Joan A. O'Keefe
Title | Associate Professor |
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Institution | Rush University, Rush Medical College |
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Department | Anatomy and Cell Biology |
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Address | 600 S. Paulina St. Chicago IL 60612
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Phone | 312-563-3940 |
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Fax | 312-942-5744 |
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vCard | Download vCard |
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Overview My Scopus ID are 55900937400 and 24290430000. My NIH COMMONS name is JOKEEFE.
Research Areas: My expertise is in the detection of gait and balance impairments in a variety of movement disorders. I am a physical therapist with doctoral and postdoctoral training in basic neurobiology and am presently conducting clinical research investigating balance and gait in several neurodegenerative disorders. I received my BS in physical therapy from the University of Illinois-Chicago and my PhD in anatomy and neurobiology from Loyola University Chicago. I am predominantly studying Fragile X tremor and ataxia syndrome (FXTAS), which occurs in some premutation (PM) carriers of the Fragile X (FMR1) gene.
My Faculty Profile at Rush University Medical Center: https://www.rushu.rush.edu/faculty/joan-okeefe-pt-phd
My Laboratory: https://www.rushu.rush.edu/research/departmental-research/cell-molecular-medicine-research/laboratory-joan-o%E2%80%99keefe-phd
My NCBI Bibliography: https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/48815277/?sort=date&direction=descending
My Scopus (Rush University): https://www.scopus.com/authid/detail.uri?authorId=55900937400
My Scopus (Loyola University): https://www.scopus.com/authid/detail.uri?authorId=24290430000
Education: PhD, Loyola University Chicago
Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Cramer LA, Wimmer MA, Malloy P, O'Keefe JA, Knowlton CB, Ferrigno C. Validity and Reliability of the Insole3 Instrumented Shoe Insole for Ground Reaction Force Measurement during Walking and Running. Sensors (Basel). 2022 Mar 11; 22(6). PMID: 35336374.
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Voss S, Zampieri C, Biskis A, Armijo N, Purcell N, Ouyang B, Liu Y, Berry-Kravis E, O'Keefe JA. Normative database of postural sway measures using inertial sensors in typically developing children and young adults. Gait Posture. 2021 10; 90:112-119. PMID: 34438292.
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O'Keefe JA, Guan J, Robertson E, Biskis A, Joyce J, Ouyang B, Liu Y, Carnes D, Purcell N, Berry-Kravis E, Hall DA. The Effects of Dual Task Cognitive Interference and Fast-Paced Walking on Gait, Turns, and Falls in Men and Women with FXTAS. Cerebellum. 2021 Apr; 20(2):212-221. PMID: 33118140.
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O'Keefe JA, Bang D, Robertson EE, Biskis A, Ouyang B, Liu Y, Pal G, Berry-Kravis E, Hall DA. Prodromal Markers of Upper Limb Deficits in FMR1 Premutation Carriers and Quantitative Outcome Measures for Future Clinical Trials in Fragile X-associated Tremor/Ataxia Syndrome. Mov Disord Clin Pract. 2020 Oct; 7(7):810-819. PMID: 33043077.
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Voss S, Joyce J, Biskis A, Parulekar M, Armijo N, Zampieri C, Tracy R, Palmer AS, Fefferman M, Ouyang B, Liu Y, Berry-Kravis E, O'Keefe JA. Normative database of spatiotemporal gait parameters using inertial sensors in typically developing children and young adults. Gait Posture. 2020 07; 80:206-213. PMID: 32531757.
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Hall DA, Robertson EE, Leehey M, McAsey A, Ouyang B, Berry-Kravis E, O'Keefe JA. Open-label pilot clinical trial of citicoline for fragile X-associated tremor/ataxia syndrome (FXTAS). PLoS One. 2020; 15(2):e0225191. PMID: 32053612.
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Gera A, O'Keefe JA, Ouyang B, Liu Y, Ruehl S, Buder M, Joyce J, Purcell N, Pal G. Gait asymmetry in glucocerebrosidase mutation carriers with Parkinson's disease. PLoS One. 2020; 15(1):e0226494. PMID: 31978134.
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Robertson EE, Hall DA, Pal G, Ouyang B, Liu Y, Joyce JM, Berry-Kravis E, O'Keefe JA. Tremorography in fragile X-associated tremor/ataxia syndrome, Parkinson's disease and essential tremor. Clin Park Relat Disord. 2020; 3:100040. PMID: 34316626.
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Purcell NL, Goldman JG, Ouyang B, Liu Y, Bernard B, O'Keefe JA. The effects of dual-task cognitive interference on gait and turning in Huntington's disease. PLoS One. 2020; 15(1):e0226827. PMID: 31910203.
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Purcell NL, Goldman JG, Ouyang B, Bernard B, O'Keefe JA. The Effects of Dual-Task Cognitive Interference and Environmental Challenges on Balance in Huntington's Disease. Mov Disord Clin Pract. 2019 Mar; 6(3):202-212. PMID: 30949551.
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O'Keefe JA, Robertson EE, Ouyang B, Carns D, McAsey A, Liu Y, Swanson M, Bernard B, Berry-Kravis E, Hall DA. Cognitive function impacts gait, functional mobility and falls in fragile X-associated tremor/ataxia syndrome. Gait Posture. 2018 10; 66:288-293. PMID: 30243213.
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Berry-Kravis E, Chin J, Hoffmann A, Winston A, Stoner R, LaGorio L, Friedmann K, Hernandez M, Ory DS, Porter FD, O'Keefe JA. Long-Term Treatment of Niemann-Pick Type C1 Disease With Intrathecal 2-Hydroxypropyl-ß-Cyclodextrin. Pediatr Neurol. 2018 03; 80:24-34. PMID: 29429782.
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Pal G, O'Keefe J, Robertson-Dick E, Bernard B, Anderson S, Hall D. Global cognitive function and processing speed are associated with gait and balance dysfunction in Parkinson's disease. J Neuroeng Rehabil. 2016 10 28; 13(1):94. PMID: 27793167.
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Hall DA, Robertson E, Shelton AL, Losh MC, Mila M, Moreno EG, Gomez-Anson B, Martínez-Cerdeño V, Grigsby J, Lozano R, Hagerman R, Maria LS, Berry-Kravis E, O'Keefe JA. Update on the Clinical, Radiographic, and Neurobehavioral Manifestations in FXTAS and FMR1 Premutation Carriers. Cerebellum. 2016 10; 15(5):578-86. PMID: 27287737.
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O'Keefe JA, Robertson-Dick EE, Hall DA, Berry-Kravis E. Gait and Functional Mobility Deficits in Fragile X-Associated Tremor/Ataxia Syndrome. Cerebellum. 2016 08; 15(4):475-82. PMID: 26298472.
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Robertson EE, Hall DA, McAsey AR, O'Keefe JA. Fragile X-associated tremor/ataxia syndrome: phenotypic comparisons with other movement disorders. Clin Neuropsychol. 2016 Aug; 30(6):849-900. PMID: 27414076.
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Hall DA, Robertson-Dick EE, O'Keefe JA, Hadd AG, Zhou L, Berry-Kravis E. X-inactivation in the clinical phenotype of fragile X premutation carrier sisters. Neurol Genet. 2016 Feb; 2(1):e45. PMID: 27066582.
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O'Keefe JA, Robertson-Dick E, Dunn EJ, Li Y, Deng Y, Fiutko AN, Berry-Kravis E, Hall DA. Characterization and Early Detection of Balance Deficits in Fragile X Premutation Carriers With and Without Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS). Cerebellum. 2015 Dec; 14(6):650-62. PMID: 25763861.
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Hall DA, Birch RC, Anheim M, Jønch AE, Pintado E, O'Keefe JA, Trollor JN, Stebbins GT, Hagerman RJ, Fahn S, Berry-Kravis E, Leehey MA. Erratum: Emerging topics in FXTAS. J Neurodev Disord. 2015; 7(1):13. PMID: 25852777.
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O'Keefe JA, Espinoza Orías AA, Khan H, Hall DA, Berry-Kravis E, Wimmer MA. Implementation of a markerless motion analysis method to quantify hyperkinesis in males with fragile X syndrome. Gait Posture. 2014 Feb; 39(2):827-30. PMID: 24252602.
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Hall DA, O'Keefe JA. Clinical neurogenetics: fragile x-associated tremor/ataxia syndrome. Neurol Clin. 2013 Nov; 31(4):1073-84. PMID: 24176424.
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Hall DA, O'keefe JA. Fragile x-associated tremor ataxia syndrome: the expanding clinical picture, pathophysiology, epidemiology, and update on treatment. Tremor Other Hyperkinet Mov (N Y). 2012; 2. PMID: 23439567.
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Cheng B, Furukawa K, O'Keefe JA, Goodman Y, Kihiko M, Fabian T, Mattson MP. Basic fibroblast growth factor selectively increases AMPA-receptor subunit GluR1 protein level and differentially modulates Ca2+ responses to AMPA and NMDA in hippocampal neurons. J Neurochem. 1995 Dec; 65(6):2525-36. PMID: 7595547.
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O'Keefe JA, Li Y, Burgess LH, Handa RJ. Estrogen receptor mRNA alterations in the developing rat hippocampus. Brain Res Mol Brain Res. 1995 May; 30(1):115-24. PMID: 7609632.
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Handa RJ, Burgess LH, Kerr JE, O'Keefe JA. Gonadal steroid hormone receptors and sex differences in the hypothalamo-pituitary-adrenal axis. Horm Behav. 1994 Dec; 28(4):464-76. PMID: 7729815.
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O'Keefe JA, Pedersen EB, Castro AJ, Handa RJ. The ontogeny of estrogen receptors in heterochronic hippocampal and neocortical transplants demonstrates an intrinsic developmental program. Brain Res Dev Brain Res. 1993 Sep 17; 75(1):105-12. PMID: 8222204.
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Pedersen EB, O'Keefe JA, Handa RJ, Castro AJ. Estrogen receptors are present in neocortical transplants. J Neural Transplant Plast. 1992 Apr-Sep; 3(2-3):135-8. PMID: 1515481.
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O'Keefe JA, Handa RJ. Transient elevation of estrogen receptors in the neonatal rat hippocampus. Brain Res Dev Brain Res. 1990 Dec 01; 57(1):119-27. PMID: 2090365.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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Year | Publications |
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1990 | 1 | 1992 | 1 | 1993 | 1 | 1994 | 1 | 1995 | 2 | 2012 | 1 | 2013 | 2 | 2015 | 2 | 2016 | 5 | 2018 | 2 | 2019 | 1 | 2020 | 7 | 2021 | 1 | 2022 | 1 |
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