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Lena Al-Harthi

TitleProfessor
InstitutionRush University, Rush Medical College
DepartmentMicrobial Pathogens and Immunity
Address1735 W. Harrison St.
Chicago IL 60612
Phone312-563-3220
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    Collapse Overview 
    Collapse overview
    Chairperson, The Thomas J. Coogan Sr., MD, Chair of Immunology, Department of Microbial Pathogens and Immunity (formerly, Immunology/Microbiology), Rush Medical College, Rush University Medical Center.
    Director of Rush Initiative to Maximize Student Development (Rush-IMSD).

    My ORCID is 0000-0003-3915-3904.
    My Scopus ID is 7004503402.
    My NIH COMMONS name is LALHARTHI.

    Research Areas:
    HIV/AIDS, HIV/host interactions.

    Articles in the press and media coverage highlight my recent work:
    https://journals.plos.org/plospathogens/article/related?id=10.1371/journal.ppat.1008381
    https://docs.google.com/document/d/1qfXvONEL91j15nVIcrpE4ZcnE4uJ0mm2KNQvfEnbVvo/edit?usp=sharing

    My Faculty Profile at Rush University Medical Center:
    https://www.rushu.rush.edu/faculty/lena-al-harthi-phd

    My Laboratory:
    https://www.rushu.rush.edu/research/departmental-research/microbial-pathogens-and-immunity-research/laboratory-lena-al-harthi-phd

    My NCBI Bibliography:
    https://www.ncbi.nlm.nih.gov/pubmed/?term=Al-Harthi+L

    My Scopus:
    https://www.scopus.com/authid/detail.uri?authorId=7004503402

    My ORCID:
    http://orcid.org/0000-0003-3915-3904

    Education:
    PhD, George Washington University


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Aboushaala K, Wong AYL, Barajas JN, Lim P, Al-Harthi L, Chee A, Forsyth CB, Oh CD, Toro SJ, Williams FMK, An HS, Samartzis D. The Human Microbiome and Its Role in Musculoskeletal Disorders. Genes (Basel). 2023 10 14; 14(10). PMID: 37895286.
      View in: PubMed
    2. Albalawi YA, Shull T, Virdi A, Subra C, Mitchell J, Slike BM, Jian N, Krebs SJ, Sacdalan C, Ratnaratorn N, Hsu DC, Phanuphak N, Spudich S, Trautmann L, Al-Harthi L. CD4dimCD8bright T cells are inversely associated with neuro-inflammatory markers among people living with HIV. AIDS. 2023 Oct 04. PMID: 37792358.
      View in: PubMed
    3. Gonzalez H, Narasipura SD, Shull T, Shetty A, Teppen TL, Naqib A, Al-Harthi L. An Efficient and Cost-Effective Approach to Generate Functional Human Inducible Pluripotent Stem Cell-Derived Astrocytes. Cells. 2023 09 26; 12(19). PMID: 37830571.
      View in: PubMed
    4. Choudhury N, Chen L, Al-Harthi L, Hu XT. Hyperactivity of medial prefrontal cortex pyramidal neurons occurs in a mouse model of early-stage Alzheimer's disease without ?-amyloid accumulation. Front Pharmacol. 2023; 14:1194869. PMID: 37465526.
      View in: PubMed
    5. Virdi AK, Ho S, Seaton MS, Olali AZ, Narasipura SD, Barbian HJ, Olivares LJ, Gonzalez H, Winchester LC, Podany AT, Ross RD, Al-Harthi L, Wallace J. An Efficient Humanized Mouse Model for Oral Anti-Retroviral Administration. Cells. 2023 03 28; 12(7). PMID: 37048107.
      View in: PubMed
    6. Wahl A, Al-Harthi L. HIV infection of non-classical cells in the brain. Retrovirology. 2023 01 13; 20(1):1. PMID: 36639783.
      View in: PubMed
    7. Agrawal S, Farfel JM, Arfanakis K, Al-Harthi L, Shull T, Teppen TL, Evia AM, Patel MB, Ely EW, Leurgans SE, Bennett DA, Mehta R, Schneider JA. Brain autopsies of critically ill COVID-19 patients demonstrate heterogeneous profile of acute vascular injury, inflammation and age-linked chronic brain diseases. Acta Neuropathol Commun. 2022 Dec 17; 10(1):186. PMID: 36528671.
      View in: PubMed
    8. Ash MK, Bhimalli PP, Cho BK, Mattamana BB, Gambut S, Tarhoni I, Fhied CL, Reyes AF, Welninski SJ, Arivalagan J, Negr?o F, Goel R, Beck TL, Hope TJ, Sha BE, Goo YA, Al-Harthi L, Mamede JI, Borgia JA, Kelleher NL, Schneider JR. Bulk IgG glycosylation predicts COVID-19 severity and vaccine antibody response. Cell Rep. 2022 12 13; 41(11):111799. PMID: 36493786.
      View in: PubMed
    9. Khodr CE, Chen L, Al-Harthi L, Hu XT. HIV-Induced Hyperactivity of Striatal Neurons Is Associated with Dysfunction of Voltage-Gated Calcium and Potassium Channels at Middle Age. Membranes (Basel). 2022 Jul 28; 12(8). PMID: 36005652.
      View in: PubMed
    10. Albalawi YA, Narasipura SD, Olivares LJ, Al-Harthi L. CD4dim CD8bright T Cells Home to the Brain and Mediate HIV Neuroinvasion. J Virol. 2022 08 10; 96(15):e0080422. PMID: 35852355.
      View in: PubMed
    11. Albalawi YA, Narasipura SD, Al-Harthi L. Wnt/?-Catenin Protects Lymphocytes from HIV-Mediated Apoptosis via Induction of Bcl-xL. Viruses. 2022 07 02; 14(7). PMID: 35891449.
      View in: PubMed
    12. Olali AZ, Carpenter KA, Myers M, Sharma A, Yin MT, Al-Harthi L, Ross RD. Bone Quality in Relation to HIV and Antiretroviral Drugs. Curr HIV/AIDS Rep. 2022 10; 19(5):312-327. PMID: 35726043.
      View in: PubMed
    13. Wallace J, Gonzalez H, Rajan R, Narasipura SD, Virdi AK, Olali AZ, Naqib A, Arbieva Z, Maienschein-Cline M, Al-Harthi L. Anti-HIV Drugs Cause Mitochondrial Dysfunction in Monocyte-Derived Macrophages. Antimicrob Agents Chemother. 2022 04 19; 66(4):e0194121. PMID: 35293780.
      View in: PubMed
    14. Barbian HJ, Seaton MS, Narasipura SD, Wallace J, Rajan R, Sha BE, Al-Harthi L. ?-catenin regulates HIV latency and modulates HIV reactivation. PLoS Pathog. 2022 03; 18(3):e1010354. PMID: 35255110.
      View in: PubMed
    15. Melani RD, Des Soye BJ, Kafader JO, Forte E, Hollas M, Blagojevic V, Negr?o F, McGee JP, Drown B, Lloyd-Jones C, Seckler HS, Camarillo JM, Compton PD, LeDuc RD, Early B, Fellers RT, Cho BK, Mattamana BB, Goo YA, Thomas PM, Ash MK, Bhimalli PP, Al-Harthi L, Sha BE, Schneider JR, Kelleher NL. Next-Generation Serology by Mass Spectrometry: Readout of the SARS-CoV-2 Antibody Repertoire. J Proteome Res. 2022 01 07; 21(1):274-288. PMID: 34878788.
      View in: PubMed
    16. Jimenez OA, Narasipura SD, Barbian HJ, Albalawi YA, Seaton MS, Robinson KF, Al-Harthi L. ?-Catenin Restricts Zika Virus Internalization by Downregulating Axl. J Virol. 2021 08 10; 95(17):e0070521. PMID: 34260264.
      View in: PubMed
    17. Ash MK, Al-Harthi L, Schneider JR. HIV in the Brain: Identifying Viral Reservoirs and Addressing the Challenges of an HIV Cure. Vaccines (Basel). 2021 Aug 05; 9(8). PMID: 34451992.
      View in: PubMed
    18. Melani RD, Soye BJD, Kafader JO, Forte E, Hollas M, Blagojevic V, Negr?o F, McGee JP, Drown B, Lloyd-Jones C, Seckler HS, Camarillo JM, Compton PD, LeDuc RD, Early B, Fellers RT, Cho BK, Mattamana BB, Goo YA, Thomas PM, Ash MK, Bhimalli PP, Al-Harthi L, Sha BE, Schneider JR, Kelleher NL. Next-generation Serology by Mass Spectrometry: Readout of the SARS-CoV-2 Antibody Repertoire. medRxiv. 2021 Jul 07. PMID: 34268518.
      View in: PubMed
    19. Olali AZ, Sharma A, Shi Q, Hoover DR, Weber KM, French AL, McKay HS, Tien PC, Al-Harthi L, Yin MT, Ross RD. Change in Circulating Undercarboxylated Osteocalcin (ucOCN) Is Associated With Fat Accumulation in HIV-Seropositive Women. J Acquir Immune Defic Syndr. 2021 04 15; 86(5):e139-e145. PMID: 33399313.
      View in: PubMed
    20. Chen L, Al-Harthi L, Hu XT. Triumeq Increases Excitability of Pyramidal Neurons in the Medial Prefrontal Cortex by Facilitating Voltage-Gated Ca2+ Channel Function. Front Pharmacol. 2020; 11:617149. PMID: 33584297.
      View in: PubMed
    21. Li J, Fink JB, Elshafei AA, Stewart LM, Barbian HJ, Mirza SH, Al-Harthi L, Vines D, Ehrmann S. Placing a mask on COVID-19 patients during high-flow nasal cannula therapy reduces aerosol particle dispersion. ERJ Open Res. 2021 Jan; 7(1). PMID: 33527076.
      View in: PubMed
    22. Virdi AK, Wallace J, Barbian H, Richards MH, Ritz EM, Sha B, Al-Harthi L. CD32 is enriched on CD4dimCD8bright T cells. PLoS One. 2020; 15(9):e0239157. PMID: 32960910.
      View in: PubMed
    23. Wallace J, Narasipura SD, Sha BE, French AL, Al-Harthi L. Canonical Wnts Mediate CD8+ T Cell Noncytolytic Anti-HIV-1 Activity and Correlate with HIV-1 Clinical Status. J Immunol. 2020 10 15; 205(8):2046-2055. PMID: 32887752.
      View in: PubMed
    24. Robinson KF, Narasipura SD, Wallace J, Ritz EM, Al-Harthi L. Negative regulation of IL-8 in human astrocytes depends on ?-catenin while positive regulation is mediated by TCFs/LEF/ATF2 interaction. Cytokine. 2020 12; 136:155252. PMID: 32818703.
      View in: PubMed
    25. Al-Harthi L, Campbell E, Schneider JA, Bennett DA. What HIV in the Brain Can Teach Us About SARS-CoV-2 Neurological Complications? AIDS Res Hum Retroviruses. 2021 04; 37(4):255-265. PMID: 32683890.
      View in: PubMed
    26. Robinson KF, Narasipura SD, Wallace J, Ritz EM, Al-Harthi L. ?-Catenin and TCFs/LEF signaling discordantly regulate IL-6 expression in astrocytes. Cell Commun Signal. 2020 06 16; 18(1):93. PMID: 32546183.
      View in: PubMed
    27. Lutgen V, Narasipura SD, Barbian HJ, Richards M, Wallace J, Razmpour R, Buzhdygan T, Ramirez SH, Prevedel L, Eugenin EA, Al-Harthi L. HIV infects astrocytes in vivo and egresses from the brain to the periphery. PLoS Pathog. 2020 06; 16(6):e1008381. PMID: 32525948.
      View in: PubMed
    28. Ross RD, Sharma A, Shi Q, Hoover DR, Weber KM, Tien PC, French AL, Al-Harthi L, Yin MT. Circulating sclerostin is associated with bone mineral density independent of HIV-serostatus. Bone Rep. 2020 Jun; 12:100279. PMID: 32455152.
      View in: PubMed
    29. Borenstein R, Hanson BA, Markosyan RM, Gallo ES, Narasipura SD, Bhutta M, Shechter O, Lurain NS, Cohen FS, Al-Harthi L, Nicholson DA. Author Correction: Ginkgolic acid inhibits fusion of enveloped viruses. Sci Rep. 2020 May 05; 10(1):7499. PMID: 32372013.
      View in: PubMed
    30. Borenstein R, Hanson BA, Markosyan RM, Gallo ES, Narasipura SD, Bhutta M, Shechter O, Lurain NS, Cohen FS, Al-Harthi L, Nicholson DA. Ginkgolic acid inhibits fusion of enveloped viruses. Sci Rep. 2020 03 16; 10(1):4746. PMID: 32179788.
      View in: PubMed
    31. Gonzalez H, Podany A, Al-Harthi L, Wallace J. The far-reaching HAND of cART: cART effects on astrocytes. J Neuroimmune Pharmacol. 2021 03; 16(1):144-158. PMID: 32147775.
      View in: PubMed
    32. Al-Harthi L, Joseph J, Nath A. Correction to: Astrocytes as an HIV CNS reservoir: highlights and reflections of an NIMH-sponsored symposium. J Neurovirol. 2019 Aug; 25(4):616. PMID: 31041681.
      View in: PubMed
    33. Chen L, Khodr CE, Al-Harthi L, Hu XT. Aging and HIV-1 alter the function of specific K+ channels in prefrontal cortex pyramidal neurons. Neurosci Lett. 2019 08 24; 708:134341. PMID: 31255727.
      View in: PubMed
    34. Al-Harthi L, Nath A. Letter to Editor. J Neuroimmune Pharmacol. 2019 03; 14(1):6. PMID: 30542907.
      View in: PubMed
    35. Dave S, Chen L, Yu C, Seaton M, Khodr CE, Al-Harthi L, Hu XT. Methamphetamine decreases K+ channel function in human fetal astrocytes by activating the trace amine-associated receptor type-1. J Neurochem. 2019 01; 148(1):29-45. PMID: 30295919.
      View in: PubMed
    36. Al-Harti L, Joseph J, Nath A. Astrocytes as an HIV CNS reservoir: highlights and reflections of an NIMH-sponsored symposium. J Neurovirol. 2018 12; 24(6):665-669. PMID: 30397827.
      View in: PubMed
    37. Khodr CE, Chen L, Al-Harthi L, Hu XT. Aging alters voltage-gated calcium channels in prefrontal cortex pyramidal neurons in the HIV brain. J Neurovirol. 2018 02; 24(1):113-118. PMID: 29090376.
      View in: PubMed
    38. Wallace J, Lutgen V, Avasarala S, St Croix B, Winn RA, Al-Harthi L. Wnt7a induces a unique phenotype of monocyte-derived macrophages with lower phagocytic capacity and differential expression of pro- and anti-inflammatory cytokines. Immunology. 2018 02; 153(2):203-213. PMID: 28872671.
      View in: PubMed
    39. Yu C, Seaton M, Letendre S, Heaton R, Al-Harthi L. Plasma dickkopf-related protein 1, an antagonist of the Wnt pathway, is associated with HIV-associated neurocognitive impairment. AIDS. 2017 06 19; 31(10):1379-1385. PMID: 28358733.
      View in: PubMed
    40. Yu C, Narasipura SD, Richards MH, Hu XT, Yamamoto B, Al-Harthi L. HIV and drug abuse mediate astrocyte senescence in a ?-catenin-dependent manner leading to neuronal toxicity. Aging Cell. 2017 10; 16(5):956-965. PMID: 28612507.
      View in: PubMed
    41. Smith MM, Knight ET, Al-Harthi L, Leichter JW. Chronic periodontitis and implant dentistry. Periodontol 2000. 2017 06; 74(1):63-73. PMID: 28429486.
      View in: PubMed
    42. Bennani V, Ibrahim H, Al-Harthi L, Lyons KM. The periodontal restorative interface: esthetic considerations. Periodontol 2000. 2017 06; 74(1):74-101. PMID: 28429482.
      View in: PubMed
    43. Lutgen V, Narasipura SD, Sharma A, Min S, Al-Harthi L. ?-Catenin signaling positively regulates glutamate uptake and metabolism in astrocytes. J Neuroinflammation. 2016 09 10; 13(1):242. PMID: 27612942.
      View in: PubMed
    44. Khodr CE, Chen L, Dave S, Al-Harthi L, Hu XT. Combined chronic blockade of hyper-active L-type calcium channels and NMDA receptors ameliorates HIV-1 associated hyper-excitability of mPFC pyramidal neurons. Neurobiol Dis. 2016 Oct; 94:85-94. PMID: 27326669.
      View in: PubMed
    45. Kerzerho J, McIlvaine EJ, Anthony P, Mack WJ, Wang CH, Frederick T, Operskalski E, Chen Z, Al-Harthi L, Landay A, Young MA, Tien PC, Augenbraun M, Strickler HD, Akbari O, Golub ET, Sharp GB, Kovacs A. Impact of Hepatitis C Virus on the Circulating Levels of IL-7 in HIV-1 Coinfected Women. J Acquir Immune Defic Syndr. 2016 Feb 01; 71(2):172-80. PMID: 26761519.
      View in: PubMed
    46. Al-Riyami IA, Thomson WM, Al-Harthi LS. Testing the Arabic short form versions of the Parental-Caregivers Perceptions Questionnaire and the Family Impact Scale in Oman. Saudi Dent J. 2016 Jan; 28(1):31-5. PMID: 26792967.
      View in: PubMed
    47. Richards MH, Narasipura SD, Seaton MS, Lutgen V, Al-Harthi L. Migration of CD8+ T Cells into the Central Nervous System Gives Rise to Highly Potent Anti-HIV CD4dimCD8bright T Cells in a Wnt Signaling-Dependent Manner. J Immunol. 2016 Jan 01; 196(1):317-27. PMID: 26582945.
      View in: PubMed
    48. Zhang YG, Wu S, Lu R, Richards MH, Huelsmann EJ, Lacek AT, Nabatiyan A, Chen D, Al-Harthi L, Zloza A, Sun J. HIV Infection Leads to Redistribution of Leaky Claudin-2 in the Intestine of Humanized SCID IL-2R(-/-) Hu-PBMC Mice. AIDS Res Hum Retroviruses. 2015 Aug; 31(8):774-5. PMID: 25853489.
      View in: PubMed
    49. Richards MH, Narasipura SD, Kim S, Seaton MS, Lutgen V, Al-Harthi L. Dynamic interaction between astrocytes and infiltrating PBMCs in context of neuroAIDS. Glia. 2015 Mar; 63(3):441-51. PMID: 25331637.
      View in: PubMed
    50. Al-Harthi L, Buch S, Geiger JD, Gendelman HE, He JJ, Jordan-Sciutto KL, Kolson DL, Rappaport J, Roy S, Zheng J, Fox HS. Cellular Interactions and Signaling in neuroAIDS: Emerging Issues Colloquium. J Neuroimmune Pharmacol. 2014 Jun; 9(3):269-76. PMID: 24789373.
      View in: PubMed
    51. Lu R, Wu S, Zhang Y, Xia Y, Huelsmann EJ, Lacek AT, Nabatiyan A, Richards MH, Narasipura SD, Lutgen V, Chen H, Kaufman HL, Chen D, Al-Harthi L, Zloza A, Sun J. HIV infection accelerates gastrointestinal tumor outgrowth in NSG-HuPBL mice. AIDS Res Hum Retroviruses. 2014 Jul; 30(7):677-84. PMID: 24593860.
      View in: PubMed
    52. Richards MH, Seaton MS, Wallace J, Al-Harthi L. Porcupine is not required for the production of the majority of Wnts from primary human astrocytes and CD8+ T cells. PLoS One. 2014; 9(3):e92159. PMID: 24647048.
      View in: PubMed
    53. Aljawai Y, Richards MH, Seaton MS, Narasipura SD, Al-Harthi L. ?-Catenin/TCF-4 signaling regulates susceptibility of macrophages and resistance of monocytes to HIV-1 productive infection. Curr HIV Res. 2014; 12(3):164-73. PMID: 24862328.
      View in: PubMed
    54. Narasipura SD, Kim S, Al-Harthi L. Epigenetic regulation of HIV-1 latency in astrocytes. J Virol. 2014 Mar; 88(5):3031-8. PMID: 24352441.
      View in: PubMed
    55. Al-Harthi LS, Cullinan MP, Leichter JW, Thomson WM. Periodontal diseases in an Omani adult population: a preliminary study. J Periodontol. 2014 May; 85(5):e104-10. PMID: 24171501.
      View in: PubMed
    56. Al-Harthi LS, Cullinan MP, Leichter JW, Thomson WM. The impact of periodontitis on oral health-related quality of life: a review of the evidence from observational studies. Aust Dent J. 2013 Sep; 58(3):274-7; quiz 384. PMID: 23981206.
      View in: PubMed
    57. Szotek EL, Narasipura SD, Al-Harthi L. 17?-Estradiol inhibits HIV-1 by inducing a complex formation between ?-catenin and estrogen receptor a on the HIV promoter to suppress HIV transcription. Virology. 2013 Sep 01; 443(2):375-83. PMID: 23769242.
      View in: PubMed
    58. Al-Harthi LS, Cullinan MP, Leichter JW, Thomson WM. Periodontitis among adult populations in the Arab World. Int Dent J. 2013 Feb; 63(1):7-11. PMID: 23410016.
      View in: PubMed
    59. Henderson LJ, Sharma A, Monaco MC, Major EO, Al-Harthi L. Human immunodeficiency virus type 1 (HIV-1) transactivator of transcription through its intact core and cysteine-rich domains inhibits Wnt/?-catenin signaling in astrocytes: relevance to HIV neuropathogenesis. J Neurosci. 2012 Nov 14; 32(46):16306-13. PMID: 23152614.
      View in: PubMed
    60. Al-Harthi L. Wnt/?-catenin and its diverse physiological cell signaling pathways in neurodegenerative and neuropsychiatric disorders. J Neuroimmune Pharmacol. 2012 Dec; 7(4):725-30. PMID: 23114888.
      View in: PubMed
    61. Al-Harthi L. Interplay between Wnt/?-catenin signaling and HIV: virologic and biologic consequences in the CNS. J Neuroimmune Pharmacol. 2012 Dec; 7(4):731-9. PMID: 23065461.
      View in: PubMed
    62. Al-Harthi L. Comment on "CD4+ CD8+ T cells represent a significant portion of the anti-HIV T cell response to acute HIV infection". J Immunol. 2012 Jun 15; 188(12):5809; author reply 5809-10. PMID: 22675214.
      View in: PubMed
    63. Henderson LJ, Narasipura SD, Adarichev V, Kashanchi F, Al-Harthi L. Identification of novel T cell factor 4 (TCF-4) binding sites on the HIV long terminal repeat which associate with TCF-4, ?-catenin, and SMAR1 to repress HIV transcription. J Virol. 2012 Sep; 86(17):9495-503. PMID: 22674979.
      View in: PubMed
    64. Zloza A, Kohlhapp FJ, Lyons GE, Schenkel JM, Moore TV, Lacek AT, O'Sullivan JA, Varanasi V, Williams JW, Jagoda MC, Bellavance EC, Marzo AL, Thomas PG, Zafirova B, Polic B, Al-Harthi L, Sperling AI, Guevara-Pati?o JA. NKG2D signaling on CD8? T cells represses T-bet and rescues CD4-unhelped CD8? T cell memory recall but not effector responses. Nat Med. 2012 Feb 26; 18(3):422-8. PMID: 22366950.
      View in: PubMed
    65. Narasipura SD, Henderson LJ, Fu SW, Chen L, Kashanchi F, Al-Harthi L. Role of ?-catenin and TCF/LEF family members in transcriptional activity of HIV in astrocytes. J Virol. 2012 Feb; 86(4):1911-21. PMID: 22156527.
      View in: PubMed
    66. Al-Harthi L, Kashanchi F. Mechanisms of HIV-1 latency post HAART treatment area. Curr HIV Res. 2011 Dec 01; 9(8):552-3. PMID: 22409272.
      View in: PubMed
    67. Wu J, Richards MH, Huang J, Al-Harthi L, Xu X, Lin R, Xie F, Gibson AW, Edberg JC, Kimberly RP. Human FasL gene is a target of ?-catenin/T-cell factor pathway and complex FasL haplotypes alter promoter functions. PLoS One. 2011; 6(10):e26143. PMID: 22022540.
      View in: PubMed
    68. Sharma A, Hu XT, Napier TC, Al-Harthi L. Methamphetamine and HIV-1 Tat down regulate ?-catenin signaling: implications for methampetamine abuse and HIV-1 co-morbidity. J Neuroimmune Pharmacol. 2011 Dec; 6(4):597-607. PMID: 21744004.
      View in: PubMed
    69. Li W, Henderson LJ, Major EO, Al-Harthi L. IFN-gamma mediates enhancement of HIV replication in astrocytes by inducing an antagonist of the beta-catenin pathway (DKK1) in a STAT 3-dependent manner. J Immunol. 2011 Jun 15; 186(12):6771-8. PMID: 21562161.
      View in: PubMed
    70. Kehn-Hall K, Guendel I, Carpio L, Skaltsounis L, Meijer L, Al-Harthi L, Steiner JP, Nath A, Kutsch O, Kashanchi F. Inhibition of Tat-mediated HIV-1 replication and neurotoxicity by novel GSK3-beta inhibitors. Virology. 2011 Jun 20; 415(1):56-68. PMID: 21514616.
      View in: PubMed
    71. Henderson LJ, Al-Harthi L. Role of ?-catenin/TCF-4 signaling in HIV replication and pathogenesis: insights to informing novel anti-HIV molecular therapeutics. J Neuroimmune Pharmacol. 2011 Jun; 6(2):247-59. PMID: 21384147.
      View in: PubMed
    72. Schenkel JM, Zloza A, Li W, Narasipura SD, Al-Harthi L. Beta-catenin signaling mediates CD4 expression on mature CD8+ T cells. J Immunol. 2010 Aug 15; 185(4):2013-9. PMID: 20631314.
      View in: PubMed
    73. Kovacs A, Karim R, Mack WJ, Xu J, Chen Z, Operskalski E, Frederick T, Landay A, Voris J, Spencer LS, Young MA, Tien PC, Augenbraun M, Strickler HD, Al-Harthi L. Activation of CD8 T cells predicts progression of HIV infection in women coinfected with hepatitis C virus. J Infect Dis. 2010 Mar 15; 201(6):823-34. PMID: 20151840.
      View in: PubMed
    74. Zloza A, Schenkel JM, Tenorio AR, Martinson JA, Jeziorczak PM, Al-Harthi L. Potent HIV-specific responses are enriched in a unique subset of CD8+ T cells that coexpresses CD4 on its surface. Blood. 2009 Oct 29; 114(18):3841-53. PMID: 19700667.
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    75. Kovacs A, Al-Harthi L, Christensen S, Mack W, Cohen M, Landay A. CD8(+) T cell activation in women coinfected with human immunodeficiency virus type 1 and hepatitis C virus. J Infect Dis. 2008 May 15; 197(10):1402-7. PMID: 18444798.
      View in: PubMed
    76. Kumar A, Zloza A, Moon RT, Watts J, Tenorio AR, Al-Harthi L. Active beta-catenin signaling is an inhibitory pathway for human immunodeficiency virus replication in peripheral blood mononuclear cells. J Virol. 2008 Mar; 82(6):2813-20. PMID: 18199649.
      View in: PubMed
    77. Al-Harthi L, MaWhinney S, Connick E, Schooley RT, Forster JE, Benson C, Thompson M, Judson F, Palella F, Landay A. Immunophenotypic alterations in acute and early HIV infection. Clin Immunol. 2007 Dec; 125(3):299-308. PMID: 17916441.
      View in: PubMed
    78. Martinson JA, Tenorio AR, Montoya CJ, Al-Harthi L, Gichinga CN, Krieg AM, Baum LL, Landay AL. Impact of class A, B and C CpG-oligodeoxynucleotides on in vitro activation of innate immune cells in human immunodeficiency virus-1 infected individuals. Immunology. 2007 Apr; 120(4):526-35. PMID: 17343615.
      View in: PubMed
    79. Carroll-Anzinger D, Kumar A, Adarichev V, Kashanchi F, Al-Harthi L. Human immunodeficiency virus-restricted replication in astrocytes and the ability of gamma interferon to modulate this restriction are regulated by a downstream effector of the Wnt signaling pathway. J Virol. 2007 Jun; 81(11):5864-71. PMID: 17392368.
      View in: PubMed
    80. Bahbouhi B, Landay A, Tenorio A, Al-Harthi L. HIV infection of primary CD4+ Th2 cells, defined by expression of the chemoattractant receptor-homologous (CRTH2), induces a Th0 phenotype. AIDS Res Hum Retroviruses. 2007 Feb; 23(2):269-77. PMID: 17331033.
      View in: PubMed
    81. Sailer CA, Pott GB, Dinarello CA, Whinney SM, Forster JE, Larson-Duran JK, Landay A, Al-Harthi L, Schooley RT, Benson CA, Judson FN, Thompson M, Palella FJ, Shapiro L. Whole-blood interleukin-18 level during early HIV-1 infection is associated with reduced CXCR4 coreceptor expression and interferon- gamma levels. J Infect Dis. 2007 Mar 01; 195(5):734-8. PMID: 17262717.
      View in: PubMed
    82. Laskus T, Operskalski EA, Radkowski M, Wilkinson J, Mack WJ, deGiacomo M, Al-Harthi L, Chen Z, Xu J, Kovacs A. Negative-strand hepatitis C virus (HCV) RNA in peripheral blood mononuclear cells from anti-HCV-positive/HIV-infected women. J Infect Dis. 2007 Jan 01; 195(1):124-33. PMID: 17152016.
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    83. Montoya CJ, Jie HB, Al-Harthi L, Mulder C, Pati?o PJ, Rugeles MT, Krieg AM, Landay AL, Wilson SB. Activation of plasmacytoid dendritic cells with TLR9 agonists initiates invariant NKT cell-mediated cross-talk with myeloid dendritic cells. J Immunol. 2006 Jul 15; 177(2):1028-39. PMID: 16818759.
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    84. Managlia EZ, Landay A, Al-Harthi L. Interleukin-7 induces HIV replication in primary naive T cells through a nuclear factor of activated T cell (NFAT)-dependent pathway. Virology. 2006 Jul 05; 350(2):443-52. PMID: 16542695.
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    85. Al-Harthi L, Voris J, Du W, Wright D, Nowicki M, Frederick T, Landay A, Kovacs A. Evaluating the impact of hepatitis C virus (HCV) on highly active antiretroviral therapy-mediated immune responses in HCV/HIV-coinfected women: role of HCV on expression of primed/memory T cells. J Infect Dis. 2006 May 01; 193(9):1202-10. PMID: 16586355.
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    86. Carroll-Anzinger D, Al-Harthi L. Gamma interferon primes productive human immunodeficiency virus infection in astrocytes. J Virol. 2006 Jan; 80(1):541-4. PMID: 16352578.
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    87. Zloza A, Al-Harthi L. Multiple populations of T lymphocytes are distinguished by the level of CD4 and CD8 coexpression and require individual consideration. J Leukoc Biol. 2006 Jan; 79(1):4-6. PMID: 16380600.
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    88. Managlia EZ, Landay A, Al-Harthi L. Interleukin-7 signalling is sufficient to phenotypically and functionally prime human CD4 naive T cells. Immunology. 2005 Mar; 114(3):322-35. PMID: 15720434.
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    89. De Vera MJ, Al-Harthi L, Gewurz AT. Assessing thymopoiesis in patients with common variable immunodeficiency as measured by T-cell receptor excision circles. Ann Allergy Asthma Immunol. 2004 Nov; 93(5):478-84. PMID: 15562888.
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    90. Managlia EZ, Carroll D, Zloza A, Al-Harthi L. Immune modulation of HIV replication: relevance to HIV immuno- and neuro-pathogenesis. Curr HIV Res. 2004 Oct; 2(4):395-401. PMID: 15544459.
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    91. Bahbouhi B, Landay A, Al-Harthi L. Dynamics of cytokine expression in HIV productively infected primary CD4+ T cells. Blood. 2004 Jun 15; 103(12):4581-7. PMID: 14764521.
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    92. Al-Harthi L, Voris J, Patterson BK, Becker S, Eron J, Smith KY, D'Amico R, Mildvan D, Snidow J, Pobiner B, Yau L, Landay A. Evaluation of the impact of highly active antiretroviral therapy on immune recovery in antiretroviral naive patients. HIV Med. 2004 Jan; 5(1):55-65. PMID: 14731171.
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    93. Bahbouhi B, al-Harthi L. Enriching for HIV-infected cells using anti-gp41 antibodies indirectly conjugated to magnetic microbeads. Biotechniques. 2004 Jan; 36(1):139-47. PMID: 14740496.
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    94. Jacobson JM, Lederman MM, Spritzler J, Valdez H, Tebas P, Skowron G, Wang R, Jackson JB, Fox L, Landay A, Gilbert MJ, O'Neil D, Bancroft L, Al-Harthi L, Jacobson MA, Merigan TC, Glesby MJ. Granulocyte-macrophage colony-stimulating factor induces modest increases in plasma human immunodeficiency virus (HIV) type 1 RNA levels and CD4+ lymphocyte counts in patients with uncontrolled HIV infection. J Infect Dis. 2003 Dec 15; 188(12):1804-14. PMID: 14673758.
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    95. Zloza A, Sullivan YB, Connick E, Landay AL, Al-Harthi L. CD8+ T cells that express CD4 on their surface (CD4dimCD8bright T cells) recognize an antigen-specific target, are detected in vivo, and can be productively infected by T-tropic HIV. Blood. 2003 Sep 15; 102(6):2156-64. PMID: 12791668.
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    96. Poirier MC, Divi RL, Al-Harthi L, Olivero OA, Nguyen V, Walker B, Landay AL, Walker VE, Charurat M, Blattner WA. Long-term mitochondrial toxicity in HIV-uninfected infants born to HIV-infected mothers. J Acquir Immune Defic Syndr. 2003 Jun 01; 33(2):175-83. PMID: 12794551.
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    97. Fleuridor R, Wilson B, Hou R, Landay A, Kessler H, Al-Harthi L. CD1d-restricted natural killer T cells are potent targets for human immunodeficiency virus infection. Immunology. 2003 Jan; 108(1):3-9. PMID: 12519296.
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    98. Smith KY, Steffens CM, Truckenbrod A, Landay A, Al-Harthi L. Immune reconstitution after successful treatment with protease inhibitor-based and protease inhibitor-sparing antiretroviral regimens. J Acquir Immune Defic Syndr. 2002 Apr 15; 29(5):544-5. PMID: 11981373.
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    99. Al-Harthi L, Guilbert LJ, Hoxie JA, Landay A. Trophoblasts are productively infected by CD4-independent isolate of HIV type 1. AIDS Res Hum Retroviruses. 2002 Jan 01; 18(1):13-7. PMID: 11804552.
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    100. Steffens CM, Smith KY, Landay A, Shott S, Truckenbrod A, Russert M, Al-Harthi L. T cell receptor excision circle (TREC) content following maximum HIV suppression is equivalent in HIV-infected and HIV-uninfected individuals. AIDS. 2001 Sep 28; 15(14):1757-64. PMID: 11579236.
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    101. Al-Harthi L, Kovacs A, Coombs RW, Reichelderfer PS, Wright DJ, Cohen MH, Cohn J, Cu-Uvin S, Watts H, Lewis S, Beckner S, Landay A. A menstrual cycle pattern for cytokine levels exists in HIV-positive women: implication for HIV vaginal and plasma shedding. AIDS. 2001 Aug 17; 15(12):1535-43. PMID: 11504986.
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    102. Sullivan YB, Landay AL, Zack JA, Kitchen SG, Al-Harthi L. Upregulation of CD4 on CD8+ T cells: CD4dimCD8bright T cells constitute an activated phenotype of CD8+ T cells. Immunology. 2001 Jul; 103(3):270-80. PMID: 11454056.
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    103. al-Harthi L, Landay A. HIV in the female genital tract: viral shedding and mucosal immunity. Clin Obstet Gynecol. 2001 Jun; 44(2):144-53. PMID: 11344984.
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    104. Steffens CM, Al-Harthi L, Shott S, Yogev R, Landay A. Evaluation of thymopoiesis using T cell receptor excision circles (TRECs): differential correlation between adult and pediatric TRECs and na?ve phenotypes. Clin Immunol. 2000 Nov; 97(2):95-101. PMID: 11027449.
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    105. Al-Harthi L, Wright DJ, Anderson D, Cohen M, Matity Ahu D, Cohn J, Cu-Unvin S, Burns D, Reichelderfer P, Lewis S, Beckner S, Kovacs A, Landay A. The impact of the ovulatory cycle on cytokine production: evaluation of systemic, cervicovaginal, and salivary compartments. J Interferon Cytokine Res. 2000 Aug; 20(8):719-24. PMID: 10954915.
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    106. Al-Harthi L, Siegel J, Spritzler J, Pottage J, Agnoli M, Landay A. Maximum suppression of HIV replication leads to the restoration of HIV-specific responses in early HIV disease. AIDS. 2000 May 05; 14(7):761-70. PMID: 10839583.
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    107. Al-Harthi L, Marchetti G, Steffens CM, Poulin J, S?kaly R, Landay A. Detection of T cell receptor circles (TRECs) as biomarkers for de novo T cell synthesis using a quantitative polymerase chain reaction-enzyme linked immunosorbent assay (PCR-ELISA). J Immunol Methods. 2000 Apr 03; 237(1-2):187-97. PMID: 10725462.
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    108. Al-Harthi L, Roebuck KA, Olinger GG, Landay A, Sha BE, Hashemi FB, Spear GT. Bacterial vaginosis-associated microflora isolated from the female genital tract activates HIV-1 expression. J Acquir Immune Defic Syndr. 1999 Jul 01; 21(3):194-202. PMID: 10421242.
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    109. Rabbi MF, Finnegan A, Al-Harthi L, Song S, Roebuck KA. Interleukin-10 enhances tumor necrosis factor-alpha activation of HIV-1 transcription in latently infected T cells. J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 01; 19(4):321-31. PMID: 9833740.
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    110. Al-Harthi L, Spear GT, Hashemi FB, Landay A, Sha BE, Roebuck KA. A human immunodeficiency virus (HIV)-inducing factor from the female genital tract activates HIV-1 gene expression through the kappaB enhancer. J Infect Dis. 1998 Nov; 178(5):1343-51. PMID: 9780254.
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    111. Rabbi MF, al-Harthi L, Saifuddin M, Roebuck KA. The cAMP-dependent protein kinase A and protein kinase C-beta pathways synergistically interact to activate HIV-1 transcription in latently infected cells of monocyte/macrophage lineage. Virology. 1998 Jun 05; 245(2):257-69. PMID: 9636365.
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    112. Al-Harthi L, Roebuck KA. Human immunodeficiency virus type-1 transcription: role of the 5'-untranslated leader region (review). Int J Mol Med. 1998 May; 1(5):875-81. PMID: 9852310.
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    113. Al-Harthi L, Roebuck KA, Landay A. Induction of HIV-1 replication by type 1-like cytokines, interleukin (IL)-12 and IL-15: effect on viral transcriptional activation, cellular proliferation, and endogenous cytokine production. J Clin Immunol. 1998 Mar; 18(2):124-31. PMID: 9533656.
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    114. Valdez H, Al-Harthi L, Landay A, Lederman MM. Rationale for immune-based therapies for HIV-1 infection. J Lab Clin Med. 1998 Mar; 131(3):197-206. PMID: 9523842.
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    115. Al-Harthi L, Owais M, Arya SK. Molecular inhibition of HIV type 1 by HIV type 2: effectiveness in peripheral blood mononuclear cells. AIDS Res Hum Retroviruses. 1998 Jan 01; 14(1):59-64. PMID: 9453252.
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    116. Al-Harthi L, Roebuck KA, Kessler H, Landay A. Inhibition of cytokine-driven human immunodeficiency virus type 1 replication by protease inhibitor. J Infect Dis. 1997 Nov; 176(5):1175-9. PMID: 9359716.
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    117. Rabbi MF, Al-Harthi L, Roebuck KA. TNFalpha cooperates with the protein kinase A pathway to synergistically increase HIV-1 LTR transcription via downstream TRE-like cAMP response elements. Virology. 1997 Oct 27; 237(2):422-9. PMID: 9356353.
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    118. Spear GT, al-Harthi L, Sha B, Saarloos MN, Hayden M, Massad LS, Benson C, Roebuck KA, Glick NR, Landay A. A potent activator of HIV-1 replication is present in the genital tract of a subset of HIV-1-infected and uninfected women. AIDS. 1997 Sep; 11(11):1319-26. PMID: 9302440.
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    119. Kelleher AD, Al-Harthi L, Landay AL. Immunological effects of antiretroviral and immune therapies for HIV. AIDS. 1997; 11 Suppl A:S149-55. PMID: 9451979.
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    120. Coyne VE, al-Harthi L. Induction of melanin biosynthesis in Vibrio cholerae. Appl Environ Microbiol. 1992 Sep; 58(9):2861-5. PMID: 1444398.
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