"Lewy Bodies" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Intracytoplasmic, eosinophilic, round to elongated inclusions found in vacuoles of injured or fragmented neurons. The presence of Lewy bodies is the histological marker of the degenerative changes in LEWY BODY DISEASE and PARKINSON DISEASE but they may be seen in other neurological conditions. They are typically found in the substantia nigra and locus coeruleus but they are also seen in the basal forebrain, hypothalamic nuclei, and neocortex.
| Descriptor ID |
D016631
|
| MeSH Number(s) |
A08.675.460 A11.284.420.460 A11.671.460
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Lewy Bodies".
Below are MeSH descriptors whose meaning is more specific than "Lewy Bodies".
This graph shows the total number of publications written about "Lewy Bodies" by people in this website by year, and whether "Lewy Bodies" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2016 | 2 | 0 | 2 |
| 2017 | 0 | 3 | 3 |
| 2019 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Lewy Bodies" by people in Profiles.
-
Effects of Cerebrovascular and Lewy Body Pathology on Parkinsonian Signs in Community-Dwelling Older Adults. Neurology. 2023 08 15; 101(7):e754-e763.
-
In situ proximity labeling identifies Lewy pathology molecular interactions in the human brain. Proc Natl Acad Sci U S A. 2022 02 01; 119(5).
-
The association of Lewy bodies with limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes and their role in cognition and Alzheimer's dementia in older persons. Acta Neuropathol Commun. 2021 09 25; 9(1):156.
-
Association of Lewy Bodies With Age-Related Clinical Characteristics in Black and White Decedents. Neurology. 2021 08 24; 97(8):e825-e835.
-
Long-term post-mortem studies following neurturin gene therapy in patients with advanced Parkinson's disease. Brain. 2020 03 01; 143(3):960-975.
-
Brain Bromine Levels Associated with Alzheimer's Disease Neuropathology. J Alzheimers Dis. 2020; 73(1):327-332.
-
Intrastriatal alpha-synuclein fibrils in monkeys: spreading, imaging and neuropathological changes. Brain. 2019 11 01; 142(11):3565-3579.
-
Sex differences in mixed neuropathologies in community-dwelling older adults. Brain Res. 2019 09 15; 1719:11-16.
-
Postmortem neurodegenerative markers and trajectories of decline in cognitive systems. Neurology. 2019 02 19; 92(8):e831-e840.
-
Association Between Brain Gene Expression, DNA Methylation, and Alteration of Ex Vivo Magnetic Resonance Imaging Transverse Relaxation in Late-Life Cognitive Decline. JAMA Neurol. 2017 12 01; 74(12):1473-1480.