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Lena Al-Harthi

TitleProfessor
InstitutionRush University, Rush Medical College
DepartmentMicrobial Pathogens and Immunity
Address1735 W. Harrison St.
Chicago IL 60612
Phone312-563-3220
ORCID ORCID Icon0000-0003-3915-3904 Additional info
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    Collapse Overview 
    Collapse overview
    Vice Dean of Research
    Head of the Division of Translational Science
    Chair of Department of Microbial Pathogens and Immunity
    Director of RUSH Initiative to Maximize Student Development (RUSH-IMSD)
    Rush Medical College

    My ORCID is 0000-0003-3915-3904.
    My Scopus ID is 7004503402.
    My NIH COMMONS name is LALHARTHI.

    Research Areas:
    HIV/SARS-CoV2/Neuroimmunology/Neurovirology

    Articles in the press and media coverage highlight my recent work:
    https://journals.plos.org/plospathogens/article/related?id=10.1371/journal.ppat.1008381
    https://docs.google.com/document/d/1qfXvONEL91j15nVIcrpE4ZcnE4uJ0mm2KNQvfEnbVvo/edit?usp=sharing

    My Faculty Profile at RUSH University Medical Center:
    https://www.rushu.rush.edu/faculty/lena-al-harthi-phd

    My Laboratory:
    https://www.rushu.rush.edu/research/departmental-research/microbial-pathogens-and-immunity-research/laboratory-lena-al-harthi-phd

    My NCBI Bibliography:
    https://www.ncbi.nlm.nih.gov/pubmed/?term=Al-Harthi+L

    My ORCID:
    http://orcid.org/0000-0003-3915-3904

    My Scopus:
    https://www.scopus.com/authid/detail.uri?authorId=7004503402

    Education:
    PhD, George Washington University

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Narasipura SD, Zayas JP, Ash MK, Reyes A, Shull T, Gambut S, Schneider JR, Lorenzo-Redondo R, Al-Harthi L, Mamede JI. HIV-1 infection promotes neuroinflammation and neuron pathogenesis in novel microglia-containing cerebral organoids. bioRxiv. 2024 Jun 20. PMID: 38915632; PMCID: PMC11195220.
      Citations:    
    2. Olali AZ, Wallace J, Gonzalez H, Carpenter KA, Patel N, Winchester LC, Podany AT, Venkatesh I, Narasipura SD, Al-Harthi L, Ross RD. The anti-HIV drug abacavir stimulates ?-catenin activity in osteoblast lineage cells. JBMR Plus. 2024 May; 8(5):ziae037. PMID: 38590756; PMCID: PMC11001392.
      Citations:    
    3. Aboushaala K, Chee AV, Toro SJ, Vucicevic R, Yuh C, Dourdourekas J, Patel IK, Espinoza-Orias A, Oh C, Al-Harthi L, Karppinen J, Goldberg EJ, Phillips FM, Colman M, Williams FMK, Borgia JA, Green S, Forsyth C, An HS, Samartzis D. Discovery of circulating blood biomarkers in patients with and without Modic changes of the lumbar spine: a preliminary analysis. Eur Spine J. 2024 Mar 07. PMID: 38451373.
      Citations:    
    4. Virdi AK, Ho S, Seaton MS, Olali AZ, Narasipura SD, Barbian HJ, Olivares LJ, Gonzalez H, Winchester LC, Podany AT, Ross RD, Al-Harthi L, Wallace J, Virdi AK, Ho S, Seaton MS, Olali AZ, Narasipura SD, Barbian HJ, Olivares LJ, Gonzalez H, Winchester LC, Podany AT, Ross RD, Al-Harthi L, Wallace J. An Efficient Humanized Mouse Model for Oral Anti-Retroviral Administration. Cells. 2023 03 28; 12(7). PMID: 37048107; PMCID: PMC10093470.
      Citations:    
    5. Ash MK, Bhimalli PP, Cho BK, Mattamana BB, Gambut S, Tarhoni I, Fhied CL, Reyes AF, Welninski SJ, Arivalagan J, Negr?o F, Goel R, Beck TL, Hope TJ, Sha BE, Goo YA, Al-Harthi L, Mamede JI, Borgia JA, Kelleher NL, Schneider JR, Ash MK, Bhimalli PP, Cho BK, Mattamana BB, Gambut S, Tarhoni I, Fhied CL, Reyes AF, Welninski SJ, Arivalagan J, Negr?o F, Goel R, Beck TL, Hope TJ, Sha BE, Goo YA, Al-Harthi L, Mamede JI, Borgia JA, Kelleher NL, Schneider JR. Bulk IgG glycosylation predicts COVID-19 severity and vaccine antibody response. Cell Rep. 2022 12 13; 41(11):111799. PMID: 36493786; PMCID: PMC9678812.
      Citations:    
    6. Olali AZ, Carpenter KA, Myers M, Sharma A, Yin MT, Al-Harthi L, Ross RD, Olali AZ, Carpenter KA, Myers M, Sharma A, Yin MT, Al-Harthi L, Ross RD. Bone Quality in Relation to HIV and Antiretroviral Drugs. Curr HIV/AIDS Rep. 2022 10; 19(5):312-327. PMID: 35726043; PMCID: PMC10309294.
      Citations:    
    7. Ash MK, Al-Harthi L, Schneider JR. HIV in the Brain: Identifying Viral Reservoirs and Addressing the Challenges of an HIV Cure. Vaccines (Basel). 2021 Aug 05; 9(8). PMID: 34451992.
      Citations:    
    8. Olali AZ, Sharma A, Shi Q, Hoover DR, Weber KM, French AL, McKay HS, Tien PC, Al-Harthi L, Yin MT, Ross RD, Olali AZ, Sharma A, Shi Q, Hoover DR, Weber KM, French AL, McKay HS, Tien PC, Al-Harthi L, Yin MT, Ross RD. Change in Circulating Undercarboxylated Osteocalcin (ucOCN) Is Associated With Fat Accumulation in HIV-Seropositive Women. J Acquir Immune Defic Syndr. 2021 04 15; 86(5):e139-e145. PMID: 33399313; PMCID: PMC7933097.
      Citations:    
    9. Chen L, Al-Harthi L, Hu XT. Triumeq Increases Excitability of Pyramidal Neurons in the Medial Prefrontal Cortex by Facilitating Voltage-Gated Ca2+ Channel Function. Front Pharmacol. 2020; 11:617149. PMID: 33584297.
      Citations:    
    10. Roy NM, Al-Harthi L, Sampat N, Al-Mujaini R, Mahadevan S, Al Adawi S, Essa MM, Al Subhi L, Al-Balushi B, Qoronfleh MW. Impact of vitamin D on neurocognitive function in dementia, depression, schizophrenia and ADHD. Front Biosci (Landmark Ed). 2021 Jan 01; 26(3):566-611. PMID: 33049684.
      Citations:    
    11. Aljuaid SM, Mirza AA, Habib LA, AlHarthi LA, Alansari BM, AlQahtani BG, Althobaiti YA. Does Caffeine Intake Increase the Incidence of Tinnitus? A Systematic Review. Int Arch Otorhinolaryngol. 2021 Oct; 25(4):e628-e632. PMID: 34737834; PMCID: PMC8558950.
      Citations:    
    12. Al Madhani A, Al Harthi L, Balkhair A, Chan MF, Albusaidi BS, Al Sibani N, Al-Adawi S. Prevalence and correlates of depressive symptoms among people living with HIV attending tertiary care hospitals in Oman. Pan Afr Med J. 2020; 37:90. PMID: 33244353; PMCID: PMC7680222.
      Citations:    
    13. Robinson KF, Narasipura SD, Wallace J, Ritz EM, Al-Harthi L. Negative regulation of IL-8 in human astrocytes depends on ?-catenin while positive regulation is mediated by TCFs/LEF/ATF2 interaction. Cytokine. 2020 12; 136:155252. PMID: 32818703.
      Citations:    
    14. Al-Harthi L, Campbell E, Schneider JA, Bennett DA. What HIV in the Brain Can Teach Us About SARS-CoV-2 Neurological Complications? AIDS Res Hum Retroviruses. 2021 04; 37(4):255-265. PMID: 32683890.
      Citations:    
    15. Lutgen V, Narasipura SD, Barbian HJ, Richards M, Wallace J, Razmpour R, Buzhdygan T, Ramirez SH, Prevedel L, Eugenin EA, Al-Harthi L. HIV infects astrocytes in vivo and egresses from the brain to the periphery. PLoS Pathog. 2020 06; 16(6):e1008381. PMID: 32525948.
      Citations:    
    16. Ross RD, Sharma A, Shi Q, Hoover DR, Weber KM, Tien PC, French AL, Al-Harthi L, Yin MT, Ross RD, Sharma A, Shi Q, Hoover DR, Weber KM, Tien PC, French AL, Al-Harthi L, Yin MT. Circulating sclerostin is associated with bone mineral density independent of HIV-serostatus. Bone Rep. 2020 Jun; 12:100279. PMID: 32455152; PMCID: PMC7235609.
      Citations:    
    17. Awad MA, El Kassas D, Al Harthi L, Abraham S, Al-Khalifa K, Khalaf M, Alhabashneh R, Bartlett D. Dentine hypersensitivity and dentine exposure in Arab patient populations. J Oral Rehabil. 2020 Apr; 47(4):473-479. PMID: 31860124.
      Citations:    
    18. Chen L, Khodr CE, Al-Harthi L, Hu XT. Aging and HIV-1 alter the function of specific K+ channels in prefrontal cortex pyramidal neurons. Neurosci Lett. 2019 08 24; 708:134341. PMID: 31255727.
      Citations:    
    19. Al-Harthi L, Nath A. Letter to Editor. J Neuroimmune Pharmacol. 2019 03; 14(1):6. PMID: 30542907.
      Citations:    
    20. Awad MA, El Kassas D, Al Harthi L, Abraham SB, Al-Khalifa KS, Khalaf ME, Al Habashneh R, Bartlett D. Prevalence, severity and explanatory factors of tooth wear in Arab populations. J Dent. 2019 Jan; 80:69-74. PMID: 30278219.
      Citations:    
    21. Al Balushi S, Thomson WM, Al-Harthi L. Dental age estimation of Omani children using Demirjian's method. Saudi Dent J. 2018 Jul; 30(3):208-213. PMID: 29942104; PMCID: PMC6011213.
      Citations:    
    22. Khodr CE, Chen L, Al-Harthi L, Hu XT. Aging alters voltage-gated calcium channels in prefrontal cortex pyramidal neurons in the HIV brain. J Neurovirol. 2018 02; 24(1):113-118. PMID: 29090376.
      Citations:    
    23. Wallace J, Lutgen V, Avasarala S, St Croix B, Winn RA, Al-Harthi L. Wnt7a induces a unique phenotype of monocyte-derived macrophages with lower phagocytic capacity and differential expression of pro- and anti-inflammatory cytokines. Immunology. 2018 02; 153(2):203-213. PMID: 28872671.
      Citations:    
    24. Yu C, Narasipura SD, Richards MH, Hu XT, Yamamoto B, Al-Harthi L. HIV and drug abuse mediate astrocyte senescence in a ?-catenin-dependent manner leading to neuronal toxicity. Aging Cell. 2017 10; 16(5):956-965. PMID: 28612507.
      Citations:    
    25. Smith MM, Knight ET, Al-Harthi L, Leichter JW. Chronic periodontitis and implant dentistry. Periodontol 2000. 2017 06; 74(1):63-73. PMID: 28429486.
      Citations:    
    26. Bennani V, Ibrahim H, Al-Harthi L, Lyons KM. The periodontal restorative interface: esthetic considerations. Periodontol 2000. 2017 06; 74(1):74-101. PMID: 28429482.
      Citations:    
    27. Khodr CE, Chen L, Dave S, Al-Harthi L, Hu XT. Combined chronic blockade of hyper-active L-type calcium channels and NMDA receptors ameliorates HIV-1 associated hyper-excitability of mPFC pyramidal neurons. Neurobiol Dis. 2016 Oct; 94:85-94. PMID: 27326669.
      Citations:    
    28. Al-Riyami IA, Thomson WM, Al-Harthi LS. Testing the Arabic short form versions of the Parental-Caregivers Perceptions Questionnaire and the Family Impact Scale in Oman. Saudi Dent J. 2016 Jan; 28(1):31-5. PMID: 26792967.
      Citations:    
    29. Al-Harthi LS, Cullinan MP, Leichter JW, Thomson WM. Periodontal diseases in an Omani adult population: a preliminary study. J Periodontol. 2014 May; 85(5):e104-10. PMID: 24171501.
      Citations:    
    30. Al-Harthi LS, Cullinan MP, Leichter JW, Thomson WM. The impact of periodontitis on oral health-related quality of life: a review of the evidence from observational studies. Aust Dent J. 2013 Sep; 58(3):274-7; quiz 384. PMID: 23981206.
      Citations:    
    31. Al-Harthi LS, Cullinan MP, Leichter JW, Thomson WM. Periodontitis among adult populations in the Arab World. Int Dent J. 2013 Feb; 63(1):7-11. PMID: 23410016.
      Citations:    
    32. Henderson LJ, Narasipura SD, Adarichev V, Kashanchi F, Al-Harthi L. Identification of novel T cell factor 4 (TCF-4) binding sites on the HIV long terminal repeat which associate with TCF-4, ?-catenin, and SMAR1 to repress HIV transcription. J Virol. 2012 Sep; 86(17):9495-503. PMID: 22674979.
      Citations:    
    33. Al-Harthi L, Kashanchi F. Mechanisms of HIV-1 latency post HAART treatment area. Curr HIV Res. 2011 Dec 01; 9(8):552-3. PMID: 22409272.
      Citations:    
    34. Wu J, Richards MH, Huang J, Al-Harthi L, Xu X, Lin R, Xie F, Gibson AW, Edberg JC, Kimberly RP. Human FasL gene is a target of ?-catenin/T-cell factor pathway and complex FasL haplotypes alter promoter functions. PLoS One. 2011; 6(10):e26143. PMID: 22022540.
      Citations:    
    35. Sharma A, Hu XT, Napier TC, Al-Harthi L. Methamphetamine and HIV-1 Tat down regulate ?-catenin signaling: implications for methampetamine abuse and HIV-1 co-morbidity. J Neuroimmune Pharmacol. 2011 Dec; 6(4):597-607. PMID: 21744004.
      Citations:    
    36. Schenkel JM, Zloza A, Li W, Narasipura SD, Al-Harthi L. Beta-catenin signaling mediates CD4 expression on mature CD8+ T cells. J Immunol. 2010 Aug 15; 185(4):2013-9. PMID: 20631314.
      Citations:    
    37. Al-Harthi L, MaWhinney S, Connick E, Schooley RT, Forster JE, Benson C, Thompson M, Judson F, Palella F, Landay A. Immunophenotypic alterations in acute and early HIV infection. Clin Immunol. 2007 Dec; 125(3):299-308. PMID: 17916441.
      Citations:    
    38. Sailer CA, Pott GB, Dinarello CA, Whinney SM, Forster JE, Larson-Duran JK, Landay A, Al-Harthi L, Schooley RT, Benson CA, Judson FN, Thompson M, Palella FJ, Shapiro L. Whole-blood interleukin-18 level during early HIV-1 infection is associated with reduced CXCR4 coreceptor expression and interferon- gamma levels. J Infect Dis. 2007 Mar 01; 195(5):734-8. PMID: 17262717.
      Citations:    
    39. Bahbouhi B, al-Harthi L. Enriching for HIV-infected cells using anti-gp41 antibodies indirectly conjugated to magnetic microbeads. Biotechniques. 2004 Jan; 36(1):139-47. PMID: 14740496.
      Citations:    
    40. Fleuridor R, Wilson B, Hou R, Landay A, Kessler H, Al-Harthi L. CD1d-restricted natural killer T cells are potent targets for human immunodeficiency virus infection. Immunology. 2003 Jan; 108(1):3-9. PMID: 12519296.
      Citations:    
    41. Nokta MA, Li XD, Al-Harthi L, Nichols J, Pou A, Asmuth D, Landay A, Pollard RB. Entrapment of recent thymic emigrants in lymphoid tissues from HIV-infected patients: association with HIV cellular viral load. AIDS. 2002 Nov 08; 16(16):2119-27. PMID: 12409732.
      Citations:    
    42. Al-Harthi L, Landay A. Immune recovery in HIV disease: role of the thymus and T cell expansion in immune reconstitution strategies. J Hematother Stem Cell Res. 2002 Oct; 11(5):777-86. PMID: 12427284.
      Citations:    
    43. Steffens CM, Managlia EZ, Landay A, Al-Harthi L. Interleukin-7-treated naive T cells can be productively infected by T-cell-adapted and primary isolates of human immunodeficiency virus 1. Blood. 2002 May 01; 99(9):3310-8. PMID: 11964298.
      Citations:    
    44. Steffens CM, Smith KY, Landay A, Shott S, Truckenbrod A, Russert M, Al-Harthi L. T cell receptor excision circle (TREC) content following maximum HIV suppression is equivalent in HIV-infected and HIV-uninfected individuals. AIDS. 2001 Sep 28; 15(14):1757-64. PMID: 11579236.
      Citations:    
    45. Al-Harthi L, Kovacs A, Coombs RW, Reichelderfer PS, Wright DJ, Cohen MH, Cohn J, Cu-Uvin S, Watts H, Lewis S, Beckner S, Landay A. A menstrual cycle pattern for cytokine levels exists in HIV-positive women: implication for HIV vaginal and plasma shedding. AIDS. 2001 Aug 17; 15(12):1535-43. PMID: 11504986.
      Citations:    
    46. Sullivan YB, Landay AL, Zack JA, Kitchen SG, Al-Harthi L. Upregulation of CD4 on CD8+ T cells: CD4dimCD8bright T cells constitute an activated phenotype of CD8+ T cells. Immunology. 2001 Jul; 103(3):270-80. PMID: 11454056.
      Citations:    
    47. Steffens CM, Al-Harthi L, Shott S, Yogev R, Landay A. Evaluation of thymopoiesis using T cell receptor excision circles (TRECs): differential correlation between adult and pediatric TRECs and na?ve phenotypes. Clin Immunol. 2000 Nov; 97(2):95-101. PMID: 11027449.
      Citations:    
    48. Al-Harthi L, Siegel J, Spritzler J, Pottage J, Agnoli M, Landay A. Maximum suppression of HIV replication leads to the restoration of HIV-specific responses in early HIV disease. AIDS. 2000 May 05; 14(7):761-70. PMID: 10839583.
      Citations:    
    49. Rabbi MF, Finnegan A, Al-Harthi L, Song S, Roebuck KA. Interleukin-10 enhances tumor necrosis factor-alpha activation of HIV-1 transcription in latently infected T cells. J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 01; 19(4):321-31. PMID: 9833740.
      Citations:    
    50. Rabbi MF, al-Harthi L, Saifuddin M, Roebuck KA. The cAMP-dependent protein kinase A and protein kinase C-beta pathways synergistically interact to activate HIV-1 transcription in latently infected cells of monocyte/macrophage lineage. Virology. 1998 Jun 05; 245(2):257-69. PMID: 9636365.
      Citations:    
    51. Al-Harthi L, Roebuck KA. Human immunodeficiency virus type-1 transcription: role of the 5'-untranslated leader region (review). Int J Mol Med. 1998 May; 1(5):875-81. PMID: 9852310.
      Citations:    
    52. Al-Harthi L, Roebuck KA, Landay A. Induction of HIV-1 replication by type 1-like cytokines, interleukin (IL)-12 and IL-15: effect on viral transcriptional activation, cellular proliferation, and endogenous cytokine production. J Clin Immunol. 1998 Mar; 18(2):124-31. PMID: 9533656.
      Citations:    
    53. Valdez H, Al-Harthi L, Landay A, Lederman MM. Rationale for immune-based therapies for HIV-1 infection. J Lab Clin Med. 1998 Mar; 131(3):197-206. PMID: 9523842.
      Citations:    
    54. Al-Harthi L, Owais M, Arya SK. Molecular inhibition of HIV type 1 by HIV type 2: effectiveness in peripheral blood mononuclear cells. AIDS Res Hum Retroviruses. 1998 Jan 01; 14(1):59-64. PMID: 9453252.
      Citations:    
    55. Al-Harthi L, Roebuck KA, Kessler H, Landay A. Inhibition of cytokine-driven human immunodeficiency virus type 1 replication by protease inhibitor. J Infect Dis. 1997 Nov; 176(5):1175-9. PMID: 9359716.
      Citations:    
    56. Rabbi MF, Al-Harthi L, Roebuck KA. TNFalpha cooperates with the protein kinase A pathway to synergistically increase HIV-1 LTR transcription via downstream TRE-like cAMP response elements. Virology. 1997 Oct 27; 237(2):422-9. PMID: 9356353.
      Citations:    
    57. Spear GT, al-Harthi L, Sha B, Saarloos MN, Hayden M, Massad LS, Benson C, Roebuck KA, Glick NR, Landay A. A potent activator of HIV-1 replication is present in the genital tract of a subset of HIV-1-infected and uninfected women. AIDS. 1997 Sep; 11(11):1319-26. PMID: 9302440.
      Citations:    
    58. Kelleher AD, Al-Harthi L, Landay AL. Immunological effects of antiretroviral and immune therapies for HIV. AIDS. 1997; 11 Suppl A:S149-55. PMID: 9451979.
      Citations:    
    59. Coyne VE, al-Harthi L. Induction of melanin biosynthesis in Vibrio cholerae. Appl Environ Microbiol. 1992 Sep; 58(9):2861-5. PMID: 1444398.
      Citations:    
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