 Tissue Plasminogen Activator
"Tissue Plasminogen Activator" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.
| Descriptor ID |
D010959
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| MeSH Number(s) |
D08.811.277.656.300.760.875 D08.811.277.656.959.350.875 D12.776.124.125.662.768 D23.119.970
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| Concept/Terms |
Tissue Plasminogen Activator- Tissue Plasminogen Activator
- Plasminogen Activator, Tissue
- Tissue Activator D-44
- Tissue Activator D 44
- Tisokinase
- Tissue-Type Plasminogen Activator
- Tissue Type Plasminogen Activator
- TTPA
- T-Plasminogen Activator
- T Plasminogen Activator
- Alteplase
- Plasminogen Activator, Tissue-Type
- Plasminogen Activator, Tissue Type
Activase- Activase
- Hoffmann-La Roche Brand of Alteplase
- Hoffmann La Roche Brand of Alteplase
- Genentech Brand of Alteplase
- Alteplase Genentech Brand
Actilyse- Actilyse
- Boehringer Ingelheim Brand of Alteplase
- Lysatec rt-PA
- Lysatec rt PA
- Lysatec rtPA
- Promeco Brand of Alteplase
- Alteplase Promeco Brand
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Below are MeSH descriptors whose meaning is more general than "Tissue Plasminogen Activator".
Below are MeSH descriptors whose meaning is more specific than "Tissue Plasminogen Activator".
This graph shows the total number of publications written about "Tissue Plasminogen Activator" by people in this website by year, and whether "Tissue Plasminogen Activator" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 1 | 0 | 1 | | 1995 | 1 | 0 | 1 | | 1998 | 1 | 0 | 1 | | 2001 | 1 | 0 | 1 | | 2002 | 2 | 1 | 3 | | 2004 | 2 | 0 | 2 | | 2005 | 1 | 0 | 1 | | 2007 | 0 | 1 | 1 | | 2008 | 1 | 0 | 1 | | 2009 | 1 | 1 | 2 | | 2010 | 1 | 0 | 1 | | 2011 | 2 | 4 | 6 | | 2012 | 3 | 0 | 3 | | 2013 | 2 | 2 | 4 | | 2014 | 2 | 3 | 5 | | 2015 | 3 | 4 | 7 | | 2016 | 3 | 1 | 4 | | 2017 | 2 | 1 | 3 | | 2018 | 3 | 0 | 3 | | 2019 | 1 | 2 | 3 | | 2020 | 4 | 0 | 4 | | 2021 | 1 | 2 | 3 | | 2022 | 0 | 2 | 2 |
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Below are the most recent publications written about "Tissue Plasminogen Activator" by people in Profiles.
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Lee VH, Howell R, Yadav R, Heaton S, Wiles KL, Lakhani S. Thrombolysis of stroke mimics via telestroke. Stroke Vasc Neurol. 2022 06; 7(3):267-270.
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Edigin E, Ojemolon PE, Eseaton PO, Shaka H, Akuna E, Asemota IR, Manadan A. Rheumatoid Arthritis Patients Have Better Outcomes Than Non-Rheumatoid Arthritis Patients When Hospitalized for Ischemic Stroke: Analysis of the National Inpatient Sample. J Clin Rheumatol. 2022 Jan 01; 28(1):e13-e17.
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Rech MA, Donahey E, DeMott JM, Coles LL, Peksa GD. The impact of antihypertensive use in the treatment of acute ischemic stroke in patients receiving alteplase. Am J Emerg Med. 2021 12; 50:93-96.
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Boyanpally A, Cutting S, Furie K. Acute Ischemic Stroke Associated with Myocardial Infarction: Challenges and Management. Semin Neurol. 2021 08; 41(4):331-339.
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Edigin E, Kaul S, Eseaton PO, Ojemolon PE, Patel A, Manadan A. Psoriasis does not worsen outcomes in patients admitted for ischemic stroke: an analysis of the National Inpatient Sample. J Investig Med. 2021 06; 69(5):994-998.
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Gopal M, Lakhani S, Lee VH. Intravenous Thrombolysis in Acute Ischemic Stroke Patients with Unsuspected Infective Endocarditis. J Stroke Cerebrovasc Dis. 2021 Mar; 30(3):105502.
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Yakhkind A, Lang AE, Montalvo M, Beland MD, Cutting S. Gastrointestinal Angioedema as a Side Effect of Alteplase for Acute Stroke. J Vasc Interv Radiol. 2020 11; 31(11):1921-1924.
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Lee VH, Thakur G, Nimjee SM, Youssef PP, Lakhani S, Heaton S, Powers CJ. Early neurologic decline in acute ischemic stroke patients receiving thrombolysis with large vessel occlusion and mild deficits. J Neurointerv Surg. 2020 Nov; 12(11):1085-1087.
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Agarwal S, Scher E, Lord A, Frontera J, Ishida K, Torres J, Rostanski S, Mistry E, Mac Grory B, Cutting S, Burton T, Silver B, Liberman AL, Lerario MP, Furie K, Grotta J, Khatri P, Saver J, Yaghi S. Redefined Measure of Early Neurological Improvement Shows Treatment Benefit of Alteplase Over Placebo. Stroke. 2020 04; 51(4):1226-1230.
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Agarwal S, Cutting S, Grory BM, Burton T, Jayaraman M, McTaggart R, Reznik M, Scher E, Chang AD, Frontera J, Lord A, Rostanski S, Ishida K, Torres J, Furie K, Yaghi S. Redefining Early Neurological Improvement After Reperfusion Therapy in Stroke. J Stroke Cerebrovasc Dis. 2020 Feb; 29(2):104526.
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