"Microglia" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The third type of glial cell, along with astrocytes and oligodendrocytes (which together form the macroglia). Microglia vary in appearance depending on developmental stage, functional state, and anatomical location; subtype terms include ramified, perivascular, ameboid, resting, and activated. Microglia clearly are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. They have also been suggested to act in several other roles including in secretion (e.g., of cytokines and neural growth factors), in immunological processing (e.g., antigen presentation), and in central nervous system development and remodeling.
| Descriptor ID |
D017628
|
| MeSH Number(s) |
A08.637.400 A11.650.400
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Microglia".
Below are MeSH descriptors whose meaning is more specific than "Microglia".
This graph shows the total number of publications written about "Microglia" by people in this website by year, and whether "Microglia" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 1998 | 2 | 2 | 4 |
| 2000 | 3 | 0 | 3 |
| 2001 | 2 | 0 | 2 |
| 2002 | 2 | 0 | 2 |
| 2003 | 2 | 1 | 3 |
| 2004 | 2 | 1 | 3 |
| 2005 | 1 | 0 | 1 |
| 2006 | 0 | 2 | 2 |
| 2007 | 2 | 2 | 4 |
| 2008 | 6 | 2 | 8 |
| 2009 | 2 | 1 | 3 |
| 2011 | 0 | 1 | 1 |
| 2012 | 1 | 2 | 3 |
| 2013 | 0 | 2 | 2 |
| 2014 | 1 | 0 | 1 |
| 2015 | 0 | 3 | 3 |
| 2016 | 2 | 3 | 5 |
| 2017 | 2 | 1 | 3 |
| 2018 | 3 | 1 | 4 |
| 2019 | 2 | 1 | 3 |
| 2020 | 7 | 1 | 8 |
| 2021 | 3 | 3 | 6 |
| 2022 | 0 | 1 | 1 |
| 2023 | 0 | 4 | 4 |
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Below are the most recent publications written about "Microglia" by people in Profiles.
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Induction of IL-2 by interleukin-12 p40 homodimer and IL-12, but not IL-23, in microglia and macrophages: Implications for multiple sclerosis. Cytokine. 2024 Feb; 174:156457.
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Dissecting the human leptomeninges at single-cell resolution. Nat Commun. 2023 11 03; 14(1):7036.
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Tau fibrils induce glial inflammation and neuropathology via TLR2 in Alzheimer's disease-related mouse models. J Clin Invest. 2023 09 15; 133(18).
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Activation of PPARa Exhibits Therapeutic Efficacy in a Mouse Model of Juvenile Neuronal Ceroid Lipofuscinosis. J Neurosci. 2023 03 08; 43(10):1814-1829.
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A prebiotic diet modulates microglial states and motor deficits in a-synuclein overexpressing mice. Elife. 2022 11 08; 11.
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The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick type C. Sci Transl Med. 2021 12; 13(622):eabg2919.
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Microglial Correlates of Late Life Physical Activity: Relationship with Synaptic and Cognitive Aging in Older Adults. J Neurosci. 2022 01 12; 42(2):288-298.
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Selective targeting of the TLR2/MyD88/NF-?B pathway reduces a-synuclein spreading in vitro and in vivo. Nat Commun. 2021 09 10; 12(1):5382.
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Epigenomic features related to microglia are associated with attenuated effect of APOE e4 on Alzheimer's disease risk in humans. Alzheimers Dement. 2022 04; 18(4):688-699.
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A novel tau-based rhesus monkey model of Alzheimer's pathogenesis. Alzheimers Dement. 2021 06; 17(6):933-945.