Last Name

Joan A. O'Keefe

TitleAssociate Professor
InstitutionRush University, Rush Medical College
DepartmentCell and Molecular Medicine
Address600 S. Paulina St.
Chicago IL 60612
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    My Scopus ID are 55900937400 and 24290430000.

    Research Areas:
    My expertise is in the detection of gait and balance impairments in a variety of movement disorders. I am a physical therapist with doctoral and postdoctoral training in basic neurobiology and am presently conducting clinical research investigating balance and gait in several neurodegenerative disorders. I received my BS in physical therapy from the University of Illinois-Chicago and my PhD in anatomy and neurobiology from Loyola University Chicago. I am predominantly studying Fragile X tremor and ataxia syndrome (FXTAS), which occurs in some premutation (PM) carriers of the Fragile X (FMR1) gene.

    My Faculty Profile at Rush University Medical Center:

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    My Scopus (Loyola University):

    PhD, Loyola University Chicago

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Gera A, O'Keefe JA, Ouyang B, Liu Y, Ruehl S, Buder M, Joyce J, Purcell N, Pal G. Gait asymmetry in glucocerebrosidase mutation carriers with Parkinson's disease. PLoS One. 2020; 15(1):e0226494. PMID: 31978134.
      View in: PubMed
    2. Purcell NL, Goldman JG, Ouyang B, Liu Y, Bernard B, O'Keefe JA. The effects of dual-task cognitive interference on gait and turning in Huntington's disease. PLoS One. 2020; 15(1):e0226827. PMID: 31910203.
      View in: PubMed
    3. Purcell NL, Goldman JG, Ouyang B, Bernard B, O'Keefe JA. The Effects of Dual-Task Cognitive Interference and Environmental Challenges on Balance in Huntington's Disease. Mov Disord Clin Pract. 2019 Mar; 6(3):202-212. PMID: 30949551.
      View in: PubMed
    4. O'Keefe JA, Robertson EE, Ouyang B, Carns D, McAsey A, Liu Y, Swanson M, Bernard B, Berry-Kravis E, Hall DA. Cognitive function impacts gait, functional mobility and falls in fragile X-associated tremor/ataxia syndrome. Gait Posture. 2018 10; 66:288-293. PMID: 30243213.
      View in: PubMed
    5. Berry-Kravis E, Chin J, Hoffmann A, Winston A, Stoner R, LaGorio L, Friedmann K, Hernandez M, Ory DS, Porter FD, O'Keefe JA. Long-Term Treatment of Niemann-Pick Type C1 Disease With Intrathecal 2-Hydroxypropyl-ß-Cyclodextrin. Pediatr Neurol. 2018 03; 80:24-34. PMID: 29429782.
      View in: PubMed
    6. Pal G, O'Keefe J, Robertson-Dick E, Bernard B, Anderson S, Hall D. Global cognitive function and processing speed are associated with gait and balance dysfunction in Parkinson's disease. J Neuroeng Rehabil. 2016 10 28; 13(1):94. PMID: 27793167.
      View in: PubMed
    7. Hall DA, Robertson E, Shelton AL, Losh MC, Mila M, Moreno EG, Gomez-Anson B, Martínez-Cerdeño V, Grigsby J, Lozano R, Hagerman R, Maria LS, Berry-Kravis E, O'Keefe JA. Update on the Clinical, Radiographic, and Neurobehavioral Manifestations in FXTAS and FMR1 Premutation Carriers. Cerebellum. 2016 10; 15(5):578-86. PMID: 27287737.
      View in: PubMed
    8. O'Keefe JA, Robertson-Dick EE, Hall DA, Berry-Kravis E. Gait and Functional Mobility Deficits in Fragile X-Associated Tremor/Ataxia Syndrome. Cerebellum. 2016 08; 15(4):475-82. PMID: 26298472.
      View in: PubMed
    9. Robertson EE, Hall DA, McAsey AR, O'Keefe JA. Fragile X-associated tremor/ataxia syndrome: phenotypic comparisons with other movement disorders. Clin Neuropsychol. 2016 Aug; 30(6):849-900. PMID: 27414076.
      View in: PubMed
    10. Hall DA, Robertson-Dick EE, O'Keefe JA, Hadd AG, Zhou L, Berry-Kravis E. X-inactivation in the clinical phenotype of fragile X premutation carrier sisters. Neurol Genet. 2016 Feb; 2(1):e45. PMID: 27066582.
      View in: PubMed
    11. O'Keefe JA, Robertson-Dick E, Dunn EJ, Li Y, Deng Y, Fiutko AN, Berry-Kravis E, Hall DA. Characterization and Early Detection of Balance Deficits in Fragile X Premutation Carriers With and Without Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS). Cerebellum. 2015 Dec; 14(6):650-62. PMID: 25763861.
      View in: PubMed
    12. Hall DA, Birch RC, Anheim M, Jønch AE, Pintado E, O'Keefe JA, Trollor JN, Stebbins GT, Hagerman RJ, Fahn S, Berry-Kravis E, Leehey MA. Erratum: Emerging topics in FXTAS. J Neurodev Disord. 2015; 7(1):13. PMID: 25852777.
      View in: PubMed
    13. O'Keefe JA, Espinoza Orías AA, Khan H, Hall DA, Berry-Kravis E, Wimmer MA. Implementation of a markerless motion analysis method to quantify hyperkinesis in males with fragile X syndrome. Gait Posture. 2014 Feb; 39(2):827-30. PMID: 24252602.
      View in: PubMed
    14. Hall DA, O'Keefe JA. Clinical neurogenetics: fragile x-associated tremor/ataxia syndrome. Neurol Clin. 2013 Nov; 31(4):1073-84. PMID: 24176424.
      View in: PubMed
    15. Hall DA, O'keefe JA. Fragile x-associated tremor ataxia syndrome: the expanding clinical picture, pathophysiology, epidemiology, and update on treatment. Tremor Other Hyperkinet Mov (N Y). 2012; 2. PMID: 23439567.
      View in: PubMed
    16. Cheng B, Furukawa K, O'Keefe JA, Goodman Y, Kihiko M, Fabian T, Mattson MP. Basic fibroblast growth factor selectively increases AMPA-receptor subunit GluR1 protein level and differentially modulates Ca2+ responses to AMPA and NMDA in hippocampal neurons. J Neurochem. 1995 Dec; 65(6):2525-36. PMID: 7595547.
      View in: PubMed
    17. O'Keefe JA, Li Y, Burgess LH, Handa RJ. Estrogen receptor mRNA alterations in the developing rat hippocampus. Brain Res Mol Brain Res. 1995 May; 30(1):115-24. PMID: 7609632.
      View in: PubMed
    18. Handa RJ, Burgess LH, Kerr JE, O'Keefe JA. Gonadal steroid hormone receptors and sex differences in the hypothalamo-pituitary-adrenal axis. Horm Behav. 1994 Dec; 28(4):464-76. PMID: 7729815.
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    19. O'Keefe JA, Pedersen EB, Castro AJ, Handa RJ. The ontogeny of estrogen receptors in heterochronic hippocampal and neocortical transplants demonstrates an intrinsic developmental program. Brain Res Dev Brain Res. 1993 Sep 17; 75(1):105-12. PMID: 8222204.
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    20. Pedersen EB, O'Keefe JA, Handa RJ, Castro AJ. Estrogen receptors are present in neocortical transplants. J Neural Transplant Plast. 1992 Apr-Sep; 3(2-3):135-8. PMID: 1515481.
      View in: PubMed
    21. O'Keefe JA, Handa RJ. Transient elevation of estrogen receptors in the neonatal rat hippocampus. Brain Res Dev Brain Res. 1990 Dec 01; 57(1):119-27. PMID: 2090365.
      View in: PubMed
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