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Antonio Bianco

TitleProfessor
InstitutionRush University, Rush Medical College
DepartmentInternal Medicine, Division of Endocrinology
Address1735 W. Harrison St.
Chicago IL 60612
Phone312-942-7131
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    Collapse Overview 
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    My ORCID is 0000-0001-7737-6813.
    My Scopus ID is 7203005318.
    My NIH COMMONS name is ACB123.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Batistuzzo A, Salas-Lucia F, Gereben B, Ribeiro MO, Bianco AC. Sustained Pituitary T3 Production Explains the T4-mediated TSH Feedback Mechanism. Endocrinology. 2023 Nov 02; 164(12). PMID: 37864846.
      View in: PubMed
    2. Penna GC, Bianco AC, Ettleson MD. A cross-sectional analysis of cardiovascular and bone healthcare utilization during treatment with thyroid hormone. J Clin Endocrinol Metab. 2023 Oct 25. PMID: 37878964.
      View in: PubMed
    3. Hidalgo-?lvarez J, Salas-Lucia F, Vera Cruz D, Fonseca TL, Bianco AC. Localized T3 production modifies the transcriptome and promotes the hepatocyte-like lineage in iPSC-derived hepatic organoids. JCI Insight. 2023 Oct 19. PMID: 37856222.
      View in: PubMed
    4. Penna GC, Salas-Lucia F, Ribeiro MO, Bianco AC. Gene polymorphisms and thyroid hormone signaling: implication for the treatment of hypothyroidism. Endocrine. 2023 Sep 23. PMID: 37740833.
      View in: PubMed
    5. Bianco AC. Emerging Therapies in Hypothyroidism. Annu Rev Med. 2023 Sep 22. PMID: 37738506.
      View in: PubMed
    6. Zhu K, Mukherjee K, Wei C, Hayek SS, Collins A, Gu C, Corapi K, Altintas MM, Wang Y, Waikar SS, Bianco AC, Koch A, Tacke F, Reiser J, Sever S. The D2D3 form of uPAR acts as an immunotoxin and may cause diabetes and kidney disease. Sci Transl Med. 2023 09 20; 15(714):eabq6492. PMID: 37729431.
      View in: PubMed
    7. Jiang C, Wolf K, Kaakati R, Oh J, Yip AT, Jonklaas J, Bianco AC, Laiteerapong N, Ettleson MD. The Effects of Patient Characteristics on the Management of Subclinical Hypothyroidism: A Survey of Faculty and Trainees. Endocr Pract. 2023 Oct; 29(10):787-793. PMID: 37549880.
      View in: PubMed
    8. Bianco AC, Bao Y, Antunez Flores O, Halpern R, Le L, Stackland S, Frieze T. Levothyroxine Treatment Adequacy and Formulation Changes in Patients with Hypothyroidism: A Retrospective Study of Real-World Data from the United States. Thyroid. 2023 08; 33(8):940-949. PMID: 37335236.
      View in: PubMed
    9. Casula S, Ettleson MD, Bianco AC. Are We Restoring Thyroid Hormone Signaling in Levothyroxine-Treated Patients With Residual Symptoms of Hypothyroidism? Endocr Pract. 2023 Jul; 29(7):581-588. PMID: 37419565.
      View in: PubMed
    10. Ettleson MD, Ibarra S, Wan W, Peterson S, Laiteerapong N, Bianco AC. Demographic, healthcare access, and dietary factors associated with thyroid hormone treatments for hypothyroidism. J Clin Endocrinol Metab. 2023 Jun 16. PMID: 37327351.
      View in: PubMed
    11. Salas-Lucia F, Fekete C, Sink? R, Egri P, Rada K, Ruska Y, Gereben B, Bianco AC. Axonal T3 uptake and transport can trigger thyroid hormone signaling in the brain. Elife. 2023 05 19; 12. PMID: 37204837.
      View in: PubMed
    12. Ettleson MD, Prieto WH, Russo PST, de Sa J, Wan W, Laiteerapong N, Maciel RMB, Bianco AC. Serum Thyrotropin and Triiodothyronine Levels in Levothyroxine-treated Patients. J Clin Endocrinol Metab. 2023 05 17; 108(6):e258-e266. PMID: 36515655.
      View in: PubMed
    13. Gambardella J, Fiordelisi A, Cerasuolo FA, Buonaiuto A, Avvisato R, Viti A, Sommella E, Merciai F, Salviati E, Campiglia P, D'Argenio V, Parisi S, Bianco A, Spinelli L, Di Vaia E, Cuocolo A, Pisani A, Riccio E, Di Risi T, Ciccarelli M, Santulli G, Sorriento D, Iaccarino G. Experimental evidence and clinical implications of Warburg effect in the skeletal muscle of Fabry disease. iScience. 2023 Mar 17; 26(3):106074. PMID: 36879801.
      View in: PubMed
    14. Sink? R, Moh?csik P, Kov?ri D, Penksza V, Wittmann G, M?csai L, Fonseca TL, Bianco AC, Fekete C, Gereben B. Different Hypothalamic Mechanisms Control Decreased Circulating Thyroid Hormone Levels in Infection and Fasting-Induced Non-Thyroidal Illness Syndrome in Male Thyroid Hormone Action Indicator Mice. Thyroid. 2023 01; 33(1):109-118. PMID: 36322711.
      View in: PubMed
    15. Salas-Lucia F, Bianco AC. T3 levels and thyroid hormone signaling. Front Endocrinol (Lausanne). 2022; 13:1044691. PMID: 36387853.
      View in: PubMed
    16. Capuano I, Buonanno P, Riccio E, Bianco A, Pisani A. Randomized Controlled Trials on Renin Angiotensin Aldosterone System Inhibitors in Chronic Kidney Disease Stages 3-5: Are They Robust? A Fragility Index Analysis. J Clin Med. 2022 Oct 20; 11(20). PMID: 36294504.
      View in: PubMed
    17. Jonklaas J, Bianco AC. Enhancing the Patient Voice: Quality of Life, Satisfaction, and Preference During Treatment of Hypothyroidism. Thyroid. 2022 Oct; 32(10):1139-1141. PMID: 36136911.
      View in: PubMed
    18. Batistuzzo A, de Almeida GG, Br?s TS, Zucato VP, Arnold AJT, Giannocco G, Sato JM, Yamanouchi LM, Dias E, Lorena FB, do Nascimento BPP, Bianco AC, Ribeiro MO. Multisensory Stimulation Improves Cognition and Behavior in Adult Male Rats Born to LT4-treated Thyroidectomized Dams. Endocrinology. 2022 09 01; 163(9). PMID: 35914267.
      View in: PubMed
    19. Ettleson MD, Bianco AC, Wan W, Laiteerapong N. Suboptimal Thyroid Hormone Replacement Is Associated With Worse Hospital Outcomes. J Clin Endocrinol Metab. 2022 07 14; 107(8):e3411-e3419. PMID: 35472082.
      View in: PubMed
    20. Lorena FB, Sato JM, Coviello BM, Arnold AJT, Batistuzzo A, Yamanouchi LM, Dias Junior E, do Nascimento BPP, Fonseca TL, Bianco AC, Ribeiro MO. Age Worsens the Cognitive Phenotype in Mice Carrying the Thr92Ala-DIO2 Polymorphism. Metabolites. 2022 Jul 08; 12(7). PMID: 35888752.
      View in: PubMed
    21. DeBolt CA, Rosenberg HM, Pruzan A, Goldberger C, Kaplowitz E, Buckley A, Vieira L, Stone J, Bianco A. Patients with resolution of low-lying placenta and placenta previa remain at increased risk of postpartum hemorrhage. Ultrasound Obstet Gynecol. 2022 07; 60(1):103-108. PMID: 34826174.
      View in: PubMed
    22. Boucai L, Salas-Lucia F, Krishnamoorthy GP, Sherman E, Rudin CM, Drilon A, Bianco AC, Fagin JA. Selpercatinib-Induced Hypothyroidism Through Off-Target Inhibition of Type 2 Iodothyronine Deiodinase. JCO Precis Oncol. 2022 06; 6:e2100496. PMID: 35704797.
      View in: PubMed
    23. de Lima Beltr?o FE, de Almeida Beltr?o DC, Carvalhal G, de Lima Beltr?o FE, de Souza Braga Filho J, de Brito Oliveira J, de Jesus JDS, Machado GJR, Dos Santos Silva H, Teixeira HMP, Rodrigues JL, de Figueiredo CAV, Dos Santos Costa R, Hecht F, Bianco AC, da Concei??o Rodrigues Gon?alves M, Ramos HE. Heterozygote Advantage of the Type II Deiodinase Thr92Ala Polymorphism on Intrahospital Mortality of COVID-19. J Clin Endocrinol Metab. 2022 05 17; 107(6):e2488-e2501. PMID: 35137147.
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    24. Fonseca TL, Russo SC, Luongo C, Salvatore D, Bianco AC. Inactivation of Type 3 Deiodinase Results in Life-long Changes in the Brown Adipose Tissue Transcriptome in the Male Mouse. Endocrinology. 2022 05 01; 163(5). PMID: 35238380.
      View in: PubMed
    25. Salvatore D, Porcelli T, Ettleson MD, Bianco AC. The relevance of T3 in the management of hypothyroidism. Lancet Diabetes Endocrinol. 2022 05; 10(5):366-372. PMID: 35240052.
      View in: PubMed
    26. Shakir MKM, Brooks DI, McAninch EA, Fonseca TL, Mai VQ, Bianco AC, Hoang TD. Response to Letter to the Editor From Bonnema et al: "Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Levothyroxine + Liothyronine in Hypothyroidism". J Clin Endocrinol Metab. 2022 02 17; 107(3):e1327-e1328. PMID: 34718640.
      View in: PubMed
    27. Heged?s L, Bianco AC, Jonklaas J, Pearce SH, Weetman AP, Perros P. Primary hypothyroidism and quality of life. Nat Rev Endocrinol. 2022 04; 18(4):230-242. PMID: 35042968.
      View in: PubMed
    28. Dumitrescu AM, Hanlon EC, Arosemena M, Duchon O, Ettleson M, Giurcanu M, Bianco AC. Extended Absorption of Liothyronine from Poly-Zinc-Liothyronine: Results from a Phase 1, Double-Blind, Randomized, and Controlled Study in Humans. Thyroid. 2022 02; 32(2):196-205. PMID: 34641706.
      View in: PubMed
    29. Ettleson MD, Raine A, Batistuzzo A, Batista SP, McAninch E, Teixeira MCTV, Jonklaas J, Laiteerapong N, Ribeiro MO, Bianco AC. Brain Fog in Hypothyroidism: Understanding the Patient's Perspective. Endocr Pract. 2022 Mar; 28(3):257-264. PMID: 34890786.
      View in: PubMed
    30. Shakir MKM, Brooks DI, McAninch EA, Fonseca TL, Mai VQ, Bianco AC, Hoang TD. Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Levothyroxine+Liothyronine in Hypothyroidism. J Clin Endocrinol Metab. 2021 10 21; 106(11):e4400-e4413. PMID: 34185829.
      View in: PubMed
    31. Agarwal S, Koh KH, Tardi NJ, Chen C, Dande RR, WerneckdeCastro JP, Sudhini YR, Luongo C, Salvatore D, Samelko B, Altintas MM, Mangos S, Bianco A, Reiser J. Deiodinase-3 is a thyrostat to regulate podocyte homeostasis. EBioMedicine. 2021 Oct; 72:103617. PMID: 34649077.
      View in: PubMed
    32. Beltr?o FEL, Beltr?o DCA, Carvalhal G, Beltr?o FEL, Brito ADS, Capistrano KHRD, Bastos IHA, Hecht F, Daltro CHDC, Bianco AC, Gon?alves MDCR, Ramos HE. Thyroid Hormone Levels During Hospital Admission Inform Disease Severity and Mortality in COVID-19 Patients. Thyroid. 2021 11; 31(11):1639-1649. PMID: 34314259.
      View in: PubMed
    33. Idrees T, Bianco AC. Letter to the Editor from Idrees and Bianco: "Treatment of Thyroid Dysfunction and Serum Lipids: A Systematic Review and Meta-analysis". J Clin Endocrinol Metab. 2021 08 18; 106(9):e3785-e3786. PMID: 33837396.
      View in: PubMed
    34. Russo SC, Salas-Lucia F, Bianco AC. Deiodinases and the Metabolic Code for Thyroid Hormone Action. Endocrinology. 2021 08 01; 162(8). PMID: 33720335.
      View in: PubMed
    35. Fonseca TL, Garcia T, Fernandes GW, Nair TM, Bianco AC. Neonatal thyroxine activation modifies epigenetic programming of the liver. Nat Commun. 2021 07 21; 12(1):4446. PMID: 34290257.
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    36. Butterfield NC, Curry KF, Steinberg J, Dewhurst H, Komla-Ebri D, Mannan NS, Adoum AT, Leitch VD, Logan JG, Waung JA, Ghirardello E, Southam L, Youlten SE, Wilkinson JM, McAninch EA, Vancollie VE, Kussy F, White JK, Lelliott CJ, Adams DJ, Jacques R, Bianco AC, Boyde A, Zeggini E, Croucher PI, Williams GR, Bassett JHD. Publisher Correction: Accelerating functional gene discovery in osteoarthritis. Nat Commun. 2021 May 28; 12(1):3302. PMID: 34050183.
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    37. Ettleson MD, Bianco AC, Zhu M, Laiteerapong N. Sociodemographic Disparities in the Treatment of Hypothyroidism: NHANES 2007-2012. J Endocr Soc. 2021 Jul 01; 5(7):bvab041. PMID: 34104843.
      View in: PubMed
    38. Idrees T, Prieto WH, Casula S, Ajith A, Ettleson M, Narchi FAA, Russo PST, Fernandes F, Johnson J, Mayampurath A, Maciel RMB, Bianco AC. Use of Statins Among Patients Taking Levothyroxine: an Observational Drug Utilization Study Across Sites. J Endocr Soc. 2021 Jul 01; 5(7):bvab038. PMID: 34141994.
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    39. Jonklaas J, Bianco AC, Cappola AR, Celi FS, Fliers E, Heuer H, McAninch EA, Moeller LC, Nygaard B, Sawka AM, Watt T, Dayan CM. Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document. Eur Thyroid J. 2021 Mar; 10(1):10-38. PMID: 33777817.
      View in: PubMed
    40. Jonklaas J, Bianco AC, Cappola AR, Celi FS, Fliers E, Heuer H, McAninch EA, Moeller LC, Nygaard B, Sawka AM, Watt T, Dayan CM. Evidence-Based Use of Levothyroxine/Liothyronine Combinations in Treating Hypothyroidism: A Consensus Document. Thyroid. 2021 02; 31(2):156-182. PMID: 33276704.
      View in: PubMed
    41. Butterfield NC, Curry KF, Steinberg J, Dewhurst H, Komla-Ebri D, Mannan NS, Adoum AT, Leitch VD, Logan JG, Waung JA, Ghirardello E, Southam L, Youlten SE, Wilkinson JM, McAninch EA, Vancollie VE, Kussy F, White JK, Lelliott CJ, Adams DJ, Jacques R, Bianco AC, Boyde A, Zeggini E, Croucher PI, Williams GR, Bassett JHD. Accelerating functional gene discovery in osteoarthritis. Nat Commun. 2021 01 20; 12(1):467. PMID: 33473114.
      View in: PubMed
    42. E Marcondes AA, Gomez TGB, Ravache TT, Batistuzzo A, Lorena FB, de Paula CS, Lowenthal R, Bianco AC, Ribeiro MO. Assessment of children in the autistic spectrum disorder that carry the Thr92Ala-DIO2 polymorphism. J Endocrinol Invest. 2021 Aug; 44(8):1775-1782. PMID: 33449341.
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    43. Bocco BMLC, Fernandes GW, Fonseca TL, Bianco AC. Iodine Deficiency Increases Fat Contribution to Energy Expenditure in Male Mice. Endocrinology. 2020 12 01; 161(12). PMID: 33091112.
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    44. Sawka AM, Alexander EK, Bianco AC, Chou R, Haugen BR, Kopp PA, Pearce EN, Ross DS, Smallridge RC, Jonklaas J. Challenges in Developing Recommendations Based on Low-Quality Evidence in Thyroid Guidelines. Thyroid. 2021 01; 31(1):3-7. PMID: 32900277.
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    45. Fran?a MM, German A, Fernandes GW, Liao XH, Bianco AC, Refetoff S, Dumitrescu AM. Human Type 1 Iodothyronine Deiodinase (DIO1) Mutations Cause Abnormal Thyroid Hormone Metabolism. Thyroid. 2021 02; 31(2):202-207. PMID: 32718224.
      View in: PubMed
    46. Martines DR, Nii F, de Almeida Medeiros KA, Carvalho BJ, Pipek LZ, de Mesquita GHA, Iuamoto LR, Oliveira GBF, Bianco ACM, Meyer A. Survival curve identifies critical period for postoperative mortality in cardiac patients undergoing emergency general surgery. Sci Rep. 2020 09 23; 10(1):15499. PMID: 32968193.
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    47. Marcelino CP, McAninch EA, Fernandes GW, Bocco BMLC, Ribeiro MO, Bianco AC. Temporal Pole Responds to Subtle Changes in Local Thyroid Hormone Signaling. J Endocr Soc. 2020 Nov 01; 4(11):bvaa136. PMID: 33123655.
      View in: PubMed
    48. Ettleson MD, Bianco AC. Individualized Therapy for Hypothyroidism: Is T4 Enough for Everyone? J Clin Endocrinol Metab. 2020 09 01; 105(9). PMID: 32614450.
      View in: PubMed
    49. Idrees T, Palmer S, Maciel RMB, Bianco AC. Liothyronine and Desiccated Thyroid Extract in the Treatment of Hypothyroidism. Thyroid. 2020 10; 30(10):1399-1413. PMID: 32279609.
      View in: PubMed
    50. Bianco AC. We All Know We Need Them, We Hope They Are Coming, But When? Thyroid. 2020 06; 30(6):791-793. PMID: 32228170.
      View in: PubMed
    51. Bianco AC, Taylor P. Levothyroxine treatment and cholesterol in hypothyroidism. Nat Rev Endocrinol. 2020 04; 16(4):193-194. PMID: 32005968.
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    52. McKeever L, Peterson SJ, Lateef O, Freels S, Fonseca TL, Bocco BMLC, Fernandes GW, Roehl K, Nowak K, Mozer M, Bianco AC, Braunschweig CA. Higher Caloric Exposure in Critically Ill Patients Transiently Accelerates Thyroid Hormone Activation. J Clin Endocrinol Metab. 2020 02 01; 105(2). PMID: 31581295.
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    53. Sawka AM, Cappola AR, Peeters RP, Kopp PA, Bianco AC, Jonklaas J. Patient Context and Thyrotropin Levels Are Important When Considering Treatment of Subclinical Hypothyroidism. Thyroid. 2019 10; 29(10):1359-1363. PMID: 31489828.
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    54. Taylor P, Bianco AC. Urgent need for further research in subclinical hypothyroidism. Nat Rev Endocrinol. 2019 09; 15(9):503-504. PMID: 31300726.
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    55. Idrees T, Price JD, Piccariello T, Bianco AC. Sustained Release T3 Therapy: Animal Models and Translational Applications. Front Endocrinol (Lausanne). 2019; 10:544. PMID: 31456749.
      View in: PubMed
    56. Bianco AC, Dumitrescu A, Gereben B, Ribeiro MO, Fonseca TL, Fernandes GW, Bocco BMLC. Paradigms of Dynamic Control of Thyroid Hormone Signaling. Endocr Rev. 2019 08 01; 40(4):1000-1047. PMID: 31033998.
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    57. McAninch EA, Bianco AC. The Swinging Pendulum in Treatment for Hypothyroidism: From (and Toward?) Combination Therapy. Front Endocrinol (Lausanne). 2019; 10:446. PMID: 31354624.
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    58. Fonseca TL, Fernandes GW, Bocco BMLC, Keshavarzian A, Jakate S, Donohue TM, Gereben B, Bianco AC. Hepatic Inactivation of the Type 2 Deiodinase Confers Resistance to Alcoholic Liver Steatosis. Alcohol Clin Exp Res. 2019 07; 43(7):1376-1383. PMID: 30908637.
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    59. Genovese C, Picerno IAM, Trimarchi G, Cannav? G, Egitto G, Cosenza B, Merlina V, Icardi G, Panatto D, Amicizia D, Orsi A, Colosio C, Marsili C, Lari C, Palamara MAR, Vitale F, Casuccio A, Costantino C, Azara A, Castiglia P, Bianco A, Curr? A, Gabutti G, Stefanati A, Sandri F, Florescu C, Marranzano M, Giorgianni G, Fiore V, Platania A, Torre I, Cappuccio A, Guillari A, Fabiani L, Giuliani AR, Appetiti A, Fauci V, Squeri A, Ragusa R, Squeri R. Vaccination coverage in healthcare workers: a multicenter cross-sectional study in Italy. J Prev Med Hyg. 2019 Mar; 60(1):E12-E17. PMID: 31041405.
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    60. Jo S, Fonseca TL, Bocco BMLC, Fernandes GW, McAninch EA, Bolin AP, Da Concei??o RR, Werneck-de-Castro JP, Ignacio DL, Egri P, N?meth D, Fekete C, Bernardi MM, Leitch VD, Mannan NS, Curry KF, Butterfield NC, Bassett JHD, Williams GR, Gereben B, Ribeiro MO, Bianco AC. Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain. J Clin Invest. 2019 01 02; 129(1):230-245. PMID: 30352046.
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    61. Da Concei??o RR, Fernandes GW, Fonseca TL, Bocco BMLC, Bianco AC. Metal Coordinated Poly-Zinc-Liothyronine Provides Stable Circulating Triiodothyronine Levels in Hypothyroid Rats. Thyroid. 2018 11; 28(11):1425-1433. PMID: 30301431.
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    62. Bianco AC, Kim BS. Pathophysiological relevance of deiodinase polymorphism. Curr Opin Endocrinol Diabetes Obes. 2018 10; 25(5):341-346. PMID: 30063552.
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    63. Trohman RG, Sharma PS, McAninch EA, Bianco AC. Amiodarone and thyroid physiology, pathophysiology, diagnosis and management. Trends Cardiovasc Med. 2019 07; 29(5):285-295. PMID: 30309693.
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    64. McAninch EA, Rajan KB, Miller CH, Bianco AC. Systemic Thyroid Hormone Status During Levothyroxine Therapy In Hypothyroidism: A Systematic Review and Meta-Analysis. J Clin Endocrinol Metab. 2018 Aug 15. PMID: 30124904.
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    65. Nascimento BPP, Bocco BMLC, Fernandes GW, Fonseca TL, McAninch EA, Cardoso CV, Bondan EF, Nassif RJ, Cysneiros RM, Bianco AC, Ribeiro MO. Induction of Type 2 Iodothyronine Deiodinase After Status Epilepticus Modifies Hippocampal Gene Expression in Male Mice. Endocrinology. 2018 08 01; 159(8):3090-3104. PMID: 29905787.
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    66. McAninch EA, Glueck JS, Bianco AC. Does Sex Bias Play a Role for Dissatisfied Patients With Hypothyroidism? J Endocr Soc. 2018 Aug 01; 2(8):970-973. PMID: 30094410.
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    67. Sirico F, Bianco A, D'Alicandro G, Castaldo C, Montagnani S, Spera R, Di Meglio F, Nurzynska D. Effects of Physical Exercise on Adiponectin, Leptin, and Inflammatory Markers in Childhood Obesity: Systematic Review and Meta-Analysis. Child Obes. 2018 May/Jun; 14(4):207-217. PMID: 29762052.
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    68. McAninch EA, Rajan KB, Evans DA, Jo S, Chaker L, Peeters RP, Bennett DA, Mash DC, Bianco AC. A Common DIO2 Polymorphism and Alzheimer Disease Dementia in African and European Americans. J Clin Endocrinol Metab. 2018 05 01; 103(5):1818-1826. PMID: 29481662.
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    69. Peterson SJ, Cappola AR, Castro MR, Dayan CM, Farwell AP, Hennessey JV, Kopp PA, Ross DS, Samuels MH, Sawka AM, Taylor PN, Jonklaas J, Bianco AC. An Online Survey of Hypothyroid Patients Demonstrates Prominent Dissatisfaction. Thyroid. 2018 06; 28(6):707-721. PMID: 29620972.
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    70. Moh?csik P, Erd?lyi F, Baranyi M, Botz B, Szab? G, T?th M, Haltrich I, Helyes Z, Sperl?gh B, T?th Z, Sink? R, Lechan RM, Bianco AC, Fekete C, Gereben B. A Transgenic Mouse Model for Detection of Tissue-Specific Thyroid Hormone Action. Endocrinology. 2018 02 01; 159(2):1159-1171. PMID: 29253128.
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    71. Fernandes GW, Bocco BMLC, Fonseca TL, McAninch EA, Jo S, Lartey LJ, O-Sullivan I, Unterman TG, Preite NZ, Voigt RM, Forsyth CB, Keshavarzian A, Sink? R, Goldfine AB, Patti ME, Ribeiro MO, Gereben B, Bianco AC. The Foxo1-Inducible Transcriptional Repressor Zfp125 Causes Hepatic Steatosis and Hypercholesterolemia. Cell Rep. 2018 01 09; 22(2):523-534. PMID: 29320745.
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    72. Chaker L, Bianco AC, Jonklaas J, Peeters RP. Hypothyroidism and hypertension: fact or myth? - Authors' reply. Lancet. 2018 01 06; 391(10115):30. PMID: 29323655.
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    73. Bianco AC, da Concei??o RR. The Deiodinase Trio and Thyroid Hormone Signaling. Methods Mol Biol. 2018; 1801:67-83. PMID: 29892818.
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    74. Yu G, Tzouvelekis A, Wang R, Herazo-Maya JD, Ibarra GH, Srivastava A, de Castro JPW, DeIuliis G, Ahangari F, Woolard T, Aurelien N, Arrojo E Drigo R, Gan Y, Graham M, Liu X, Homer RJ, Scanlan TS, Mannam P, Lee PJ, Herzog EL, Bianco AC, Kaminski N. Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function. Nat Med. 2018 01; 24(1):39-49. PMID: 29200204.
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    75. de Blasio F, Santaniello MG, de Blasio F, Mazzarella G, Bianco A, Lionetti L, Franssen FME, Scalfi L. Raw BIA variables are predictors of muscle strength in patients with chronic obstructive pulmonary disease. Eur J Clin Nutr. 2017 11; 71(11):1336-1340. PMID: 28901331.
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    76. Del Prete M, Di Sarno A, Modica R, Lassandro F, Giorgio A, Bianco A, Muto M, Gasperi M, Del Prete F, Colao A, Montesarchio V, Faggiano A. Role of contrast-enhanced ultrasound to define prognosis and predict response to biotherapy in pancreatic neuroendocrine tumors. J Endocrinol Invest. 2017 Dec; 40(12):1373-1380. PMID: 28667452.
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    77. Paolino BS, Pomerantzeff PM, Dallan LAO, Gaiotto FA, Preite NZ, Latr?nico AC, Nicolau JC, Bianco AC, Giraldez RRCV. Myocardial Inactivation of Thyroid Hormones in Patients with Aortic Stenosis. Thyroid. 2017 05; 27(5):738-745. PMID: 28095748.
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    78. Chaker L, Bianco AC, Jonklaas J, Peeters RP. Hypothyroidism. Lancet. 2017 Sep 23; 390(10101):1550-1562. PMID: 28336049.
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    79. Ignacio DL, Silvestre DH, Anne-Palmer E, Bocco BM, Fonseca TL, Ribeiro MO, Gereben B, Bianco AC, Werneck-de-Castro JP. Early Developmental Disruption of Type 2 Deiodinase Pathway in Mouse Skeletal Muscle Does Not Impair Muscle Function. Thyroid. 2017 04; 27(4):577-586. PMID: 27967605.
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    80. Peterson SJ, McAninch EA, Bianco AC. Is a Normal TSH Synonymous With "Euthyroidism" in Levothyroxine Monotherapy? J Clin Endocrinol Metab. 2016 12; 101(12):4964-4973. PMID: 27700539.
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    81. Preite NZ, Nascimento BP, Muller CR, Am?rico AL, Higa TS, Evangelista FS, Lancellotti CL, Henriques FS, Batista ML, Bianco AC, Ribeiro MO. Disruption of beta3 adrenergic receptor increases susceptibility to DIO in mouse. J Endocrinol. 2016 12; 231(3):259-269. PMID: 27672060.
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    82. Rajan KB, Arvanitakis Z, Lynch EB, McAninch EA, Wilson RS, Weuve J, Barnes LL, Bianco AC, Evans DA. Cognitive decline following incident and preexisting diabetes mellitus in a population sample. Neurology. 2016 Oct 18; 87(16):1681-1687. PMID: 27655734.
      View in: PubMed
    83. Lowe K, Bianco AC, Canar J, Kasdorf K, Mantei B, Smith BT. The Relationship Between Work Relative Value Unit Awareness and Work Relative Value Unit Accumulation Among Physicians. J Med Pract Manage. 2016 09; 32(2):86-91. PMID: 29944795.
      View in: PubMed
    84. Bocco BM, Louzada RA, Silvestre DH, Santos MC, Anne-Palmer E, Rangel IF, Abdalla S, Ferreira AC, Ribeiro MO, Gereben B, Carvalho DP, Bianco AC, Werneck-de-Castro JP. Thyroid hormone activation by type?2 deiodinase mediates exercise-induced peroxisome proliferator-activated receptor-? coactivator-1a expression in skeletal muscle. J Physiol. 2016 09 15; 594(18):5255-69. PMID: 27302464.
      View in: PubMed
    85. Bocco BM, Werneck-de-Castro JP, Oliveira KC, Fernandes GW, Fonseca TL, Nascimento BP, McAninch EA, Ricci E, Kv?rta-Papp Z, Fekete C, Bernardi MM, Gereben B, Bianco AC, Ribeiro MO. Type 2 Deiodinase Disruption in Astrocytes Results in Anxiety-Depressive-Like Behavior in Male Mice. Endocrinology. 2016 09; 157(9):3682-95. PMID: 27501182.
      View in: PubMed
    86. Abboud CS, de Souza EE, Zandonadi EC, Borges LS, Miglioli L, Monaco FC, Barbosa VL, Cortez D, Bianco AC, Braz A, Monteiro J. Carbapenem-resistant Enterobacteriaceae on a cardiac surgery intensive care unit: successful measures for infection control. J Hosp Infect. 2016 Sep; 94(1):60-4. PMID: 27451040.
      View in: PubMed
    87. Bocco BM, Fernandes GW, Lorena FB, Cysneiros RM, Christoffolete MA, Grecco SS, Lancellotti CL, Romoff P, Lago JH, Bianco AC, Ribeiro MO. Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice. Braz J Med Biol Res. 2016 Mar; 49(3). PMID: 26840707.
      View in: PubMed
    88. McAninch EA, Bianco AC. The History and Future of Treatment of Hypothyroidism. Ann Intern Med. 2016 Jan 05; 164(1):50-6. PMID: 26747302.
      View in: PubMed
    89. McAninch EA, Bianco AC. Of rats and men: thyroid homeostasis in rodents and human beings - Authors' reply. Lancet Diabetes Endocrinol. 2015 Dec; 3(12):933. PMID: 26590685.
      View in: PubMed
    90. Leone V, Langella C, Esposito F, De Martino M, Decaussin-Petrucci M, Chiappetta G, Bianco A, Fusco A. miR-130b-3p Upregulation Contributes to the Development of Thyroid Adenomas Targeting CCDC6 Gene. Eur Thyroid J. 2015 Dec; 4(4):213-21. PMID: 26835423.
      View in: PubMed
    91. Fonseca TL, Fernandes GW, McAninch EA, Bocco BM, Abdalla SM, Ribeiro MO, Moh?csik P, Fekete C, Li D, Xing X, Wang T, Gereben B, Bianco AC. Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity. Proc Natl Acad Sci U S A. 2015 Nov 10; 112(45):14018-23. PMID: 26508642.
      View in: PubMed
    92. Lartey LJ, Werneck-de-Castro JP, O-Sullivan I, Unterman TG, Bianco AC. Coupling between Nutrient Availability and Thyroid Hormone Activation. J Biol Chem. 2015 Dec 18; 290(51):30551-61. PMID: 26499800.
      View in: PubMed
    93. Gereben B, McAninch EA, Ribeiro MO, Bianco AC. Scope and limitations of iodothyronine deiodinases in hypothyroidism. Nat Rev Endocrinol. 2015 Nov; 11(11):642-652. PMID: 26416219.
      View in: PubMed
    94. McAninch EA, Bianco AC. New insights into the variable effectiveness of levothyroxine monotherapy for hypothyroidism. Lancet Diabetes Endocrinol. 2015 Oct; 3(10):756-8. PMID: 26362364.
      View in: PubMed
    95. Werneck-de-Castro JP, Fonseca TL, Ignacio DL, Fernandes GW, Andrade-Feraud CM, Lartey LJ, Ribeiro MB, Ribeiro MO, Gereben B, Bianco AC. Thyroid Hormone Signaling in Male Mouse Skeletal Muscle Is Largely Independent of D2 in Myocytes. Endocrinology. 2015 Oct; 156(10):3842-52. PMID: 26214036.
      View in: PubMed
    96. Fliers E, Bianco AC, Langouche L, Boelen A. Thyroid function in critically ill patients. Lancet Diabetes Endocrinol. 2015 Oct; 3(10):816-25. PMID: 26071885.
      View in: PubMed
    97. Roberts SC, Bianco AC, Stapleton HM. Disruption of type 2 iodothyronine deiodinase activity in cultured human glial cells by polybrominated diphenyl ethers. Chem Res Toxicol. 2015 Jun 15; 28(6):1265-74. PMID: 26004626.
      View in: PubMed
    98. McAninch EA, Fonseca TL, Poggioli R, Panos AL, Salerno TA, Deng Y, Li Y, Bianco AC, Iacobellis G. Epicardial adipose tissue has a unique transcriptome modified in severe coronary artery disease. Obesity (Silver Spring). 2015 Jun; 23(6):1267-78. PMID: 25959145.
      View in: PubMed
    99. Cacciola NA, Calabrese C, Malapelle U, Pellino G, De Stefano A, Sepe R, Sgariglia R, Quintavalle C, Federico A, Bianco A, Uchimura Bastos A, Milone M, Bellevicine C, Milone F, Carlomagno C, Selvaggi F, Troncone G, Fusco A, Pallante P. UbcH10 expression can predict prognosis and sensitivity to the antineoplastic treatment for colorectal cancer patients. Mol Carcinog. 2016 May; 55(5):793-807. PMID: 25917796.
      View in: PubMed
    100. Cao Y, Gomes SA, Rangel EB, Paulino EC, Fonseca TL, Li J, Teixeira MB, Gouveia CH, Bianco AC, Kapiloff MS, Balkan W, Hare JM. S-nitrosoglutathione reductase-dependent PPAR? denitrosylation participates in MSC-derived adipogenesis and osteogenesis. J Clin Invest. 2015 Apr; 125(4):1679-91. PMID: 25798618.
      View in: PubMed
    101. McAninch EA, Jo S, Preite NZ, Farkas E, Moh?csik P, Fekete C, Egri P, Gereben B, Li Y, Deng Y, Patti ME, Zevenbergen C, Peeters RP, Mash DC, Bianco AC. Prevalent polymorphism in thyroid hormone-activating enzyme leaves a genetic fingerprint that underlies associated clinical syndromes. J Clin Endocrinol Metab. 2015 Mar; 100(3):920-33. PMID: 25569702.
      View in: PubMed
    102. Werneck de Castro JP, Fonseca TL, Ueta CB, McAninch EA, Abdalla S, Wittmann G, Lechan RM, Gereben B, Bianco AC. Differences in hypothalamic type 2 deiodinase ubiquitination explain localized sensitivity to thyroxine. J Clin Invest. 2015 Feb; 125(2):769-81. PMID: 25555216.
      View in: PubMed
    103. Jonklaas J, Bianco AC, Bauer AJ, Burman KD, Cappola AR, Celi FS, Cooper DS, Kim BW, Peeters RP, Rosenthal MS, Sawka AM. Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task force on thyroid hormone replacement. Thyroid. 2014 Dec; 24(12):1670-751. PMID: 25266247.
      View in: PubMed
    104. Abdalla SM, Bianco AC. Defending plasma T3 is a biological priority. Clin Endocrinol (Oxf). 2014 Nov; 81(5):633-41. PMID: 25040645.
      View in: PubMed
    105. Medina MC, Fonesca TL, Molina J, Fachado A, Castillo M, Dong L, Soares R, Hern?ndez A, Caicedo A, Bianco AC. Maternal inheritance of an inactive type III deiodinase gene allele affects mouse pancreatic ?-cells and disrupts glucose homeostasis. Endocrinology. 2014 Aug; 155(8):3160-71. PMID: 24885572.
      View in: PubMed
    106. Fernandes GW, Ueta CB, Fonseca TL, Gouveia CH, Lancellotti CL, Brum PC, Christoffolete MA, Bianco AC, Ribeiro MO. Inactivation of the adrenergic receptor ?2 disrupts glucose homeostasis in mice. J Endocrinol. 2014 Jun; 221(3):381-90. PMID: 24868110.
      View in: PubMed
    107. McAninch EA, Bianco AC. Thyroid hormone signaling in energy homeostasis and energy metabolism. Ann N Y Acad Sci. 2014 Apr; 1311:77-87. PMID: 24697152.
      View in: PubMed
    108. Leiva AG, Chen AL, Devarajan P, Chen Z, Damanpour S, Hall JA, Bianco AC, Li J, Badiavas EV, Zaias J, Miteva M, Romanelli P, Nouri K, Cao Wikramanayake T. Loss of Mpzl3 function causes various skin abnormalities and greatly reduced adipose depots. J Invest Dermatol. 2014 Jul; 134(7):1817-1827. PMID: 24531688.
      View in: PubMed
    109. Fonseca TL, Werneck-De-Castro JP, Castillo M, Bocco BM, Fernandes GW, McAninch EA, Ignacio DL, Moises CC, Ferreira AR, Ferreira A, Gereben B, Bianco AC. Tissue-specific inactivation of type 2 deiodinase reveals multilevel control of fatty acid oxidation by thyroid hormone in the mouse. Diabetes. 2014 May; 63(5):1594-604. PMID: 24487027.
      View in: PubMed
    110. Bianco AC, Anderson G, Forrest D, Galton VA, Gereben B, Kim BW, Kopp PA, Liao XH, Obregon MJ, Peeters RP, Refetoff S, Sharlin DS, Simonides WS, Weiss RE, Williams GR. American Thyroid Association Guide to investigating thyroid hormone economy and action in rodent and cell models. Thyroid. 2014 Jan; 24(1):88-168. PMID: 24001133.
      View in: PubMed
    111. Arrojo E Drigo R, Egri P, Jo S, Gereben B, Bianco AC. The type II deiodinase is retrotranslocated to the cytoplasm and proteasomes via p97/Atx3 complex. Mol Endocrinol. 2013 Dec; 27(12):2105-15. PMID: 24196352.
      View in: PubMed
    112. Vose LR, Vinukonda G, Jo S, Miry O, Diamond D, Korumilli R, Arshad A, Zia MT, Hu F, Kayton RJ, La Gamma EF, Bansal R, Bianco AC, Ballabh P. Treatment with thyroxine restores myelination and clinical recovery after intraventricular hemorrhage. J Neurosci. 2013 Oct 30; 33(44):17232-46. PMID: 24174657.
      View in: PubMed
    113. Bianco AC, McAninch EA. The role of thyroid hormone and brown adipose tissue in energy homoeostasis. Lancet Diabetes Endocrinol. 2013 Nov; 1(3):250-8. PMID: 24622373.
      View in: PubMed
    114. Poggioli R, Ueta CB, Drigo RA, Castillo M, Fonseca TL, Bianco AC. Dexamethasone reduces energy expenditure and increases susceptibility to diet-induced obesity in mice. Obesity (Silver Spring). 2013 Sep; 21(9):E415-20. PMID: 23408649.
      View in: PubMed
    115. Hong EG, Kim BW, Jung DY, Kim JH, Yu T, Seixas Da Silva W, Friedline RH, Bianco SD, Seslar SP, Wakimoto H, Berul CI, Russell KS, Lee KW, Larsen PR, Bianco AC, Kim JK. Cardiac expression of human type 2 iodothyronine deiodinase increases glucose metabolism and protects against doxorubicin-induced cardiac dysfunction in male mice. Endocrinology. 2013 Oct; 154(10):3937-46. PMID: 23861374.
      View in: PubMed
    116. Sampaio MC, M?ximo CA, Montenegro CM, Mota DM, Fernandes TR, Bianco AC, Amodeo C, Cordeiro AC. Comparison of diagnostic criteria for acute kidney injury in cardiac surgery. Arq Bras Cardiol. 2013 Jul; 101(1):18-25. PMID: 23752340.
      View in: PubMed
    117. Jonklaas J, Burman KD, Bianco AC. Treatment of hypothyroidism: possibilities on the horizon. Thyroid. 2013 Apr; 23(4):ix-xi. PMID: 23521210.
      View in: PubMed
    118. Fonseca TL, Correa-Medina M, Campos MP, Wittmann G, Werneck-de-Castro JP, Arrojo e Drigo R, Mora-Garzon M, Ueta CB, Caicedo A, Fekete C, Gereben B, Lechan RM, Bianco AC. Coordination of hypothalamic and pituitary T3 production regulates TSH expression. J Clin Invest. 2013 Apr; 123(4):1492-500. PMID: 23524969.
      View in: PubMed
    119. Bianco AC. Cracking the code for thyroid hormone signaling. Trans Am Clin Climatol Assoc. 2013; 124:26-35. PMID: 23874007.
      View in: PubMed
    120. Quintavalle C, Fiore D, De Micco F, Visconti G, Focaccio A, Golia B, Ricciardelli B, Donnarumma E, Bianco A, Zabatta MA, Troncone G, Colombo A, Briguori C, Condorelli G. Impact of a high loading dose of atorvastatin on contrast-induced acute kidney injury. Circulation. 2012 Dec 18; 126(25):3008-16. PMID: 23147173.
      View in: PubMed
    121. Arrojo E Drigo R, Fonseca TL, Werneck-de-Castro JP, Bianco AC. Role of the type 2 iodothyronine deiodinase (D2) in the control of thyroid hormone signaling. Biochim Biophys Acta. 2013 Jul; 1830(7):3956-64. PMID: 22967761.
      View in: PubMed
    122. Bianco AC, Casula S. Thyroid hormone replacement therapy: three 'simple' questions, complex answers. Eur Thyroid J. 2012 Jul; 1(2):88-98. PMID: 24783002.
      View in: PubMed
    123. Ueta CB, Fernandes GW, Capelo LP, Fonseca TL, Maculan FD, Gouveia CH, Brum PC, Christoffolete MA, Aoki MS, Lancellotti CL, Kim B, Bianco AC, Ribeiro MO. ?(1) Adrenergic receptor is key to cold- and diet-induced thermogenesis in mice. J Endocrinol. 2012 Sep; 214(3):359-65. PMID: 22728333.
      View in: PubMed
    124. Jo S, Kall? I, Bard?czi Z, Arrojo e Drigo R, Ze?ld A, Liposits Z, Oliva A, Lemmon VP, Bixby JL, Gereben B, Bianco AC. Neuronal hypoxia induces Hsp40-mediated nuclear import of type 3 deiodinase as an adaptive mechanism to reduce cellular metabolism. J Neurosci. 2012 Jun 20; 32(25):8491-500. PMID: 22723689.
      View in: PubMed
    125. Kall? I, Moh?csik P, Vida B, Ze?ld A, Bard?czi Z, Zavacki AM, Farkas E, K?d?r A, Hrabovszky E, Arrojo E Drigo R, Dong L, Barna L, Palkovits M, Borsay BA, Herczeg L, Lechan RM, Bianco AC, Liposits Z, Fekete C, Gereben B. A novel pathway regulates thyroid hormone availability in rat and human hypothalamic neurosecretory neurons. PLoS One. 2012; 7(6):e37860. PMID: 22719854.
      View in: PubMed
    126. Casula S, Bianco AC. Thyroid hormone deiodinases and cancer. Front Endocrinol (Lausanne). 2012; 3:74. PMID: 22675319.
      View in: PubMed
    127. Ueta CB, Oskouei BN, Olivares EL, Pinto JR, Correa MM, Simovic G, Simonides WS, Hare JM, Bianco AC. Absence of myocardial thyroid hormone inactivating deiodinase results in restrictive cardiomyopathy in mice. Mol Endocrinol. 2012 May; 26(5):809-18. PMID: 22403173.
      View in: PubMed
    128. Arrojo E Drigo R, Fonseca TL, Castillo M, Salathe M, Simovic G, Moh?csik P, Gereben B, Bianco AC. Endoplasmic reticulum stress decreases intracellular thyroid hormone activation via an eIF2a-mediated decrease in type 2 deiodinase synthesis. Mol Endocrinol. 2011 Dec; 25(12):2065-75. PMID: 22053000.
      View in: PubMed
    129. Colucci A, Bianco A, Pomara F, Petrucci M, Grosso F, De Vita A, Adamo V, Palma A. Disease management of type 2 diabetes: a follow-up analysis in a sanitary district of Sicily. Minerva Gastroenterol Dietol. 2011 Sep; 57(3):241-6. PMID: 21769074.
      View in: PubMed
    130. Moh?csik P, Ze?ld A, Bianco AC, Gereben B. Thyroid hormone and the neuroglia: both source and target. J Thyroid Res. 2011; 2011:215718. PMID: 21876836.
      View in: PubMed
    131. Iacobellis G, Bianco AC. Epicardial adipose tissue: emerging physiological, pathophysiological and clinical features. Trends Endocrinol Metab. 2011 Nov; 22(11):450-7. PMID: 21852149.
      View in: PubMed
    132. Medina MC, Molina J, Gadea Y, Fachado A, Murillo M, Simovic G, Pileggi A, Hern?ndez A, Edlund H, Bianco AC. The thyroid hormone-inactivating type III deiodinase is expressed in mouse and human beta-cells and its targeted inactivation impairs insulin secretion. Endocrinology. 2011 Oct; 152(10):3717-27. PMID: 21828183.
      View in: PubMed
    133. Ueta CB, Olivares EL, Bianco AC. Responsiveness to thyroid hormone and to ambient temperature underlies differences between brown adipose tissue and skeletal muscle thermogenesis in a mouse model of diet-induced obesity. Endocrinology. 2011 Sep; 152(9):3571-81. PMID: 21771890.
      View in: PubMed
    134. Bianco AC. Minireview: cracking the metabolic code for thyroid hormone signaling. Endocrinology. 2011 Sep; 152(9):3306-11. PMID: 21712363.
      View in: PubMed
    135. Arrojo E Drigo R, Bianco AC. Type 2 deiodinase at the crossroads of thyroid hormone action. Int J Biochem Cell Biol. 2011 Oct; 43(10):1432-41. PMID: 21679772.
      View in: PubMed
    136. Quintavalle C, Brenca M, De Micco F, Fiore D, Romano S, Romano MF, Apone F, Bianco A, Zabatta MA, Troncone G, Briguori C, Condorelli G. In vivo and in vitro assessment of pathways involved in contrast media-induced renal cells apoptosis. Cell Death Dis. 2011 May 12; 2:e155. PMID: 21562587.
      View in: PubMed
    137. Flato UA, Buhatem T, Merluzzi T, Bianco AC. New anticoagulants in critical care settings. Rev Bras Ter Intensiva. 2011 Mar; 23(1):68-77. PMID: 25299557.
      View in: PubMed
    138. Ribeiro MO, Bianco AC. Crossing the hurdles of thyroid hormone receptor-a activation. Endocrinology. 2011 Mar; 152(3):745-7. PMID: 21339380.
      View in: PubMed
    139. Castillo M, Hall JA, Correa-Medina M, Ueta C, Kang HW, Cohen DE, Bianco AC. Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality. Diabetes. 2011 Apr; 60(4):1082-9. PMID: 21335378.
      View in: PubMed
    140. da-Silva WS, Ribich S, Arrojo e Drigo R, Castillo M, Patti ME, Bianco AC. The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure. FEBS Lett. 2011 Feb 04; 585(3):539-44. PMID: 21237159.
      View in: PubMed
    141. Rosene ML, Wittmann G, Arrojo e Drigo R, Singru PS, Lechan RM, Bianco AC. Inhibition of the type 2 iodothyronine deiodinase underlies the elevated plasma TSH associated with amiodarone treatment. Endocrinology. 2010 Dec; 151(12):5961-70. PMID: 20926587.
      View in: PubMed
    142. Hall JA, Ribich S, Christoffolete MA, Simovic G, Correa-Medina M, Patti ME, Bianco AC. Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis. Endocrinology. 2010 Sep; 151(9):4573-82. PMID: 20660060.
      View in: PubMed
    143. Yoon JC, Ng A, Kim BH, Bianco A, Xavier RJ, Elledge SJ. Wnt signaling regulates mitochondrial physiology and insulin sensitivity. Genes Dev. 2010 Jul 15; 24(14):1507-18. PMID: 20634317.
      View in: PubMed
    144. Acosta BM, Bianco AC. New insights into thyroid hormone replacement therapy. F1000 Med Rep. 2010 May 11; 2. PMID: 20948851.
      View in: PubMed
    145. Freitas BC, Gereben B, Castillo M, Kall? I, Ze?ld A, Egri P, Liposits Z, Zavacki AM, Maciel RM, Jo S, Singru P, Sanchez E, Lechan RM, Bianco AC. Paracrine signaling by glial cell-derived triiodothyronine activates neuronal gene expression in the rodent brain and human cells. J Clin Invest. 2010 Jun; 120(6):2206-17. PMID: 20458138.
      View in: PubMed
    146. Castillo M, Freitas BC, Rosene ML, Drigo RA, Grozovsky R, Maciel RM, Patti ME, Ribeiro MO, Bianco AC. Impaired metabolic effects of a thyroid hormone receptor beta-selective agonist in a mouse model of diet-induced obesity. Thyroid. 2010 May; 20(5):545-53. PMID: 20406106.
      View in: PubMed
    147. Christoffolete MA, Doleschall M, Egri P, Liposits Z, Zavacki AM, Bianco AC, Gereben B. Regulation of thyroid hormone activation via the liver X-receptor/retinoid X-receptor pathway. J Endocrinol. 2010 May; 205(2):179-86. PMID: 20176747.
      View in: PubMed
    148. Ribeiro MO, Bianco SD, Kaneshige M, Schultz JJ, Cheng SY, Bianco AC, Brent GA. Expression of uncoupling protein 1 in mouse brown adipose tissue is thyroid hormone receptor-beta isoform specific and required for adaptive thermogenesis. Endocrinology. 2010 Jan; 151(1):432-40. PMID: 19906816.
      View in: PubMed
    149. Gereben B, Bianco AC. Covering the base-pairs in iodothyronine deiodinase-1 biology: holes remain in the lineup. Thyroid. 2009 Oct; 19(10):1027-9. PMID: 19803788.
      View in: PubMed
    150. Amorim BS, Ueta CB, Freitas BC, Nassif RJ, Gouveia CH, Christoffolete MA, Moriscot AS, Lancelloti CL, Llimona F, Barbeiro HV, de Souza HP, Catanozi S, Passarelli M, Aoki MS, Bianco AC, Ribeiro MO. A TRbeta-selective agonist confers resistance to diet-induced obesity. J Endocrinol. 2009 Nov; 203(2):291-9. PMID: 19713219.
      View in: PubMed
    151. Zavacki AM, Arrojo E Drigo R, Freitas BC, Chung M, Harney JW, Egri P, Wittmann G, Fekete C, Gereben B, Bianco AC. The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase. Mol Cell Biol. 2009 Oct; 29(19):5339-47. PMID: 19651899.
      View in: PubMed
    152. Pihlajam?ki J, Boes T, Kim EY, Dearie F, Kim BW, Schroeder J, Mun E, Nasser I, Park PJ, Bianco AC, Goldfine AB, Patti ME. Thyroid hormone-related regulation of gene expression in human fatty liver. J Clin Endocrinol Metab. 2009 Sep; 94(9):3521-9. PMID: 19549744.
      View in: PubMed
    153. Kang HW, Ribich S, Kim BW, Hagen SJ, Bianco AC, Cohen DE. Mice lacking Pctp /StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue. J Lipid Res. 2009 Nov; 50(11):2212-21. PMID: 19502644.
      View in: PubMed
    154. Hall JA, Bianco AC. Triumphs of the thyroid despite lesser conversion. Endocrinology. 2009 Jun; 150(6):2502-4. PMID: 19458245.
      View in: PubMed
    155. Kim BW, Bianco AC. For some, L-thyroxine replacement might not be enough: a genetic rationale. J Clin Endocrinol Metab. 2009 May; 94(5):1521-3. PMID: 19420275.
      View in: PubMed
    156. Patti ME, Houten SM, Bianco AC, Bernier R, Larsen PR, Holst JJ, Badman MK, Maratos-Flier E, Mun EC, Pihlajamaki J, Auwerx J, Goldfine AB. Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism. Obesity (Silver Spring). 2009 Sep; 17(9):1671-7. PMID: 19360006.
      View in: PubMed
    157. Streijger F, Pluk H, Oerlemans F, Beckers G, Bianco AC, Ribeiro MO, Wieringa B, Van der Zee CE. Mice lacking brain-type creatine kinase activity show defective thermoregulation. Physiol Behav. 2009 Apr 20; 97(1):76-86. PMID: 19419668.
      View in: PubMed
    158. Grozovsky R, Ribich S, Rosene ML, Mulcahey MA, Huang SA, Patti ME, Bianco AC, Kim BW. Type 2 deiodinase expression is induced by peroxisomal proliferator-activated receptor-gamma agonists in skeletal myocytes. Endocrinology. 2009 Apr; 150(4):1976-83. PMID: 19036883.
      View in: PubMed
    159. Gereben B, Zavacki AM, Ribich S, Kim BW, Huang SA, Simonides WS, Ze?ld A, Bianco AC. Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling. Endocr Rev. 2008 Dec; 29(7):898-938. PMID: 18815314.
      View in: PubMed
    160. Capelo LP, Beber EH, Huang SA, Zorn TM, Bianco AC, Gouveia CH. Deiodinase-mediated thyroid hormone inactivation minimizes thyroid hormone signaling in the early development of fetal skeleton. Bone. 2008 Nov; 43(5):921-30. PMID: 18682303.
      View in: PubMed
    161. S?nchez E, Singru PS, Acharya R, Bodria M, Fekete C, Zavacki AM, Bianco AC, Lechan RM. Differential effects of refeeding on melanocortin-responsive neurons in the hypothalamic paraventricular nucleus. Endocrinology. 2008 Sep; 149(9):4329-35. PMID: 18467436.
      View in: PubMed
    162. Sagar GD, Gereben B, Callebaut I, Mornon JP, Ze?ld A, Curcio-Morelli C, Harney JW, Luongo C, Mulcahey MA, Larsen PR, Huang SA, Bianco AC. The thyroid hormone-inactivating deiodinase functions as a homodimer. Mol Endocrinol. 2008 Jun; 22(6):1382-93. PMID: 18356288.
      View in: PubMed
    163. Simonides WS, Mulcahey MA, Redout EM, Muller A, Zuidwijk MJ, Visser TJ, Wassen FW, Crescenzi A, da-Silva WS, Harney J, Engel FB, Obregon MJ, Larsen PR, Bianco AC, Huang SA. Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats. J Clin Invest. 2008 Mar; 118(3):975-83. PMID: 18259611.
      View in: PubMed
    164. Gereben B, Ze?ld A, Dentice M, Salvatore D, Bianco AC. Activation and inactivation of thyroid hormone by deiodinases: local action with general consequences. Cell Mol Life Sci. 2008 Feb; 65(4):570-90. PMID: 17989921.
      View in: PubMed
    165. Bianco AC. Metabolic effects of thyroid hormones-beyond traditional prospects. Thyroid. 2008 Feb; 18(2):99-100. PMID: 18279009.
      View in: PubMed
    166. Huang SA, Bianco AC. Reawakened interest in type III iodothyronine deiodinase in critical illness and injury. Nat Clin Pract Endocrinol Metab. 2008 Mar; 4(3):148-55. PMID: 18212764.
      View in: PubMed
    167. Adams BA, Gray SL, Isaac ER, Bianco AC, Vidal-Puig AJ, Sherwood NM. Feeding and metabolism in mice lacking pituitary adenylate cyclase-activating polypeptide. Endocrinology. 2008 Apr; 149(4):1571-80. PMID: 18162530.
      View in: PubMed
    168. Dentice M, Luongo C, Huang S, Ambrosio R, Elefante A, Mirebeau-Prunier D, Zavacki AM, Fenzi G, Grachtchouk M, Hutchin M, Dlugosz AA, Bianco AC, Missero C, Larsen PR, Salvatore D. Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes. Proc Natl Acad Sci U S A. 2007 Sep 04; 104(36):14466-71. PMID: 17720805.
      View in: PubMed
    169. Piantedosi FV, Caputo F, Mazzarella G, Gilli M, Pontillo A, D'Agostino D, Campbell S, Marsico SA, Bianco A. Gemcitabine, ifosfamide and paclitaxel in advanced/metastatic non-small cell lung cancer patients: a phase II study. Cancer Chemother Pharmacol. 2008 Apr; 61(5):803-7. PMID: 17639396.
      View in: PubMed
    170. Olivares EL, Marassi MP, Fortunato RS, da Silva AC, Costa-e-Sousa RH, Ara?jo IG, Mattos EC, Masuda MO, Mulcahey MA, Huang SA, Bianco AC, Carvalho DP. Thyroid function disturbance and type 3 iodothyronine deiodinase induction after myocardial infarction in rats a time course study. Endocrinology. 2007 Oct; 148(10):4786-92. PMID: 17628010.
      View in: PubMed
    171. Fekete C, Freitas BC, Ze?ld A, Wittmann G, K?d?r A, Liposits Z, Christoffolete MA, Singru P, Lechan RM, Bianco AC, Gereben B. Expression patterns of WSB-1 and USP-33 underlie cell-specific posttranslational control of type 2 deiodinase in the rat brain. Endocrinology. 2007 Oct; 148(10):4865-74. PMID: 17628004.
      View in: PubMed
    172. Wajner SM, dos Santos Wagner M, Melo RC, Parreira GG, Chiarini-Garcia H, Bianco AC, Fekete C, Sanchez E, Lechan RM, Maia AL. Type 2 iodothyronine deiodinase is highly expressed in germ cells of adult rat testis. J Endocrinol. 2007 Jul; 194(1):47-54. PMID: 17592020.
      View in: PubMed
    173. Bianco AC, Ribich S, Kim BW. An inside job. Endocrinology. 2007 Jul; 148(7):3077-9. PMID: 17575061.
      View in: PubMed
    174. Sagar GD, Gereben B, Callebaut I, Mornon JP, Ze?ld A, da Silva WS, Luongo C, Dentice M, Tente SM, Freitas BC, Harney JW, Zavacki AM, Bianco AC. Ubiquitination-induced conformational change within the deiodinase dimer is a switch regulating enzyme activity. Mol Cell Biol. 2007 Jul; 27(13):4774-83. PMID: 17452445.
      View in: PubMed
    175. Crunkhorn S, Dearie F, Mantzoros C, Gami H, da Silva WS, Espinoza D, Faucette R, Barry K, Bianco AC, Patti ME. Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation. J Biol Chem. 2007 May 25; 282(21):15439-50. PMID: 17416903.
      View in: PubMed
    176. Villicev CM, Freitas FR, Aoki MS, Taffarel C, Scanlan TS, Moriscot AS, Ribeiro MO, Bianco AC, Gouveia CH. Thyroid hormone receptor beta-specific agonist GC-1 increases energy expenditure and prevents fat-mass accumulation in rats. J Endocrinol. 2007 Apr; 193(1):21-9. PMID: 17400799.
      View in: PubMed
    177. Souza SC, Christoffolete MA, Ribeiro MO, Miyoshi H, Strissel KJ, Stancheva ZS, Rogers NH, D'Eon TM, Perfield JW, Imachi H, Obin MS, Bianco AC, Greenberg AS. Perilipin regulates the thermogenic actions of norepinephrine in brown adipose tissue. J Lipid Res. 2007 Jun; 48(6):1273-9. PMID: 17401109.
      View in: PubMed
    178. da-Silva WS, Harney JW, Kim BW, Li J, Bianco SD, Crescenzi A, Christoffolete MA, Huang SA, Bianco AC. The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation. Diabetes. 2007 Mar; 56(3):767-76. PMID: 17327447.
      View in: PubMed
    179. Capparelli R, Alfano F, Amoroso MG, Borriello G, Fenizia D, Bianco A, Roperto S, Roperto F, Iannelli D. Protective effect of the Nramp1 BB genotype against Brucella abortus in the water buffalo (Bubalus bubalis). Infect Immun. 2007 Feb; 75(2):988-96. PMID: 17145946.
      View in: PubMed
    180. Christoffolete MA, Arrojo e Drigo R, Gazoni F, Tente SM, Goncalves V, Amorim BS, Larsen PR, Bianco AC, Zavacki AM. Mice with impaired extrathyroidal thyroxine to 3,5,3'-triiodothyronine conversion maintain normal serum 3,5,3'-triiodothyronine concentrations. Endocrinology. 2007 Mar; 148(3):954-60. PMID: 17138654.
      View in: PubMed
    181. Bianco AC, Kim BW. Deiodinases: implications of the local control of thyroid hormone action. J Clin Invest. 2006 Oct; 116(10):2571-9. PMID: 17016550.
      View in: PubMed
    182. Ze?ld A, Porm?ller L, Dentice M, Harney JW, Curcio-Morelli C, Tente SM, Bianco AC, Gereben B. Metabolic instability of type 2 deiodinase is transferable to stable proteins independently of subcellular localization. J Biol Chem. 2006 Oct 20; 281(42):31538-43. PMID: 16928685.
      View in: PubMed
    183. Ze?ld A, Doleschall M, Haffner MC, Capelo LP, Menyh?rt J, Liposits Z, da Silva WS, Bianco AC, Kacskovics I, Fekete C, Gereben B. Characterization of the nuclear factor-kappa B responsiveness of the human dio2 gene. Endocrinology. 2006 Sep; 147(9):4419-29. PMID: 16728495.
      View in: PubMed
    184. Miyoshi H, Souza SC, Zhang HH, Strissel KJ, Christoffolete MA, Kovsan J, Rudich A, Kraemer FB, Bianco AC, Obin MS, Greenberg AS. Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and -independent mechanisms. J Biol Chem. 2006 Jun 09; 281(23):15837-44. PMID: 16595669.
      View in: PubMed
    185. Galderisi M, Vitale G, Bianco A, Pivonello R, Lombardi G, Divitiis Od, Colao A. Pulsed tissue Doppler identifies subclinical myocardial biventricular dysfunction in active acromegaly. Clin Endocrinol (Oxf). 2006 Apr; 64(4):390-7. PMID: 16584510.
      View in: PubMed
    186. Watanabe M, Houten SM, Mataki C, Christoffolete MA, Kim BW, Sato H, Messaddeq N, Harney JW, Ezaki O, Kodama T, Schoonjans K, Bianco AC, Auwerx J. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature. 2006 Jan 26; 439(7075):484-9. PMID: 16400329.
      View in: PubMed
    187. Christoffolete MA, Ribeiro R, Singru P, Fekete C, da Silva WS, Gordon DF, Huang SA, Crescenzi A, Harney JW, Ridgway EC, Larsen PR, Lechan RM, Bianco AC. Atypical expression of type 2 iodothyronine deiodinase in thyrotrophs explains the thyroxine-mediated pituitary thyrotropin feedback mechanism. Endocrinology. 2006 Apr; 147(4):1735-43. PMID: 16396983.
      View in: PubMed
    188. Sharma V, Hays WR, Wood WM, Pugazhenthi U, St Germain DL, Bianco AC, Krezel W, Chambon P, Haugen BR. Effects of rexinoids on thyrotrope function and the hypothalamic-pituitary-thyroid axis. Endocrinology. 2006 Mar; 147(3):1438-51. PMID: 16306084.
      View in: PubMed
    189. Bianco AC, Timerman A, Paes AT, Gun C, Ramos RF, Freire RB, Vela CN, Fagundes Junior AA, Martins LC, Piegas LS. [Prospective risk analysis in patients submitted to myocardial revascularization surgery]. Arq Bras Cardiol. 2005 Oct; 85(4):254-61. PMID: 16283031.
      View in: PubMed
    190. Fekete C, Singru PS, Sanchez E, Sarkar S, Christoffolete MA, Riberio RS, Rand WM, Emerson CH, Bianco AC, Lechan RM. Differential effects of central leptin, insulin, or glucose administration during fasting on the hypothalamic-pituitary-thyroid axis and feeding-related neurons in the arcuate nucleus. Endocrinology. 2006 Jan; 147(1):520-9. PMID: 16210367.
      View in: PubMed
    191. Fekete C, Sarkar S, Christoffolete MA, Emerson CH, Bianco AC, Lechan RM. Bacterial lipopolysaccharide (LPS)-induced type 2 iodothyronine deiodinase (D2) activation in the mediobasal hypothalamus (MBH) is independent of the LPS-induced fall in serum thyroid hormone levels. Brain Res. 2005 Sep 14; 1056(1):97-9. PMID: 16095572.
      View in: PubMed
    192. Monte O, Zyngier S, Kimura ET, Bianco AC. [Dopaminergic and somatostatinergic pathways decrease serum thyrotropin in rats bearing the 256-Walker mammary carcinoma]. Arq Bras Endocrinol Metabol. 2005 Apr; 49(2):253-64. PMID: 16184254.
      View in: PubMed
    193. Bianco AC, Larsen PR. Cellular and structural biology of the deiodinases. Thyroid. 2005 Aug; 15(8):777-86. PMID: 16131321.
      View in: PubMed
    194. Dentice M, Bandyopadhyay A, Gereben B, Callebaut I, Christoffolete MA, Kim BW, Nissim S, Mornon JP, Zavacki AM, Ze?ld A, Capelo LP, Curcio-Morelli C, Ribeiro R, Harney JW, Tabin CJ, Bianco AC. The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate. Nat Cell Biol. 2005 Jul; 7(7):698-705. PMID: 15965468.
      View in: PubMed
    195. Bianco AC, Maia AL, da Silva WS, Christoffolete MA. Adaptive activation of thyroid hormone and energy expenditure. Biosci Rep. 2005 Jun-Aug; 25(3-4):191-208. PMID: 16283553.
      View in: PubMed
    196. Kalaany NY, Gauthier KC, Zavacki AM, Mammen PP, Kitazume T, Peterson JA, Horton JD, Garry DJ, Bianco AC, Mangelsdorf DJ. LXRs regulate the balance between fat storage and oxidation. Cell Metab. 2005 Apr; 1(4):231-44. PMID: 16054068.
      View in: PubMed
    197. Canani LH, Capp C, Dora JM, Meyer EL, Wagner MS, Harney JW, Larsen PR, Gross JL, Bianco AC, Maia AL. The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab. 2005 Jun; 90(6):3472-8. PMID: 15797963.
      View in: PubMed
    198. Zavacki AM, Ying H, Christoffolete MA, Aerts G, So E, Harney JW, Cheng SY, Larsen PR, Bianco AC. Type 1 iodothyronine deiodinase is a sensitive marker of peripheral thyroid status in the mouse. Endocrinology. 2005 Mar; 146(3):1568-75. PMID: 15591136.
      View in: PubMed
    199. Gouveia CH, Christoffolete MA, Zaitune CR, Dora JM, Harney JW, Maia AL, Bianco AC. Type 2 iodothyronine selenodeiodinase is expressed throughout the mouse skeleton and in the MC3T3-E1 mouse osteoblastic cell line during differentiation. Endocrinology. 2005 Jan; 146(1):195-200. PMID: 15471965.
      View in: PubMed
    200. Bianco AC. [Impact factor. The editor's report?]. Arq Bras Endocrinol Metabol. 2004 Jun; 48(3):335-6. PMID: 15640894.
      View in: PubMed
    201. Bianco AC. Triplets! Unexpected structural similarity among the three enzymes that catalyze initiation and termination of thyroid hormone effects. Arq Bras Endocrinol Metabol. 2004 Feb; 48(1):16-24. PMID: 15611815.
      View in: PubMed
    202. Carvalho-Bianco SD, Kim BW, Zhang JX, Harney JW, Ribeiro RS, Gereben B, Bianco AC, Mende U, Larsen PR. Chronic cardiac-specific thyrotoxicosis increases myocardial beta-adrenergic responsiveness. Mol Endocrinol. 2004 Jul; 18(7):1840-9. PMID: 15131256.
      View in: PubMed
    203. Christoffolete MA, Linardi CC, de Jesus L, Ebina KN, Carvalho SD, Ribeiro MO, Rabelo R, Curcio C, Martins L, Kimura ET, Bianco AC. Mice with targeted disruption of the Dio2 gene have cold-induced overexpression of the uncoupling protein 1 gene but fail to increase brown adipose tissue lipogenesis and adaptive thermogenesis. Diabetes. 2004 Mar; 53(3):577-84. PMID: 14988240.
      View in: PubMed
    204. Fekete C, Gereben B, Doleschall M, Harney JW, Dora JM, Bianco AC, Sarkar S, Liposits Z, Rand W, Emerson C, Kacskovics I, Larsen PR, Lechan RM. Lipopolysaccharide induces type 2 iodothyronine deiodinase in the mediobasal hypothalamus: implications for the nonthyroidal illness syndrome. Endocrinology. 2004 Apr; 145(4):1649-55. PMID: 14684601.
      View in: PubMed
    205. Citro R, Galderisi M, Guarini P, Cicala S, Mattioli D, Bianco A, de Divitiis O, Gregorio G. Left bundle branch block with and without coronary artery disease: which value for a tissue Doppler-derived post-systolic motion? Ital Heart J. 2003 Oct; 4(10):706-12. PMID: 14664284.
      View in: PubMed
    206. Freitas FR, Moriscot AS, Jorgetti V, Soares AG, Passarelli M, Scanlan TS, Brent GA, Bianco AC, Gouveia CH. Spared bone mass in rats treated with thyroid hormone receptor TR beta-selective compound GC-1. Am J Physiol Endocrinol Metab. 2003 Nov; 285(5):E1135-41. PMID: 12965872.
      View in: PubMed
    207. Kim BW, Zavacki AM, Curcio-Morelli C, Dentice M, Harney JW, Larsen PR, Bianco AC. Endoplasmic reticulum-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2. Mol Endocrinol. 2003 Dec; 17(12):2603-12. PMID: 12933904.
      View in: PubMed
    208. Callebaut I, Curcio-Morelli C, Mornon JP, Gereben B, Buettner C, Huang S, Castro B, Fonseca TL, Harney JW, Larsen PR, Bianco AC. The iodothyronine selenodeiodinases are thioredoxin-fold family proteins containing a glycoside hydrolase clan GH-A-like structure. J Biol Chem. 2003 Sep 19; 278(38):36887-96. PMID: 12847093.
      View in: PubMed
    209. Curcio-Morelli C, Zavacki AM, Christofollete M, Gereben B, de Freitas BC, Harney JW, Li Z, Wu G, Bianco AC. Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation. J Clin Invest. 2003 Jul; 112(2):189-96. PMID: 12865408.
      View in: PubMed
    210. Curcio-Morelli C, Gereben B, Zavacki AM, Kim BW, Huang S, Harney JW, Larsen PR, Bianco AC. In vivo dimerization of types 1, 2, and 3 iodothyronine selenodeiodinases. Endocrinology. 2003 Mar; 144(3):937-46. PMID: 12586771.
      View in: PubMed
    211. Nakayama A, Bianco AC, Zhang CY, Lowell BB, Frangioni JV. Quantitation of brown adipose tissue perfusion in transgenic mice using near-infrared fluorescence imaging. Mol Imaging. 2003 01; 2(1):37-49. PMID: 12926236.
      View in: PubMed
    212. Fekete C, Sarkar S, Rand WM, Harney JW, Emerson CH, Bianco AC, Lechan RM. Agouti-related protein (AGRP) has a central inhibitory action on the hypothalamic-pituitary-thyroid (HPT) axis; comparisons between the effect of AGRP and neuropeptide Y on energy homeostasis and the HPT axis. Endocrinology. 2002 Oct; 143(10):3846-53. PMID: 12239096.
      View in: PubMed
    213. Cohen WM, Bianco A, Connan F, Camoin L, Dalod M, Lauvau G, Ferri?s E, Culmann-Penciolelli B, van Endert PM, Briand JP, Choppin J, Guillet JG. Study of antigen-processing steps reveals preferences explaining differential biological outcomes of two HLA-A2-restricted immunodominant epitopes from human immunodeficiency virus type 1. J Virol. 2002 Oct; 76(20):10219-25. PMID: 12239297.
      View in: PubMed
    214. Bachman ES, Dhillon H, Zhang CY, Cinti S, Bianco AC, Kobilka BK, Lowell BB. betaAR signaling required for diet-induced thermogenesis and obesity resistance. Science. 2002 Aug 02; 297(5582):843-5. PMID: 12161655.
      View in: PubMed
    215. Bicudo JE, Bianco AC, Vianna CR. Adaptive thermogenesis in hummingbirds. J Exp Biol. 2002 Aug; 205(Pt 15):2267-73. PMID: 12110660.
      View in: PubMed
    216. Frasci G, Lorusso V, Panza N, Comella P, Nicolella G, Bianco A, DeCataldis G, Belli M, Iannelli N, Massidda B, Mascia V, Comella G, De Lena M. Gemcitabine plus vinorelbine yields better survival outcome than vinorelbine alone in elderly patients with advanced non-small cell lung cancer. A Southern Italy Cooperative Oncology Group (SICOG) phase III trial. Lung Cancer. 2001 Dec; 34 Suppl 4:S65-9. PMID: 11742706.
      View in: PubMed
    217. de Jesus LA, Carvalho SD, Ribeiro MO, Schneider M, Kim SW, Harney JW, Larsen PR, Bianco AC. The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue. J Clin Invest. 2001 Nov; 108(9):1379-85. PMID: 11696583.
      View in: PubMed
    218. Ribeiro MO, Carvalho SD, Schultz JJ, Chiellini G, Scanlan TS, Bianco AC, Brent GA. Thyroid hormone--sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform--specific. J Clin Invest. 2001 Jul; 108(1):97-105. PMID: 11435461.
      View in: PubMed
    219. Curcio C, Baqui MM, Salvatore D, Rihn BH, Mohr S, Harney JW, Larsen PR, Bianco AC. The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line. J Biol Chem. 2001 Aug 10; 276(32):30183-7. PMID: 11425850.
      View in: PubMed
    220. Choppin J, Cohen W, Bianco A, Briand JP, Connan F, Dalod M, Guillet JG. Characteristics of HIV-1 Nef regions containing multiple CD8+ T cell epitopes: wealth of HLA-binding motifs and sensitivity to proteasome degradation. J Immunol. 2001 May 15; 166(10):6164-9. PMID: 11342637.
      View in: PubMed
    221. Vianna CR, Hagen T, Zhang CY, Bachman E, Boss O, Gereben B, Moriscot AS, Lowell BB, Bicudo JE, Bianco AC. Cloning and functional characterization of an uncoupling protein homolog in hummingbirds. Physiol Genomics. 2001 Apr 02; 5(3):137-45. PMID: 11285367.
      View in: PubMed
    222. Baqui MM, Gereben B, Harney JW, Larsen PR, Bianco AC. Distinct subcellular localization of transiently expressed types 1 and 2 iodothyronine deiodinases as determined by immunofluorescence confocal microscopy. Endocrinology. 2000 Nov; 141(11):4309-12. PMID: 11089566.
      View in: PubMed
    223. Gereben B, Goncalves C, Harney JW, Larsen PR, Bianco AC. Selective proteolysis of human type 2 deiodinase: a novel ubiquitin-proteasomal mediated mechanism for regulation of hormone activation. Mol Endocrinol. 2000 Nov; 14(11):1697-708. PMID: 11075806.
      View in: PubMed
    224. Bianco A, Furrer J, Limal D, Guichard G, Elbayed K, Raya J, Piotto M, Briand JP. Multistep synthesis of 2,5-diketopiperazines on different solid supports monitored by high resolution magic angle spinning NMR spectroscopy. J Comb Chem. 2000 Nov-Dec; 2(6):681-90. PMID: 11126296.
      View in: PubMed
    225. Ribeiro MO, Lebrun FL, Christoffolete MA, Branco M, Crescenzi A, Carvalho SD, Negr?o N, Bianco AC. Evidence of UCP1-independent regulation of norepinephrine-induced thermogenesis in brown fat. Am J Physiol Endocrinol Metab. 2000 Aug; 279(2):E314-22. PMID: 10913031.
      View in: PubMed
    226. Arnhold IJ, Oliveira SB, Osorio MG, Carrilho AJ, Nicolau W, Bianco AC, Mendonca BB. Lack of reduction in body fat after treatment with insulin-like growth factor-I in two children with growth hormone gene deletions. J Endocrinol Invest. 2000 Apr; 23(4):258-62. PMID: 10853714.
      View in: PubMed
    227. Steinsapir J, Bianco AC, Buettner C, Harney J, Larsen PR. Substrate-induced down-regulation of human type 2 deiodinase (hD2) is mediated through proteasomal degradation and requires interaction with the enzyme's active center. Endocrinology. 2000 Mar; 141(3):1127-35. PMID: 10698189.
      View in: PubMed
    228. Bianco AC, Malvestiti LF, Gouveia CH, Wehba S, Lewin S, Marone MM. Morphometric dual-energy X-ray absorptiometry of the spine: report of a large series and correlation with axial bone mineral density. J Bone Miner Res. 1999 Sep; 14(9):1605-13. PMID: 10469290.
      View in: PubMed
    229. Curcio C, Lopes AM, Ribeiro MO, Francoso OA, Carvalho SD, Lima FB, Bicudo JE, Bianco AC. Development of compensatory thermogenesis in response to overfeeding in hypothyroid rats. Endocrinology. 1999 Aug; 140(8):3438-43. PMID: 10433198.
      View in: PubMed
    230. Comella P, Frasci G, Panza N, Manzione L, Lorusso V, Di Rienzo G, Cioffi R, De Cataldis G, Maiorino L, Bilancia D, Nicolella G, Natale M, Carpagnano F, Pacilio C, De Lena M, Bianco A, Comella G. Cisplatin, gemcitabine, and vinorelbine combination therapy in advanced non-small-cell lung cancer: a phase II randomized study of the Southern Italy Cooperative Oncology Group. J Clin Oncol. 1999 May; 17(5):1526-34. PMID: 10334540.
      View in: PubMed
    231. Branco M, Ribeiro M, Negr?o N, Bianco AC. 3,5,3'-Triiodothyronine actively stimulates UCP in brown fat under minimal sympathetic activity. Am J Physiol. 1999 01; 276(1):E179-87. PMID: 9886965.
      View in: PubMed
    232. Bianco AC, Carvalho SD, Carvalho CR, Rabelo R, Moriscot AS. Thyroxine 5'-deiodination mediates norepinephrine-induced lipogenesis in dispersed brown adipocytes. Endocrinology. 1998 Feb; 139(2):571-8. PMID: 9449627.
      View in: PubMed
    233. Gouveia CH, Jorgetti V, Bianco AC. Effects of thyroid hormone administration and estrogen deficiency on bone mass of female rats. J Bone Miner Res. 1997 Dec; 12(12):2098-107. PMID: 9421243.
      View in: PubMed
    234. Marone MM, Gouveia CH, Lewin S, Wehba S, Malvestiti LF, Bianco AC. Influence of body composition on the bone mass of postmenopausal women. Sao Paulo Med J. 1997 Nov-Dec; 115(6):1580-8. PMID: 9640795.
      View in: PubMed
    235. Lewin S, Gouveia CH, Marone MM, Wehba S, Malvestiti LF, Bianco AC. [Vertebral and femoral bone mineral density of 724 caucasian Brazilian women: influence of age and body weight]. Rev Assoc Med Bras (1992). 1997 Apr-Jun; 43(2):127-36. PMID: 9336048.
      View in: PubMed
    236. Comella P, Frasci G, De Cataldis G, Panza N, Cioffi R, Curcio C, Belli M, Bianco A, Ianniello G, Maiorino L, Della Vittoria M, Perchard J, Comella G. Cisplatin/carboplatin + etoposide + vinorelbine in advanced non-small-cell lung cancer: a multicentre randomised trial. Gruppo Oncologico Campano. Br J Cancer. 1996 Dec; 74(11):1805-11. PMID: 8956797.
      View in: PubMed
    237. Carvalho SD, Bianco AC, Silva JE. Effects of hypothyroidism on brown adipose tissue adenylyl cyclase activity. Endocrinology. 1996 Dec; 137(12):5519-29. PMID: 8940379.
      View in: PubMed
    238. Ribela MT, Bianco AC, Bartolini P. The use of recombinant human thyrotropin produced by Chinese hamster ovary cells for the preparation of immunoassay reagents. J Clin Endocrinol Metab. 1996 Jan; 81(1):249-56. PMID: 8550760.
      View in: PubMed
    239. Gun C, Piegas LS, Bianco AC, Freire RB, Ramos RF, Timerman A. [Value of the use of milrinone in the treatment of acute crisis in patients with congestive heart failure]. Arq Bras Cardiol. 1995 Sep; 65(3):255-8. PMID: 8579514.
      View in: PubMed
    240. Latronico AC, Mendon?a BB, Bianco AC, Villares SM, Lucon MA, Nicolau W, Wajchenberg BL. Calcium-dependent protein kinase-C activity in human adrenocortical neoplasms, hyperplastic adrenals, and normal adrenocortical tissue. J Clin Endocrinol Metab. 1994 Sep; 79(3):736-9. PMID: 7521351.
      View in: PubMed
    241. Moriscot A, Rabelo R, Bianco AC. Corticosterone inhibits uncoupling protein gene expression in brown adipose tissue. Am J Physiol. 1993 Jul; 265(1 Pt 1):E81-7. PMID: 8338156.
      View in: PubMed
    242. Carvalho SD, Negr?o N, Bianco AC. Hormonal regulation of malic enzyme and glucose-6-phosphate dehydrogenase in brown adipose tissue. Am J Physiol. 1993 Jun; 264(6 Pt 1):E874-81. PMID: 8333512.
      View in: PubMed
    243. Bianco AC, Kieffer JD, Silva JE. Adenosine 3',5'-monophosphate and thyroid hormone control of uncoupling protein messenger ribonucleic acid in freshly dispersed brown adipocytes. Endocrinology. 1992 May; 130(5):2625-33. PMID: 1374009.
      View in: PubMed
    244. Rehnmark S, Bianco AC, Kieffer JD, Silva JE. Transcriptional and posttranscriptional mechanisms in uncoupling protein mRNA response to cold. Am J Physiol. 1992 Jan; 262(1 Pt 1):E58-67. PMID: 1733251.
      View in: PubMed
    245. Carvalho SD, Kimura ET, Bianco AC, Silva JE. Central role of brown adipose tissue thyroxine 5'-deiodinase on thyroid hormone-dependent thermogenic response to cold. Endocrinology. 1991 Apr; 128(4):2149-59. PMID: 2004619.
      View in: PubMed
    246. Dorgan Neto V, Saad J?nior R, Hell NS, Bianco AC, Santo GC, Rasslan S. [Gastrin changes in the gastric antrum G-cells and in serum gastrin levels after 80% jejunoileal resection in rats]. Rev Paul Med. 1991 Mar-Apr; 109(2):71-6. PMID: 1887181.
      View in: PubMed
    247. Dias J?nior AA, Scalissi NM, Marone MM, Correa PH, Bianco AC. [Basedow-Graves' disease: analysis of various parameters in the prognosis of remission after clinical treatment]. Rev Paul Med. 1989 Mar-Apr; 107(2):69-74. PMID: 2629056.
      View in: PubMed
    248. Bianco AC, Sheng XY, Silva JE. Triiodothyronine amplifies norepinephrine stimulation of uncoupling protein gene transcription by a mechanism not requiring protein synthesis. J Biol Chem. 1988 Dec 05; 263(34):18168-75. PMID: 3192531.
      View in: PubMed
    249. Bianco AC, Silva JE. Cold exposure rapidly induces virtual saturation of brown adipose tissue nuclear T3 receptors. Am J Physiol. 1988 Oct; 255(4 Pt 1):E496-503. PMID: 3177636.
      View in: PubMed
    250. Saad J?nior R, Rasslan S, Bianco AC, Doine AI, Hell NS, Medeiros LO. [Histologic and histochemical evaluation of the exocrine pancreas in rats subjected to resection or extensive jejunoileal bypass]. AMB Rev Assoc Med Bras. 1988 Jul-Aug; 34(4):123-8. PMID: 2469110.
      View in: PubMed
    251. Bianco AC, Silva JE. Optimal response of key enzymes and uncoupling protein to cold in BAT depends on local T3 generation. Am J Physiol. 1987 Sep; 253(3 Pt 1):E255-63. PMID: 3631256.
      View in: PubMed
    252. Bianco AC, Nunes MT, Hell NS, Maciel RM. The role of glucocorticoids in the stress-induced reduction of extrathyroidal 3,5,3'-triiodothyronine generation in rats. Endocrinology. 1987 Mar; 120(3):1033-8. PMID: 3803308.
      View in: PubMed
    253. Bianco AC, Silva JE. Nuclear 3,5,3'-triiodothyronine (T3) in brown adipose tissue: receptor occupancy and sources of T3 as determined by in vivo techniques. Endocrinology. 1987 Jan; 120(1):55-62. PMID: 3780570.
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    254. Bianco AC, Silva JE. Intracellular conversion of thyroxine to triiodothyronine is required for the optimal thermogenic function of brown adipose tissue. J Clin Invest. 1987 Jan; 79(1):295-300. PMID: 3793928.
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    255. Nunes MT, Bianco AC. Extrathyroidal conversion of thyroxine to 3,5,3'-triiodothyronine in cold-acclimated thyroxine-maintained thyroidectomized rats. Braz J Med Biol Res. 1986; 19(2):311-8. PMID: 3828577.
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    256. Nunes MT, Bianco AC, Migala A, Agostini B, Hasselbach W. Thyroxine induced transformation in sarcoplasmic reticulum of rabbit soleus and psoas muscles. Z Naturforsch C Biosci. 1985 Sep-Oct; 40(9-10):726-34. PMID: 2934902.
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    257. Bianco AC, Marone MM, Nunes MT, Santo GC, Correa PH, Marigo C, Auriemo CR. [Characterization of the binding of 125I-TSH to its receptor in low-uptake thyroid hyperplasias]. Rev Paul Med. 1985 Jul-Aug; 103(4):176-81. PMID: 3008296.
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    258. Bianco AC, Nunes MT, Marone MS, Correa PH. Conversion of thyroxine (T4) to T3 and rT3 in human leucocyte suspension: its application to clinical investigation. Endocrinol Exp. 1985 Mar; 19(1):53-61. PMID: 3921342.
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    259. Bianco AC, Nunes MT, Marone MM, Scalissi NM, Correa PH, Douglas CR. [Thyroxine (T4) to 3,5,3'-triiodothyronine (T3) and 3,3',5'-triiodothyronine (reverse T3) conversion in human leukocyte suspensions. Study in hyper and hypothyroidism states]. Rev Paul Med. 1984 Mar-Apr; 102(2):61-4. PMID: 6474031.
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    260. Bianco AC, Nunes MT, Douglas CR. Influence of mast cells on thyroid function. Endocrinol Exp. 1983 Jun; 17(2):99-106. PMID: 6411454.
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    261. Bianco AC, Nunes MT, Martins O, Roesner I, Douglas RA, Pereira RC, Douglas CR. Possible mechanism of action of cholesterol enriched diet on the thyroid. Endocrinol Exp. 1981 Dec; 15(4):277-85. PMID: 6976263.
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