Lymphocytes with cytotoxic activity induce rapid microtubule axonal destabilization independently and before signs of neuronal death.
Miller NM, Shriver LP, Bodiga VL, Ray A, Basu S, Ahuja R, Jana A, Pahan K, Dittel BN. Lymphocytes with cytotoxic activity induce rapid microtubule axonal destabilization independently and before signs of neuronal death. ASN Neuro. 2013 Feb 06; 5(1):e00105.
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Animals
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Axons
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Bacterial Proteins
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CD4-Positive T-Lymphocytes
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Cell Death
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Cells, Cultured
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Culture Media, Conditioned
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Cytokines
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Embryo, Mammalian
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Encephalomyelitis, Autoimmune, Experimental
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Granzymes
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In Situ Nick-End Labeling
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Killer Cells, Natural
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Luminescent Proteins
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Lymphocytes
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Mice
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Mice, Inbred C57BL
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Mice, Transgenic
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Microscopy, Confocal
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Microtubules
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Models, Biological
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Myelin Basic Protein
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Neurons
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Perforin
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Th1 Cells
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Th17 Cells