"Tubulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A microtubule subunit protein found in large quantities in mammalian brain. It has also been isolated from SPERM FLAGELLUM; CILIA; and other sources. Structurally, the protein is a dimer with a molecular weight of approximately 120,000 and a sedimentation coefficient of 5.8S. It binds to COLCHICINE; VINCRISTINE; and VINBLASTINE.
| Descriptor ID |
D014404
|
| MeSH Number(s) |
D05.750.078.734.800 D12.776.220.600.800 D12.776.631.920
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Tubulin".
Below are MeSH descriptors whose meaning is more specific than "Tubulin".
This graph shows the total number of publications written about "Tubulin" by people in this website by year, and whether "Tubulin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 2 | 2 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 3 | 3 |
| 2004 | 0 | 3 | 3 |
| 2007 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Tubulin" by people in Profiles.
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Clinical relevance of lung-restricted antibodies in lung transplantation. Hum Immunol. 2019 Aug; 80(8):595-601.
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The role of Runx2 in facilitating autophagy in metastatic breast cancer cells. J Cell Physiol. 2018 Jan; 233(1):559-571.
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The zebrafish fleer gene encodes an essential regulator of cilia tubulin polyglutamylation. Mol Biol Cell. 2007 Nov; 18(11):4353-64.
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Critical role of the atypical {lambda} isoform of protein kinase C (PKC-{lambda}) in oxidant-induced disruption of the microtubule cytoskeleton and barrier function of intestinal epithelium. J Pharmacol Exp Ther. 2005 Feb; 312(2):458-71.
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Early changes in Huntington's disease patient brains involve alterations in cytoskeletal and synaptic elements. J Neurocytol. 2004 Sep; 33(5):517-33.
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Theta-isoform of PKC is required for alterations in cytoskeletal dynamics and barrier permeability in intestinal epithelium: a novel function for PKC-theta. Am J Physiol Cell Physiol. 2004 Jul; 287(1):C218-34.
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Zeta isoform of protein kinase C prevents oxidant-induced nuclear factor-kappaB activation and I-kappaBalpha degradation: a fundamental mechanism for epidermal growth factor protection of the microtubule cytoskeleton and intestinal barrier integrity. J Pharmacol Exp Ther. 2003 Oct; 307(1):53-66.
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Increases in free radicals and cytoskeletal protein oxidation and nitration in the colon of patients with inflammatory bowel disease. Gut. 2003 May; 52(5):720-8.
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The delta-isoform of protein kinase C causes inducible nitric-oxide synthase and nitric oxide up-regulation: key mechanism for oxidant-induced carbonylation, nitration, and disassembly of the microtubule cytoskeleton and hyperpermeability of barrier of intestinal epithelia. J Pharmacol Exp Ther. 2003 May; 305(2):482-94.
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PKC-zeta prevents oxidant-induced iNOS upregulation and protects the microtubules and gut barrier integrity. Am J Physiol Gastrointest Liver Physiol. 2002 Oct; 283(4):G909-22.