"Dactinomycin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
| Descriptor ID |
D003609
|
| MeSH Number(s) |
D03.633.300.200 D04.345.566.252 D12.644.641.252
|
| Concept/Terms |
Cosmegen- Cosmegen
- Cosmegen Lyovac
- Lyovac, Cosmegen
- Lyovac-Cosmegen
- Lyovac Cosmegen
- LyovacCosmegen
|
Below are MeSH descriptors whose meaning is more general than "Dactinomycin".
Below are MeSH descriptors whose meaning is more specific than "Dactinomycin".
This graph shows the total number of publications written about "Dactinomycin" by people in this website by year, and whether "Dactinomycin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 1 | 2 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Dactinomycin" by people in Profiles.
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Vitamin D receptor is a novel transcriptional regulator for Axin1. J Steroid Biochem Mol Biol. 2017 01; 165(Pt B):430-437.
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Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis. Neuron. 2008 Dec 26; 60(6):988-1009.
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Modulation of VEGF expression in rat bone marrow stromal cells by GDF-5. Connect Tissue Res. 2007; 48(6):324-31.
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Interleukin-1 alpha mediates the growth proliferative effects of transforming growth factor-beta in p21 null MCF-10A human mammary epithelial cells. Oncogene. 2006 Sep 07; 25(40):5561-9.
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An interaction between type 1 and type 2 programmed cell death and clonogenic survival. Med Hypotheses. 2003 Nov-Dec; 61(5-6):583-5.
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Caspase-dependent and -independent panc-1 cell death due to actinomycin D and MK 886 are additive but increase clonogenic survival. Exp Biol Med (Maywood). 2003 Sep; 228(8):915-25.
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Adenosine 3',5'-monophosphate and thyroid hormone control of uncoupling protein messenger ribonucleic acid in freshly dispersed brown adipocytes. Endocrinology. 1992 May; 130(5):2625-33.
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Transcriptional and posttranscriptional mechanisms in uncoupling protein mRNA response to cold. Am J Physiol. 1992 Jan; 262(1 Pt 1):E58-67.