Primary Graft Dysfunction
"Primary Graft Dysfunction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A form of ischemia-reperfusion injury occurring in the early period following transplantation. Significant pathophysiological changes in MITOCHONDRIA are the main cause of the dysfunction. It is most often seen in the transplanted lung, liver, or kidney and can lead to GRAFT REJECTION.
| Descriptor ID |
D055031
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| MeSH Number(s) |
C14.907.725.675 C23.550.767.877.750
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Primary Graft Dysfunction".
Below are MeSH descriptors whose meaning is more specific than "Primary Graft Dysfunction".
This graph shows the total number of publications written about "Primary Graft Dysfunction" by people in this website by year, and whether "Primary Graft Dysfunction" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2015 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Primary Graft Dysfunction" by people in Profiles.
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Crosstalk between nonclassical monocytes and alveolar macrophages mediates transplant ischemia-reperfusion injury through classical monocyte recruitment. JCI Insight. 2021 03 22; 6(6).
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Residual endotoxin induces primary graft dysfunction through ischemia/reperfusion-primed alveolar macrophages. J Clin Invest. 2020 08 03; 130(8):4456-4469.
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Saphenous vein graft disease, pathophysiology, prevention, and treatment. A review of the literature. J Card Surg. 2020 Jun; 35(6):1314-1321.
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Donor pulmonary intravascular nonclassical monocytes recruit recipient neutrophils and mediate primary lung allograft dysfunction. Sci Transl Med. 2017 06 14; 9(394).
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Conditioning With Sevoflurane in Liver Transplantation: Results of a Multicenter Randomized Controlled Trial. Transplantation. 2015 Aug; 99(8):1606-12.
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Report from a consensus conference on primary graft dysfunction after cardiac transplantation. J Heart Lung Transplant. 2014 Apr; 33(4):327-40.