 Dactinomycin
"Dactinomycin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
| Descriptor ID |
D003609
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| MeSH Number(s) |
D03.494.200 D04.345.566.252 D12.644.641.252
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| Concept/Terms |
Cosmegen- Cosmegen
- Lyovac-Cosmegen
- MSD Brand of Dactinomycin
- Merck Frosst Brand of Dactinomycin
- Merck Sharp & Dohme Brand of Dactinomycin
- Cosmegen Lyovac
- Lyovac, Cosmegen
- Merck Brand of Dactinomycin
Ac-De- Ac-De
- Lemery Brand of Dactinomycin
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Below are MeSH descriptors whose meaning is more general than "Dactinomycin".
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This graph shows the total number of publications written about "Dactinomycin" by people in this website by year, and whether "Dactinomycin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 0 | 2 | 2 | | 2003 | 1 | 1 | 2 | | 2007 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Dactinomycin" by people in Profiles.
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Jin D, Zhang YG, Wu S, Lu R, Lin Z, Zheng Y, Chen H, Cs-Szabo G, Sun J. Vitamin D receptor is a novel transcriptional regulator for Axin1. J Steroid Biochem Mol Biol. 2017 01; 165(Pt B):430-437.
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O'Connor T, Sadleir KR, Maus E, Velliquette RA, Zhao J, Cole SL, Eimer WA, Hitt B, Bembinster LA, Lammich S, Lichtenthaler SF, H?bert SS, De Strooper B, Haass C, Bennett DA, Vassar R. Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis. Neuron. 2008 Dec 26; 60(6):988-1009.
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Sena K, Sumner DR, Virdi AS. Modulation of VEGF expression in rat bone marrow stromal cells by GDF-5. Connect Tissue Res. 2007; 48(6):324-31.
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Anderson KM, Bonomi P, Hu Y, Harris JE. An interaction between type 1 and type 2 programmed cell death and clonogenic survival. Med Hypotheses. 2003 Nov-Dec; 61(5-6):583-5.
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Anderson KM, Alrefai W, Bonomi P, Seed TM, Dudeja P, Hu Y, Harris JE. Caspase-dependent and -independent panc-1 cell death due to actinomycin D and MK 886 are additive but increase clonogenic survival. Exp Biol Med (Maywood). 2003 Sep; 228(8):915-25.
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Bianco AC, Kieffer JD, Silva JE. Adenosine 3',5'-monophosphate and thyroid hormone control of uncoupling protein messenger ribonucleic acid in freshly dispersed brown adipocytes. Endocrinology. 1992 May; 130(5):2625-33.
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Rehnmark S, Bianco AC, Kieffer JD, Silva JE. Transcriptional and posttranscriptional mechanisms in uncoupling protein mRNA response to cold. Am J Physiol. 1992 Jan; 262(1 Pt 1):E58-67.
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