 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.
| Descriptor ID |
D015632
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| MeSH Number(s) |
D03.383.725.450
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine".
Below are MeSH descriptors whose meaning is more specific than "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine".
This graph shows the total number of publications written about "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine" by people in this website by year, and whether "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1990 | 1 | 1 | 2 | | 1993 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2006 | 0 | 2 | 2 | | 2007 | 0 | 1 | 1 | | 2008 | 1 | 0 | 1 | | 2009 | 0 | 1 | 1 |
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Below are the most recent publications written about "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine" by people in Profiles.
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Ghosh A, Roy A, Matras J, Brahmachari S, Gendelman HE, Pahan K. Simvastatin inhibits the activation of p21ras and prevents the loss of dopaminergic neurons in a mouse model of Parkinson's disease. J Neurosci. 2009 Oct 28; 29(43):13543-56.
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Kanaan NM, Kordower JH, Collier TJ. Age and region-specific responses of microglia, but not astrocytes, suggest a role in selective vulnerability of dopamine neurons after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure in monkeys. Glia. 2008 Aug 15; 56(11):1199-214.
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Ghosh A, Roy A, Liu X, Kordower JH, Mufson EJ, Hartley DM, Ghosh S, Mosley RL, Gendelman HE, Pahan K. Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A. 2007 Nov 20; 104(47):18754-9.
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Soderstrom K, O'Malley J, Steece-Collier K, Kordower JH. Neural repair strategies for Parkinson's disease: insights from primate models. Cell Transplant. 2006; 15(3):251-65.
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Carvey PM, Punati A, Newman MB. Progressive dopamine neuron loss in Parkinson's disease: the multiple hit hypothesis. Cell Transplant. 2006; 15(3):239-50.
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Collier TJ, Dung Ling Z, Carvey PM, Fletcher-Turner A, Yurek DM, Sladek JR, Kordower JH. Striatal trophic factor activity in aging monkeys with unilateral MPTP-induced parkinsonism. Exp Neurol. 2005 Feb; 191 Suppl 1:S60-7.
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Collier TJ, Steece-Collier K, Kordower JH. Primate models of Parkinson's disease. Exp Neurol. 2003 Oct; 183(2):258-62.
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Palfi S, Leventhal L, Chu Y, Ma SY, Emborg M, Bakay R, Déglon N, Hantraye P, Aebischer P, Kordower JH. Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration. J Neurosci. 2002 Jun 15; 22(12):4942-54.
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Kordower JH, Emborg ME, Bloch J, Ma SY, Chu Y, Leventhal L, McBride J, Chen EY, Palfi S, Roitberg BZ, Brown WD, Holden JE, Pyzalski R, Taylor MD, Carvey P, Ling Z, Trono D, Hantraye P, Déglon N, Aebischer P. Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Science. 2000 Oct 27; 290(5492):767-73.
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Diederich NJ, Goetz CG. [Fetal and adrenal transplantation in Parkinson disease: theoretical bases and clinical results]. Bull Soc Sci Med Grand Duche Luxemb. 1993; 130(1):25-36.
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