TDP-43 Proteinopathies
"TDP-43 Proteinopathies" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Diseases characterized by the presence of abnormally phosphorylated, ubiquitinated, and cleaved DNA-binding protein TDP-43 in affected brain and spinal cord. Inclusions of the pathologic protein in neurons and glia, without the presence of AMYLOID, is the major feature of these conditions, thus making these proteinopathies distinct from most other neurogenerative disorders in which protein misfolding leads to brain amyloidosis. Both frontotemporal lobar degeneration and AMYOTROPHIC LATERAL SCLEROSIS exhibit this common method of pathogenesis and thus they may represent two extremes of a continuous clinicopathological spectrum of one disease.
Descriptor ID |
D057177
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MeSH Number(s) |
C10.574.950 C18.452.845.800
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Concept/Terms |
TDP-43 Proteinopathies- TDP-43 Proteinopathies
- Proteinopathies, TDP-43
- Proteinopathy, TDP-43
- TDP 43 Proteinopathies
- TDP-43 Proteinopathy
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Below are MeSH descriptors whose meaning is more general than "TDP-43 Proteinopathies".
Below are MeSH descriptors whose meaning is more specific than "TDP-43 Proteinopathies".
This graph shows the total number of publications written about "TDP-43 Proteinopathies" by people in this website by year, and whether "TDP-43 Proteinopathies" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2014 | 0 | 1 | 1 | 2015 | 3 | 0 | 3 | 2016 | 2 | 0 | 2 | 2017 | 1 | 2 | 3 | 2018 | 1 | 0 | 1 | 2019 | 4 | 1 | 5 | 2020 | 5 | 0 | 5 | 2021 | 4 | 1 | 5 | 2022 | 1 | 0 | 1 | 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "TDP-43 Proteinopathies" by people in Profiles.
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Oveisgharan S, Yu L, Agrawal S, Nag S, Bennett DA, Buchman AS, Schneider JA. Relation of Motor Impairments to Neuropathologic Changes of Limbic-Predominant Age-Related TDP-43 Encephalopathy in Older Adults. Neurology. 2023 Oct 10; 101(15):e1542-e1553.
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Tazwar M, Evia AM, Tamhane AA, Ridwan AR, Leurgans SE, Bennett DA, Schneider JA, Arfanakis K. Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is associated with lower R2 relaxation rate: an ex-vivo MRI and pathology investigation. Neurobiol Aging. 2022 09; 117:128-138.
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Dugan AJ, Nelson PT, Katsumata Y, Shade LMP, Teylan MA, Boehme KL, Mukherjee S, Kauwe JSK, Hohman TJ, Schneider JA, Fardo DW. Association between WWOX/MAF variants and dementia-related neuropathologic endophenotypes. Neurobiol Aging. 2022 03; 111:95-106.
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Agrawal S, Yu L, Nag S, Arfanakis K, Barnes LL, Bennett DA, Schneider JA. The association of Lewy bodies with limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes and their role in cognition and Alzheimer's dementia in older persons. Acta Neuropathol Commun. 2021 09 25; 9(1):156.
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Buchman AS, Yu L, Oveisgharan S, Farfel JM, Schneider JA, Bennett DA. Person-Specific Contributions of Brain Pathologies to Progressive Parkinsonism in Older Adults. J Gerontol A Biol Sci Med Sci. 2021 03 31; 76(4):615-621.
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Agrawal S, Yu L, Kapasi A, James BD, Arfanakis K, Barnes LL, Bennett DA, Nag S, Schneider JA. Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change and microvascular pathologies in community-dwelling older persons. Brain Pathol. 2021 05; 31(3):e12939.
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Kapasi A, Yu L, Stewart C, Schneider JA, Bennett DA, Boyle PA. Association of Amyloid-? Pathology with Decision Making and Scam Susceptibility. J Alzheimers Dis. 2021; 83(2):879-887.
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Yu L, Schneider JA, Kapasi A, Bennett DA, Boyle PA. Limbic-predominant Age-related TDP-43 Encephalopathy and Distinct Longitudinal Profiles of Domain-specific Literacy. Alzheimer Dis Assoc Disord. 2020 Oct-Dec; 34(4):299-305.
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Nag S, Barnes LL, Yu L, Wilson RS, Bennett DA, Schneider JA. Limbic-predominant age-related TDP-43 encephalopathy in Black and White decedents. Neurology. 2020 10 13; 95(15):e2056-e2064.
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Kapasi A, Yu L, Boyle PA, Barnes LL, Bennett DA, Schneider JA. Limbic-predominant age-related TDP-43 encephalopathy, ADNC pathology, and cognitive decline in aging. Neurology. 2020 10 06; 95(14):e1951-e1962.
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