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overview My Scopus ID is 7005554863. My NIH COMMONS name is TSHANNON. Research Areas: Ionic channels, voltage gated ionic channels, fluorescence signal detection and electrophysiology, particularly as they relate to excitation-contraction coupling in striated muscle. Shannon uses multiple biochemical, biophysical and molecular approaches to study the control of the concentration of calcium in the storage organelle (the sarcoplasmic reticulum) of normal and abnormal cells of the heart. My Faculty Profile at Rush University Medical Center: https://www.rushu.rush.edu/faculty/thomas-shannon-dvm-phd My Laboratory: https://www.rushu.rush.edu/research/departmental-research/physiology-and-biophysics-research/laboratory-thomas-r-shannon-dvm-phd My NCBI Bibliography: https://www.ncbi.nlm.nih.gov/pubmed/?term=Shannon+TR My Scopus: https://www.scopus.com/authid/detail.uri?authorId=7005554863 Education: PhD, Univeristy of Missouri DVM, University of Missouri

One or more keywords matched the following items that are connected to Shannon, Tom

Item TypeName
Concept Calcium Channel Blockers
Concept Calcium-Calmodulin-Dependent Protein Kinases
Concept Calcium Channels
Concept Calcium-Binding Proteins
Concept Calcium Channels, L-Type
Concept Sodium-Calcium Exchanger
Concept S100 Calcium Binding Protein G
Concept Calcium
Concept Sarcoplasmic Reticulum Calcium-Transporting ATPases
Concept Calcium Signaling
Concept Calcium-Transporting ATPases
Concept Calcium-Calmodulin-Dependent Protein Kinase Type 2
Concept Ryanodine Receptor Calcium Release Channel
Academic Article Confocal imaging of CICR events from isolated and immobilized SR vesicles.
Academic Article Flux regulation of cardiac ryanodine receptor channels.
Academic Article Dynamic calcium movement inside cardiac sarcoplasmic reticulum during release.
Academic Article Effects of FK-506 on contraction and Ca2+ transients in rat cardiac myocytes.
Academic Article Sarcoplasmic reticulum Ca2+, Mg2+, K+, and Cl- concentrations adjust quickly as heart rate changes.
Academic Article Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure.
Academic Article Intra-sarcoplasmic reticulum free [Ca2+] and buffering in arrhythmogenic failing rabbit heart.
Academic Article Isoproterenol increases the fraction of spark-dependent RyR-mediated leak in ventricular myocytes.
Academic Article Ca sparks do not explain all ryanodine receptor-mediated SR Ca leak in mouse ventricular myocytes.
Academic Article Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase.
Academic Article Depletion "skraps" and dynamic buffering inside the cellular calcium store.
Academic Article Confocal imaging of [Ca2+] in cellular organelles by SEER, shifted excitation and emission ratioing of fluorescence.
Academic Article ß-Adrenergic induced SR Ca2+ leak is mediated by an Epac-NOS pathway.
Academic Article Sarcoplasmic Reticulum Structure and Functional Properties that Promote Long-Lasting Calcium Sparks.
Academic Article Nitric oxide-dependent activation of CaMKII increases diastolic sarcoplasmic reticulum calcium release in cardiac myocytes in response to adrenergic stimulation.
Academic Article Calcium movements inside the sarcoplasmic reticulum of cardiac myocytes.
Academic Article Longitudinal and transversal propagation of excitation along the tubular system of rat fast-twitch muscle fibres studied by high speed confocal microscopy.
Academic Article Effects of increased systolic Ca²? and phospholamban phosphorylation during ß-adrenergic stimulation on Ca²? transient kinetics in cardiac myocytes.
Academic Article Spontaneous Ca waves in ventricular myocytes from failing hearts depend on Ca(2+)-calmodulin-dependent protein kinase II.
Academic Article Ryanodine receptor Ca2+ sensitivity and excitation-contraction coupling in muscular dystrophy and heart failure: similar and yet different.
Academic Article Diastolic release of calcium from the sarcoplasmic reticulum: a potential target for treating triggered arrhythmias and heart failure.
Academic Article Linking calsequestrin to lumenal control of SR Ca2+ release.
Academic Article Regulation of cardiac sarcoplasmic reticulum Ca release by luminal [Ca] and altered gating assessed with a mathematical model.
Academic Article A mathematical treatment of integrated Ca dynamics within the ventricular myocyte.
Academic Article Integrated Ca2+ management in cardiac myocytes.
Academic Article Elevated sarcoplasmic reticulum Ca2+ leak in intact ventricular myocytes from rabbits in heart failure.
Academic Article Ca2+ scraps: local depletions of free [Ca2+] in cardiac sarcoplasmic reticulum during contractions leave substantial Ca2+ reserve.
Academic Article Quantitative assessment of the SR Ca2+ leak-load relationship.
Academic Article Allosteric regulation of Na/Ca exchange current by cytosolic Ca in intact cardiac myocytes.
Academic Article Regulatory role of phospholamban in the efficiency of cardiac sarcoplasmic reticulum Ca2+ transport.
Academic Article Phospholamban decreases the energetic efficiency of the sarcoplasmic reticulum Ca pump.
Academic Article Potentiation of fractional sarcoplasmic reticulum calcium release by total and free intra-sarcoplasmic reticulum calcium concentration.
Academic Article Reverse mode of the sarcoplasmic reticulum calcium pump and load-dependent cytosolic calcium decline in voltage-clamped cardiac ventricular myocytes.
Academic Article Reverse mode of the sarcoplasmic reticulum Ca pump limits sarcoplasmic reticulum Ca uptake in permeabilized and voltage-clamped myocytes.
Academic Article Cyclic stretch down-regulates calcium transporter gene expression in neonatal rat ventricular myocytes.
Academic Article Passive Ca2+ binding in ventricular myocardium of neonatal and adult rats.
Academic Article Ca flux, contractility, and excitation-contraction coupling in hypertrophic rat ventricular myocytes.
Academic Article Assessment of intra-SR free [Ca] and buffering in rat heart.
Academic Article Downregulation of sarcoplasmic reticulum Ca(2+)-ATPase during progression of left ventricular hypertrophy.
Academic Article Interaction of cardiac Na-Ca exchanger and exchange inhibitory peptide with membrane phospholipids.

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