1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.
| Descriptor ID |
D015632
|
| MeSH Number(s) |
D03.383.725.450
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine".
Below are MeSH descriptors whose meaning is more specific than "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine".
This graph shows the total number of publications written about "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine" by people in this website by year, and whether "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 2 | 2 |
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine" by people in Profiles.
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Experimental colitis promotes sustained, sex-dependent, T-cell-associated neuroinflammation and parkinsonian neuropathology. Acta Neuropathol Commun. 2021 08 19; 9(1):139.
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Microglia, inflammation and gut microbiota responses in a progressive monkey model of Parkinson's disease: A case series. Neurobiol Dis. 2020 10; 144:105027.
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Simvastatin inhibits the activation of p21ras and prevents the loss of dopaminergic neurons in a mouse model of Parkinson's disease. J Neurosci. 2009 Oct 28; 29(43):13543-56.
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Age and region-specific responses of microglia, but not astrocytes, suggest a role in selective vulnerability of dopamine neurons after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure in monkeys. Glia. 2008 Aug 15; 56(11):1199-214.
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Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A. 2007 Nov 20; 104(47):18754-9.
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Neural repair strategies for Parkinson's disease: insights from primate models. Cell Transplant. 2006; 15(3):251-65.
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Progressive dopamine neuron loss in Parkinson's disease: the multiple hit hypothesis. Cell Transplant. 2006; 15(3):239-50.
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Striatal trophic factor activity in aging monkeys with unilateral MPTP-induced parkinsonism. Exp Neurol. 2005 Feb; 191 Suppl 1:S60-7.
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Primate models of Parkinson's disease. Exp Neurol. 2003 Oct; 183(2):258-62.
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Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration. J Neurosci. 2002 Jun 15; 22(12):4942-54.