"Lewy Bodies" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Intracytoplasmic, eosinophilic, round to elongated inclusions found in vacuoles of injured or fragmented neurons. The presence of Lewy bodies is the histological marker of the degenerative changes in LEWY BODY DISEASE and PARKINSON DISEASE but they may be seen in other neurological conditions. They are typically found in the substantia nigra and locus coeruleus but they are also seen in the basal forebrain, hypothalamic nuclei, and neocortex.
| Descriptor ID |
D016631
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| MeSH Number(s) |
A08.675.460 A11.284.420.460 A11.671.460
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Lewy Bodies".
Below are MeSH descriptors whose meaning is more specific than "Lewy Bodies".
This graph shows the total number of publications written about "Lewy Bodies" by people in this website by year, and whether "Lewy Bodies" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2016 | 2 | 0 | 2 |
| 2017 | 0 | 3 | 3 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Lewy Bodies" by people in Profiles.
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Postmortem neurodegenerative markers and trajectories of decline in cognitive systems. Neurology. 2019 02 19; 92(8):e831-e840.
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Association Between Brain Gene Expression, DNA Methylation, and Alteration of Ex Vivo Magnetic Resonance Imaging Transverse Relaxation in Late-Life Cognitive Decline. JAMA Neurol. 2017 12 01; 74(12):1473-1480.
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Sleep fragmentation and Parkinson's disease pathology in older adults without Parkinson's disease. Mov Disord. 2017 Dec; 32(12):1729-1737.
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Age and the association of dementia-related pathology with trajectories of cognitive decline. Neurobiol Aging. 2018 01; 61:138-145.
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Temporal course of neurodegenerative effects on cognition in old age. Neuropsychology. 2016 07; 30(5):591-9.
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Evaluation of alpha-synuclein immunohistochemical methods for the detection of Lewy-type synucleinopathy in gastrointestinal biopsies. Acta Neuropathol Commun. 2016 Apr 04; 4:35.
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The prion hypothesis of Parkinson's disease: this hot topic just got hotter. Mov Disord. 2014 Jul; 29(8):988.
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Association of Parkinson disease risk loci with mild parkinsonian signs in older persons. JAMA Neurol. 2014 Apr; 71(4):429-35.
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Can intrabodies serve as neuroprotective therapies for Parkinson's disease? Beginning thoughts. J Parkinsons Dis. 2013; 3(4):581-91.
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Loss of basic lexical knowledge in old age. J Neurol Neurosurg Psychiatry. 2011 Apr; 82(4):369-72.