 Apoptosis
"Apoptosis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
| Descriptor ID |
D017209
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| MeSH Number(s) |
G04.299.139.160
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| Concept/Terms |
Apoptosis- Apoptosis
- Programmed Cell Death, Type I
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Below are MeSH descriptors whose meaning is more general than "Apoptosis".
Below are MeSH descriptors whose meaning is more specific than "Apoptosis".
This graph shows the total number of publications written about "Apoptosis" by people in this website by year, and whether "Apoptosis" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 0 | 1 | 1 | | 1994 | 1 | 0 | 1 | | 1995 | 1 | 0 | 1 | | 1996 | 5 | 3 | 8 | | 1997 | 1 | 4 | 5 | | 1998 | 2 | 2 | 4 | | 1999 | 6 | 3 | 9 | | 2000 | 3 | 1 | 4 | | 2001 | 4 | 2 | 6 | | 2002 | 5 | 4 | 9 | | 2003 | 6 | 5 | 11 | | 2004 | 6 | 7 | 13 | | 2005 | 2 | 9 | 11 | | 2006 | 6 | 3 | 9 | | 2007 | 9 | 4 | 13 | | 2008 | 3 | 4 | 7 | | 2009 | 4 | 2 | 6 | | 2010 | 4 | 6 | 10 | | 2011 | 3 | 6 | 9 | | 2012 | 3 | 6 | 9 | | 2013 | 5 | 8 | 13 | | 2014 | 3 | 10 | 13 | | 2015 | 2 | 7 | 9 | | 2016 | 0 | 3 | 3 | | 2017 | 1 | 7 | 8 | | 2018 | 1 | 6 | 7 | | 2019 | 1 | 4 | 5 |
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Below are the most recent publications written about "Apoptosis" by people in Profiles.
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Zhang X, Hou G, Liu A, Xu H, Guan Y, Wu Y, Deng J, Cao X. Matrine inhibits the development and progression of ovarian cancer by repressing cancer associated phosphorylation signaling pathways. Cell Death Dis. 2019 10 10; 10(10):770.
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Kugyelka R, Prenek L, Olasz K, Kohl Z, Botz B, Glant TT, Berki T, Boldizsár F. ZAP-70 Regulates Autoimmune Arthritis via Alterations in T Cell Activation and Apoptosis. Cells. 2019 05 24; 8(5).
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Giri B, Gupta VK, Yaffe B, Modi S, Roy P, Sethi V, Lavania SP, Vickers SM, Dudeja V, Banerjee S, Watts J, Saluja A. Pre-clinical evaluation of Minnelide as a therapy for acute myeloid leukemia. J Transl Med. 2019 05 20; 17(1):163.
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Duan L, Perez RE, Lai X, Chen L, Maki CG. The histone demethylase JMJD2B is critical for p53-mediated autophagy and survival in Nutlin-treated cancer cells. J Biol Chem. 2019 06 07; 294(23):9186-9197.
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Mittal N, Li L, Sheng Y, Hu C, Li F, Zhu T, Qiao X, Qian Z. A critical role of epigenetic inactivation of miR-9 in EVI1high pediatric AML. Mol Cancer. 2019 02 27; 18(1):30.
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Duan L, Perez RE, Maki CG. Alpha ketoglutarate levels, regulated by p53 and OGDH, determine autophagy and cell fate/apoptosis in response to Nutlin-3a. Cancer Biol Ther. 2019; 20(3):252-260.
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Beck-Schimmer B, Roth Z'graggen B, Booy C, Köppel S, Spahn DR, Schläpfer M, Schadde E. Sevoflurane Protects Hepatocytes From Ischemic Injury by Reducing Reactive Oxygen Species Signaling of Hepatic Stellate Cells: Translational Findings Based on a Clinical Trial. Anesth Analg. 2018 10; 127(4):1058-1065.
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Kaminski A, Gupta KH, Goldufsky JW, Lee HW, Gupta V, Shafikhani SH. Pseudomonas aeruginosa ExoS Induces Intrinsic Apoptosis in Target Host Cells in a Manner That is Dependent on its GAP Domain Activity. Sci Rep. 2018 09 19; 8(1):14047.
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Duan L, Perez RE, Chen L, Blatter LA, Maki CG. p53 promotes AKT and SP1-dependent metabolism through the pentose phosphate pathway that inhibits apoptosis in response to Nutlin-3a. J Mol Cell Biol. 2018 08 01; 10(4):331-340.
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Nascimento BPP, Bocco BMLC, Fernandes GW, Fonseca TL, McAninch EA, Cardoso CV, Bondan EF, Nassif RJ, Cysneiros RM, Bianco AC, Ribeiro MO. Induction of Type 2 Iodothyronine Deiodinase After Status Epilepticus Modifies Hippocampal Gene Expression in Male Mice. Endocrinology. 2018 08 01; 159(8):3090-3104.
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