothelial cells. Cell Calcium. 2008 Apr; 43(4):405-15.
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Kapur N, Mignery GA, Banach K. Cell cycle-dependent calcium oscillations in mouse embryonic stem cells. Am J Physiol Cell Physiol. 2007 Apr; 292(4):C1510-8.
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Dedkova EN, Blatter LA. Nitric oxide inhibits capacitative Ca2+ entry and enhances endoplasmic reticulum Ca2+ uptake in bovine vascular endothelial cells. J Physiol. 2002 Feb 15; 539(Pt 1):77-91.
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Shannon TR, Chu G, Kranias EG, Bers DM. Phospholamban decreases the energetic efficiency of the sarcoplasmic reticulum Ca pump. J Biol Chem. 2001 Mar 09; 276(10):7195-201.
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Frank K, Tilgmann C, Shannon TR, Bers DM, Kranias EG. Regulatory role of phospholamban in the efficiency of cardiac sarcoplasmic reticulum Ca2+ transport. Biochemistry. 2000 Nov 21; 39(46):14176-82.
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Holda JR, Oberti C, Perez-Reyes E, Blatter LA. Characterization of an oxytocin-induced rise in [Ca2+]i in single human myometrium smooth muscle cells. Cell Calcium. 1996 Jul; 20(1):43-51.
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