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Joan A. O'Keefe

TitleAssistant Professor
InstitutionRush University, Rush Medical College
DepartmentCell and Molecular Medicine
Address600 S. Paulina St.
Chicago IL 60612
Phone312-563-3940
Fax312-942-5744
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    Collapse Overview 
    Collapse overview
    Associate Professor of Department of Cell & Molecular Medicine, Rush Medical College.

    My Scopus ID are 55900937400 and 24290430000.
    My NIH COMMONS name is JOKEEFE.

    Research Areas:
    My expertise is in the detection of gait and balance impairments in a variety of movement disorders. I am a physical therapist with doctoral and postdoctoral training in basic neurobiology and am presently conducting clinical research investigating balance and gait in several neurodegenerative disorders. I received my BS in physical therapy from the University of Illinois-Chicago and my PhD in anatomy and neurobiology from Loyola University Chicago. I am predominantly studying Fragile X tremor and ataxia syndrome (FXTAS), which occurs in some premutation (PM) carriers of the Fragile X (FMR1) gene.

    My Faculty Profile at Rush University Medical Center:
    https://www.rushu.rush.edu/faculty/joan-okeefe-pt-phd

    My Laboratory:
    https://www.rushu.rush.edu/research/departmental-research/cell-molecular-medicine-research/laboratory-joan-o%E2%80%99keefe-phd

    My NCBI Bibliography:
    https://www.ncbi.nlm.nih.gov/pubmed/?term=O%27Keefe+JA

    My Scopus (Rush University):
    https://www.scopus.com/authid/detail.uri?authorId=55900937400

    My Scopus (Loyola University):
    https://www.scopus.com/authid/detail.uri?authorId=24290430000

    Education:
    PhD, Loyola University Chicago


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Pal G, O'Keefe J, Robertson-Dick E, Bernard B, Anderson S, Hall D. Global cognitive function and processing speed are associated with gait and balance dysfunction in Parkinson's disease. J Neuroeng Rehabil. 2016 Oct 28; 13(1):94. PMID: 27793167.
      View in: PubMed
    2. Hall DA, Robertson E, Shelton AL, Losh MC, Mila M, Moreno EG, Gomez-Anson B, Martínez-Cerdeño V, Grigsby J, Lozano R, Hagerman R, Maria LS, Berry-Kravis E, O'Keefe JA. Update on the Clinical, Radiographic, and Neurobehavioral Manifestations in FXTAS and FMR1 Premutation Carriers. Cerebellum. 2016 Oct; 15(5):578-86. PMID: 27287737.
      View in: PubMed
    3. O'Keefe JA, Robertson-Dick EE, Hall DA, Berry-Kravis E. Gait and Functional Mobility Deficits in Fragile X-Associated Tremor/Ataxia Syndrome. Cerebellum. 2016 08; 15(4):475-82. PMID: 26298472.
      View in: PubMed
    4. Robertson EE, Hall DA, McAsey AR, O'Keefe JA. Fragile X-associated tremor/ataxia syndrome: phenotypic comparisons with other movement disorders. Clin Neuropsychol. 2016 Aug; 30(6):849-900. PMID: 27414076.
      View in: PubMed
    5. Hall DA, Robertson-Dick EE, O'Keefe JA, Hadd AG, Zhou L, Berry-Kravis E. X-inactivation in the clinical phenotype of fragile X premutation carrier sisters. Neurol Genet. 2016 Feb; 2(1):e45. PMID: 27066582; PMCID: PMC4817899.
    6. O'Keefe JA, Robertson-Dick E, Dunn EJ, Li Y, Deng Y, Fiutko AN, Berry-Kravis E, Hall DA. Characterization and Early Detection of Balance Deficits in Fragile X Premutation Carriers With and Without Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS). Cerebellum. 2015 Dec; 14(6):650-62. PMID: 25763861.
      View in: PubMed
    7. Hall DA, Birch RC, Anheim M, Jønch AE, Pintado E, O'Keefe JA, Trollor JN, Stebbins GT, Hagerman RJ, Fahn S, Berry-Kravis E, Leehey MA. Erratum: Emerging topics in FXTAS. J Neurodev Disord. 2015; 7(1):13. PMID: 25852777; PMCID: PMC4387583.
    8. O'Keefe JA, Espinoza Orías AA, Khan H, Hall DA, Berry-Kravis E, Wimmer MA. Implementation of a markerless motion analysis method to quantify hyperkinesis in males with fragile X syndrome. Gait Posture. 2014 Feb; 39(2):827-30. PMID: 24252602.
      View in: PubMed
    9. Hall DA, O'Keefe JA. Clinical neurogenetics: fragile x-associated tremor/ataxia syndrome. Neurol Clin. 2013 Nov; 31(4):1073-84. PMID: 24176424.
      View in: PubMed
    10. Hall DA, O'keefe JA. Fragile x-associated tremor ataxia syndrome: the expanding clinical picture, pathophysiology, epidemiology, and update on treatment. Tremor Other Hyperkinet Mov (N Y). 2012; 2. PMID: 23439567; PMCID: PMC3570061.
    11. Cheng B, Furukawa K, O'Keefe JA, Goodman Y, Kihiko M, Fabian T, Mattson MP. Basic fibroblast growth factor selectively increases AMPA-receptor subunit GluR1 protein level and differentially modulates Ca2+ responses to AMPA and NMDA in hippocampal neurons. J Neurochem. 1995 Dec; 65(6):2525-36. PMID: 7595547.
      View in: PubMed
    12. O'Keefe JA, Li Y, Burgess LH, Handa RJ. Estrogen receptor mRNA alterations in the developing rat hippocampus. Brain Res Mol Brain Res. 1995 May; 30(1):115-24. PMID: 7609632.
      View in: PubMed
    13. O'Keefe JA, Crowley RS, Hrivnak P, Kim NB, Amico JA. Effect of testosterone and its metabolites upon the level of vasopressin messenger ribonucleic acid in the hypothalamus of the hyperosmotically stimulated male rat. Neuroendocrinology. 1995 Apr; 61(4):405-11. PMID: 7783853.
      View in: PubMed
    14. Amico JA, Crowley RS, Insel TR, Thomas A, O'Keefe JA. Effect of gonadal steroids upon hypothalamic oxytocin expression. Adv Exp Med Biol. 1995; 395:23-35. PMID: 8713949.
      View in: PubMed
    15. Crowley RS, Insel TR, O'Keefe JA, Kim NB, Amico JA. Increased accumulation of oxytocin messenger ribonucleic acid in the hypothalamus of the female rat: induction by long term estradiol and progesterone administration and subsequent progesterone withdrawal. Endocrinology. 1995 Jan; 136(1):224-31. PMID: 7828535.
      View in: PubMed
    16. Handa RJ, Burgess LH, Kerr JE, O'Keefe JA. Gonadal steroid hormone receptors and sex differences in the hypothalamo-pituitary-adrenal axis. Horm Behav. 1994 Dec; 28(4):464-76. PMID: 7729815.
      View in: PubMed
    17. Crowley RS, Insel TR, O'Keefe JA, Amico JA. Cytoplasmic oxytocin and vasopressin gene transcripts decline postpartum in the hypothalamus of the lactating rat. Endocrinology. 1993 Dec; 133(6):2704-10. PMID: 7612074.
      View in: PubMed
    18. O'Keefe JA, Pedersen EB, Castro AJ, Handa RJ. The ontogeny of estrogen receptors in heterochronic hippocampal and neocortical transplants demonstrates an intrinsic developmental program. Brain Res Dev Brain Res. 1993 Sep 17; 75(1):105-12. PMID: 8222204.
      View in: PubMed
    19. Pedersen EB, O'Keefe JA, Handa RJ, Castro AJ. Estrogen receptors are present in neocortical transplants. J Neural Transplant Plast. 1992 Apr-Sep; 3(2-3):135-8. PMID: 1515481; PMCID: PMC2565143.
    20. O'Keefe JA, Handa RJ. Transient elevation of estrogen receptors in the neonatal rat hippocampus. Brain Res Dev Brain Res. 1990 Dec 01; 57(1):119-27. PMID: 2090365.
      View in: PubMed
    21. Wolpaw JR, O'Keefe JA, Noonan PA, Sanders MG. Adaptive plasticity in primate spinal stretch reflex: persistence. J Neurophysiol. 1986 Feb; 55(2):272-9. PMID: 3950691.
      View in: PubMed
    22. Glass BP, O'keefe JA. Lunar sample 14425: corrected analysis. Science. 1985 Sep 27; 229(4720):1410. PMID: 17798386.
      View in: PubMed
    23. Wolpaw JR, O'Keefe JA, Kieffer VA, Sanders MG. Reduced day-to-day variation accompanies adaptive plasticity in the primate spinal stretch reflex. Neurosci Lett. 1985 Mar 15; 54(2-3):165-71. PMID: 3991057.
      View in: PubMed
    24. O'keefe JA, Glass BP. Lunar sample 14425: characterization and resemblance to high-magnesium microtektites. Science. 1985 Feb 01; 227(4686):515-6. PMID: 17733476.
      View in: PubMed
    25. Wolpaw JR, O'Keefe JA. Adaptive plasticity in the primate spinal stretch reflex: evidence for a two-phase process. J Neurosci. 1984 Nov; 4(11):2718-24. PMID: 6502200.
      View in: PubMed
    26. Wolpaw JR, Noonan PA, O'Keefe JA. Adaptive plasticity and diurnal rhythm in the primate spinal stretch reflex are independent phenomena. Brain Res. 1984 May 23; 300(2):385-91. PMID: 6539634.
      View in: PubMed
    27. Wolpaw JR, Seegal RF, O'Keefe JA. Adaptive plasticity in primate spinal stretch reflex: behavior of synergist and antagonist muscles. J Neurophysiol. 1983 Dec; 50(6):1312-9. PMID: 6663328.
      View in: PubMed
    28. Urey HC, O'keefe JA. Tektites from the Earth. Science. 1971 Jan 22; 171(3968):312-4. PMID: 17736224.
      View in: PubMed
    29. King EA, Martin R, Nance WB, O'keefe JA. Tektite glass not in apollo 12 sample. Science. 1970 Oct 09; 170(3954):199-200. PMID: 17833502.
      View in: PubMed
    30. O'keefe JA. Tektite glass in apollo 12 sample. Science. 1970 Jun 05; 168(3936):1209-10. PMID: 17843588.
      View in: PubMed
    31. O'keefe JA. Water on the moon and a new nondimensional number. Science. 1969 Feb 14; 163(3868):669-70. PMID: 17742733.
      View in: PubMed
    32. O'keefe JA. Isostasy on the moon. Science. 1968 Dec 20; 162(3860):1405-6. PMID: 17752642.
      View in: PubMed
    33. O'keefe JA, Scott RF. Chondritic meteorites and the lunar surface. Science. 1967 Dec 01; 158(3805):1174-6. PMID: 17734304.
      View in: PubMed
    34. Gault DE, Adams JB, Collins RJ, Green J, Kuiper GP, Mazursky H, O'keefe JA, Phinney RA, Shoemaker EM. Surveyor v: discussion of chemical analysis. Science. 1967 Nov 03; 158(3801):641-2. PMID: 17732958.
      View in: PubMed
    35. O'keefe JA, Lowman PD, Cameron WS. Lunar ring dikes from orbiter I. Science. 1967 Jan 06; 155(3758):77-9. PMID: 17799150.
      View in: PubMed
    36. O'keefe JA. Lunar atlas. Science. 1966 May 13; 152(3724):954-5. PMID: 17819803.
      View in: PubMed
    37. Liu HS, O'keefe JA. Theory of Rotation for the Planet Mercury. Science. 1965 Dec 24; 150(3704):1717. PMID: 17768871.
      View in: PubMed
    38. O'keefe JA. Interpretation of Ranger Photographs. Science. 1964 Oct 23; 146(3643):514-5. PMID: 17806803.
      View in: PubMed
    39. O'keefe JA, Walter LS, Wood FM. Hydrogen in a Tektite Vesicle. Science. 1964 Jan 03; 143(3601):39-40. PMID: 17733771.
      View in: PubMed
    40. O'keefe JA, Kaula WM. Stress Differences and the Reference Ellipsoid. Science. 1963 Oct 18; 142(3590):382. PMID: 17799481.
      View in: PubMed
    41. O'keefe JA, Shute BE. Origin of Tektites. Science. 1963 Mar 29; 139(3561):1288-90. PMID: 17757065.
      View in: PubMed
    42. Carpenter MS, O'keefe JA, Dunkelman L. Visual Observations of Nightglow from Manned Spacecraft. Science. 1962 Nov 30; 138(3544):978-80. PMID: 17829469.
      View in: PubMed
    43. O'keefe JA, Lowman PD, Dunning KL. Gases in Tektite Bubbles. Science. 1962 Jul 20; 137(3525):228. PMID: 17801113.
      View in: PubMed
    44. Glenn JH, O'keefe JA. The Mercury-Atlas-6 Space Flight: John H. Glenn, Jr., describes his astronomical, meteorological, and terrestrial observations. John A. O'Keefe comments on the scientific results of the flight. Science. 1962 Jun 29; 136(3522):1093-9. PMID: 17736851.
      View in: PubMed
    45. O'keefe JA. Tektites as Natural Earth Satellites: Observations indicate that orbiting tektites, on entering the atmosphere, fall in a few revolutions. Science. 1961 Feb 24; 133(3452):562-6. PMID: 17777085.
      View in: PubMed
    46. O'keefe JA. Determination of the Earth's Gravitational Field. Science. 1960 Feb 26; 131(3400):607-8. PMID: 17775547.
      View in: PubMed
    47. O'keefe JA. Origin of Tektites. Science. 1959 Jul 10; 130(3367):97-8. PMID: 17738598.
      View in: PubMed
    48. O'keefe JA, Eckeis A, Squires RK. Vanguard Measurements Give Pear-Shaped Component of Earth's Figure. Science. 1959 Feb 27; 129(3348):565-6. PMID: 17733645.
      View in: PubMed
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