 Toll-Like Receptor 2
"Toll-Like Receptor 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pattern recognition receptor that forms heterodimers with other TOLL-LIKE RECEPTORS. It interacts with multiple ligands including PEPTIDOGLYCAN, bacterial LIPOPROTEINS, lipoarabinomannan, and a variety of PORINS.
| Descriptor ID |
D051195
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| MeSH Number(s) |
D12.776.543.750.705.910.500.200
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Toll-Like Receptor 2".
Below are MeSH descriptors whose meaning is more specific than "Toll-Like Receptor 2".
This graph shows the total number of publications written about "Toll-Like Receptor 2" by people in this website by year, and whether "Toll-Like Receptor 2" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 | | 2005 | 0 | 2 | 2 | | 2008 | 2 | 1 | 3 | | 2009 | 1 | 1 | 2 | | 2012 | 1 | 1 | 2 | | 2013 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 | | 2016 | 1 | 1 | 2 | | 2018 | 2 | 0 | 2 | | 2019 | 0 | 1 | 1 | | 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Toll-Like Receptor 2" by people in Profiles.
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Dutta D, Jana M, Majumder M, Mondal S, Roy A, Pahan K. Selective targeting of the TLR2/MyD88/NF-?B pathway reduces a-synuclein spreading in vitro and in vivo. Nat Commun. 2021 09 10; 12(1):5382.
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Zewinger S, Reiser J, Jankowski V, Alansary D, Hahm E, Triem S, Klug M, Schunk SJ, Schmit D, Kramann R, Körbel C, Ampofo E, Laschke MW, Selejan SR, Paschen A, Herter T, Schuster S, Silbernagel G, Sester M, Sester U, Aßmann G, Bals R, Kostner G, Jahnen-Dechent W, Menger MD, Rohrer L, März W, Böhm M, Jankowski J, Kopf M, Latz E, Niemeyer BA, Fliser D, Laufs U, Speer T. Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation. Nat Immunol. 2020 01; 21(1):30-41.
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Rangasamy SB, Jana M, Roy A, Corbett GT, Kundu M, Chandra S, Mondal S, Dasarathi S, Mufson EJ, Mishra RK, Luan CH, Bennett DA, Pahan K. Selective disruption of TLR2-MyD88 interaction inhibits inflammation and attenuates Alzheimer's pathology. J Clin Invest. 2018 10 01; 128(10):4297-4312.
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Miller RE, Ishihara S, Tran PB, Golub SB, Last K, Miller RJ, Fosang AJ, Malfait AM. An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2. JCI Insight. 2018 03 22; 3(6).
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Samelko L, Landgraeber S, McAllister K, Jacobs J, Hallab NJ. TLR4 (not TLR2) dominate cognate TLR activity associated with CoCrMo implant particles. J Orthop Res. 2017 05; 35(5):1007-1017.
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Malfait AM. Osteoarthritis year in review 2015: biology. Osteoarthritis Cartilage. 2016 Jan; 24(1):21-6.
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Siewe B, Pham JT, Cohen M, Hessol NA, Levine A, Martinez-Maza O, Landay A. Dysregulated B-cell TLR2 expression and elevated regulatory B-cell frequency precede the diagnosis of AIDS-related non-Hodgkin lymphoma. AIDS. 2015 Aug 24; 29(13):1659-64.
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Guo Y, Siewe B, Epeldegui M, Detels R, Landay AL, Martínez-Maza O. TLR2-activated B cells are phenotypically similar to the abnormal circulating B cells seen preceding the diagnosis of AIDS-related NHL diagnosis. J Acquir Immune Defic Syndr. 2013 Oct 01; 64(2):204-10.
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Nair A, Kanda V, Bush-Joseph C, Verma N, Chubinskaya S, Mikecz K, Glant TT, Malfait AM, Crow MK, Spear GT, Finnegan A, Scanzello CR. Synovial fluid from patients with early osteoarthritis modulates fibroblast-like synoviocyte responses to toll-like receptor 4 and toll-like receptor 2 ligands via soluble CD14. Arthritis Rheum. 2012 Jul; 64(7):2268-77.
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Ellman MB, Kim JS, An HS, Chen D, KC R, An J, Dittakavi T, van Wijnen AJ, Cs-Szabo G, Li X, Xiao G, An S, Kim SG, Im HJ. Toll-like receptor adaptor signaling molecule MyD88 on intervertebral disk homeostasis: in vitro, ex vivo studies. Gene. 2012 Sep 01; 505(2):283-90.
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