"ADAM10 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A disintegrin and metalloproteinase domain-containing protein. It cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA between ALANINE 76 and VALINE 77 to its functional form, as well as several other CELL SURFACE PROTEINS to their soluble forms, including AMYLOID BETA-PROTEIN PRECURSOR and PRION PROTEIN.
| Descriptor ID |
D000072197
|
| MeSH Number(s) |
D08.811.277.656.675.374.102.250 D09.400.430.500.250 D12.776.395.033.250
|
| Concept/Terms |
ADAM10 Protein- ADAM10 Protein
- CD156w Antigen
- Antigen, CD156w
- CD156c Antigen
- Antigen, CD156c
- Disintegrin and Metalloproteinase Domain-Containing Protein 10
- Disintegrin and Metalloproteinase Domain Containing Protein 10
- ADAM-10 Protein
- ADAM 10 Protein
|
Below are MeSH descriptors whose meaning is more general than "ADAM10 Protein".
Below are MeSH descriptors whose meaning is more specific than "ADAM10 Protein".
This graph shows the total number of publications written about "ADAM10 Protein" by people in this website by year, and whether "ADAM10 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "ADAM10 Protein" by people in Profiles.
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Treadmill workout activates PPARa in the hippocampus to upregulate ADAM10, decrease plaques and improve cognitive functions in 5XFAD mouse model of Alzheimer's disease. Brain Behav Immun. 2023 03; 109:204-218.
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Activation of peroxisome proliferator-activated receptor a stimulates ADAM10-mediated proteolysis of APP. Proc Natl Acad Sci U S A. 2015 Jul 07; 112(27):8445-50.
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ADAM-10 protein is present in human articular cartilage primarily in the membrane-bound form and is upregulated in osteoarthritis and in response to IL-1alpha in bovine nasal cartilage. J Histochem Cytochem. 2001 Sep; 49(9):1165-76.
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ADAM-10 message is expressed in human articular cartilage. J Histochem Cytochem. 1998 Jun; 46(6):723-9.