NF-KappaB Inhibitor alpha
"NF-KappaB Inhibitor alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An I-kappa B protein that inhibits the activity of dimeric NF-KAPPA B P50-REL complexes, sequesters transcription factor NF-kappaB as an inactive complex in the cytoplasm; and prevents NF-kappaB nuclear translocation and DNA binding.
| Descriptor ID |
D000072000
|
| MeSH Number(s) |
D12.644.360.365.500 D12.776.260.420.500 D12.776.476.381.500 D12.776.930.326.500
|
| Concept/Terms |
NF-KappaB Inhibitor alpha- NF-KappaB Inhibitor alpha
- Inhibitor alpha, NF-KappaB
- NF KappaB Inhibitor alpha
- alpha, NF-KappaB Inhibitor
- Major Histocompatibility Complex Enhancer-Binding Protein MAD3
- Major Histocompatibility Complex Enhancer Binding Protein MAD3
- IKappaB-alpha
- IKappaB alpha
- p40 Protein (IKappaB-alpha)
- I Kappa B-alpha Protein
- I Kappa B alpha Protein
- IKappaBalpha
|
Below are MeSH descriptors whose meaning is more general than "NF-KappaB Inhibitor alpha".
Below are MeSH descriptors whose meaning is more specific than "NF-KappaB Inhibitor alpha".
This graph shows the total number of publications written about "NF-KappaB Inhibitor alpha" by people in this website by year, and whether "NF-KappaB Inhibitor alpha" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2007 | 0 | 2 | 2 |
| 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "NF-KappaB Inhibitor alpha" by people in Profiles.
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Suppression of nuclear factor-?B activation and inflammation in microglia by physically modified saline. J Biol Chem. 2012 Aug 24; 287(35):29529-42.
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Involvement of phosphatidylinositol 3-kinase-mediated up-regulation of I kappa B alpha in anti-inflammatory effect of gemfibrozil in microglia. J Immunol. 2007 Sep 15; 179(6):4142-52.
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NF-kappaB activation as a key mechanism in ethanol-induced disruption of the F-actin cytoskeleton and monolayer barrier integrity in intestinal epithelium. Alcohol. 2007 Sep; 41(6):447-60.
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PKC-beta1 isoform activation is required for EGF-induced NF-kappaB inactivation and IkappaBalpha stabilization and protection of F-actin assembly and barrier function in enterocyte monolayers. Am J Physiol Cell Physiol. 2004 Mar; 286(3):C723-38.
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Evidence that nuclear factor-kappa B activation is critical in oxidant-induced disruption of the microtubule cytoskeleton and barrier integrity and that its inactivation is essential in epidermal growth factor-mediated protection of the monolayers of intestinal epithelia. J Pharmacol Exp Ther. 2003 Jul; 306(1):13-28.
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Down-regulation of procollagen alpha1[I]] messenger RNA by titanium particles correlates with nuclear factor kappaB (NF-kappaB) activation and increased rel A and NF-kappaB1 binding to the collagen promoter. J Bone Miner Res. 2001 Mar; 16(3):501-10.