Last Name

Ruben Markosyan

TitleAssistant Professor
InstitutionRush University, Rush Medical College
DepartmentPhysiology and Biophysics
Address1750 West Harrison St
Chicago IL 60612
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    Collapse Overview 
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    My Scopus ID is 6604074194.

    Research Areas:
    Viral entry into cells: receptor-mediated fusion of virus to membranes, retroviral fusion in ebola, HIV, SFV and VSV, formation and evolution of fusion pores, mechanisms of insertion of viral proteins into membranes, mechanism for pH- dependence of membrane fusion protein activity, role of transmembrane potential across endosomal membrane for viral fusion, effect of redox potential in the regulation of fusion.

    My Faculty Profile at Rush University Medical Center:

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    PhD, Institute of Physiology, National Academy of Sciences of Armenia
    Master's degree, physics, Yerevan State University, Armenia
    Master's degree, medical cybernetics, Yerevan Polytechnic Institute, Armenia

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Suddala KC, Lee CC, Meraner P, Marin M, Markosyan RM, Desai TM, Cohen FS, Brass AL, Melikyan GB. Interferon-induced transmembrane protein 3 blocks fusion of sensitive but not resistant viruses by partitioning into virus-carrying endosomes. PLoS Pathog. 2019 01; 15(1):e1007532. PMID: 30640957.
      View in: PubMed
    2. Markosyan RM, Miao C, Zheng YM, Melikyan GB, Liu SL, Cohen FS. Induction of Cell-Cell Fusion by Ebola Virus Glycoprotein: Low pH Is Not a Trigger. PLoS Pathog. 2016 Jan; 12(1):e1005373. PMID: 26730950.
      View in: PubMed
    3. Markosyan RM, Cohen FS. The transmembrane domain and acidic lipid flip-flop regulates voltage-dependent fusion mediated by class II and III viral proteins. PLoS One. 2013; 8(10):e76174. PMID: 24124539; PMCID: PMC3790697.
    4. Li K, Markosyan RM, Zheng YM, Golfetto O, Bungart B, Li M, Ding S, He Y, Liang C, Lee JC, Gratton E, Cohen FS, Liu SL. IFITM proteins restrict viral membrane hemifusion. PLoS Pathog. 2013 Jan; 9(1):e1003124. PMID: 23358889; PMCID: PMC3554583.
    5. Markosyan RM, Cohen FS. Negative potentials across biological membranes promote fusion by class II and class III viral proteins. Mol Biol Cell. 2010 Jun 15; 21(12):2001-12. PMID: 20427575.
      View in: PubMed
    6. Markosyan RM, Leung MY, Cohen FS. The six-helix bundle of human immunodeficiency virus Env controls pore formation and enlargement and is initiated at residues proximal to the hairpin turn. J Virol. 2009 Oct; 83(19):10048-57. PMID: 19625396; PMCID: PMC2748045.
    7. Markosyan RM, Kielian M, Cohen FS. Fusion induced by a class II viral fusion protein, semliki forest virus E1, is dependent on the voltage of the target cell. J Virol. 2007 Oct; 81(20):11218-25. PMID: 17686870; PMCID: PMC2045574.
    8. Markosyan RM, Cohen FS, Melikyan GB. Time-resolved imaging of HIV-1 Env-mediated lipid and content mixing between a single virion and cell membrane. Mol Biol Cell. 2005 Dec; 16(12):5502-13. PMID: 16195349.
      View in: PubMed
    9. Mkrtchyan SR, Markosyan RM, Eadon MT, Moore JP, Melikyan GB, Cohen FS. Ternary complex formation of human immunodeficiency virus type 1 Env, CD4, and chemokine receptor captured as an intermediate of membrane fusion. J Virol. 2005 Sep; 79(17):11161-9. PMID: 16103167; PMCID: PMC1193594.
    10. Markosyan RM, Bates P, Cohen FS, Melikyan GB. A study of low pH-induced refolding of Env of avian sarcoma and leukosis virus into a six-helix bundle. Biophys J. 2004 Nov; 87(5):3291-8. PMID: 15339808; PMCID: PMC1304797.
    11. Melikyan GB, Barnard RJ, Markosyan RM, Young JA, Cohen FS. Low pH is required for avian sarcoma and leukosis virus Env-induced hemifusion and fusion pore formation but not for pore growth. J Virol. 2004 Apr; 78(7):3753-62. PMID: 15016895; PMCID: PMC371058.
    12. Borrego-Diaz E, Peeples ME, Markosyan RM, Melikyan GB, Cohen FS. Completion of trimeric hairpin formation of influenza virus hemagglutinin promotes fusion pore opening and enlargement. Virology. 2003 Nov 25; 316(2):234-44. PMID: 14644606.
      View in: PubMed
    13. Abrahamyan LG, Markosyan RM, Moore JP, Cohen FS, Melikyan GB. Human immunodeficiency virus type 1 Env with an intersubunit disulfide bond engages coreceptors but requires bond reduction after engagement to induce fusion. J Virol. 2003 May; 77(10):5829-36. PMID: 12719576; PMCID: PMC154041.
    14. Markosyan RM, Cohen FS, Melikyan GB. HIV-1 envelope proteins complete their folding into six-helix bundles immediately after fusion pore formation. Mol Biol Cell. 2003 Mar; 14(3):926-38. PMID: 12631714.
      View in: PubMed
    15. Markosyan RM, Ma X, Lu M, Cohen FS, Melikyan GB. The mechanism of inhibition of HIV-1 env-mediated cell-cell fusion by recombinant cores of gp41 ectodomain. Virology. 2002 Oct 10; 302(1):174-84. PMID: 12429526.
      View in: PubMed
    16. Markosyan RM, Melikyan GB, Cohen FS. Evolution of intermediates of influenza virus hemagglutinin-mediated fusion revealed by kinetic measurements of pore formation. Biophys J. 2001 Feb; 80(2):812-21. PMID: 11159448; PMCID: PMC1301279.
    17. Melikyan GB, Markosyan RM, Roth MG, Cohen FS. A point mutation in the transmembrane domain of the hemagglutinin of influenza virus stabilizes a hemifusion intermediate that can transit to fusion. Mol Biol Cell. 2000 Nov; 11(11):3765-75. PMID: 11071905.
      View in: PubMed
    18. Melikyan GB, Markosyan RM, Hemmati H, Delmedico MK, Lambert DM, Cohen FS. Evidence that the transition of HIV-1 gp41 into a six-helix bundle, not the bundle configuration, induces membrane fusion. J Cell Biol. 2000 Oct 16; 151(2):413-23. PMID: 11038187; PMCID: PMC2192659.
    19. Markosyan RM, Cohen FS, Melikyan GB. The lipid-anchored ectodomain of influenza virus hemagglutinin (GPI-HA) is capable of inducing nonenlarging fusion pores. Mol Biol Cell. 2000 Apr; 11(4):1143-52. PMID: 10749920.
      View in: PubMed
    20. Melikyan GB, Markosyan RM, Brener SA, Rozenberg Y, Cohen FS. Role of the cytoplasmic tail of ecotropic moloney murine leukemia virus Env protein in fusion pore formation. J Virol. 2000 Jan; 74(1):447-55. PMID: 10590134; PMCID: PMC111556.
    21. Markosyan RM, Melikyan GB, Cohen FS. Tension of membranes expressing the hemagglutinin of influenza virus inhibits fusion. Biophys J. 1999 Aug; 77(2):943-52. PMID: 10423439; PMCID: PMC1300385.
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