Cyclic Nucleotide Phosphodiesterases, Type 3
"Cyclic Nucleotide Phosphodiesterases, Type 3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cyclic nucleotide phosphodiesterase subfamily that is inhibited by the binding of CYCLIC GMP to an allosteric domain found on the enzyme and through phosphorylation by regulatory kinases such as PROTEIN KINASE A and PROTEIN KINASE B. The two members of this family are referred to as type 3A, and type 3B, and are each product of a distinct gene. In addition multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing.
| Descriptor ID |
D054684
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| MeSH Number(s) |
D08.811.277.352.640.150.300 D12.644.360.008.300 D12.776.476.008.300
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| Concept/Terms |
Cyclic Nucleotide Phosphodiesterases, Type 3- Cyclic Nucleotide Phosphodiesterases, Type 3
- cGMP-Inhibited Cyclic Nucleotide Phosphodiesterase
- cGMP Inhibited Cyclic Nucleotide Phosphodiesterase
- Cyclic Nucleotide Phosphodiesterase PDE3 Family
- Phosphodiesterase III
- cGMP-Inhibited Phosphodiesterase
- Phosphodiesterase, cGMP-Inhibited
- cGMP Inhibited Phosphodiesterase
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Below are MeSH descriptors whose meaning is more general than "Cyclic Nucleotide Phosphodiesterases, Type 3".
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Below are the most recent publications written about "Cyclic Nucleotide Phosphodiesterases, Type 3" by people in Profiles.
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Sphingomyelinase-like phosphodiesterase 3b expression levels determine podocyte injury phenotypes in glomerular disease. J Am Soc Nephrol. 2015 Jan; 26(1):133-47.
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Negative feedback exerted by cAMP-dependent protein kinase and cAMP phosphodiesterase on subsarcolemmal cAMP signals in intact cardiac myocytes: an in vivo study using adenovirus-mediated expression of CNG channels. J Biol Chem. 2004 Dec 10; 279(50):52095-105.