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Antonio Bianco

TitleProfessor
InstitutionRush University, Rush Medical College
DepartmentInternal Medicine, Division of Endocrinology
Address1735 W. Harrison St.
Chicago IL 60612
Phone312-942-7131
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    Collapse Overview 
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    My ORCID is 0000-0001-7737-6813.
    My Scopus ID is 7203005318.
    My NIH COMMONS name is ACB123.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Paolino BS, Pomerantzeff PM, Dallan LAO, Gaiotto FA, Preite NZ, Latrônico AC, Nicolau JC, Bianco AC, Giraldez RRCV. Myocardial Inactivation of Thyroid Hormones in Patients with Aortic Stenosis. Thyroid. 2017 May; 27(5):738-745. PMID: 28095748.
      View in: PubMed
    2. Chaker L, Bianco AC, Jonklaas J, Peeters RP. Hypothyroidism. Lancet. 2017 Mar 20. PMID: 28336049.
      View in: PubMed
    3. Ignacio DL, Silvestre DH, Anne-Palmer E, Bocco BM, Fonseca TL, Ribeiro MO, Gereben B, Bianco AC, Werneck-de-Castro JP. Early Developmental Disruption of Type 2 Deiodinase Pathway in Mouse Skeletal Muscle Does Not Impair Muscle Function. Thyroid. 2017 Apr; 27(4):577-586. PMID: 27967605.
      View in: PubMed
    4. Peterson SJ, McAninch EA, Bianco AC. Is a Normal TSH Synonymous With "Euthyroidism" in Levothyroxine Monotherapy? J Clin Endocrinol Metab. 2016 Dec; 101(12):4964-4973. PMID: 27700539.
      View in: PubMed
    5. Preite NZ, Nascimento BP, Muller CR, Américo AL, Higa TS, Evangelista FS, Lancellotti CL, Henriques FS, Batista ML, Bianco AC, Ribeiro MO. Disruption of beta3 adrenergic receptor increases susceptibility to DIO in mouse. J Endocrinol. 2016 12; 231(3):259-269. PMID: 27672060.
      View in: PubMed
    6. Rajan KB, Arvanitakis Z, Lynch EB, McAninch EA, Wilson RS, Weuve J, Barnes LL, Bianco AC, Evans DA. Cognitive decline following incident and preexisting diabetes mellitus in a population sample. Neurology. 2016 Oct 18; 87(16):1681-1687. PMID: 27655734.
      View in: PubMed
    7. Bocco BM, Louzada RA, Silvestre DH, Santos MC, Anne-Palmer E, Rangel IF, Abdalla S, Ferreira AC, Ribeiro MO, Gereben B, Carvalho DP, Bianco AC, Werneck-de-Castro JP. Thyroid hormone activation by type 2 deiodinase mediates exercise-induced peroxisome proliferator-activated receptor-? coactivator-1a expression in skeletal muscle. J Physiol. 2016 Sep 15; 594(18):5255-69. PMID: 27302464.
      View in: PubMed
    8. Bocco BM, Werneck-de-Castro JP, Oliveira KC, Fernandes GW, Fonseca TL, Nascimento BP, McAninch EA, Ricci E, Kvárta-Papp Z, Fekete C, Bernardi MM, Gereben B, Bianco AC, Ribeiro MO. Type 2 Deiodinase Disruption in Astrocytes Results in Anxiety-Depressive-Like Behavior in Male Mice. Endocrinology. 2016 Sep; 157(9):3682-95. PMID: 27501182; PMCID: PMC5007895 [Available on 09/01/17].
    9. Abboud CS, de Souza EE, Zandonadi EC, Borges LS, Miglioli L, Monaco FC, Barbosa VL, Cortez D, Bianco AC, Braz A, Monteiro J. Carbapenem-resistant Enterobacteriaceae on a cardiac surgery intensive care unit: successful measures for infection control. J Hosp Infect. 2016 Sep; 94(1):60-4. PMID: 27451040.
      View in: PubMed
    10. Bocco BM, Fernandes GW, Lorena FB, Cysneiros RM, Christoffolete MA, Grecco SS, Lancellotti CL, Romoff P, Lago JH, Bianco AC, Ribeiro MO. Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice. Braz J Med Biol Res. 2016 Mar; 49(3). PMID: 26840707; PMCID: PMC4763817.
    11. McAninch EA, Bianco AC. The History and Future of Treatment of Hypothyroidism. Ann Intern Med. 2016 Jan 05; 164(1):50-6. PMID: 26747302; PMCID: PMC4980994.
    12. McAninch EA, Bianco AC. Of rats and men: thyroid homeostasis in rodents and human beings - Authors' reply. Lancet Diabetes Endocrinol. 2015 Dec; 3(12):933. PMID: 26590685.
      View in: PubMed
    13. Leone V, Langella C, Esposito F, De Martino M, Decaussin-Petrucci M, Chiappetta G, Bianco A, Fusco A. miR-130b-3p Upregulation Contributes to the Development of Thyroid Adenomas Targeting CCDC6 Gene. Eur Thyroid J. 2015 Dec; 4(4):213-21. PMID: 26835423; PMCID: PMC4716415.
    14. Fonseca TL, Fernandes GW, McAninch EA, Bocco BM, Abdalla SM, Ribeiro MO, Mohácsik P, Fekete C, Li D, Xing X, Wang T, Gereben B, Bianco AC. Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity. Proc Natl Acad Sci U S A. 2015 Nov 10; 112(45):14018-23. PMID: 26508642; PMCID: PMC4653175.
    15. Lartey LJ, Werneck-de-Castro JP, O-Sullivan I, Unterman TG, Bianco AC. Coupling between Nutrient Availability and Thyroid Hormone Activation. J Biol Chem. 2015 Dec 18; 290(51):30551-61. PMID: 26499800; PMCID: PMC4683275 [Available on 12/18/16].
    16. Gereben B, McAninch EA, Ribeiro MO, Bianco AC. Scope and limitations of iodothyronine deiodinases in hypothyroidism. Nat Rev Endocrinol. 2015 Nov; 11(11):642-52. PMID: 26416219; PMCID: PMC5003781.
    17. McAninch EA, Bianco AC. New insights into the variable effectiveness of levothyroxine monotherapy for hypothyroidism. Lancet Diabetes Endocrinol. 2015 Oct; 3(10):756-8. PMID: 26362364; PMCID: PMC5006060.
    18. Werneck-de-Castro JP, Fonseca TL, Ignacio DL, Fernandes GW, Andrade-Feraud CM, Lartey LJ, Ribeiro MB, Ribeiro MO, Gereben B, Bianco AC. Thyroid Hormone Signaling in Male Mouse Skeletal Muscle Is Largely Independent of D2 in Myocytes. Endocrinology. 2015 Oct; 156(10):3842-52. PMID: 26214036; PMCID: PMC4588812 [Available on 10/01/16].
    19. Fliers E, Bianco AC, Langouche L, Boelen A. Thyroid function in critically ill patients. Lancet Diabetes Endocrinol. 2015 Oct; 3(10):816-25. PMID: 26071885; PMCID: PMC4979220.
    20. Roberts SC, Bianco AC, Stapleton HM. Disruption of type 2 iodothyronine deiodinase activity in cultured human glial cells by polybrominated diphenyl ethers. Chem Res Toxicol. 2015 Jun 15; 28(6):1265-74. PMID: 26004626; PMCID: PMC4827872.
    21. McAninch EA, Fonseca TL, Poggioli R, Panos AL, Salerno TA, Deng Y, Li Y, Bianco AC, Iacobellis G. Epicardial adipose tissue has a unique transcriptome modified in severe coronary artery disease. Obesity (Silver Spring). 2015 Jun; 23(6):1267-78. PMID: 25959145; PMCID: PMC5003780.
    22. Cacciola NA, Calabrese C, Malapelle U, Pellino G, De Stefano A, Sepe R, Sgariglia R, Quintavalle C, Federico A, Bianco A, Uchimura Bastos A, Milone M, Bellevicine C, Milone F, Carlomagno C, Selvaggi F, Troncone G, Fusco A, Pallante P. UbcH10 expression can predict prognosis and sensitivity to the antineoplastic treatment for colorectal cancer patients. Mol Carcinog. 2016 May; 55(5):793-807. PMID: 25917796.
      View in: PubMed
    23. Cao Y, Gomes SA, Rangel EB, Paulino EC, Fonseca TL, Li J, Teixeira MB, Gouveia CH, Bianco AC, Kapiloff MS, Balkan W, Hare JM. S-nitrosoglutathione reductase-dependent PPAR? denitrosylation participates in MSC-derived adipogenesis and osteogenesis. J Clin Invest. 2015 Apr; 125(4):1679-91. PMID: 25798618; PMCID: PMC4396480.
    24. McAninch EA, Jo S, Preite NZ, Farkas E, Mohácsik P, Fekete C, Egri P, Gereben B, Li Y, Deng Y, Patti ME, Zevenbergen C, Peeters RP, Mash DC, Bianco AC. Prevalent polymorphism in thyroid hormone-activating enzyme leaves a genetic fingerprint that underlies associated clinical syndromes. J Clin Endocrinol Metab. 2015 Mar; 100(3):920-33. PMID: 25569702; PMCID: PMC4333048.
    25. Werneck de Castro JP, Fonseca TL, Ueta CB, McAninch EA, Abdalla S, Wittmann G, Lechan RM, Gereben B, Bianco AC. Differences in hypothalamic type 2 deiodinase ubiquitination explain localized sensitivity to thyroxine. J Clin Invest. 2015 Feb; 125(2):769-81. PMID: 25555216; PMCID: PMC4319436.
    26. Jonklaas J, Bianco AC, Bauer AJ, Burman KD, Cappola AR, Celi FS, Cooper DS, Kim BW, Peeters RP, Rosenthal MS, Sawka AM. Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task force on thyroid hormone replacement. Thyroid. 2014 Dec; 24(12):1670-751. PMID: 25266247; PMCID: PMC4267409.
    27. Abdalla SM, Bianco AC. Defending plasma T3 is a biological priority. Clin Endocrinol (Oxf). 2014 Nov; 81(5):633-41. PMID: 25040645; PMCID: PMC4699302.
    28. Medina MC, Fonesca TL, Molina J, Fachado A, Castillo M, Dong L, Soares R, Hernández A, Caicedo A, Bianco AC. Maternal inheritance of an inactive type III deiodinase gene allele affects mouse pancreatic ß-cells and disrupts glucose homeostasis. Endocrinology. 2014 Aug; 155(8):3160-71. PMID: 24885572; PMCID: PMC4097999.
    29. Fernandes GW, Ueta CB, Fonseca TL, Gouveia CH, Lancellotti CL, Brum PC, Christoffolete MA, Bianco AC, Ribeiro MO. Inactivation of the adrenergic receptor ß2 disrupts glucose homeostasis in mice. J Endocrinol. 2014 Jun; 221(3):381-90. PMID: 24868110; PMCID: PMC4976625.
    30. McAninch EA, Bianco AC. Thyroid hormone signaling in energy homeostasis and energy metabolism. Ann N Y Acad Sci. 2014 Apr; 1311:77-87. PMID: 24697152; PMCID: PMC4451242.
    31. Leiva AG, Chen AL, Devarajan P, Chen Z, Damanpour S, Hall JA, Bianco AC, Li J, Badiavas EV, Zaias J, Miteva M, Romanelli P, Nouri K, Wikramanayake TC. Loss of Mpzl3 function causes various skin abnormalities and greatly reduced adipose depots. J Invest Dermatol. 2014 Jul; 134(7):1817-27. PMID: 24531688; PMCID: PMC4057944.
    32. Fonseca TL, Werneck-De-Castro JP, Castillo M, Bocco BM, Fernandes GW, McAninch EA, Ignacio DL, Moises CC, Ferreira AR, Ferreira A, Gereben B, Bianco AC. Tissue-specific inactivation of type 2 deiodinase reveals multilevel control of fatty acid oxidation by thyroid hormone in the mouse. Diabetes. 2014 May; 63(5):1594-604. PMID: 24487027; PMCID: PMC3994955.
    33. Bianco AC, Anderson G, Forrest D, Galton VA, Gereben B, Kim BW, Kopp PA, Liao XH, Obregon MJ, Peeters RP, Refetoff S, Sharlin DS, Simonides WS, Weiss RE, Williams GR. American Thyroid Association Guide to investigating thyroid hormone economy and action in rodent and cell models. Thyroid. 2014 Jan; 24(1):88-168. PMID: 24001133; PMCID: PMC3887458.
    34. Arrojo E Drigo R, Egri P, Jo S, Gereben B, Bianco AC. The type II deiodinase is retrotranslocated to the cytoplasm and proteasomes via p97/Atx3 complex. Mol Endocrinol. 2013 Dec; 27(12):2105-15. PMID: 24196352; PMCID: PMC3857201.
    35. Vose LR, Vinukonda G, Jo S, Miry O, Diamond D, Korumilli R, Arshad A, Zia MT, Hu F, Kayton RJ, La Gamma EF, Bansal R, Bianco AC, Ballabh P. Treatment with thyroxine restores myelination and clinical recovery after intraventricular hemorrhage. J Neurosci. 2013 Oct 30; 33(44):17232-46. PMID: 24174657; PMCID: PMC3812500.
    36. Bianco AC, McAninch EA. The role of thyroid hormone and brown adipose tissue in energy homoeostasis. Lancet Diabetes Endocrinol. 2013 Nov; 1(3):250-8. PMID: 24622373; PMCID: PMC4976626.
    37. Poggioli R, Ueta CB, Drigo RA, Castillo M, Fonseca TL, Bianco AC. Dexamethasone reduces energy expenditure and increases susceptibility to diet-induced obesity in mice. Obesity (Silver Spring). 2013 Sep; 21(9):E415-20. PMID: 23408649; PMCID: PMC4451231.
    38. Hong EG, Kim BW, Jung DY, Kim JH, Yu T, Seixas Da Silva W, Friedline RH, Bianco SD, Seslar SP, Wakimoto H, Berul CI, Russell KS, Lee KW, Larsen PR, Bianco AC, Kim JK. Cardiac expression of human type 2 iodothyronine deiodinase increases glucose metabolism and protects against doxorubicin-induced cardiac dysfunction in male mice. Endocrinology. 2013 Oct; 154(10):3937-46. PMID: 23861374; PMCID: PMC4411365.
    39. Sampaio MC, Máximo CA, Montenegro CM, Mota DM, Fernandes TR, Bianco AC, Amodeo C, Cordeiro AC. Comparison of diagnostic criteria for acute kidney injury in cardiac surgery. Arq Bras Cardiol. 2013 Jul; 101(1):18-25. PMID: 23752340; PMCID: PMC3998168.
    40. Jonklaas J, Burman KD, Bianco AC. Treatment of hypothyroidism: possibilities on the horizon. Thyroid. 2013 Apr; 23(4):ix-xi. PMID: 23521210.
      View in: PubMed
    41. Fonseca TL, Correa-Medina M, Campos MP, Wittmann G, Werneck-de-Castro JP, Arrojo e Drigo R, Mora-Garzon M, Ueta CB, Caicedo A, Fekete C, Gereben B, Lechan RM, Bianco AC. Coordination of hypothalamic and pituitary T3 production regulates TSH expression. J Clin Invest. 2013 Apr; 123(4):1492-500. PMID: 23524969; PMCID: PMC3613903.
    42. Bianco AC. Cracking the code for thyroid hormone signaling. Trans Am Clin Climatol Assoc. 2013; 124:26-35. PMID: 23874007; PMCID: PMC3715916.
    43. Quintavalle C, Fiore D, De Micco F, Visconti G, Focaccio A, Golia B, Ricciardelli B, Donnarumma E, Bianco A, Zabatta MA, Troncone G, Colombo A, Briguori C, Condorelli G. Impact of a high loading dose of atorvastatin on contrast-induced acute kidney injury. Circulation. 2012 Dec 18; 126(25):3008-16. PMID: 23147173.
      View in: PubMed
    44. Arrojo E Drigo R, Fonseca TL, Werneck-de-Castro JP, Bianco AC. Role of the type 2 iodothyronine deiodinase (D2) in the control of thyroid hormone signaling. Biochim Biophys Acta. 2013 Jul; 1830(7):3956-64. PMID: 22967761; PMCID: PMC4979226.
    45. Bianco AC, Casula S. Thyroid hormone replacement therapy: three 'simple' questions, complex answers. Eur Thyroid J. 2012 Jul; 1(2):88-98. PMID: 24783002; PMCID: PMC3821470.
    46. Ueta CB, Fernandes GW, Capelo LP, Fonseca TL, Maculan FD, Gouveia CH, Brum PC, Christoffolete MA, Aoki MS, Lancellotti CL, Kim B, Bianco AC, Ribeiro MO. ß(1) Adrenergic receptor is key to cold- and diet-induced thermogenesis in mice. J Endocrinol. 2012 Sep; 214(3):359-65. PMID: 22728333; PMCID: PMC4977996.
    47. Jo S, Kalló I, Bardóczi Z, Arrojo e Drigo R, Zeöld A, Liposits Z, Oliva A, Lemmon VP, Bixby JL, Gereben B, Bianco AC. Neuronal hypoxia induces Hsp40-mediated nuclear import of type 3 deiodinase as an adaptive mechanism to reduce cellular metabolism. J Neurosci. 2012 Jun 20; 32(25):8491-500. PMID: 22723689; PMCID: PMC3752066.
    48. Kalló I, Mohácsik P, Vida B, Zeöld A, Bardóczi Z, Zavacki AM, Farkas E, Kádár A, Hrabovszky E, Arrojo E Drigo R, Dong L, Barna L, Palkovits M, Borsay BA, Herczeg L, Lechan RM, Bianco AC, Liposits Z, Fekete C, Gereben B. A novel pathway regulates thyroid hormone availability in rat and human hypothalamic neurosecretory neurons. PLoS One. 2012; 7(6):e37860. PMID: 22719854; PMCID: PMC3377717.
    49. Casula S, Bianco AC. Thyroid hormone deiodinases and cancer. Front Endocrinol (Lausanne). 2012; 3:74. PMID: 22675319; PMCID: PMC3365412.
    50. Ueta CB, Oskouei BN, Olivares EL, Pinto JR, Correa MM, Simovic G, Simonides WS, Hare JM, Bianco AC. Absence of myocardial thyroid hormone inactivating deiodinase results in restrictive cardiomyopathy in mice. Mol Endocrinol. 2012 May; 26(5):809-18. PMID: 22403173; PMCID: PMC3355550.
    51. Arrojo E Drigo R, Fonseca TL, Castillo M, Salathe M, Simovic G, Mohácsik P, Gereben B, Bianco AC. Endoplasmic reticulum stress decreases intracellular thyroid hormone activation via an eIF2a-mediated decrease in type 2 deiodinase synthesis. Mol Endocrinol. 2011 Dec; 25(12):2065-75. PMID: 22053000; PMCID: PMC3231828.
    52. Colucci A, Bianco A, Pomara F, Petrucci M, Grosso F, De Vita A, Adamo V, Palma A. Disease management of type 2 diabetes: a follow-up analysis in a sanitary district of Sicily. Minerva Gastroenterol Dietol. 2011 Sep; 57(3):241-6. PMID: 21769074.
      View in: PubMed
    53. Mohácsik P, Zeöld A, Bianco AC, Gereben B. Thyroid hormone and the neuroglia: both source and target. J Thyroid Res. 2011; 2011:215718. PMID: 21876836; PMCID: PMC3163027.
    54. Iacobellis G, Bianco AC. Epicardial adipose tissue: emerging physiological, pathophysiological and clinical features. Trends Endocrinol Metab. 2011 Nov; 22(11):450-7. PMID: 21852149; PMCID: PMC4978122.
    55. Medina MC, Molina J, Gadea Y, Fachado A, Murillo M, Simovic G, Pileggi A, Hernández A, Edlund H, Bianco AC. The thyroid hormone-inactivating type III deiodinase is expressed in mouse and human beta-cells and its targeted inactivation impairs insulin secretion. Endocrinology. 2011 Oct; 152(10):3717-27. PMID: 21828183; PMCID: PMC3176649.
    56. Ueta CB, Olivares EL, Bianco AC. Responsiveness to thyroid hormone and to ambient temperature underlies differences between brown adipose tissue and skeletal muscle thermogenesis in a mouse model of diet-induced obesity. Endocrinology. 2011 Sep; 152(9):3571-81. PMID: 21771890; PMCID: PMC3159782.
    57. Bianco AC. Minireview: cracking the metabolic code for thyroid hormone signaling. Endocrinology. 2011 Sep; 152(9):3306-11. PMID: 21712363; PMCID: PMC3159779.
    58. Arrojo E Drigo R, Bianco AC. Type 2 deiodinase at the crossroads of thyroid hormone action. Int J Biochem Cell Biol. 2011 Oct; 43(10):1432-41. PMID: 21679772; PMCID: PMC3163779.
    59. Quintavalle C, Brenca M, De Micco F, Fiore D, Romano S, Romano MF, Apone F, Bianco A, Zabatta MA, Troncone G, Briguori C, Condorelli G. In vivo and in vitro assessment of pathways involved in contrast media-induced renal cells apoptosis. Cell Death Dis. 2011 May 12; 2:e155. PMID: 21562587; PMCID: PMC3122117.
    60. Flato UA, Buhatem T, Merluzzi T, Bianco AC. New anticoagulants in critical care settings. Rev Bras Ter Intensiva. 2011 Mar; 23(1):68-77. PMID: 25299557.
      View in: PubMed
    61. Ribeiro MO, Bianco AC. Crossing the hurdles of thyroid hormone receptor-a activation. Endocrinology. 2011 Mar; 152(3):745-7. PMID: 21339380.
      View in: PubMed
    62. Castillo M, Hall JA, Correa-Medina M, Ueta C, Kang HW, Cohen DE, Bianco AC. Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality. Diabetes. 2011 Apr; 60(4):1082-9. PMID: 21335378; PMCID: PMC3064082.
    63. da-Silva WS, Ribich S, Arrojo e Drigo R, Castillo M, Patti ME, Bianco AC. The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure. FEBS Lett. 2011 Feb 04; 585(3):539-44. PMID: 21237159; PMCID: PMC3133948.
    64. Rosene ML, Wittmann G, Arrojo e Drigo R, Singru PS, Lechan RM, Bianco AC. Inhibition of the type 2 iodothyronine deiodinase underlies the elevated plasma TSH associated with amiodarone treatment. Endocrinology. 2010 Dec; 151(12):5961-70. PMID: 20926587; PMCID: PMC2999495.
    65. Hall JA, Ribich S, Christoffolete MA, Simovic G, Correa-Medina M, Patti ME, Bianco AC. Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis. Endocrinology. 2010 Sep; 151(9):4573-82. PMID: 20660060; PMCID: PMC2940501.
    66. Yoon JC, Ng A, Kim BH, Bianco A, Xavier RJ, Elledge SJ. Wnt signaling regulates mitochondrial physiology and insulin sensitivity. Genes Dev. 2010 Jul 15; 24(14):1507-18. PMID: 20634317; PMCID: PMC2904941.
    67. Acosta BM, Bianco AC. New insights into thyroid hormone replacement therapy. F1000 Med Rep. 2010 May 11; 2. PMID: 20948851; PMCID: PMC2950057.
    68. Freitas BC, Gereben B, Castillo M, Kalló I, Zeöld A, Egri P, Liposits Z, Zavacki AM, Maciel RM, Jo S, Singru P, Sanchez E, Lechan RM, Bianco AC. Paracrine signaling by glial cell-derived triiodothyronine activates neuronal gene expression in the rodent brain and human cells. J Clin Invest. 2010 Jun; 120(6):2206-17. PMID: 20458138; PMCID: PMC2877954.
    69. Castillo M, Freitas BC, Rosene ML, Drigo RA, Grozovsky R, Maciel RM, Patti ME, Ribeiro MO, Bianco AC. Impaired metabolic effects of a thyroid hormone receptor beta-selective agonist in a mouse model of diet-induced obesity. Thyroid. 2010 May; 20(5):545-53. PMID: 20406106; PMCID: PMC2941403.
    70. Christoffolete MA, Doleschall M, Egri P, Liposits Z, Zavacki AM, Bianco AC, Gereben B. Regulation of thyroid hormone activation via the liver X-receptor/retinoid X-receptor pathway. J Endocrinol. 2010 May; 205(2):179-86. PMID: 20176747; PMCID: PMC3133926.
    71. Ribeiro MO, Bianco SD, Kaneshige M, Schultz JJ, Cheng SY, Bianco AC, Brent GA. Expression of uncoupling protein 1 in mouse brown adipose tissue is thyroid hormone receptor-beta isoform specific and required for adaptive thermogenesis. Endocrinology. 2010 Jan; 151(1):432-40. PMID: 19906816; PMCID: PMC2817565.
    72. Gereben B, Bianco AC. Covering the base-pairs in iodothyronine deiodinase-1 biology: holes remain in the lineup. Thyroid. 2009 Oct; 19(10):1027-9. PMID: 19803788.
      View in: PubMed
    73. Amorim BS, Ueta CB, Freitas BC, Nassif RJ, Gouveia CH, Christoffolete MA, Moriscot AS, Lancelloti CL, Llimona F, Barbeiro HV, de Souza HP, Catanozi S, Passarelli M, Aoki MS, Bianco AC, Ribeiro MO. A TRbeta-selective agonist confers resistance to diet-induced obesity. J Endocrinol. 2009 Nov; 203(2):291-9. PMID: 19713219; PMCID: PMC3133532.
    74. Zavacki AM, Arrojo E Drigo R, Freitas BC, Chung M, Harney JW, Egri P, Wittmann G, Fekete C, Gereben B, Bianco AC. The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase. Mol Cell Biol. 2009 Oct; 29(19):5339-47. PMID: 19651899; PMCID: PMC2747977.
    75. Pihlajamäki J, Boes T, Kim EY, Dearie F, Kim BW, Schroeder J, Mun E, Nasser I, Park PJ, Bianco AC, Goldfine AB, Patti ME. Thyroid hormone-related regulation of gene expression in human fatty liver. J Clin Endocrinol Metab. 2009 Sep; 94(9):3521-9. PMID: 19549744; PMCID: PMC2741713.
    76. Kang HW, Ribich S, Kim BW, Hagen SJ, Bianco AC, Cohen DE. Mice lacking Pctp /StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue. J Lipid Res. 2009 Nov; 50(11):2212-21. PMID: 19502644; PMCID: PMC2759827.
    77. Hall JA, Bianco AC. Triumphs of the thyroid despite lesser conversion. Endocrinology. 2009 Jun; 150(6):2502-4. PMID: 19458245.
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    78. Kim BW, Bianco AC. For some, L-thyroxine replacement might not be enough: a genetic rationale. J Clin Endocrinol Metab. 2009 May; 94(5):1521-3. PMID: 19420275.
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    79. Patti ME, Houten SM, Bianco AC, Bernier R, Larsen PR, Holst JJ, Badman MK, Maratos-Flier E, Mun EC, Pihlajamaki J, Auwerx J, Goldfine AB. Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism. Obesity (Silver Spring). 2009 Sep; 17(9):1671-7. PMID: 19360006.
      View in: PubMed
    80. Streijger F, Pluk H, Oerlemans F, Beckers G, Bianco AC, Ribeiro MO, Wieringa B, Van der Zee CE. Mice lacking brain-type creatine kinase activity show defective thermoregulation. Physiol Behav. 2009 Apr 20; 97(1):76-86. PMID: 19419668; PMCID: PMC3133955.
    81. Grozovsky R, Ribich S, Rosene ML, Mulcahey MA, Huang SA, Patti ME, Bianco AC, Kim BW. Type 2 deiodinase expression is induced by peroxisomal proliferator-activated receptor-gamma agonists in skeletal myocytes. Endocrinology. 2009 Apr; 150(4):1976-83. PMID: 19036883; PMCID: PMC2659265.
    82. Gereben B, Zavacki AM, Ribich S, Kim BW, Huang SA, Simonides WS, Zeöld A, Bianco AC. Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling. Endocr Rev. 2008 Dec; 29(7):898-938. PMID: 18815314; PMCID: PMC2647704.
    83. Capelo LP, Beber EH, Huang SA, Zorn TM, Bianco AC, Gouveia CH. Deiodinase-mediated thyroid hormone inactivation minimizes thyroid hormone signaling in the early development of fetal skeleton. Bone. 2008 Nov; 43(5):921-30. PMID: 18682303.
      View in: PubMed
    84. Sánchez E, Singru PS, Acharya R, Bodria M, Fekete C, Zavacki AM, Bianco AC, Lechan RM. Differential effects of refeeding on melanocortin-responsive neurons in the hypothalamic paraventricular nucleus. Endocrinology. 2008 Sep; 149(9):4329-35. PMID: 18467436; PMCID: PMC2553369.
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    86. Simonides WS, Mulcahey MA, Redout EM, Muller A, Zuidwijk MJ, Visser TJ, Wassen FW, Crescenzi A, da-Silva WS, Harney J, Engel FB, Obregon MJ, Larsen PR, Bianco AC, Huang SA. Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats. J Clin Invest. 2008 Mar; 118(3):975-83. PMID: 18259611; PMCID: PMC2230657.
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    90. Adams BA, Gray SL, Isaac ER, Bianco AC, Vidal-Puig AJ, Sherwood NM. Feeding and metabolism in mice lacking pituitary adenylate cyclase-activating polypeptide. Endocrinology. 2008 Apr; 149(4):1571-80. PMID: 18162530; PMCID: PMC2276722.
    91. Dentice M, Luongo C, Huang S, Ambrosio R, Elefante A, Mirebeau-Prunier D, Zavacki AM, Fenzi G, Grachtchouk M, Hutchin M, Dlugosz AA, Bianco AC, Missero C, Larsen PR, Salvatore D. Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes. Proc Natl Acad Sci U S A. 2007 Sep 04; 104(36):14466-71. PMID: 17720805; PMCID: PMC1964817.
    92. Fekete C, Freitas BC, Zeöld A, Wittmann G, Kádár A, Liposits Z, Christoffolete MA, Singru P, Lechan RM, Bianco AC, Gereben B. Expression patterns of WSB-1 and USP-33 underlie cell-specific posttranslational control of type 2 deiodinase in the rat brain. Endocrinology. 2007 Oct; 148(10):4865-74. PMID: 17628004.
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    93. Olivares EL, Marassi MP, Fortunato RS, da Silva AC, Costa-e-Sousa RH, Araújo IG, Mattos EC, Masuda MO, Mulcahey MA, Huang SA, Bianco AC, Carvalho DP. Thyroid function disturbance and type 3 iodothyronine deiodinase induction after myocardial infarction in rats a time course study. Endocrinology. 2007 Oct; 148(10):4786-92. PMID: 17628010.
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    94. Wajner SM, dos Santos Wagner M, Melo RC, Parreira GG, Chiarini-Garcia H, Bianco AC, Fekete C, Sanchez E, Lechan RM, Maia AL. Type 2 iodothyronine deiodinase is highly expressed in germ cells of adult rat testis. J Endocrinol. 2007 Jul; 194(1):47-54. PMID: 17592020.
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    95. Bianco AC, Ribich S, Kim BW. An inside job. Endocrinology. 2007 Jul; 148(7):3077-9. PMID: 17575061.
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    97. Crunkhorn S, Dearie F, Mantzoros C, Gami H, da Silva WS, Espinoza D, Faucette R, Barry K, Bianco AC, Patti ME. Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation. J Biol Chem. 2007 May 25; 282(21):15439-50. PMID: 17416903.
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    98. Villicev CM, Freitas FR, Aoki MS, Taffarel C, Scanlan TS, Moriscot AS, Ribeiro MO, Bianco AC, Gouveia CH. Thyroid hormone receptor beta-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats. J Endocrinol. 2007 Apr; 193(1):21-9. PMID: 17400799.
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    99. Souza SC, Christoffolete MA, Ribeiro MO, Miyoshi H, Strissel KJ, Stancheva ZS, Rogers NH, D'Eon TM, Perfield JW, Imachi H, Obin MS, Bianco AC, Greenberg AS. Perilipin regulates the thermogenic actions of norepinephrine in brown adipose tissue. J Lipid Res. 2007 Jun; 48(6):1273-9. PMID: 17401109.
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    100. da-Silva WS, Harney JW, Kim BW, Li J, Bianco SD, Crescenzi A, Christoffolete MA, Huang SA, Bianco AC. The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation. Diabetes. 2007 Mar; 56(3):767-76. PMID: 17327447.
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    101. Capparelli R, Alfano F, Amoroso MG, Borriello G, Fenizia D, Bianco A, Roperto S, Roperto F, Iannelli D. Protective effect of the Nramp1 BB genotype against Brucella abortus in the water buffalo (Bubalus bubalis). Infect Immun. 2007 Feb; 75(2):988-96. PMID: 17145946; PMCID: PMC1828489.
    102. Christoffolete MA, Arrojo e Drigo R, Gazoni F, Tente SM, Goncalves V, Amorim BS, Larsen PR, Bianco AC, Zavacki AM. Mice with impaired extrathyroidal thyroxine to 3,5,3'-triiodothyronine conversion maintain normal serum 3,5,3'-triiodothyronine concentrations. Endocrinology. 2007 Mar; 148(3):954-60. PMID: 17138654.
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    103. Bianco AC, Kim BW. Deiodinases: implications of the local control of thyroid hormone action. J Clin Invest. 2006 Oct; 116(10):2571-9. PMID: 17016550; PMCID: PMC1578599.
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    105. Zeöld A, Doleschall M, Haffner MC, Capelo LP, Menyhért J, Liposits Z, da Silva WS, Bianco AC, Kacskovics I, Fekete C, Gereben B. Characterization of the nuclear factor-kappa B responsiveness of the human dio2 gene. Endocrinology. 2006 Sep; 147(9):4419-29. PMID: 16728495.
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    106. Miyoshi H, Souza SC, Zhang HH, Strissel KJ, Christoffolete MA, Kovsan J, Rudich A, Kraemer FB, Bianco AC, Obin MS, Greenberg AS. Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and -independent mechanisms. J Biol Chem. 2006 Jun 09; 281(23):15837-44. PMID: 16595669.
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    107. Galderisi M, Vitale G, Bianco A, Pivonello R, Lombardi G, Divitiis Od, Colao A. Pulsed tissue Doppler identifies subclinical myocardial biventricular dysfunction in active acromegaly. Clin Endocrinol (Oxf). 2006 Apr; 64(4):390-7. PMID: 16584510.
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    108. Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, Sato H, Messaddeq N, Harney JW, Ezaki O, Kodama T, Schoonjans K, Bianco AC, Auwerx J. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature. 2006 Jan 26; 439(7075):484-9. PMID: 16400329.
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    109. Christoffolete MA, Ribeiro R, Singru P, Fekete C, da Silva WS, Gordon DF, Huang SA, Crescenzi A, Harney JW, Ridgway EC, Larsen PR, Lechan RM, Bianco AC. Atypical expression of type 2 iodothyronine deiodinase in thyrotrophs explains the thyroxine-mediated pituitary thyrotropin feedback mechanism. Endocrinology. 2006 Apr; 147(4):1735-43. PMID: 16396983.
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    110. Sharma V, Hays WR, Wood WM, Pugazhenthi U, St Germain DL, Bianco AC, Krezel W, Chambon P, Haugen BR. Effects of rexinoids on thyrotrope function and the hypothalamic-pituitary-thyroid axis. Endocrinology. 2006 Mar; 147(3):1438-51. PMID: 16306084.
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    111. Bianco AC, Timerman A, Paes AT, Gun C, Ramos RF, Freire RB, Vela CN, Fagundes Junior AA, Martins LC, Piegas LS. [Prospective risk analysis in patients submitted to myocardial revascularization surgery]. Arq Bras Cardiol. 2005 Oct; 85(4):254-61. PMID: 16283031.
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    112. Fekete C, Singru PS, Sanchez E, Sarkar S, Christoffolete MA, Riberio RS, Rand WM, Emerson CH, Bianco AC, Lechan RM. Differential effects of central leptin, insulin, or glucose administration during fasting on the hypothalamic-pituitary-thyroid axis and feeding-related neurons in the arcuate nucleus. Endocrinology. 2006 Jan; 147(1):520-9. PMID: 16210367.
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    113. Fekete C, Sarkar S, Christoffolete MA, Emerson CH, Bianco AC, Lechan RM. Bacterial lipopolysaccharide (LPS)-induced type 2 iodothyronine deiodinase (D2) activation in the mediobasal hypothalamus (MBH) is independent of the LPS-induced fall in serum thyroid hormone levels. Brain Res. 2005 Sep 14; 1056(1):97-9. PMID: 16095572.
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    114. Monte O, Zyngier S, Kimura ET, Bianco AC. [Dopaminergic and somatostatinergic pathways decrease serum thyrotropin in rats bearing the 256-Walker mammary carcinoma]. Arq Bras Endocrinol Metabol. 2005 Apr; 49(2):253-64. PMID: 16184254.
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    115. Bianco AC, Larsen PR. Cellular and structural biology of the deiodinases. Thyroid. 2005 Aug; 15(8):777-86. PMID: 16131321.
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    116. Dentice M, Bandyopadhyay A, Gereben B, Callebaut I, Christoffolete MA, Kim BW, Nissim S, Mornon JP, Zavacki AM, Zeöld A, Capelo LP, Curcio-Morelli C, Ribeiro R, Harney JW, Tabin CJ, Bianco AC. The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate. Nat Cell Biol. 2005 Jul; 7(7):698-705. PMID: 15965468; PMCID: PMC1761694.
    117. Bianco AC, Maia AL, da Silva WS, Christoffolete MA. Adaptive activation of thyroid hormone and energy expenditure. Biosci Rep. 2005 Jun-Aug; 25(3-4):191-208. PMID: 16283553.
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    118. Kalaany NY, Gauthier KC, Zavacki AM, Mammen PP, Kitazume T, Peterson JA, Horton JD, Garry DJ, Bianco AC, Mangelsdorf DJ. LXRs regulate the balance between fat storage and oxidation. Cell Metab. 2005 Apr; 1(4):231-44. PMID: 16054068.
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    119. Canani LH, Capp C, Dora JM, Meyer EL, Wagner MS, Harney JW, Larsen PR, Gross JL, Bianco AC, Maia AL. The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab. 2005 Jun; 90(6):3472-8. PMID: 15797963.
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    120. Zavacki AM, Ying H, Christoffolete MA, Aerts G, So E, Harney JW, Cheng SY, Larsen PR, Bianco AC. Type 1 iodothyronine deiodinase is a sensitive marker of peripheral thyroid status in the mouse. Endocrinology. 2005 Mar; 146(3):1568-75. PMID: 15591136.
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    121. Gouveia CH, Christoffolete MA, Zaitune CR, Dora JM, Harney JW, Maia AL, Bianco AC. Type 2 iodothyronine selenodeiodinase is expressed throughout the mouse skeleton and in the MC3T3-E1 mouse osteoblastic cell line during differentiation. Endocrinology. 2005 Jan; 146(1):195-200. PMID: 15471965.
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    122. Bianco AC. [Impact factor. The editor's report?]. Arq Bras Endocrinol Metabol. 2004 Jun; 48(3):335-6. PMID: 15640894.
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    123. Bianco AC. Triplets! Unexpected structural similarity among the three enzymes that catalyze initiation and termination of thyroid hormone effects. Arq Bras Endocrinol Metabol. 2004 Feb; 48(1):16-24. PMID: 15611815.
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    124. Carvalho-Bianco SD, Kim BW, Zhang JX, Harney JW, Ribeiro RS, Gereben B, Bianco AC, Mende U, Larsen PR. Chronic cardiac-specific thyrotoxicosis increases myocardial beta-adrenergic responsiveness. Mol Endocrinol. 2004 Jul; 18(7):1840-9. PMID: 15131256.
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    125. Christoffolete MA, Linardi CC, de Jesus L, Ebina KN, Carvalho SD, Ribeiro MO, Rabelo R, Curcio C, Martins L, Kimura ET, Bianco AC. Mice with targeted disruption of the Dio2 gene have cold-induced overexpression of the uncoupling protein 1 gene but fail to increase brown adipose tissue lipogenesis and adaptive thermogenesis. Diabetes. 2004 Mar; 53(3):577-84. PMID: 14988240.
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    126. Fekete C, Gereben B, Doleschall M, Harney JW, Dora JM, Bianco AC, Sarkar S, Liposits Z, Rand W, Emerson C, Kacskovics I, Larsen PR, Lechan RM. Lipopolysaccharide induces type 2 iodothyronine deiodinase in the mediobasal hypothalamus: implications for the nonthyroidal illness syndrome. Endocrinology. 2004 Apr; 145(4):1649-55. PMID: 14684601.
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    127. Citro R, Galderisi M, Guarini P, Cicala S, Mattioli D, Bianco A, de Divitiis O, Gregorio G. Left bundle branch block with and without coronary artery disease: which value for a tissue Doppler-derived post-systolic motion? Ital Heart J. 2003 Oct; 4(10):706-12. PMID: 14664284.
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    128. Freitas FR, Moriscot AS, Jorgetti V, Soares AG, Passarelli M, Scanlan TS, Brent GA, Bianco AC, Gouveia CH. Spared bone mass in rats treated with thyroid hormone receptor TR beta-selective compound GC-1. Am J Physiol Endocrinol Metab. 2003 Nov; 285(5):E1135-41. PMID: 12965872.
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    129. Kim BW, Zavacki AM, Curcio-Morelli C, Dentice M, Harney JW, Larsen PR, Bianco AC. Endoplasmic reticulum-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2. Mol Endocrinol. 2003 Dec; 17(12):2603-12. PMID: 12933904.
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    130. Callebaut I, Curcio-Morelli C, Mornon JP, Gereben B, Buettner C, Huang S, Castro B, Fonseca TL, Harney JW, Larsen PR, Bianco AC. The iodothyronine selenodeiodinases are thioredoxin-fold family proteins containing a glycoside hydrolase clan GH-A-like structure. J Biol Chem. 2003 Sep 19; 278(38):36887-96. PMID: 12847093.
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    131. Curcio-Morelli C, Zavacki AM, Christofollete M, Gereben B, de Freitas BC, Harney JW, Li Z, Wu G, Bianco AC. Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation. J Clin Invest. 2003 Jul; 112(2):189-96. PMID: 12865408; PMCID: PMC164294.
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    133. Nakayama A, Bianco AC, Zhang CY, Lowell BB, Frangioni JV. Quantitation of brown adipose tissue perfusion in transgenic mice using near-infrared fluorescence imaging. Mol Imaging. 2003 Jan; 2(1):37-49. PMID: 12926236.
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    134. Fekete C, Sarkar S, Rand WM, Harney JW, Emerson CH, Bianco AC, Beck-Sickinger A, Lechan RM. Neuropeptide Y1 and Y5 receptors mediate the effects of neuropeptide Y on the hypothalamic-pituitary-thyroid axis. Endocrinology. 2002 Dec; 143(12):4513-9. PMID: 12446577.
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    135. Baqui M, Botero D, Gereben B, Curcio C, Harney JW, Salvatore D, Sorimachi K, Larsen PR, Bianco AC. Human type 3 iodothyronine selenodeiodinase is located in the plasma membrane and undergoes rapid internalization to endosomes. J Biol Chem. 2003 Jan 10; 278(2):1206-11. PMID: 12419801.
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    136. Fekete C, Sarkar S, Rand WM, Harney JW, Emerson CH, Bianco AC, Lechan RM. Agouti-related protein (AGRP) has a central inhibitory action on the hypothalamic-pituitary-thyroid (HPT) axis; comparisons between the effect of AGRP and neuropeptide Y on energy homeostasis and the HPT axis. Endocrinology. 2002 Oct; 143(10):3846-53. PMID: 12239096.
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    137. Cohen WM, Bianco A, Connan F, Camoin L, Dalod M, Lauvau G, Ferriès E, Culmann-Penciolelli B, van Endert PM, Briand JP, Choppin J, Guillet JG. Study of antigen-processing steps reveals preferences explaining differential biological outcomes of two HLA-A2-restricted immunodominant epitopes from human immunodeficiency virus type 1. J Virol. 2002 Oct; 76(20):10219-25. PMID: 12239297; PMCID: PMC136577.
    138. Botero D, Gereben B, Goncalves C, De Jesus LA, Harney JW, Bianco AC. Ubc6p and ubc7p are required for normal and substrate-induced endoplasmic reticulum-associated degradation of the human selenoprotein type 2 iodothyronine monodeiodinase. Mol Endocrinol. 2002 Sep; 16(9):1999-2007. PMID: 12198238.
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    139. Bachman ES, Dhillon H, Zhang CY, Cinti S, Bianco AC, Kobilka BK, Lowell BB. betaAR signaling required for diet-induced thermogenesis and obesity resistance. Science. 2002 Aug 02; 297(5582):843-5. PMID: 12161655.
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    140. Bicudo JE, Bianco AC, Vianna CR. Adaptive thermogenesis in hummingbirds. J Exp Biol. 2002 Aug; 205(Pt 15):2267-73. PMID: 12110660.
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    141. Bianco AC, Salvatore D, Gereben B, Berry MJ, Larsen PR. Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev. 2002 Feb; 23(1):38-89. PMID: 11844744.
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    142. Cristovão FC, Bisi H, Mendonça BB, Bianco AC, Bloise W. Severe and mild neonatal hypothyroidism mediate opposite effects on Leydig cells of rats. Thyroid. 2002 Jan; 12(1):13-8. PMID: 11838725.
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    143. Frasci G, Lorusso V, Panza N, Comella P, Nicolella G, Bianco A, DeCataldis G, Belli M, Iannelli N, Massidda B, Mascia V, Comella G, De Lena M. Gemcitabine plus vinorelbine yields better survival outcome than vinorelbine alone in elderly patients with advanced non-small cell lung cancer. A Southern Italy Cooperative Oncology Group (SICOG) phase III trial. Lung Cancer. 2001 Dec; 34 Suppl 4:S65-9. PMID: 11742706.
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    144. de Jesus LA, Carvalho SD, Ribeiro MO, Schneider M, Kim SW, Harney JW, Larsen PR, Bianco AC. The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue. J Clin Invest. 2001 Nov; 108(9):1379-85. PMID: 11696583; PMCID: PMC209445.
    145. Gouveia CH, Schultz JJ, Bianco AC, Brent GA. Thyroid hormone stimulation of osteocalcin gene expression in ROS 17/2.8 cells is mediated by transcriptional and post-transcriptional mechanisms. J Endocrinol. 2001 Sep; 170(3):667-75. PMID: 11524248.
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    146. Timerman A, Sauaia N, Piegas LS, Ramos RF, Gun C, Santos ES, Bianco AC, Sousa JE. Prognostic factors of the results of cardiopulmonary resuscitation in a cardiology hospital. Arq Bras Cardiol. 2001 Aug; 77(2):142-60. PMID: 11514826.
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    147. Peeters R, Fekete C, Goncalves C, Legradi G, Tu HM, Harney JW, Bianco AC, Lechan RM, Larsen PR. Regional physiological adaptation of the central nervous system deiodinases to iodine deficiency. Am J Physiol Endocrinol Metab. 2001 Jul; 281(1):E54-61. PMID: 11404222.
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    148. Ribeiro MO, Carvalho SD, Schultz JJ, Chiellini G, Scanlan TS, Bianco AC, Brent GA. Thyroid hormone--sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform--specific. J Clin Invest. 2001 Jul; 108(1):97-105. PMID: 11435461; PMCID: PMC209342.
    149. Curcio C, Baqui MM, Salvatore D, Rihn BH, Mohr S, Harney JW, Larsen PR, Bianco AC. The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line. J Biol Chem. 2001 Aug 10; 276(32):30183-7. PMID: 11425850.
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    150. Choppin J, Cohen W, Bianco A, Briand JP, Connan F, Dalod M, Guillet JG. Characteristics of HIV-1 Nef regions containing multiple CD8+ T cell epitopes: wealth of HLA-binding motifs and sensitivity to proteasome degradation. J Immunol. 2001 May 15; 166(10):6164-9. PMID: 11342637.
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    151. Joseph C, Stier G, O'Brien R, Politou AS, Atkinson RA, Bianco A, Ladbury JE, Martin SR, Pastore A. A structural characterization of the interactions between titin Z-repeats and the alpha-actinin C-terminal domain. Biochemistry. 2001 Apr 24; 40(16):4957-65. PMID: 11305911.
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    152. Vianna CR, Hagen T, Zhang CY, Bachman E, Boss O, Gereben B, Moriscot AS, Lowell BB, Bicudo JE, Bianco AC. Cloning and functional characterization of an uncoupling protein homolog in hummingbirds. Physiol Genomics. 2001 Apr 02; 5(3):137-45. PMID: 11285367.
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    153. Fryer AA, Spiteri MA, Bianco A, Hepple M, Jones PW, Strange RC, Makki R, Tavernier G, Smilie FI, Custovic A, Woodcock AA, Ollier WE, Hajeer AH. The -403 G-->A promoter polymorphism in the RANTES gene is associated with atopy and asthma. Genes Immun. 2000 Dec; 1(8):509-14. PMID: 11197694.
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    154. Bianco A, Furrer J, Limal D, Guichard G, Elbayed K, Raya J, Piotto M, Briand JP. Multistep synthesis of 2,5-diketopiperazines on different solid supports monitored by high resolution magic angle spinning NMR spectroscopy. J Comb Chem. 2000 Nov-Dec; 2(6):681-90. PMID: 11126296.
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    155. Baqui MM, Gereben B, Harney JW, Larsen PR, Bianco AC. Distinct subcellular localization of transiently expressed types 1 and 2 iodothyronine deiodinases as determined by immunofluorescence confocal microscopy. Endocrinology. 2000 Nov; 141(11):4309-12. PMID: 11089566.
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    156. Gereben B, Goncalves C, Harney JW, Larsen PR, Bianco AC. Selective proteolysis of human type 2 deiodinase: a novel ubiquitin-proteasomal mediated mechanism for regulation of hormone activation. Mol Endocrinol. 2000 Nov; 14(11):1697-708. PMID: 11075806.
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    157. Ribeiro MO, Lebrun FL, Christoffolete MA, Branco M, Crescenzi A, Carvalho SD, Negrão N, Bianco AC. Evidence of UCP1-independent regulation of norepinephrine-induced thermogenesis in brown fat. Am J Physiol Endocrinol Metab. 2000 Aug; 279(2):E314-22. PMID: 10913031.
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    158. Arnhold IJ, Oliveira SB, Osorio MG, Carrilho AJ, Nicolau W, Bianco AC, Mendonca BB. Lack of reduction in body fat after treatment with insulin-like growth factor-I in two children with growth hormone gene deletions. J Endocrinol Invest. 2000 Apr; 23(4):258-62. PMID: 10853714.
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    159. Steinsapir J, Bianco AC, Buettner C, Harney J, Larsen PR. Substrate-induced down-regulation of human type 2 deiodinase (hD2) is mediated through proteasomal degradation and requires interaction with the enzyme's active center. Endocrinology. 2000 Mar; 141(3):1127-35. PMID: 10698189.
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    160. Bianco AC, Malvestiti LF, Gouveia CH, Wehba S, Lewin S, Marone MM. Morphometric dual-energy X-ray absorptiometry of the spine: report of a large series and correlation with axial bone mineral density. J Bone Miner Res. 1999 Sep; 14(9):1605-13. PMID: 10469290.
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    161. Curcio C, Lopes AM, Ribeiro MO, Francoso OA, Carvalho SD, Lima FB, Bicudo JE, Bianco AC. Development of compensatory thermogenesis in response to overfeeding in hypothyroid rats. Endocrinology. 1999 Aug; 140(8):3438-43. PMID: 10433198.
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    162. Branco M, Ribeiro M, Negrão N, Bianco AC. 3,5,3'-Triiodothyronine actively stimulates UCP in brown fat under minimal sympathetic activity. Am J Physiol. 1999 Jan; 276(1 Pt 1):E179-87. PMID: 9886965.
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    163. Bianco AC, Carvalho SD, Carvalho CR, Rabelo R, Moriscot AS. Thyroxine 5'-deiodination mediates norepinephrine-induced lipogenesis in dispersed brown adipocytes. Endocrinology. 1998 Feb; 139(2):571-8. PMID: 9449627.
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    164. Bianco AC, Carvalho SD, Carvalho CR, Rabelo RR, Moriscot AS. Thyroxine 5'-Deiodination Mediates Norepinephrine-Induced Lipogenesis in Dispersed Brown Adipocytes. Endocrinology. 1998 Feb 01; 139(2):571-578. PMID: 28200442.
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    165. Gouveia CH, Jorgetti V, Bianco AC. Effects of thyroid hormone administration and estrogen deficiency on bone mass of female rats. J Bone Miner Res. 1997 Dec; 12(12):2098-107. PMID: 9421243.
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    166. Marone MM, Gouveia CH, Lewin S, Wehba S, Malvestiti LF, Bianco AC. Influence of body composition on the bone mass of postmenopausal women. Sao Paulo Med J. 1997 Nov-Dec; 115(6):1580-8. PMID: 9640795.
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    167. Pessoa JH, Lewin S, Longui CA, Mendonça BB, Bianco AC. [Bone mineral density: correlation with body weight, height, bone age and insulin-like growth factor]. J Pediatr (Rio J). 1997 Jul-Aug; 73(4):259-64. PMID: 14685400.
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    168. Lewin S, Gouveia CH, Marone MM, Wehba S, Malvestiti LF, Bianco AC. [Vertebral and femoral bone mineral density of 724 caucasian Brazilian women: influence of age and body weight]. Rev Assoc Med Bras (1992). 1997 Apr-Jun; 43(2):127-36. PMID: 9336048.
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    169. Comella P, Frasci G, De Cataldis G, Panza N, Cioffi R, Curcio C, Belli M, Bianco A, Ianniello G, Maiorino L, Della Vittoria M, Perchard J, Comella G. Cisplatin/carboplatin + etoposide + vinorelbine in advanced non-small-cell lung cancer: a multicentre randomised trial. Gruppo Oncologico Campano. Br J Cancer. 1996 Dec; 74(11):1805-11. PMID: 8956797; PMCID: PMC2077209.
    170. Carvalho SD, Bianco AC, Silva JE. Effects of hypothyroidism on brown adipose tissue adenylyl cyclase activity. Endocrinology. 1996 Dec; 137(12):5519-29. PMID: 8940379.
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    171. Ribela MT, Bianco AC, Bartolini P. The use of recombinant human thyrotropin produced by Chinese hamster ovary cells for the preparation of immunoassay reagents. J Clin Endocrinol Metab. 1996 Jan; 81(1):249-56. PMID: 8550760.
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    172. Gun C, Piegas LS, Bianco AC, Freire RB, Ramos RF, Timerman A. [Value of the use of milrinone in the treatment of acute crisis in patients with congestive heart failure]. Arq Bras Cardiol. 1995 Sep; 65(3):255-8. PMID: 8579514.
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    173. Latronico AC, Mendonça BB, Bianco AC, Villares SM, Lucon MA, Nicolau W, Wajchenberg BL. Calcium-dependent protein kinase-C activity in human adrenocortical neoplasms, hyperplastic adrenals, and normal adrenocortical tissue. J Clin Endocrinol Metab. 1994 Sep; 79(3):736-9. PMID: 7521351.
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    174. Moriscot A, Rabelo R, Bianco AC. Corticosterone inhibits uncoupling protein gene expression in brown adipose tissue. Am J Physiol. 1993 Jul; 265(1 Pt 1):E81-7. PMID: 8338156.
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    175. Carvalho SD, Negrão N, Bianco AC. Hormonal regulation of malic enzyme and glucose-6-phosphate dehydrogenase in brown adipose tissue. Am J Physiol. 1993 Jun; 264(6 Pt 1):E874-81. PMID: 8333512.
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    176. Bianco AC, Kieffer JD, Silva JE. Adenosine 3',5'-monophosphate and thyroid hormone control of uncoupling protein messenger ribonucleic acid in freshly dispersed brown adipocytes. Endocrinology. 1992 May; 130(5):2625-33. PMID: 1374009.
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    177. Rehnmark S, Bianco AC, Kieffer JD, Silva JE. Transcriptional and posttranscriptional mechanisms in uncoupling protein mRNA response to cold. Am J Physiol. 1992 Jan; 262(1 Pt 1):E58-67. PMID: 1733251.
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    178. Carvalho SD, Kimura ET, Bianco AC, Silva JE. Central role of brown adipose tissue thyroxine 5'-deiodinase on thyroid hormone-dependent thermogenic response to cold. Endocrinology. 1991 Apr; 128(4):2149-59. PMID: 2004619.
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    179. Dorgan Neto V, Saad Júnior R, Hell NS, Bianco AC, Santo GC, Rasslan S. [Gastrin changes in the gastric antrum G-cells and in serum gastrin levels after 80% jejunoileal resection in rats]. Rev Paul Med. 1991 Mar-Apr; 109(2):71-6. PMID: 1887181.
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    180. Dias Júnior AA, Scalissi NM, Marone MM, Correa PH, Bianco AC. [Basedow-Graves' disease: analysis of various parameters in the prognosis of remission after clinical treatment]. Rev Paul Med. 1989 Mar-Apr; 107(2):69-74. PMID: 2629056.
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    181. Bianco AC, Sheng XY, Silva JE. Triiodothyronine amplifies norepinephrine stimulation of uncoupling protein gene transcription by a mechanism not requiring protein synthesis. J Biol Chem. 1988 Dec 05; 263(34):18168-75. PMID: 3192531.
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    182. Bianco AC, Silva JE. Cold exposure rapidly induces virtual saturation of brown adipose tissue nuclear T3 receptors. Am J Physiol. 1988 Oct; 255(4 Pt 1):E496-503. PMID: 3177636.
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    183. Saad Júnior R, Rasslan S, Bianco AC, Doine AI, Hell NS, Medeiros LO. [Histologic and histochemical evaluation of the exocrine pancreas in rats subjected to resection or extensive jejunoileal bypass]. AMB Rev Assoc Med Bras. 1988 Jul-Aug; 34(4):123-8. PMID: 2469110.
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    184. Bianco AC, Silva JE. Optimal response of key enzymes and uncoupling protein to cold in BAT depends on local T3 generation. Am J Physiol. 1987 Sep; 253(3 Pt 1):E255-63. PMID: 3631256.
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    185. Bianco AC, Nunes MT, Hell NS, Maciel RM. The role of glucocorticoids in the stress-induced reduction of extrathyroidal 3,5,3'-triiodothyronine generation in rats. Endocrinology. 1987 Mar; 120(3):1033-8. PMID: 3803308.
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    186. Bianco AC, Silva JE. Nuclear 3,5,3'-triiodothyronine (T3) in brown adipose tissue: receptor occupancy and sources of T3 as determined by in vivo techniques. Endocrinology. 1987 Jan; 120(1):55-62. PMID: 3780570.
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    187. Bianco AC, Silva JE. Intracellular conversion of thyroxine to triiodothyronine is required for the optimal thermogenic function of brown adipose tissue. J Clin Invest. 1987 Jan; 79(1):295-300. PMID: 3793928; PMCID: PMC424048.
    188. Nunes MT, Bianco AC. Extrathyroidal conversion of thyroxine to 3,5,3'-triiodothyronine in cold-acclimated thyroxine-maintained thyroidectomized rats. Braz J Med Biol Res. 1986; 19(2):311-8. PMID: 3828577.
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    189. Nunes MT, Bianco AC, Migala A, Agostini B, Hasselbach W. Thyroxine induced transformation in sarcoplasmic reticulum of rabbit soleus and psoas muscles. Z Naturforsch C. 1985 Sep-Oct; 40(9-10):726-34. PMID: 2934902.
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    190. Bianco AC, Marone MM, Nunes MT, Santo GC, Correa PH, Marigo C, Auriemo CR. [Characterization of the binding of 125I-TSH to its receptor in low-uptake thyroid hyperplasias]. Rev Paul Med. 1985 Jul-Aug; 103(4):176-81. PMID: 3008296.
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    191. Saad Júnior R, Bianco AC, de Minas RM, Chazanas JC, de Oliveira AM, Hell NS, Rasslan S. [Metabolic changes in rats subjected to massive intestinal resection or jejunoileal bypass]. Rev Paul Med. 1985 Jul-Aug; 103(4):171-5. PMID: 3914047.
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    192. Bianco AC, Nunes MT, Marone MS, Correa PH. Conversion of thyroxine (T4) to T3 and rT3 in human leucocyte suspension: its application to clinical investigation. Endocrinol Exp. 1985 Mar; 19(1):53-61. PMID: 3921342.
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    193. Bianco AC, Nunes MT, Marone MM, Scalissi NM, Correa PH, Douglas CR. [Thyroxine (T4) to 3,5,3'-triiodothyronine (T3) and 3,3',5'-triiodothyronine (reverse T3) conversion in human leukocyte suspensions. Study in hyper and hypothyroidism states]. Rev Paul Med. 1984 Mar-Apr; 102(2):61-4. PMID: 6474031.
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    194. Bianco AC, Nunes MT, Douglas CR. Influence of mast cells on thyroid function. Endocrinol Exp. 1983 Jun; 17(2):99-106. PMID: 6411454.
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    195. Bianco AC, Nunes MT, Martins O, Roesner I, Douglas RA, Pereira RC, Douglas CR. Possible mechanism of action of cholesterol enriched diet on the thyroid. Endocrinol Exp. 1981 Dec; 15(4):277-85. PMID: 6976263.
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    196. MINOZZI M, FAGGIANO M, BIANCO A, D AMORA G. [USE OF THE ANALYSIS OF DISCRIMINATING FUNCTIONS IN THYROID FUNCTIONAL DIAGNOSIS. II. CAPACITY OF SEVERAL VARIOUSLY COMBINED THYROID FUNCTION TESTS TO DISCRIMINATE BETWEEN NORMAL AND HYPOTHYROID SUBJECTS]. Folia Endocrinol. 1964 Apr; 17:191-8. PMID: 14167557.
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