"ADAMTS4 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An ADAMTS protease similar to ADAMTS5 PROTEIN. It contains a single C-terminal thrombospondin (TS) motif and cleaves AGGRECAN in CARTILAGE. It may also be involved in the destruction of aggrecan in ARTHRITIS.
| Descriptor ID |
D000071121
|
| MeSH Number(s) |
D08.811.277.656.675.374.102.500.844 D09.400.430.500.500.844 D12.776.395.033.500.844 D12.776.860.300.085.844
|
| Concept/Terms |
ADAMTS4 Protein- ADAMTS4 Protein
- Aggrecanase-1
- Aggrecanase 1
- A Disintegrin And Metalloproteinase With Thrombospondin Motifs 4 Protein
- ADAMTS-4 Protein
- ADAMTS 4 Protein
|
Below are MeSH descriptors whose meaning is more general than "ADAMTS4 Protein".
Below are MeSH descriptors whose meaning is more specific than "ADAMTS4 Protein".
This graph shows the total number of publications written about "ADAMTS4 Protein" by people in this website by year, and whether "ADAMTS4 Protein" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 3 | 3 |
| 2008 | 0 | 2 | 2 |
| 2009 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "ADAMTS4 Protein" by people in Profiles.
-
The "elusive DMOAD": Aggrecanase inhibition from laboratory to clinic. Clin Exp Rheumatol. 2019 Sep-Oct; 37 Suppl 120(5):130-134.
-
An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2. JCI Insight. 2018 03 22; 3(6).
-
Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors. J Biol Chem. 2009 Sep 04; 284(36):24185-91.
-
The action of resveratrol, a phytoestrogen found in grapes, on the intervertebral disc. Spine (Phila Pa 1976). 2008 Nov 15; 33(24):2586-95.
-
Proprotein convertase activation of aggrecanases in cartilage in situ. Arch Biochem Biophys. 2008 Oct 01; 478(1):43-51.
-
Substrate-dependent inhibition kinetics of an active site-directed inhibitor of ADAMTS-4 (Aggrecanase 1). Biochemistry. 2007 May 29; 46(21):6393-401.
-
Identification of an ADAMTS-4 cleavage motif using phage display leads to the development of fluorogenic peptide substrates and reveals matrilin-3 as a novel substrate. J Biol Chem. 2007 Apr 13; 282(15):11101-9.
-
Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5. Arthritis Rheum. 2007 Feb; 56(2):575-85.
-
ADAMTS-4 (aggrecanase-1): N-terminal activation mechanisms. Arch Biochem Biophys. 2005 Dec 01; 444(1):34-44.
-
Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (Aggrecanase-1) in the trans-Golgi network. J Biol Chem. 2004 Apr 09; 279(15):15434-40.